Histotripsy is a non-thermal, non-invasive, focused ultrasound ablation method that uses acoustic cavitation to mechanically break down tissues [1-8]. Histotripsy is heavily dependent on the mechanical properties of the tissue, allowing it to mechanically ablate tissues of lower mechanical stiffness while preserving the stiffer critical structures [15]. However, the mechanical properties of clinically relevant abdominal tissues and critical structures have not yet been adequately quantified under uniform testing parameters. Previous studies have tested and modeled the tissue selectivity of histotripsy, but these studies have been limited by the lack of mechanical property data available for these tissue types. In addition, there remains a need for additional experimental studies directly comparing the differential treatment doses required to induce histotripsy tissue damage in intra-abdominal tissue types. This thesis investigates the mechanical properties of intra-abdominal tissues under uniaxial tension, the effect of histotripsy treatment dose on intra-abdominal soft tissues and critical structures, and the potential of inducing damage to critical structures along the acoustic path pre-focal to the targeted histotripsy treatment. Results show that there are significant differences between the parenchymal tissues (liver, kidney) and the critical structure (stomach, gallbladder, small intestine, ducts, and vessels) elastic modulus, yield stress, yield strain, post-yield strain, energy to yield, and maximum stress and strain at yield. In general, histology analysis from the histotripsy experiments showed that there was an increase in tissue damage with increasing histotripsy pulses/point for all tissues. Critical structures with higher mechanical strength were more resistant to ablation compared to tissues with lower mechanical strength. Pre-focal studies showed damage to gallbladder and small intestine only in cases in which pre-focal cavitation was observed, while no damage occurred in skin and stomach for any samples treated at varying distances from the bubble cloud. Overall, this work improves our understanding of tissue selectivity of histotripsy and provides mechanical properties measurements for clinically relevant tissues that can be used to improve predictive models of tissue-selective histotripsy treatments. This work can be used in the planning of histotripsy treatments to establish proper margins of safety for treating intra-abdominal tumors. / Master of Science / Histotripsy is a non-invasive cancer treatment that mechanically breaks down tissues by rapidly forming and bursting bubbles within the tumor [1-8]. Histotripsy is heavily dependent on the mechanical properties of the tissue, allowing it to destroy weaker tissues while preserving the stiffer tissues in the surrounding area [15]. The mechanical properties of clinically relevant intra-abdominal tissues have not been quantified under uniform testing parameters. Previous studies have tested and modeled the tissue selectivity of histotripsy, but these studies have been limited by the mechanical property data available. This thesis investigates the mechanical properties of intra-abdominal tissues under tension, the effect of histotripsy treatment dose on intra-abdominal tissue damage, and the damage to critical structures from histotripsy treatment at varying distances from the tissue. Results show that there are significant differences between the liver and kidney mechanical stiffness and strength compared to the other tissues. In general, histology analysis showed that there is an increase in tissue damage with increasing histotripsy dose. Tissues with higher mechanical strength were more resistant to damage at lower doses compared to tissues with lower mechanical strength. Histotripsy damage to critical structures that are along the beam path, set distances in front of the focal point of the cavitation bubble cloud was studied. This study showed damage to gallbladder and small intestine only in cases in which pre-focal cavitation, cavitation bubbles that are not within the focal point of the cloud but are in contact with the tissue, was observed, while no damage occurred in skin and stomach for any samples treated at varying distances from the bubble cloud. Overall, this work improves our understanding of tissue selectivity of histotripsy and provides mechanical properties for clinically relevant tissues that can be used to improve predictive models of tissue-selective histotripsy treatments. This work can be used in the planning of histotripsy treatments to establish proper margins of safety for treating intra-abdominal tumors.

