OBJECTIVE: To determine the effect of total dietary fat intake on the prevalence of hand osteoarthritis (HOA) utilizing data collected in the Osteoarthritis Initiative (OAI) study cohort. METHODS: This is an observational cross-sectional study. Subjects from the OAI cohort with hand radiographs were analyzed for HOA, defined as a Kellgren-Lawrence score of ≥2 in two or more joints on different fingers. Dietary data and socioeconomic factors were collected from the baseline study visit. Logistic regression analysis assessed the association of total fat intake and disease prevalence. Odds ratios were calculated from the coefficients and confidence intervals were calculated with log-likelihood. RESULTS: HOA was prevalent in 1,106 out of the 2,993 participants (37%). Total fat intake did not show a significant relationship to disease prevalence when adjusted for age, education, income, race, smoking, BMI, prescription NSAID use, calcium intake, protein intake, total calories, saturated/monounsaturated fats, and alcohol consumption. There was a significant association of HOA with age, sex, education, race, total calories, and alcohol intake. Sex was analyzed independently to assess for effect modification, showing an association with age (P<0.01) OR (95%CI) 1.03 (1.02,1.03), race (P<0.01) 1.16 (1.09,1.23), and alcohol consumption (P<0.01) 1.06 (1.02,1.09) among only female subjects. Male subjects showed a strong association with age (P<0.01) 1.02 (1.01,1.02). CONCLUSION: Total fat intake does not show a significant association with HOA prevalence with the study sample from the OAI cohort. Age, race, and alcohol consumption showed significant associations depending on sex. More research is needed to further investigation these associations among different groups.

2 pp. / [Healthy Fats -- Guide for Improving the Quality of Fat Intake] / The fact sheet reviews healthy fats and how to incorporate a healthy amount of fat into our diet. Fats are necessary for our bodies to function properly. In fact, fats are an important part of a healthy diet and we can't live without them. Fats can be grouped into two groups: saturated and unsaturated. Unsaturated fats include polyunsaturated and monounsaturated fats. Both these fats, when eaten in moderation and used in place of saturated and trans fats, can help lower cholesterol levels and decrease the risk of heart disease. We provide a list of "Do's" and "Tips" which gives examples of how to select fats wisely and incorporate healthy changes into our diet. We also provide a guide for selecting an appropriate portion size of fat.

2 pp. / The fact sheet reviews healthy fats and how to incorporate a healthy amount of fat into our diet. Fats are necessary for our bodies to function properly. In fact, fats are an important part of a healthy diet and we can't live without them. Fats can be grouped into two groups: saturated and unsaturated. Unsaturated fats include polyunsaturated and monounsaturated fats. Both these fats, when eaten in moderation and used in place of saturated and trans fats, can help lower cholesterol levels and decrease the risk of heart disease. We provide a list of "Do's" and "Tips" which gives examples of how to select fats wisely and incorporate healthy changes into our diet. We also provide a guide for selecting an appropriate portion size of fat.

This study was designed to compare the fatty acid and fruit and vegetable intake of people with and without periodontal disease. Periodontal disease affects approximately 15 percent of the developed world population. Participants filled out a food frequency questionnaire (FFQ) for both fruit and vegetable and fat intake. A sample of whole blood (EDTA) was collected to determine the fatty acid profile of participants’ red blood cell (RBC) membrane. This analytical procedure determines the average fatty acid intake of the participant over the previous 90 to 120 days. Participants were classified as case (n=10, patients diagnosed with periodontal disease) or control group (n=10, patients without periodontal disease). Our hypothesis was that the case group would have higher fat intake and lower fruit and vegetable intake, with lower levels of omega-3 fatty acids and higher levels of omega-6 fatty acids in the RBC membrane. FFQ results indicated that case participants consumed significantly higher amounts of total fat (109.02 vs. 94.46g/d; p= .05), saturated fat (35.102 vs. 28.242g/d; p= .033) and their diets had a higher percentage of total dietary fat (38.73% vs. 34.99%; p=.044). FFQ for fruit and vegetable intake showed no significance between the case and control groups (4.41 vs. 4.56 servings/d; p=.871). For the most part, there were no significant differences between the percent composition of the individual fatty acids isolated from the RBC membrane or in ratios of omega-3 to omega-6 fatty acid groups as determined by RBC fatty acid analysis. Results indicated a numerically lower intake of omega-3 fatty acids in the case than in the control group. Likewise, there was a numerically higher intake of omega-6 fatty acids in the case group. These numbers demonstrate a trend towards the hypothesis being correct and patients with periodontal disease consuming more omega-6 fatty acids and less omega-3 fatty acids.

