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The study of the reciprocating internal combustion engine is of prime importance to the student engineer. In our present civilization, the number of units and the total rated power of internal combustion engines in use is far greater than that of all other prime movers combined. Many basic engineering problems are present in the study of the operation of internal combustion engines. A number of mechanical and electrical devices have been developed to aid the engineer in his studies of engine performance. The purpose of this project is to provide the Mechanical Engineering Department of the North Dakota State University with an addition to its laboratory facilities which will enable the student to do additional experimental work in the internal combustion engines field. / North Dakota State University (NDSU)

Medical examination is the use of modern physical and chemical methods, laboratory technology, medical equipment for clinical diagnosis and treatment, provide a reference. In vitro diagnostic medical devices (IVD) known as the medical testing equipment in addition to early and accurate diagnosis, as well as effective monitoring of patient treatment. "Medical Technology" is a very professional industry knowledge and application of the medical laboratory is through the manufacturers to develop transferred to the medical practitioners, industrial and information technology improved rapidly in recent years, resulting in the medical inspection of product innovation; as knowledge economy era, the diversification of customer needs, business risk increases, more intense market competition, companies want to stand out in a competitive environment, it is necessary to construct their own core competence in order to create competitive advantage. Operators to think about how to find, identify the core competitiveness of the way, helping the enterprise training, consolidation, application and conversion of the core competitiveness in order to obtain sustainable competitive advantage. In this study, on the one hand through literature, to understand the definition of the core competence, type and resolution; the other hand, the AHP method, defined in accordance with the core competence of literature, characteristics, and characteristics of the industry of medical testing equipment industry made the questionnaire,expert questionnaire, and a successful visit to the case of high-end decision-making management of mid-level management and senior grassroots cadres of 20 experts, to discuss the company's core competence of medical testing equipment. According to the results: the core competence of the medical testing equipment industry in order (1) after-sales service, (2) professional and executive power, (3) high-end quality of decision making, (4) Product Marketing, (5) Management capabilities, (6) network capacity, (7) human Resource Management, (8) product competence, (9) organizational culture, (10) logistics Management, (11) Brand / goodwill (12) market coverage.

This thesis solves problems of design and construction of testing equipment for testing lubricants for deep drawing and experimental evaluation of suitability of different types of lubricants for specified tests conditions. Most of all it is about finding environmentally friendly lubricant which would provide similar results as lubricants containing chlorine compounds when drawing a stainless austenitic Cr-Ni steel 1.4301. As for lubricants provided for testing by leading home and abroad manufacturers, the ATLAS 3374-140 from Quaker Chemical and the WISURA ZW 3356 from FUCHS, were evaluated as the most suitable environmentally friendly lubricants.

Thesis (MSc) -- Stellenbosch University, 2003. / ENGLISH ABSTRACT: Software testing tools simplify and automate the menial work associated with testing. Moreover, for complex concurrent software such as computer protocols, testing tools allow testing on an abstract level that is independent of specific implementations. Standard conformance testing methodologies and a number of testing tools are commercially available, but detailed descriptions of the implementation of such testing tools are not widely available. This thesis investigates the development of a tool for automated protocol testing in the ETH Oberon development environment. The need to develop a protocol testing tool that automates the execution of specified test cases was identified in collaboration with a local company that develops protocols in the programming language Oberon. Oberon is a strongly typed secure language that supports modularisation and promotes a readable programming style. The required tool should translate specified test cases into executable test code supported by a runtime environment. A test case consists of a sequence of input