2 pp. / [Healthy Fats -- Guide for Improving the Quality of Fat Intake] / The fact sheet reviews healthy fats and how to incorporate a healthy amount of fat into our diet. Fats are necessary for our bodies to function properly. In fact, fats are an important part of a healthy diet and we can't live without them. Fats can be grouped into two groups: saturated and unsaturated. Unsaturated fats include polyunsaturated and monounsaturated fats. Both these fats, when eaten in moderation and used in place of saturated and trans fats, can help lower cholesterol levels and decrease the risk of heart disease. We provide a list of "Do's" and "Tips" which gives examples of how to select fats wisely and incorporate healthy changes into our diet. We also provide a guide for selecting an appropriate portion size of fat.

2 pp. / The fact sheet reviews healthy fats and how to incorporate a healthy amount of fat into our diet. Fats are necessary for our bodies to function properly. In fact, fats are an important part of a healthy diet and we can't live without them. Fats can be grouped into two groups: saturated and unsaturated. Unsaturated fats include polyunsaturated and monounsaturated fats. Both these fats, when eaten in moderation and used in place of saturated and trans fats, can help lower cholesterol levels and decrease the risk of heart disease. We provide a list of "Do's" and "Tips" which gives examples of how to select fats wisely and incorporate healthy changes into our diet. We also provide a guide for selecting an appropriate portion size of fat.

Orientador: Eliana Pereira Araújo / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Enfermagem / Made available in DSpace on 2018-08-25T14:33:22Z (GMT). No. of bitstreams: 1 Bugni_EvaLorenaArantes_M.pdf: 6142586 bytes, checksum: f0837fcd2a4052534af5f2b203ec28bb (MD5) Previous issue date: 2014 / Resumo: O processo cicatricial é um fenômeno complexo e altamente especializado, onde é necessário a integração de vários tipos de células, fatores de crescimento e enzimas. O processo ocorre através de várias fases: formação do coágulo; inflamação; reepitelização; angiogênse; formação do tecido de granulação; contração da ferida; formação da cicatriz; e, remodelamento do tecido. Estudos recentes revelaram que o receptor acoplado a proteína G, GPR120, é ativado por ácidos graxos insaturados de cadeia longa e é importante sinalizador relacionado com vários aspectos da função celular, incluindo o efeito anti-inflamatório exercido através da ligação do GPR120 com estes ácidos graxos. Nosso objetivo foi avaliar a expressão e atividade do GPR120 em pele íntegra e em feridas cutâneas de ratos Wistar tratados com o ácido docosahexaenóico (DHA). Tal estudo se justifica pela importância do melhor entendimento dos mecanismos imunoreguladores e inflamatórios da cicatrização de feridas que levem a abordagens terapêuticas mais efetivas. Para tal, pele íntegra e feridas cutâneas de ratos Wistar foram avaliadas por imunohistoquímica, imunoblot e PCR em tempo real. Nós encontramos que o GPR120 é expresso na pele e em tecido cicatricial de Wistar, fato ainda nunca relatado na literatura. Além disso, o GPR120 foi co-localizado em queratinócitos importante células nativas da epiderme. O tratamento tópico das feridas com DHA acelerou a cicatrização. Os efeitos moleculares deste tratamento na ferida foram: a associação de GPR120 e 'beta'-arrestina; diminuição de Interleucina-1 Beta (IL-1'beta'); aumento do Fator Transformador Beta (TGF-'beta') e Ivolucrin (IVL), um marcador de queratinócitos / Abstract: Wound healing is a complex process and highly specialized, where it is necessary to integrate various types of cells, growth factors and enzymes. The healing process involves several phases: clot formation, inflammation, reepithelialization, angiogenesis, formation of granulation tissue, wound contraction, scar formation, and tissue remodeling. Recent studies have shown that the G protein-coupled receptor, GPR120 is activated unsaturated long chain, such as docohexaenoic acid, and are important signaling relating to various aspects of cellular function, including inflammatory effect exerted by connecting the GPR120 with these fatty acids. Our objective was to evaluate the expression and activity of the GPR120 in intact skin and in skin wounds in rats treated with docosahexaenoic acid (DHA). This study is justified by the importance of better understanding of inflammatory and immunoregulatory mechanisms of wound healing leading to more effective therapeutic approaches. For this purpose, intact skin and wounds of rats were evaluated by immunohistochemistry, immunoblotting and real-time PCR. We found that GPR120 is expressed in the skin and scar tissue of Wistar fact still never been reported in the literature. Additionally, the GPR120 co-located important native keratinocyte cells of the epidermis. The topical treatment of wounds with DHA accelerated healing. The molecular effects of this treatment on the wound were: the association of 'beta'-arrestin and GPR120; decreased interleucin - 1 beta ( IL - 1'beta'), increasing the Transformer Factor Beta (TGF - 'beta') and Ivolucrin (IVL), a marker of keratinocyte / Mestrado / Enfermagem e Trabalho / Mestra em Enfermagem