In educational research, a prevalent topic of discussion is African-centered pedagogy. This phenomenological study records the unique perspectives of adults who specifically grew up in African-centered learning environments from a young age. The sample includes 10 African American adults, aged 18-45, from various cities in the United States. Mixed methods are applied in this study: group concept mapping strategies are implemented to yield both qualitative and quantitative results for analysis. Data is further supplemented with one-on-one interviews, and a review of themes from interview transcripts using multiple coding processes. Findings from this particular demographic can add another dimension to the current literature on the relevancy and need for culturally relevant pedagogical practice for African-American children. The ultimate goal of this generative study is to serve as a resource for educators, parents and students – which includes documented practices and methods for further consideration and application.

The clathrin-independent endosomal system is required for cellular homeostasis and specialized modifications of the plasma membrane such as cell spreading and polarization. Clathrin-independent endocytosis (CIE) has been demonstrated in adherent cells including fibroblasts and epithelial cells. However, non-adherent cells also have highly dynamic clathrin-independent pathways, which have not been well described. Here, I have characterized Arf6-associated clathrin-independent endocytosis (CIE) in the human T cell line Jurkat and identified it's importance in immunological synapse formation. Our findings indicate that the CIE pathway is similar in Jurkat cells as compared to other cell types including rates of endocytosis and sorting after internalization. Two GTPases, Arf6 and Rab22, have been shown to regulate the clathrin-independent endosomal system and play a role in cell spreading. We found that wild type and constitutively active Arf6 co-localized with CIE cargo in resting T cells. Arf6 constitutively active mutant inhibited CIE cargo internalization but not internalization of CME cargo. Rab22 co-localized with CIE cargo at the endocytic-recycling compartment. Expression of the dominant negative Rab22 mutant also inhibited internalization of MHCI indicating it plays a direct role in CIE cargo internalization. T cells must modify their membranes to specifically interact with antigen presenting cells. To establish the role of CIE in this process, we then examined the role of Arf6 and Rab22 in T cell/antigen presenting cell conjugate formation. Both expression of dominant negative or constitutively active mutants of Arf6 reduced T cell conjugate formation while expression of only the Rab22 dominant negative mutant inhibited T cell/APC conjugate formation. Furthermore, T cells expressing the dominant negative mutant of Rab22 were not able to spread on antibody-coated coverslips that normally cause T cell activation. These results indicate that the clathrin independent endosomal system is required for membrane remodeling events necessary for T cell conjugate formation and T cell spreading during activation. I also conducted a proteomics screen to identify binding partners of CIE cargo proteins. I identified multiple proteins that could possibly play a role in CIE internalization and discovered a subset of proteins that specifically interact with A cargo proteins and not B cargo proteins. It is possible they could play a role in cargo retention at the plasma membrane or sorting after internalization. Three proteins of interest that interact with A cargo include NHERF-1 and ezrin, which participate in actin arrangements, and Dlg-1, a known scaffolding protein for synaptic vesicles. Ezrin and Dlg-1 co-localize with the CIE cargo protein CD98 in HeLa cells indicating that they could be interacting in cells.

This contribution presents an operating strategy for a novel valve structure for mobile machines’ working hydraulics which combines the flexibility and energetic benefits of individual metering with the functionality of common primary pressure compensation (IPC). The aim is to set up a system that uses a minimal amount of sensors and simple control algorithms. A control strategy theoretically described in /1/ is modified to facilitate the practical implementation on a mini excavator implement as a test rig. This test rig consists only of components that are currently available off-the-shelf to show that it is possible to develop an individual metering system under these economic restrictions. The novel is more energy efficient than common flow sharing systems but provides the same functionality. The control algorithm is experimentally evaluated in terms of functionality and energy consumption. Simulations show potential for further improvements.

As intelligent hydraulic systems with embedded sensors become more ubiquitous, the real or perceived reliability challenge associated with sensors must be addressed to encourage their adoption. In this paper, a fault-tolerant control strategy for an intelligent independent metering valve that allows continued operation if a sensor fails is described. The twin-spool valve example utilizes position sensors to stabilize the spool positions and eliminate hysteresis, and pressure sensors to provide digital pressure compensation, electronic load sensing, and other features. An independent metering valve has redundancy provided by four sensors working together to control the flow into and out of a single actuator. Although two sensors are needed to control the flow through a spool, the controller can be reconfigured to ensure the flow is always controlled on the spool with both sensors working. To accomplish this, the concept of cross-port pressure control is introduced that uses the faulty side of the valve to maintain constant pressure on the non-faulty side. By maintaining a constant pressure, the flow in and out of the actuator are balanced. Experimental results on the boom of a backhoe demonstrate the operation of the fault tolerant control strategy.

International Telemetering Conference Proceedings / October 30-November 02, 1995 / Riviera Hotel, Las Vegas, Nevada / Two retrodirective antenna systems that autonomously point high gain beams to a signal source without requiring a priori knowledge of location are described. The first is a stationary phased array requiring no phase shifters or switches for its operation. The second is a steerable platform with a thinned receive array for signal acquisition and platform pointing and dish(es) to satisfy the high gain function.