actions to which the software under test is expected to respond by executing observable output actions. A number of issues are considered of which the first is concerned with the representation of test case specifications. For this, a notation was used that is basically a subset of the test specification language TTCN-3 as standardised by the European Telecommunications Standards Institute. The second issue is the format of executable test cases and a suitable runtime environment. A translator was developed that generates executable Oberon code from specified test cases. The compiled test code is supported by a runtime library, which is part of the tool. Due to the concurrent nature of a protocol environment, concurrent processes in the runtime environment are identified. Since ETH Oberon supports multitasking in a limited sense, test cases are executed as cooperating background tasks. The third issue is concerned with the interaction between an executing test case and a system under test. It is addressed by an implementation dependent interface that maps specified test interactions onto real interactions as required by the test context in which an implementation under test operates. A supporting protocol to access the service boundary of an implementation under test remotely and underlying protocol service providers are part of a test context. The ETH Oberon system provides a platform that simplifies the implementation of protocol test systems, due to its size and simple task mechanism. Operating system functionality considered as essential is pointed out in general terms since other systems could be used to support such testing tools. In conclusion, directions for future work are proposed. / AFRIKAANSE OPSOMMING: Toetsstelsels vir programmatuur vereenvoudig en outomatiseer die slaafse werk wat met toetsing assosieer word. 'n Toetsstelsel laat verder toe dat komplekse gelyklopende programmatuur, soos rekenaarprotokolle, op 'n abstrakte vlak getoets word, wat onafhanklik van spesifieke implementasies is. Daar bestaan standaard metodes vir konformeringstoetsing en 'n aantal toetsstelsels is kommersiëel beskikbaar. Uitvoerige beskrywings van die implementering van sulke stelsels is egter nie algemeen beskikbaar nie. Hierdie tesis ondersoek die ontwikkeling van 'n stelsel vir outomatiese toetsing van protokolle in die ontwikkelingsomgewing van ETH Oberon. Die behoefte om 'n protokoltoetsstelsel te ontwikkel, wat die uitvoering van gespesifiseerde toetsgevalle outomatiseer, is geïdentifiseer in oorleg met 'n plaaslike maatskappy wat protokolle ontwikkel in die Oberon programmeertaal. Oberon is 'n sterkgetipeerde taal wat modularisering ondersteun en a leesbare programmeerstyl bevorder. Die toestsstelsel moet gespesifiseerde toetsgevalle vertaal na uitvoerbare toetskode wat ondersteun word deur 'n looptydomgewing. 'n Toetsgeval bestaan uit 'n reeks van toevoeraksies waarop verwag word dat die programmatuur wat getoets word, sal reageer deur die uitvoering van afvoeraksies wat waargeneem kan word. 'n Aantal kwessies word aangeraak, waarvan die eerste te make het met die voorstelling van die spesifikasie van toetsgevalle. Hiervoor is 'n notasie gebruik wat in wese 'n subversameling van die toetsspesifikasietaal TTCN-3 is. TTCN-3 is gestandardiseer deur die European Telecommunications Standards Institute. Die tweede kwessie is die formaat van uitvoerbare toetsgevalle en 'n geskikte looptydomgewing. 'n Vertaler is ontwikkel wat uitvoerbare Oberon-kode genereer vanaf gespesifiseerde toetsgevalle. Die vertaalde toetskode word ondersteun deur 'n biblioteek van looptydfunksies, wat deel van die stelsel is. As gevolg van die eienskap dat 'n protokolomgewing uit gelyklopende prosesse bestaan, word daar verskillende tipes van gelyklopende prosesse in 'n protokoltoetsstelsel geïdentifiseer. Aangesien ETH Oberon 'n beperkte multitaakstelsel is, word toetsgevalle vertaal na eindige outomate wat uitgevoer word as samewerkende agtergrondtake. Die derde kwessie het te make met die interaksie tussen 'n toetsgeval wat uitgevoer word en die stelsel wat getoets word. Dit word aangespreek deur 'n koppelvlak wat gespesifiseerde interaksies afbeeld op werklike interaksies soos vereis deur die konteks waarin 'n implementasie onderworpe aan toetsing uitvoer. 'n Ondersteunende protokolom die dienskoppelvlak van die implementasie oor 'n afstand te bereik en ander onderliggende protokoldienste is deel van 'n toetskonteks. Die ETH Oberon-stelsel help in die vereenvoudiging van die implementasie van protokol toetsstelsels, as gevolg van die stelsel se grootte en die eenvoudige taakhanteerder . Die essensiële funksionaliteit van bedryfsstelsels word uitgelig in algemene terme omdat ander stelsels gebruik kan word om toetsstelsels te ondersteun. Ten slotte word voorstelle vir opvolgwerk gemaak.