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The study was performed at Billerudkorsnäs at the section Box Lab which offers knowledge and solutions for packaging. Paper that can be used to create packaging interacts with the surrounding environment, but has only been tested for a few climates. This thesis aims to investigate more climates and see how paper is affected by humidity and temperature and try to determine the cause of the results. The methods used to measure this was primary tensile test and moisture content analysis but also a test to evaluate creep was performed in climates with high humidity. From this, the mechanical properties of the paper were calculated. The test was performed in a climate chamber and the choice of methods was limited by what could be performed in the climate chamber. The materials tested were chosen to give a good representation of what is commonly used in the containerboard business. The climates for testing were selected from the ability of the climate chamber as well as interesting climates for the company. The results show that the papers are weakest at high RH, but the results indicate that the temperature solely impacts the properties of the paper. The highest moisture content does not necessarily mean the lowest value for a chosen property. The causes for the results are not clear since the patterns found are not bound to a certain quality but rather to paper in general. Therefore, more research on the area is suggested to try to determine what causes the material to react to temperature.

Composites have high strength-to-weight ratios, which is particularly desired for applications with weight restrictions. Common composite materials such as carbon fiber reinforced plastic (CF) and fiber glass reinforced plastic (FG) were used in this research. While composite materials possess high stiffness and strength properties, the stiffness of composite laminates may be maximized by changing the geometry. By adding corrugations, the flexural stiffness is increased in one direction compared to the stiffness of a flat part with the same amount of material. Thus, stiffness increases without a change in weight. The primary goal of this research was to investigate the stiffness characteristics of corrugated composite laminates under tensile and flexural load. The chosen corrugation geometry for investigation was a trapezoid. To observe the effects of corrugations, both flat and corrugated coupons were tested experimentally with the same procedures. Stiffness was calculated experimentally, analytically, and numerically in both directions. In this study, the longitudinal direction was defined as perpendicular to the corrugations and transverse direction was defined as the direction along the corrugations. The effects on stiffnesses of corrugated and flat composites were measured by comparing changes to the stiffness ratios in tension and bending. The stiffness ratio is the ratio of longitudinal stiffness to transverse stiffness. The secondary aim of this research was to compare the corrugation effects on FG weave and cross-ply CF. This was interesting to observe the difference in corrugation effects on different composite materials. The FG laminates were manufactured from four plies of pre-impregnated Cytec MXB 7701/7781. The CF laminate consisted of five plies of pre-impregnated unidirectional Tencate TC250/M46J. The layup orientation of the CF laminate had alternating 0◦ and 90◦ plies, where the 0 ◦ plies were in the transverse direction. Plies were directly laid on a flat plate and aluminum mold for flat and corrugated specimens, respectively. All flat and corrugated composites were cured in an autoclave under respective recommended cure cycles for each material. The tension and three-point bend tests were conducted on an Instron 8800 where the load was applied at a rate of 0.05 inches per minute. The tensile ultimate load was the same between corrugated and flat specimens in the longitudinal direction. Meanwhile, the tensile ultimate load was greatly reduced for corrugated specimens in the transverse direction when compared to the flat specimens. Thus, corrugations had a larger impact in the transverse direction under tensile load for both materials. By corrugating the composite layups, the ratio of stiffness in the longitudinal to extensional direction increases. For FG test coupons, the extensional stiffness ratio was increased from 1.0 to 49.3 due to corrugations. The flexural stiffness ratio was increased from 0.3 to 187.1 in corrugated FG coupons. For CF test coupons, the extensional stiffness ratio increased from 0.7 to 61.3. The flexural stiffness ratio of CF test coupons increased from 0.3 to 81.4. Corrugations had a greater effect on the cross-ply CF for both extensional and flexural stiffnesses.

