Global ETD Search

11	Repair of skeletal muscle transection injury with tissue loss Merritt, Edward Kelly, 1979- 19 October 2009 (has links) A traumatic skeletal muscle injury that involves the loss of a substantial portion of tissue will not regenerate on its own. Little is understood about the ability of the muscle to recover function after such a defect injury, and few research models exist to further elucidate the repair and regeneration processes of defected skeletal muscle. In the current research, a model of muscle injury was developed in the lateral gastrocnemius (LGAS) of the rat. In this model, the muscle gradually remodels but functional recovery does not occur over 42 days. Repair of the defect with muscle-derived extracellular matrix (ECM), improves the morphology of the LGAS. Blood vessels and myofibers grow into the ECM implant in vivo, but functional recovery does not occur. Addition of bone marrow-derived mesenchymal stem cells (MSCs) to the implanted ECM in the LGAS increases the number of blood vessels and regenerating myofibers within the ECM. Following 42 days of recovery, the cell-seeded ECM implanted LGAS produces significantly higher isometric force than the non-repaired and non-cell seeded ECM muscles. These results suggest that the LGAS muscle defect is a suitable model for the study of traumatic skeletal muscle injury with tissue loss. Additionally, MSCs seeded on an implanted ECM lead to functional restoration of the defected LGAS. / text Skeletal muscle transection injury Traumatic skeletal muscle injury Tissue loss Skeletal muscle repair Skeletal muscle regeneration Lateral gastrocnemius Extracellular matrix Mesenchymal stem cells
12	The Effects of Testicular Nerve Transection and Epididymal White Adipose Tissue Lipectomy on Spermatogenesis in Syrian Hamster Spence, Jeremiah E 30 July 2008 (has links) Previous investigators demonstrated that epididymal white adipose tissue (EWAT) lipectomy suppressed spermatogenesis and caused atrophy of the seminiferous tubules. EWAT lipectomy, however, may disrupt testicular innervation, which reportedly compromises testicular function. To resolve this confound and better clarify the role of EWAT in spermatogenesis, three experimental groups of hamsters were created in which: i.) the superior and inferior spermatic nerves were transected (SSNx) at the testicular level, ii.) EWAT was extirpated (EWATx), and iii.) testicular nerves and EWAT were left intact (SHAM controls). It was hypothesized that transection of the superior and inferior spermatic nerves would disrupt normal spermatogenesis. The findings indicate a significant reduction in spermatogenic activity and marked seminal tubule atrophy within the EWATx testis, as compared to the SSNx and controls testes, which did not differ significantly from each other. From these data, it is concluded that EWAT, and not testicular innervation, is central to normal spermatogenesis.
13	The Effects of Testicular Nerve Transection and Epididymal White Adipose Tissue Lipectomy on Spermatogenesis in Syrian Hamster Spence, Jeremiah E. 30 July 2008 (has links) Previous investigators demonstrated that epididymal white adipose tissue (EWAT) lipectomy suppressed spermatogenesis and caused atrophy of the seminiferous tubules. EWAT lipectomy, however, may disrupt testicular innervation, which reportedly compromises testicular function. To resolve this confound and better clarify the role of EWAT in spermatogenesis, three experimental groups of hamsters were created in which: i.) the superior and inferior spermatic nerves were transected (SSNx) at the testicular level, ii.) EWAT was extirpated (EWATx), and iii.) testicular nerves and EWAT were left intact (SHAM controls). It was hypothesized that transection of the superior and inferior spermatic nerves would disrupt normal spermatogenesis. The findings indicate a significant reduction in spermatogenic activity and marked seminal tubule atrophy within the EWATx testis, as compared to the SSNx and controls testes, which did not differ significantly from each other. From these data, it is concluded that EWAT, and not testicular innervation, is central to normal spermatogenesis. Testes Syrian hamster Seminiferous tubule Spermatogenesis Superior and inferior spermatic nerve Norepinephrine Male reproduction Gonadal fat pad EWAT lipectomy Epididymal white adipose tissue (EWAT) Biology, general
14	Changes in Sympathetic Preganglionic Neurons and Associated Glial Cells following Injury Coulibaly, Aminata P. 17 August 2010 (has links) No description available. Biology Biomedical Research Cellular Biology Molecular Biology Choline acetyltransferase chat cervical sympathetic trunk cst preganglionic neurons intermediolateral cell column IML spinal cord activating transcription factor-3 ATF-3 distal axonal injury transection astrocytes microglia
15	Détermination des facteurs bénéfiques et néfastes à la récupération locomotrice à la suite d’une section spinale complète chez la souris Jeffrey-Gauthier, Renaud 12 1900 (has links) No description available. moelle épinière section hémisection locomotion plasticité générateur de patron central sérotonine inflammation réflexe de Hoffmann dépression post-activation désinhibition afférences sensorielles nociception Spinal cord Transection Plasticity Central pattern generator Serotonin Neuromodulation Hoffmann reflex Frequency-dependent depression Sensory afferents

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