Dieser Vortrag stellt einen neuartigen Prüfstand vor, mit welchem das Chip & Cut Verhalten von Elastomeren charakterisiert werden kann. Sowohl theoretischer Hintergrund als auch praktische Erkenntnisse werden diskutiert. Die Vorstellung der Praxisrelevanz dieser Untersuchungen steht im Fokus des Vortrags.

Thesis (PhD (Pathology. Medical Microbiology))--University of Stellenbosch, 2009. / ENGLISH ABSTRACT: Due to modern high-throughput technologies, large numbers of compounds are produced by parallel synthesis and combinatorial chemistry. The pharmaceutical industry therefore requires rapid and accurate methods to screen new drugs leads for membrane permeability potential in the early stages of drug discovery. Around 50 % of all investigational new drugs fail in pre-clinical and clinical phases of development due to inadequate absorption/permeation, distribution, metabolism, excretion and/or unacceptable toxicity. This may be decreased by applying in vitro screening methods early in the discovery process. Reliable in vitro models can be applied to determine permeation of the test compounds, which will help avoid the wasting of valuable resources for the development of drugs that are destined to fail in preclinical and clinical phases due to insufficient permeability properties. It is important to decide as early as possible on the most promising compound and physical formulation for the intended route of administration. With awareness of the increasing importance of in vitro models in the investigations of the permeability properties of drug compounds, this research project was specifically devoted to determine the suitability of our in vitro model to evaluate and predict drug permeability. A continuous flow-through diffusion system was employed to evaluate the permeability of nine different compounds/drugs with different chemical properties, across three biological membranes. The biological membranes chosen for the present study were human vaginal mucosa, human skin tissue and human small intestine mucosa. The continuous flow-through diffusion system was furthermore utilised to investigate the effects of de-epithelialisation of mucosal surfaces, chemical enhancers, temperature, permeant concentration and formulation on the permeability of the test compounds/drugs. The in vitro permeability information and data from the flow-through diffusion model were compared to in vitro and in vivo literature studies and drug profile. An in vitro model that is able to reliably predict in vivo data will shorten the drug development period, economise resources and may potentially lead to improved product quality. In this thesis research results are reported on the permeability of the mentioned biological membranes to the various chemical markers, including anti-HIV (human immunodeficiency virus) drugs. The permeability studies will be discussed in three sections: vaginal mucosa, skin tissue, small intestine mucosa. The results of the vaginal permeability studies showed that the three peptides (MEA- 5, MDY-19 and PCI) readily penetrated the vaginal mucosa. MDY-19 had a higher flux rate than MEA-5, commensurate with its smaller molecular size (weight). The surfactant enhanced the flux rate of MDY-19 approximately 1.3 times and decreased the lag time of the peptide. Removal of the vaginal epithelium increased the flux rates of the peptides across the mucosa and may have implications for a more rapid uptake of these and other microbicides in vivo. The permeability of 1 mM MDY-19 and PCI at 37 °C were significantly (p<0.05) higher than at 20 °C. At 37 °C the AUCs of the overall mean flux values of MDY-19 and PCI increased with concentration according to well-established diffusion theory. The experiments on the permeability of different terbinafine hydrochloride formulations through human skin demonstrated that the terbinafine hydrochloride formulations used in this study, readily diffused into the skin tissue. However, no flux values for any of the terbinafine hydrochloride