M.Cur. / HIV and AIDS education as a prevention strategy is priority number one in the National Strategic Plan for South Africa. Prevention of illnesses is also an integral part of primary health care (Department of Health, 2007: 10). There are different role players offering age-appropriate HIV and AIDS education to primary school learners, such as educators (within the Life Orientation programme), school health nurses (as part of health promotion) and non-governmental organisation (NGO) peer educators who visit schools per invitation or as part of their programme. Knowledge of collaboration amongst different role payers is necessary in order to pool the complementary strengths and maximise the positive impact of education on adolescents’ sexual behaviour. The design used in this research is quantitative and descriptive in nature. The respondents were clustered according to categories, namely school health nurses, primary school educators and NGO peer educators. As school health nurses (n=8) and peer educators (n=15) constituted a small population, they were all included in the study. Systematic random sampling was used to select respondents from the population of educators (N=75: n=42). A developed questionnaire was distributed to the consenting respondents who met the inclusion criteria. A checklist was also developed to review policies and guidelines used as a framework for providing HIV and AIDS education to learners by role players. A pilot study was conducted. The Statistical Package for Social Science (SPSS14.0) for Windows was used to analyse the data.

M.A. / The study is based on the social model of disability focusing on issues of human rights for people with intellectual disabilities. Disability is defined as the social restriction confronted by people with disabilities living in a society that is not organized to take account of their needs. Disability is not an individual condition but rather an issue of equal opportunities. Self-determination for people with intellectual disability should be respected as it is a central aspect of personal well being based on the understanding that disability is a result of social attitudes, architectural, and legal barriers that confront people with disabilities. The research was aimed at the acquisition of information on the knowledge of people with intellectual disabilities about sexuality and if that knowledge is appropriately linked to HIV and AIDS. The study uses research as a scientific tool that will assist policy makers and programme developers to dispel the myths on issues affecting people with intellectual disabilities. Self-advocacy of people with intellectual disabilities in research was key to the research method that was applied. People with mental retardation, head injury, other or any type of actual or perceived mental or cognitive disability are often marginalized by society. The HIV/AIDS global epidemic has greatly exceeded earlier predictions. About 95% of all people infected are living in developing countries, which have to cope with poverty and health problems. HIV and AIDS prevalence can remain undetected for long periods, particularly in local groupings and settings. HIV remains localized before the epidemic spreads to involve the wider population. These localized groupings can be classified as having no known cases. It is during this period that the proactive interventions should be implemented. It is for these reasons that this study was undertaken to address HIV and AIDS among the grouping of people with intellectual disabilities.