The objectives of this research were to evaluate the sensitivity of indirect tensile strength (ITS) test results to stabilizer type, stabilizer concentration, and curing time for multiple clayey soils with varying plasticity indices (PIs), identify cases in which an ITS of 30 psi can be obtained, and create a general linear model that predicts ITS. The scope of work included laboratory testing of three clayey soils sampled from Monticello, Utah; Bloomington, Indiana; and San Antonio, Texas. Each soil was tested using two stabilizers, cement or lime, at three concentrations, and two replicate samples were prepared for each combination. ITS testing was performed on two specimens of each combination at curing times of both 7 days and 28 days, for a total of 72 tests. The procedures outlined in this study include soil characterization, determination of moisture-density relationships, Eades and Grim testing, soil preparation, soil compaction, ITS testing, and statistical analysis. Regarding stabilizer type, treatment with cement consistently yielded higher ITS values than treatment with lime. Regarding stabilization concentration, ITS consistently increased with increasing concentrations of cement for all three soils; however, the effect of lime concentration depended on the PI of the soil, where increasing ITS values were only apparent with higher PI values. Regarding curing time, the ITS values corresponding to 28 days were generally higher than those corresponding to 7 days. Differences in ITS among the soils were largely attributable to differences in PI, which can influence pozzolanic reactivity. A cement or lime concentration that was equal to or 2% above the lime concentration indicated by the Eades and Grim test was typically required for a minimum 28-day ITS value of 30 psi to be attained. For the model developed to predict ITS, the significant predictor variables included PI, stabilizer type, actual stabilizer concentration, and curing time, as well as the two-way interactions between PI and stabilizer type, PI and actual stabilizer concentration, PI and curing time, and stabilizer type and actual stabilizer concentration. Overall, the model has an R2 value of 0.943 and an adjusted R2 value of 0.936. The model is best suited for soils having a fines content greater than 50%, a PI greater than 20, and a soluble sulfate concentration less than 3000 ppm.

Moisture damage in asphalt pavement has always been a problem for drivers, bicyclists, and pedestrians. The primary objective of this study is to evaluate moisture susceptibility of Hot-Mix Asphalt (HMA) and to investigate mitigation techniques using different antistripping agents. Three types of antistripping agents were used in this research investigation. Two of which are chemical based and the other is hydrated lime. The two types of liquid antistripping agents used in this study include Arr Maz CC LOF-6500 and Arr Maz CC XL-9000. These two liquid antistripping agents were tested at 0.25%, 0.50%, and 0.75%. Hydrated Lime was tested at 1.0%, 1.5%, and 2.0%. The binder used in this study is Asphalt Performance Grade (PG) 64-16 provided by Oxnard Refinery. The crushed stone aggregate used in this study was provided by Cal Portland. This study follows the guidelines of standardized AASHTO, ASTM, and SuperPave mix design for all preparation and test procedures. A total of 120 4-inch by 2.83-inch core specimens with void ratios between 6 to 8 percent were created to test for moisture susceptibility in accordance with the Modified Lottman Test, which tested for Indirect Tensile Strength and Immersion Compression Test, which tested for Compression Strength and Elasticity. During the test, half of these specimens were placed in a hot water bath for 24 hours to condition the sample to represent field performance and the other half were unconditioned. Based on the results, the best liquid antistripping agent is XL-9000 at 0.50% and hydrated lime is most efficient at a dosage rate of 1.5%. The best performing antistripping additive for the value is hydrated lime at 1.5%.

Three different polymers (a high-density polymer and two other polymers) were tested for use as an x-ray catheter in a radiation therapy application. This report describes the testing of these three materials to determine which material is the best option for a long use catheter. Tests included tensile, simulated clinical life, and other tests. Some testing was performed using nitrogen and an industrial coolant. Testing revealed significant non-circularities for some catheters. With increasing pressure, the circularity of these catheters increased. The tensile tests were performed on samples with varying doses of radiation. Tensile testing showed significant decreases in ultimate tensile strength with increasing radiation dose for both polyurethanes. Other testing was performed on the two polyurethanes to determine their compatibility with the industrial coolant. The test showed good compatibility with the coolant. Simulated clinical life tests were performed on a test fixture and with software to run the radiation source automatically for several hours at a time. Overall, one material was found to have very low ductility, made lower with increasing radiation. The material with the higher ductility was chosen as the better catheter material despite some disadvantages when compared to the stiffer polymer. This report describes necessary tests for thin polymer geometries used in applications where resistance to radiation, mechanical integrity, and coolant compatibility are the main considerations.