formulations through the skin into the acceptor fluid were found. The mean terbinafine concentrations in the skin after 24 h exposure to the three commercial, terbinafine hydrochloride formulations were 3.589, 1.590 and 4.219 μg/ml respectively. The mean terbinafine concentration in the skin exposed to the 10 mg/ml PBS/Methanol solution was higher than those from the three commercial formulations. The results of the temperature study demonstrated that an increase of 5 ºC caused a significant increase in flux values of tritiated water across skin. The flux values for tritiated water across skin at 37 ºC were on average double those at a temperature of 32 ºC. The permeability of excised human small intestine mucosa to different oral dosage drugs was investigated over a 24 h period. The four drugs selected were zidovudine, propranolol hydrochloride, didanosine and enalapril maleate. They were selected as representative model compounds of drug classes 1 (high solubility, high permeability) and 3 (high solubility, low permeability) according to the Biopharmaceutics Classification System. The flux rates of the four chosen test drugs were influenced by the length of the experiment. Between the time periods 2-4 h and 4-6 h, zidovudine’s mean flux values across small intestine tissue were respectively 1.8 and 2.0 times higher than didanosine and 2.3 and 2.2 times higher than enalapril. Propranolol’s mean flux values were respectively 1.2 and 1.4 times higher than didanosine and 1.6 higher than enalapril during both the 2-4 and 4-6 h time periods. Between both the time periods 2-4 and 4-6 h AZT’s mean flux values were 1.4 times higher than propranolol and didanosine’s mean flux values were respectively 1.3 and 1.1 times higher than enalapril during the mentioned time periods. Class 1 drugs showed a significantly higher flux rate across the jejunal mucosa compared to the class 3 drugs and these results are in line with their Biopharmaceutics Classification System classification. The in vitro model has proved to be reliable to predict permeability of class 1 and 3 drugs and also showed correlation with human in vivo data. It seems that the in vitro flow-through diffusion model used in the present study have the potential to overcome some of the problems and limitations demonstrated by other in vitro techniques and may potentially serve as a future tool for pharmaceutical companies to predict the diffusion characteristics of new drugs and different formulations, across different biological membranes. Furthermore, it may serve as a prospective method for assessing the bioequivalence of alternative (generic) vehicles or formulations containing the same drug/compound. / AFRIKAANSE OPSOMMING: As gevolg van moderne hoë spoed tegnologie kan groot hoeveelhede middels vervaardig word deur ooreenkomende sintese en kombinasieleer chemie. Die farmaseutiese industrie benodig dus vinnige en akkurate metodes om nuwe geneesmiddels te evalueer t.o.v. membraan deurlaatbaarheid. Hierdie evaluasie moet verkieslik so vroeg moontlik in die geneesmiddel se ontwikkelingsproses geskied. Ongeveer 50 % van alle potensiële geneesmiddels misluk in pre-kliniese en kliniese fases van geneesmiddelontwikkeling. Die mislukte pogings kan toegskryf word aan onvoldoende absorbsie/deurlaatbaarheid, distribusie, metabolisme, ekskresie en/of onaanvaarbare middel toksisiteit. Dit is daarom belangrik om so vroeg moontlik in die geneesmiddelontwikkelingsproses te besluit op die mees belowende middel, asook die geskikte formulasie vir die spesifieke roete van toediening van die middel. Die farmaseutiese industrie benodig tans in vitro modelle met die potensiaal om die deurlaatbaarheid van geneesmiddels te bepaal en te voorspel. Betroubare in vitro modelle kan aangewend word om die deurlaatbaarheid van potensiële geneesmiddels te toets. Sodoende sal die onnodige uitgawes op die ontwikkkeling van geneesmiddels wat in elk geval later gaan faal in pre-kliniese en kliniese fases van geneesmiddelproewe