L'imagerie sismique de la Terre permet de retrouver la structure de sous-sol. Cette opération est classiquement décomposée en deux étapes : une première phase a pour objectif de déterminer la cinématique de propagation des ondes (modèle de vitesse de référence) ; la seconde phase vise à retrouver la position des interfaces dans le sous-sol. Si cette seconde phase est maintenant classique, la détermination du modèle de vitesse de référence reste un sujet d’actualité en imagerie sismique. Une technique pour estimer le modèle de référence sépare les données en sous-ensembles, par exemple en points de tir. Une image partielle du sous-sol est obtenue pour chaque point de tir. Si ces images sont cohérentes les unes avec les autres, alors le modèle de vitesse qui a servi à obtenir ces images est dit correct. Cette technique s'est avérée très utile, en particulier pour l'imagerie des zones complexes, car elle ne requière pas a priori d'identifier des événements. Cependant, la technique est intrinsèquement liée aux données réfléchies. Elle ne prend pas en compte les arrivées transmises, les réflexions multiples, les ondes de surface, … L'objectif de la thèse de doctorat est de prendre en compte à la fois les arrivées réfléchies et les arrivées transmises (ondes directes et plongeantes) pour l'analyse de vitesse. Pour cela, le formalisme de l'analyse de vitesse doit être revu pour prendre en compte des développements récents (modèle « étendu » défini en 2008). Si une telle approche s’avère possible, alors il ne serait plus nécessaire d'extraire les ondes réfléchies des données. Par ailleurs, les ondes réfléchies ont des trajets essentiellement verticaux. Les ondes transmises ont des trajets plutôt horizontaux. La prise en compte des deux types d'ondes permettrait donc de mieux contraindre le modèle de vitesse et alors de déterminer des paramètres d'anisotropie. Au cours de la thèse, il s'agira de modifier le formalisme actuel d'analyse de vitesse pour prendre en compte les ondes réfléchies et transmises. Des applications seront développées sur les données synthétiques et réelles pour démontrer l'apport de l'approche combinée. Enfin, une analyse fine devra être menée pour voir si les ondes réfractées (en opposition aux ondes plongeantes) peuvent également être prises en compte. / Seismic imaging aims at retrieving the Earth's structures. It is classically split into two steps: firstly, the objective is to retrieve the background velocity model containing the large-scale structures of the velocity model. Secondly, one needs to determine the reflectivity part with the positions of the interfaces. The first part still remains a difficult challenge. Migration Velocity Analysis consists of migrating subsets of the total input data set (e.g. single shots). If all associated images are consistent, then the model used for imaging is said to be correct. This is a very useful method, in particular for the imaging of complex structures, as it does not a prioiri require any picking nor event identification. However, it is intrinsically restricted to reflected data: it does not take into account transmitted waves, multiple reflections, surface waves, ... The objective of the Ph.D work is to simultaneously consider reflected and transmitted (direct and diving) waves in the context of Migration Velocity Analysis. For that, one needs to reconsider the basis for velocity analysis. Recent developments around the « extended model » should be considered. If feasible, then it would not be anymore needed to extract reflected energy from a shot gather. More importantly, the combined inversion would better constrain the model: reflected waves are mainly associated to vertical propagation, whereas transmitted waves recorded at large offsets are more associated to horizontal propagation. This could offer the possibility to better estimate anisotropy parameters.

Master of Public Health - MPH / The overall aim of this study was to evaluate quality of STI services in Umjindi local municipality. A concrete objective was to investigate the health system issues that may have a negative impact in the provision of quality STI service in the local municipality. These include accessibility of the STI services to the community, training of health workers in syndromic management, availability of necessary equipment and supplies for STI management, turn-around time for blood results and infrastructure of the facilities. / South Africa

Master of Public Health - MPH / Curricula should be strengthened by teaching the curability of STIs and the importance of STI treatment to prevent HIV transmission. This study focused on the control of sexually transmitted infections as a key HIV prevention strategy. Sexually transmitted infections act as a strong cofactor in the sexual transmission of HIV. Effective STI management can limit the spread of HIV. / South Africa

Doctor Pharmaceuticae - DPharm / The effect of industrialisation has thrust the pharmaceutical profession into a clinical paradigm where the approcah to pharmaceutical decisions is more disease and patient orientated. Consequently, South African community pharmacies are inundated with requests from the public for advice and treatment on a wide range of medical conditions, including sexually transmitted infections (STI's). Although community pharmacies are often the first port of call for undiagnosed STI, limited diagnostic skills and legally-imposed prescribing restrictions preclude pharmacists from providing the necessary clinical management. The overarching goal of this dissertation was to present objective arguments and evidences (new and existing) around an expanded role for pharmacists in STI partner management. / South Africa

