No description available.

Thesis--Zürich. / Vita. Includes bibliographical references (p. 300-307).

Thesis (M.S.)--University of Wisconsin - Madison. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 75-80).

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My thesis will discuss British Romantic period author and philanthropist Hannah More. I aim to portray her from a perspective that demonstrates her compelling and varying nature, that includes religion and rhetoric as persuasive tools met at times with resistance and at other times compliance. Her work called for educational reform on two accounts: firstly, for a system of education for the poor, and secondly, to reeducate middle and upper class women’s philanthropy. I focus on her didactic literature, namely Cheap Repository Tracts, and the prevalence of her Evangelical zeal embedded in the tracts. I draw particular attention to the stories of The Shepherd of Salisbury Plain, Black Giles the Poacher, and Betty Brown, the St. Giles’s Orange Girl. I argue that traditional understandings of didactic narratives as a low form of literature are misleading and that More’s work exemplifies didactic fiction as a form of literature capable of empowering readers and authors alike. Furthermore, I study the social function aspects of Cheap Repository Tracts as they demonstrated a newfound accessibility to a large and varying audience.

My thesis will discuss British Romantic period author and philanthropist Hannah More. I aim to portray her from a perspective that demonstrates her compelling and varying nature, that includes religion and rhetoric as persuasive tools met at times with resistance and at other times compliance. Her work called for educational reform on two accounts: firstly, for a system of education for the poor, and secondly, to reeducate middle and upper class women’s philanthropy. I focus on her didactic literature, namely Cheap Repository Tracts, and the prevalence of her Evangelical zeal embedded in the tracts. I draw particular attention to the stories of The Shepherd of Salisbury Plain, Black Giles the Poacher, and Betty Brown, the St. Giles’s Orange Girl. I argue that traditional understandings of didactic narratives as a low form of literature are misleading and that More’s work exemplifies didactic fiction as a form of literature capable of empowering readers and authors alike. Furthermore, I study the social function aspects of Cheap Repository Tracts as they demonstrated a newfound accessibility to a large and varying audience.

Texte remanié de: Diss.--Philosophische Fakultät--Bonn--Friedrich-Wilhelms-Universität, 1993.