a.g.v. deurlaatbaarheidseienskappe, vermy word. Hierdie navorsingsprojek was dus spesifiek onderneem om die waarde en toepaslikheid van ‘n in vitro deurlopende-vloei perfusie model te ondersoek. Die model se potensiaal om geneesmiddels se deurlaatbaarheid en absorpsie te voorspel was geëvalueer. Die deurlopende-vloei perfusie apparaat was gebruik om die deurlaatbaarheidsvloede van drie verskillende biologiese membrane t.o.v. nege chemiese stowwe (MEA-5, MDY-19, PCI, terbinafien hidrochloried, getritieerde water, zidovudien, propranolol, hidrochloried, didanosien, enalapril maleaat) te bepaal. Die drie biologiese membrane wat gebruik was, was vaginale weefsel, vel en klein intestinale weefsel. Al drie weefsel tipes was van menslike oorsprong. Die deurlopende-vloei perfusie apparaat was ook gebruik om die effek wat verwydering van die mukosa se epiteellaag op deurlaatbaarheidsvloede het, te ondersoek. Verder was navorsing gedoen op die effek van temperatuur en die konsentrasie en formulasie van die toetsmiddels op hulle diffusie vloedwaardes. Daar was ook gekyk na die invloed van ander chemiese stowwe op die toetsmiddels se diffusie vloedwaardes. Die in vitro deurlaatbaarheidsinformasie en -gegewens was vergelyk met ander in vitro en in vivo literatuurstudies en geneesmiddel databasisse. ‘n In vitro model wat in staat is om in vivo resultate betroubaar te voorspel, het die potensiaal om die tyd wat dit neem om geneesmiddels te ontwikkel, te verkort, finansiële uitgawes te besnoei en om geneesmiddelkwaliteit te verseker. In die tesis word dan die resultate gerapporteer van die deurlaatbaarheidsvloede van die verskillende tipes weefsel ten op sigte van verskeie chemiese stowwe, insluitende anti-MIV (menslike immuniteitsgebreksvirus) middels. Die deurlaatbaarheidstudies word bespreek in drie afdelings: vaginale mukosa, vel en klein intestinale mukosa. Die resultate van die deurlaatbaarheidstudies op die vaginale weefsel dui daarop dat die drie peptiede (MEA-5, MDY-19 and PCI) die vaginale mukosa goed penetreer. Soos verwag, het MDY-19 hoër diffusie vloedwaardes as MEA-5 gehad. Dit kan toegeskryf word aan MDY-19 se kleiner molekulere grootte (gewig). Surfaktant het die diffusie vloedwaardes van MDY-19 1.3 keer vergroot en het ook die tyd na vaste vlak verminder. Die verwydering van die vaginale epiteel het die diffusie vloedwaardes van die peptiede verhoog en mag dus dui op die vinniger opname van peptiede en moontlike ander mikrobisiede in vivo, wanneer die belyning van die epiteel onderbreek. Die deurlaatbaarheid van 1 mM MDY-19 en PCI by 37 °C was satisties beduidend (p<0.05) hoer as teem 20 °C. Die area onder die kurwe (AOK) van die gemiddelde vloedwaardes van MDY-19 en PCI by 37 °C, het toegeneem met ‘n toename in die konsentrasie van hierdie peptiede. Die toename vloedwaardes ondersteun dus die alombekende diffusie teorie. Die transdermale diffusie eksperimente van verskillende terbinafien formulasies het getoon dat terbinafien geredelik vrygestel word vanuit hierdie formulasies na die vel. Geen terbinafien vloedwaardes, van enige van die formulasies, was egter gevind in die ontvangselle van die deurlopende-vloei perfusie apparaat nie. Die gemiddelde terbinafien konsentrasies in die vel na 24 h se blootstelling aan drie kommersiële terbinafien hidrochloried formulasies was onderskeidelik 3.589, 1.590 en 4.219 μg/ml. Die gemiddelde terbinafien konsentrasie in die vel wat aan 10 mg/ml PBS/metanol blootgestel was, was hoër as die konsentrasies in die vel wat aan die drie kommersiële formulasies blootgestel was. Die resultate van die temperatuurstudie op vel het aangetoon dat ‘n temperatuur toename van 5 ºC ‘n statisties beduidende toename in vloedwaardes van getritieerde water oor vel veroorsaak. Die vloedwaardes van die getritieerde water oor vel teen ‘n temperatuur van 37 ºC was gemiddeld dubbeld so veel as teen 32 ºC. Die deurlaatbaarheidsvloede van klein intestinale mukosa ten opsigte van verskillende geneesmiddels (wat oraal toegedien word) was ondersoek gedurende ‘n 24 h eksperiment. Die vier geneesmiddels wat gebruik was, was zidovudine, propranolol hidrochloried, didanosien en enalapril maleaat. Hierdie geneesmiddels is verteenwoordigers van die Biofarmaseutiese Klassifikasie Sisteem se klas 1 (hoë oplosbaarheid, hoë deurlaatbaarheid) en klas 3 (hoë oplosbaarheid, lae deurlaatbaarheid) geneesmiddels. Die vloedwaardes van die vier geneesmiddels het gewissel na aanleiding van die tydsverloop in die eksperiment. Zidovudien se gemiddelde vloedwaardes tussen 2-4 en 4-6 h was onderskeidelik 1.8 en 2.0 keer hoër as didanosien se gemiddelde vloedwaardes vir hierdie tyd periodes en onderskeidelik 2.3 en 2.2 keer hoër as enalapril se gemiddelde vloedwaardes. Tydens hierdie selfde periodes was propranolol se gemiddelde vloedwaardes 1.2 en 1.4 keer hoër as didanosien en vir beide periods 1.6 keer hoër as enalapril se gemiddelde vloedwaardes. Gedurende beide genoemde tyd periodes was zidovudien se gemiddelde vloedwaardes 1.4 keer hoer as propranolol en didanosien se gemiddelde vloedwaardes was onderskeidelik 1.3 en 1.1 keer hoër as enalapril tydens 2-4 en 4-6 h. Die klas 1 geneesmiddels het statisties beduidende hoër vloedwaardes gehad as die klas 3 geneesmiddels. Hierdie resultate stem ooreen met die geneesmiddels se Biofarmaseutiese Klassifikasie Sisteem klassifikasie. Dit wil dus voorkom asof die in vitro model wat gebruik was in die studie, gebruik kan word om die deurlaatbaarheidsvloede van klas 1 en 3 te voorspel. Die resultate van hierdie studie stem ooreen met ander in vivo studies. Dit wil voorkom asof die in vitro deurlopende-vloei perfusie apparaat die potensiaal het om sommige van die probleme en tekortkominge van ander in vitro modelle te oorkom en dat dit moontlik die potensiaal het om die diffusie-eienskappe van nuwe geneesmiddels en verskillende formulasies oor verskillende biologiese membrane te voorspel. Die model kan verder moontlik dien as ‘n potensiële toestel om biogelykbaarheid van alternatiewe (generiese) formulasies, wat dieselfde geneesmiddel/chemiese stof bevat, te bepaal.

Aus der Einführung: "Dräger ist ein international führendes Unternehmen der Medizin- und Sicherheitstechnik. Das 1889 in Lübeck gegründeten Familienunternehmen besteht in der fünften Generation und hat sich zu einem globalen börsennotierten Konzern entwickelt. „Technik für das Leben“ ist die Leitidee des Unternehmens. Ob im Operationsbereich, auf der Intensivstation, bei der Feuerwehr oder im Rettungsdienst: Dräger-Produkte schützen, unterstützen und retten Leben. Dräger bietet seinen Kunden unter anderem Anästhesie-Arbeitsplätze, Beatmungsgeräte für die Intensiv- und Notfallmedizin, Patientenmonitoring sowie die medizinische Versorgung von Frühchen und Neugeborenen. Mit Deckenversorgungseinheiten, IT-Lösungen für den OP und Gasmanagementsystemen steht das Unternehmen seinen Kunden im gesamten Krankenhaus zur Seite. Feuerwehren, Rettungsdienste, Behörden und die Industrie vertrauen auf das ganzheitliche Gefahrenmanagement von Dräger, insbesondere für den Personen- und Anlagenschutz. Dazu gehören: Atemschutzausrüstungen, stationäre und mobile Gasmesssysteme, professionelle Tauchtechnik sowie Alkohol- und Drogenmessgeräte. Darüber hinaus entwickelt Dräger gemeinsam mit seinen Kunden maßgeschneiderte Lösungen wie komplette Brandübungsanlagen, Trainingskonzepte und Schulungen. ..."

The thesis deals with the design of automated testing equipment of selected types of pneumatic valves. The problem of manual control process is its inefficiency, both in terms of human error rate and time loss caused by further assembly. The automated manual inspection process eliminates the problem. In the theoretical part, the types of switchgear are described, selected measuring procedures and methods of measurement are described. In the practical part, the measuring procedure was set out and on the basis of it there were designed variants of the testing machine and test circuit. The conclusion of the thesis contains evaluation of the whole project.