Magister Public Health - MPH / Background: STIs are of major public health concern in developing countries, not least because they facilitate transmission of HIV, but also because they are important causes of mortality and morbidity among African populations, resulting in, among other things, adverse birth outcomes, neonatal and infant infections, ectopic pregnancy, anogenital cancer,infertility, pelvic inflammatory disease, and death. Thus, effective treatment needs to be prompt and accurate to control the spread, and morbidity and mortality of STIs. Even though syndromic approach to the management of STIs is effective, most evaluations have focused on syndromic STI management within STI clinics as opposed to research studies. Partner notification is an integral component of the syndromic approach and is aimed at preventing onward transmission of infection as well as re-infection. It includes informing sexual partners of infected people of their exposure, administering presumptive treatment, and providing advice about the prevention of future infection.Methods: This is a cross sectional descriptive study based on a retrospective review of STI data of study participants in KICoS aged 18 to 34 years. A non probability convenience sampling method was used to recruit study participants. A total of 1,277 participants were prescreened into KICoS of whom 847 were enrolled into this study. Data was collected using CAPI and ACASI questionnaires as well as Teleforms which was analysed in SAS for windows 9.1. Results: Syndromic prevalence of STIs was 5.7% while the aetiological prevalence was 32.8%.Risk factors to STI acquisition included, being female, having multiple sexual partners,having lower than tertiary education, using recreational drugs and being HIV. Agreement between the interviewing methods as well between the syndromic and laboratory diagnosis ranged from fair to substantial. This was also true for the agreement between laboratory and CAPI as well as between the laboratory and ACASI. Sensitivity was generally low while specificity was high. Uptake of contact tracing cards was high though with very low uptake of contact treatment with only 2.1% and 0.4% partners of the syndromically and aetiologically diagnosed participants coming for treatment.Conclusions: STI is a problem in this community and thus there should be more emphasis on risk reduction messages in patient education to mitigate the spread of STIs. The performance of syndromic management was very poor against the aetiological diagnosis thus there needs to further review the use of syndromic diagnosis of STIs in research settings. Partner tracing needs to be intensified since there was very poor partner treatment even with high uptake of contact cards.Acknowledgements: This study would have not been what it was without the immense support I received from many individuals all of whom cannot be mentioned here. I would however want to thank the Dr Wairimu Chege (Principal Investigator, KICoS) for her inspiration and encouragement. I would also like to thank my supervisor, Ernie Kunneke for going through this study with me repeated times including on a ride to the airport. On the same note I would also like to thank my lecturers and student administrators at the SOPH. My gratitude also goes to my colleagues Richard Ndivo, Sherri Pals and Eleanor McLellan-Lemal for all the support they accorded me throughout this research.I would also want to give my heartfelt gratitude to my family. My daughter Akinyi who used to type with me at night, her mother Auma for understanding my late nights up and finally to my Parents Mr and Mrs Gideon and Monica Otieno for understanding the importance of education and taking me to school through all the difficulties. Last but not least I would like to express my gratitude to the almighty God for having seen me through this process.

Background: Cacao swollen shoot virus (CSSV), Cacao swollen shoot CD virus (CSSCDV), and Cacao swollen shoot Togo A virus (CSSTAV) cause cacao swollen shoot disease (CSSD) in West Africa. During 2000-2003, leaf and shoot-swelling symptoms and rapid tree death were observed in cacao in Cote d'Ivoire and Ghana. Molecular tests showed positive infection in only similar to 50-60% of symptomatic trees, suggesting the possible emergence of an unknown badnavirus. Methods: The DNA virome was determined from symptomatic cacao samples using Illumina-Hi Seq, and sequence accuracy was verified by Sanger sequencing. The resultant 14, and seven previously known, full-length badnaviral genomic and RT-RNase H sequences were analyzed by pairwise distance analysis to resolve species relationships, and by Maximum likelihood (ML) to reconstruct phylogenetic relationships. The viral coding and non-coding sequences, genome organization, and predicted conserved protein domains (CPDs) were identified and characterized at the species level. Results: The 21 CSSD-badnaviral genomes and RT-RNase H sequences shared 70-100% and 72-100% identity, respectively. The RT-RNase H analysis predicted four species, based on an >= 80% species cutoff. The ML genome sequence tree resolved three well-supported clades, with >= 70% bootstrap, whereas, the RT-RNase H phylogeny was poorly resolved, however, both trees grouped CSSD isolates within one large clade, including the newly discovered Cacao red vein virus (CRVV) proposed species. The genome arrangement of the four species consists of four, five, or six predicted open reading frames (ORFs), and the CPDs have similar architectures. By comparison, two New World cacao-infecting badnaviruses encode four ORFs, and harbor CPDs like the West African species. Conclusions: Three previously recognized West African cacao-infecting badnaviral species were identified, and a fourth, previously unidentified species, CRVV, is described for the first time. The CRVV is a suspect causal agent of the rapid decline phenotype, however Koch's Postulates have not been proven. To reconcile viral evolutionary with epidemiology considerations, more detailed information about CSSD-genomic variability is essential. Also, the functional basis for the multiple genome arrangements and subtly distinct CPD architectures among cacao-infecting badnaviruses is poorly understood. New knowledge about functional relationships may help explain the diverse symptomatologies observed in affected cacao trees.