Thesis (MsCMedSc)--Stellenbosch University, 2012. / ENGLISH ABSTRACT: The gastrointestinal morphology and the distribution of the different types of mucin secreting goblet cells were investigated in three mammalian insectivorous species, namely A. spinosissimus, C. cyanea and A. hottentotus. The aim of the study was to provide a comprehensive morphological comparison between the different species. Another aim was to illustrate and compare the distribution of mucins (neutral, sulfo- and sialomucins) in the gastrointestinal tracts (GITs) of these species, in order to better understand the quality of the biofilm in the GIT. Mucins secreted onto the surface of the GIT have an effect on the colonisation of microflora in the mucosal layer, constructing a biofilm which protects the GIT surface from opportunistic pathogens. The shape, proportional length, and proportional surface areas of the different gastrointestinal regions were recorded and compared in the three species. Histochemical staining methods were used to detect and to distinguish between neutral, sulfo- and sialomucins. The number of goblet cells in the GIT containing each of the above mucins in the epithelium lining the surface or crypts was quantified, and the data expressed as the number of neutral, sulfo- or sialomucin containing goblet cells per mm2 of the surface or crypt epithelium. In all three species the stomach was uncompartmentalised. The internal aspect of the stomach in A. spinosissimus was hemi-glandular, containing stratified squamous epithelium in the fundus, with glandular epithelium in the body and pyloric region. However, C. cyanea and A. hottentotus had wholly glandular stomachs. A. spinosissimus was the only species studied that had a caecum which demonstrated transverse mucosal folds and V-shaped mucosal folds in the proximal colon. Both C. cyanea and A. hottentotus had villi up to the distal part of the GIT. Longitudinal mucosal folds were present in the distal colon. The GITs of both C. cyanea and A. hottentotus showed little morphological differentiation namely a simple, glandular stomach and the lack of a caecum. Mixed (neutral and acid) mucins and mixed acid (sulfo- and sialomucins) mucin secreting goblet cells were prominent mucin cell types in all three mammalian insectivorous species. Despite these general similarities, marked differences were observed in the qualitative expression and distribution of the three types of mucins throughout the GIT. The overall similarity between the three insectivores and other distantly related mammalian species suggests that mixed mucin secreting goblet cell types are prominent contributors to the maintenance of the intestinal biofilm in the majority of mammals, irrespective of their diet or taxonomy. / AFRIKAANSE OPSOMMING: Die bestudering van die morfologie van die spysverteringskanaal (SVK) en die verspreiding van die verskillende musien produserende bekerselle was in drie insek-etende soogdier spesies uitgevoer, naamlik in A. spinosissimus, C. cyanea en A. hottentotus. Die doel van die studie was om „n omvattende morfologiese vergelyking te maak tussen die drie spesies, sowel as om die verspreiding van die verskillende musiene te beskryf in die SVK. Kennis van die verspreiding van die verskillende tipes musiene (neutral, sulfaat en nie-sulfaat bevattende musiene) kan moontlik inligting verskaf aangaande die kwaliteit van die biofilm in the SVK. Die laasgenoemde musiene wat gesekreteer word op die oppervlak van die SVK, bepaal die kolonisasie van die mikroflora in die mukosale laag wat „n biofilm vorm en die SVK beskerm teen patogene. Die vorm, proportionele lengte en proportionele oppervlaks areas van die verskillende SVK gebiede is opgeteken, waarna dit vergelyk is tussen die drie insektivore spesies. Histochemiese kleurings tegnieke is gebruik om die musiene waar te neem en om te onderskei tussen die neutraal, sulfaat en nie-sulfaat bevattende musiene. Die aantal beker selle wat elk van die bogenoemde musiene bevat het, is getel in die oppervlaks epiteel- en kript areas van die SVK. Hierdie data is weergegee as die aantal neutraal, sulfaat en nie-sulfaat bevattende beker selle per oppervlaks epiteel- of kript area (mm2). Die vorm van die maag in al drie spesies was eenvoudig en nie gekompartementaliseer nie. Die interne aspek van die maag in A. spinosissimus het meerlagige plaveisel epiteel in die fundus gehad en klieragtige epiteel in die liggaam en pilorus gedeeltes. Daarbenewens het C. cyanea en A. hottentotus slegs klieragtige epiteel in die maag gehad. A. spinosissimus was die enigste spesie in hierdie studie wat „n sekum gehad het met dwars voue, asook V-vormige mukosale voue in die proksimale kolon. Beide C. cyanea en A. hottentotus het villi tot in die distale gedeelte van die SVK gehad. Longitudinale mukosale voue was teenwoordig in die distale gedeelte van die kolon. Die SVK van beide C. cyanea en A. hottentotus het min morfologiese differensiasie getoon deurdat die spesies „n eenvoudige, klieragtige maag gehad het en geen sekum nie. Gemenge (neutral en suur) musiene asook gemengde suur (sulfaat en nie-sulfaat bevattende) musiene was die dominante musien tipes in the SVK van al drie insek-etende soogdier spesies. Ten spyte van die algemene ooreenkomste, was daar merkwaardige verskille in die getalle en verspreiding van die verskillende musiene in die SVK. Die algemene ooreenkomste tussen die drie insektivore soogdier spesies met soogdiere van ander families, stel voor dat die gemende musien sekreterende beker selle „n prominente bydrae maak tot die onderhoud van die biofilm in the SVK in die meerderheid van soogdiere, ongeag van hul dieet of spesie klassifikasie.