This thesis sheds light on the social relationships, work practices and identities that shape the small scale sector of independent game production. Harnessing elements of the Production of Culture and Cultural Industries/Work perspectives, it aims to clarify the specifics of independent game production and its relationship with the large-scale sector of the industry. Drawing on a multi-sided ethnography, the thesis captures gamework practices, motivations, ideas and conventions deployed in a diverse range of online and physical spaces where independent developers interact. Given the complex relationships and messiness found in the industry, the results of the thesis initially clarify general aspects, characterising both the corporate structure of the games industry and its independent sector. It then examines the cultures that inform independent work as well as emergent 'indie' praxis. After a historical review of the digital games industry, the thesis addresses how the corporate structure of the industry has created a viable game producing field, with a highly rationalised but not unproblematic process of game production. The independent sector is then analysed in relation to this material culture. The thesis discusses the technologic affordances, structural relationships, market approach and organisational forms supporting the production of independent games. It also examines the motivations, ethics and general culture informing independent developers work, as well as the emergence of independent networked scenes as social spaces where creative, organisational, technical and cultural aspects of independent game production are shaped. The analysis of empirical evidence reveals how the uneven struggle to control or access the means for game production, distribution and reproduction, in both retail and digital distribution business models, shapes the material conditions of the small scale sector game production. The thesis highlights the relationship between production, independent developers' preferences, and their identity as 'indies' as central in understanding how this novel sector of the games industry is being structured. By understanding both the structure and informal practices of independent production, this research offers novel insights in this under-researched area, insights that reveal the intricacies of processes of social change and cultural diversification within the digital games industry as a whole.

The aim of this research was to investigate the structures and processes of pharmacist prescribing in Great Britain, focusing on primary care settings. A ‘sequential-mixed methods’ was employed in the conduct of the research. The first phase was a cross-sectional postal questionnaire of all pharmacist prescribers (n= 1654 in January 2009), to quantify the extent and nature of prescribing and key factors associated with prescribing practice. Response rate was 42.3% (n=695). The pharmacy practice setting was significantly associated with prescribing (those in hospital or general medical practice were more likely to have prescribed (p< 0.05), than respondents in community practice). Factor analysis of attitudinal statements on prescribing implementation revealed factors, grouped as: ‘administrative structures and processes’, ‘perceptions of pharmacists’ prescribing role’ and ‘facilities for prescribing’. Scores for ‘facilities for prescribing’ varied depending on practice setting. Respondents in community practice recorded lower median scores compared with those in general medical practices. However, there were no statistically significant differences in median scores between respondents based in GP and hospital settings. In-depth qualitative work undertaken in the second phase further explored facilitators of, and challenges to prescribing practice (e.g. the lack of defined prescribing roles) identified in phase one. Semi-structured interviews were conducted with a purposive sample of 34 prescribers. Prescribers were selected from diverse settings, including secondary care from England and Scotland, to highlight key factors contributing to prescribing success which could potentially inform extrapolations of successful practice from one setting to the other. The ‘framework’ approach to qualitative data analysis was rigorously applied, revealing that the professional isolation and issues around access to clinical data and administrative support in the community setting may have negatively impacted on prescribing implementation. Notably, a perceived lack of clarity and definition of the pharmacist prescribing role was a key theme in hindering prescribing practice of pharmacists irrespective of setting. Participants described ‘ideal’ roles which they perceived as potentially providing clarity, definition and direction to facilitate implementation. The original data generated through this research highlights that prescribing implementation is less than desired, especially in community pharmacies. Pharmacist prescribing appears to have progressed little since supplementary prescribing developments in 2004, even with the much heralded arrival of independent prescribing in 2006. Interestingly, phase 2 participants suggested a ‘hybrid supplementary/independent’ prescribing model, as more likely to succeed. In this model, pharmacist prescribers favour a cooperative practice arrangement in which doctors diagnose and pharmacists prescribe. The implication of these findings and specific recommendations for policy makers, other key stakeholders and practitioners are discussed in detail within the thesis.

published_or_final_version / abstract / Linguistics / Master / Master of Arts in Applied Linguistics

Our thesis work focuses on Frequency-domain Blind Source Separation (BSS) in which the received mixed signals are converted into the frequency domain and Independent Component Analysis (ICA) is applied to instantaneous mixtures at each frequency bin. Computational complexity is also reduced by using this method. We also investigate the famous problem associated with Frequency-Domain Blind Source Separation using ICA referred to as the Permutation and Scaling ambiguities, using methods proposed by some researchers. This is our main target in this project; to solve the permutation and scaling ambiguities in real time applications / Gozie: modebelu2001@yahoo.com Anayo: ezeudea@yahoo.com

In recent years, judicial elections have undergone a transformation: races once characterized by low levels of competition, interest and participation are now comparable, in some states, to races for governor or senator. Elections for the bench as a whole are now more expensive, competitive and politicized than ever before. Arguably the most influential change in the last ten years has been the emergence of independent expenditures by political action committees and other groups in races for seats on state supreme courts. Despite the growth of this type of spending, our understanding of independent expenditures is rather limited, as the distinction between independent expenditures and direct contributions to candidates is rarely made clear.I address this in this dissertation by examining the patterns of independent spending in states with elected supreme courts. In doing so, I develop a theoretical framework to explain the decision of individual groups to support a judicial candidate independently. I argue that this decision is shaped largely by the campaign regulations imposed on judicial candidates and their potential supporters. Expectations from this theory are tested throughout the remainder of the dissertation using an original set of data drawn directly from state disclosure records. I find that independent expenditures have been concentrated in only a few states in recent years and that campaign regulations are influential in shaping this aggregate behavior. Contribution limits, in particular, redirect money from candidates' campaigns to independent expenditures. This is particularly significant due to the unique nature of judicial elections and the role of a judge in American politics. The results of the statistical and case study analyses should give pause to participants in the normative debates regarding campaign finance and judicial reform as they suggest that regulations can have unintended, but important consequences.