Introduction: Oil/gas communities across Northeastern British Columbia are experiencing rapid in-migration of young, primarily male workers in response to an economic ‘boom’ in the oil/gas sectors. Accompanying the ‘boom’ has been a rise in rates of sexually transmitted infections (STIs) among young people, with Chlamydia rates among youth in the Northeast exceeding the provincial average by 22%. Previous research indicates that socio-cultural and structural determinants of youth sexual behaviour and access to STI testing are important for understanding youth sexual health disparities – and represent key targets for STI prevention efforts. No other research has explored STIs in this rapidly developing, under-resourced context. Therefore, objectives of this thesis were to: (1) Examine how socio-cultural and structural features related to the oil/gas ‘boom’ affect the sexual behaviour of young people in Fort St. John (FSJ), BC; (2) Gather the perspectives of youth and their service providers on the socio-cultural and structural barriers to STI testing in FSJ; (3) Develop recommendations to improve the accessibility of STI testing. Results: Participants identified 4 main ways in which the socio-cultural and structural conditions created by the ‘boom’ affect sexual behaviours, fuelling the spread of STIs in FSJ: mobility of oil/gas workers; binge partying; high levels of disposable income; and gendered power dynamics. As well, 5 key barriers to STI testing among youth were identified: limited opportunities for access; geographic inaccessibility; local social norms; limited information; and negative interactions with providers. Discussion: These data indicate that the conditions fostered by the ‘boom’ in FSJ exacerbate sexual health inequalities among young people. They can be more widely contextualized as an example of the unintended – but not unexpected – health and social implications of a resource-extraction ‘boom’, illustrating the fallacy of ‘development’ as representing uniformly positive ‘progress’. Recommended actions include STI prevention and testing service delivery models that incorporate a locally tailored public awareness campaign, outreach to oil/gas workers, condom distribution, expanded clinic hours and drop-in appointments, specialized training for health care providers, and intersectoral partnerships between public health, non-profit organizations, and industry. An ongoing knowledge translation internship has been undertaken to implement some of these recommendations. / Medicine, Faculty of / Population and Public Health (SPPH), School of / Graduate

The HIV and AIDS epidemic continues to affect communities worldwide particularly so in South Africa. Youth, also the so-called Coloured youth, continue to remain at risk of infection, in spite of having been exposed to information about HIV and AIDS. This study explores the views of Coloured secondary school youth in a rural town in the Eastern Cape, on HIV and AIDS. Fifteen secondary school learners, both boys and girls, from Grades 10 to 12 were purposively selected. This qualitative study, framed within an interpretivist paradigm, draws on a phenomenological methodology. The data was generated from using drawing and focus group interviews and analysed using thematic analysis. The research adhered to ethical principles and trustworthiness was ensured. Constructivism and Bronfenbrenner’s bio-ecological systems theory were used to frame the study and to make meaning of the findings. In response to the primary research question, What views do Coloured youth attending a secondary school in a rural town have of HIV and AIDS?, five themes emerged, namely: individuals spread HIV, impoverished family life increases youth vulnerability to HIV, youth under pressure from peers knowingly engage in risky behaviour, misconceptions fuel the epidemic, and HIV and AIDS “captures the community in its net”. Drawing on the findings and in response to the secondary research question, What guidelines can be developed to assist educators to facilitate learners taking action against the spread of HIV and AIDS?, several guidelines were developed. They suggest that teachers should use participatory pedagogies to engage secondary school learners when teaching HIV and AIDS, build self-esteem in their learners, assist learners in dealing with peer pressure, engage learners in erasing misconceptions, and enable learners to break free from being “caught in the net” of HIV and AIDS. Collectively these guidelines could enable learners to take action in protecting themselves and their community against the spread of the HI virus. The study concludes that the views that Coloured secondary school learners from a rural town have about HIV and AIDS show their awareness of the realities of the epidemic affecting the individual, the family, the school and their community. They have constructed their views of HIV and AIDS in a way which shows their understanding of the complexities of the epidemic.