L'imagerie IRM permet d'observer les principaux faisceaux de fibres de substance blanche dans le cerveau. Cette imagerie offre de nombreuses applications potentielles pour mieux comprendre le développement du cerveau sain et pathologique ou pour étudier l'impact de substances thérapeutiques. Pour observer ces fibres, il faut combiner une acquisition IRM bien maitrisée aujourd'hui avec une procédure de traitement de données qui est encore le sujet de différents projets de recherche. Pour caractériser ces fibres qui ne font que quelques microns de diamètre, il faut porter la résolution spatiale de l'IRM au-delà de la résolution spatiale d'acquisition. Pour obtenir cette super-résolution, il a été proposé de combiner une modélisation biophysique du signal avec différentes mesures du signal IRM. L'ensemble permet d'accéder par exemple à des mesures du diamètre axonal, comme par exemple l'approche AxCaliber (Assaf 2008). Un des intérêts de cette mesure est qu'elle est corrélée à la vitesse de conduction des signaux électriques (Horowitz 2015). Ces développements méthodologiques sont principalement réalisés chez l'homme. Pourtant, de nombreux modèles animaux sont utilisés pour comprendre le cerveau sain et pathologique. Dans le cadre d'une collaboration entre l'équipe UNIRS de Neurospin (Cyril Poupon) et l'équipe 5 du GIN (Emmanuel Barbier), nous avons initié des travaux pour porter chez la souris les outils actuellement employés chez l'homme. / Magnetic resonance imaging (MRI) allows the observation of the major white matter fiber tracts in the brain. It can thus be used in many applications to have a better understanding of the development of healthy and pathological brains and to study the effect of potential therapeutic treatments. In order to observe these fibers, one must combine a today well-controlled MRI acquisition with a data processing procedure that is still under investigation for many research projects. To characterize those fibers whose diameters are only a few microns wide, the MRI spatial resolution must be raised beyond the spatial resolution of the acquisition. This super-resolution achievement can be obtained by combining biophysical models with several measures of the MRI signal. Together, one can gain access to axon diameter measures for example, as was done by Assaf in 2008 (AxCaliber approach). One of the interests of this measure is its correlation with the conduction velocity of the electric signals (Horowitz 2015). These methodological developments are mainly done in human research. However, many animal models are used to understand the healthy as well as the pathological brains. In the context of a collaboration between team UNIRS of NeuroSpin (Cyril Poupon) and team 5 of GIN (Grenoble Institute of Neuroscience) (Emmanuel Barbier), we have initiated the transfer for the mouse of the tools currently used for human.

Esta pesquisa tem como objetivo principal desenvolver formas de representação da densidade demográfica para a Região Metropolitana de São Paulo (RMSP). Acredita-se que estes estudos possam estabelecer metodologias de trabalho úteis para subsidiar ações de planejamento e gestão desta complexa metrópole. Os estudos desenvolvem um procedimento com análise espacial realizado em ambiente SIG, o tratamento dasimétrico. O tratamento dasimétrico procura resolver certas incoerências do método coroplético, quando este é aplicado a bases censitárias, para isso conta com bases auxiliares de informação para melhor localizar a distribuição de densidade populacional. Tal procedimento é oportuno pois conta-se com considerável patrimônio cartográfico disponível para a área em estudo. Para dar coerência aos procedimentos realizados, faz uma revisão com um viés humanista, procurando entender o estado da evolução da Cartografia, posicionando a análise espacial em meio a outras linguagens, correntes cartográficas e suas discussões. / This research has as main purpose to develop types of demographic density representation from the Região Metropolitana de São Paulo (RMSP). Its believed that studies could establish useful work methodologies to subsidize planning actions and management of this complex metropolis. Studies develop a procedure with spatial analysis accomplished in GIS environment, the dasymetric treatment. The dasymetric treatment seeks to solve certain inconsistencies from choropleth method, when this is applied to a census basis, for this auxiliary basis of information is needed to better locate the distribution of population density. Such procedure is timely because it can count on considerable cartographic property available to the study site. To give consistency for performed procedures, revises with a humanistic bias, looking for understand the evolution status of Cartography, positioning the spatial analysis amid other languages, cartographic chains and their discussions.