Composite materials are extensively used as an advanced engineering material, particularly in aerospace, automotive, and buildings industries due to its superior properties such as high strength to weight ratios and resistance to corrosion. As composite materials are rapidly replacing traditional materials in aircraft manufacturing, improved methods of identifying damage and critical failure is in development. One of the most commonly used procedures utilizes a health monitoring system that relies on transducers to monitor transmitted waves generated by ultrasonics. By replacing this method with a nanotechnology-based one, it is possible to efficiently detect damage without the time-extensive process of scanning the structure. This research investigated the development of a nanomaterial-based sensor for health monitoring of composite structures. To develop the sensor, carbon nanotube/epoxy mixture (2%wt CNT) was coated on a strand of E-glass fibre to be adhered onto a fiberglass composite specimen. The selection of E-glass fibre and fibreglass plate was largely due to its electrical insulating properties to demonstrate that the carbon nanotube is driving the sensing capabilities through its highly conductive nature. In addition, by adhering the coated E-glass fiber to a fibreglass coupon, the homogeneity and material properties were approximately maintained. Tensile testing of the specimen conducted through a Lloyd LD50 tensile testing machine provided data on the actual strain which was correlated with the experimental differential resistances measured by a multimeter, both at the same specified tensile loading conditions. With two sets of data, the experimental resistance data was calibrated with the actual strain data collected. Ultimately, the experimental sensors created a sample of gauge factors which represents 91.24% probability of replicating the observed range of gauge factors by using the same manufacturing procedures, providing a valid alternative and consistent method to detecting composite damage.

Yes / Tensile properties of powder metallurgy 3% manganese-0·8% carbon (content of green compact) steels were determined following laboratory sintering in (nearly) full, semiclosed containers with no getter powders in dry, 0-100% hydrogen-nitrogen atmospheres. Manganese was mixed with the NC 100·24 sponge iron powder as low carbon ferromanganese and carbon as a graphite addition. Dogbone compacts were pressed at 660 MPa, the sintering temperatures were 1120 and 1250°C and cooling rates ∼65 K min- 1. In specimens sintered in nitrogen containing atmospheres at 1120°C, final carbon content was ∼0·7% and for those processed at 1250°C ∼0·6%. Sintering in dry hydrogen resulted in lower carbon and oxygen contents. Independent of the H2/N2 ratio in the furnace atmosphere, however, all the specimens were ductile and exhibited similar strengths. Yield strengths R 0·2 were in the range: 426-464 MPa, tensile strengths Rm were 724-780 MPa and strains to failure were 1·6-2·0% after sintering at 1250°C. The 1120°C sintering temperature resulted in 10-15% lower strength values. The microstructures, significantly devoid of oxide networks, comprised mainly mixtures of bainite and fine (divorced) pearlite, with very little martensite and retained austenite. Reproducibly successful sintering of manganese containing compacts requires that reduction conditions exist at the sintering temperature. Ellingham Richardson diagrams dictate that the dewpoints of hydrogen required are-55 and-40°C at 1120 and 1250°C, respectively. A semiclosed container, how ever, ensures a different microclimate. It is suggested that then the initial relevant reactions there are: Mn[vapour]+H2O=MnO+H2, 3Fe2O3 +H2= 2Fe3O4+H2O, Fe3O4+H2=3FeO+H2O, FeO+H2= Fe+H2O and C+O2=CO2, which provide hydrogen andwater vapour,also within the pores. The manganese vapour further acts as a ‘shield’ by generating further hydrogen from the water vapour. The following reactions involving carbon monoxide are postulated above 927°C, when CO is a more effective reducing agent than hydrogen: C+H2O=H2+CO, 3Fe2O3+ CO=2Fe3O4+CO2, Fe3O4+CO=3FeO+CO2, FeO+CO=Fe+CO2 and C+CO2=2CO. Accordingly, irrespective of whether it is hydrogen or nitrogen in the semiclosed container, if there is a supply of carbon, reducing conditions prevail at the sintering temperature,embrittling oxidenetworks arenot formed and ductile manganese steels are processed.