Aim and objectives: This study set out to investigate the diet and blood lipid profiles of subjects in transition in the North West Province in South Africa. It looked specifically at how the diet differed between rural and urban areas, how the blood lipid profiles differed between rural and urban subjects, establishing an association between dietary fat, fatty acid and cholesterol intakes respectively and blood lipid profiles, as well as investigating the differences in blood lipid profiles at different ages, body mass index (BMI) and genders respectively in rural and urban areas. Design: The present study was a cross–sectional data analysis nested within the Prospective Urban and Rural Epidemiology (PURE) study that is currently undertaken in the North West Province of South Africa amongst other countries. Methods: Baseline data was obtained in 2005. A randomised paper selection was done of people between 35 - 70 years of age with no reported chronic diseases of lifestyle, TB or HIV of those enrolled into the PURE study if they had provided written consent. Eventually a paper selection was made of 2000 subjects, 500 people in each of the four communities (rural, urban–rural, urban, established urban). For the interpretation purposes of this study, data was stratified for rural (1000 subjects) and urban (1000 subjects) only, with no further sub–division into communities. Physical activity levels and habitual diets were obtained from these subjects. Demographic and dietary intake data in the PURE study was collected using validated, culture sensitive questionnaires. Anthropometric measures and lipid analysis were determined using standardised methodology. Descriptive statistics (means, standard deviations and proportions) were calculated. One–way analysis of variance (ANOVA) was used to determine differences between the different levels of urbanisation on blood lipid profiles and dietary intake. When a dietary intake variable proved to be significant for different levels of a factor (urbanisation, blood lipid profile), post–hoc tests were calculated to determine which levels for specific variables differed significantly. Bonferroni–type adjustments were made for the multiple comparisons. Spearman correlations were calculated to determine associations. Results: Mean fat intake was significantly higher in urban areas than in rural areas (67.16 ± 33.78 g vs. 32.56 ± 17.66 g, p<0.001); and the same was true for the individual fatty acid intakes. Fat and fatty acid intakes were still within recommendations even for urban areas, and low for rural areas. N–3 intake was very low in both rural and urban areas. Serum lipids did not differ significantly between rural and urban areas. Almost half of rural (43%) and urban (47%) subjects presented with elevated total cholesterol (5.0 mmol/L). In rural areas 52% and in urban areas 55% of subjects had elevated LDL–C (3.0 mmol/L). Amongst 23% of males in rural areas and 18% of males in urban areas HDL–C levels were decreased. Of the females living in rural areas 34.3% had decreased HDL–C levels and 39% of those who lived in urban areas presented with lowered HDL–C levels. In rural areas 16.3% of subjects and in urban areas 23% of subjects presented with high triglyceride levels. TC, LDL–C and triglyceride levels were higher in higher body mass index (BMI) classes, however, obese subjects did not differ significantly from overweight subjects in terms of blood lipids, suggesting that values stabilise after reaching overweight status. These blood lipids were also higher in higher age groups and higher in women than men, probably due to the high incidence of obesity in women. Conclusions: Associations between the diet and blood lipid profiles were weak, and diet is not likely to be the only factor responsible for high TC and LDL–C levels. Blood lipid profiles did not differ significantly between rural and urban areas due to the fact that the diet was prudent in terms of fat intake in both rural and urban areas. Higher prevalence of underweight was noted in males (32% in rural areas and 28% in urban areas), while overwieght was a bigger problem amongst women (48% in rural areas and 54% in urban areas). TC, LDL–C and TAG were higher with higher BMI’s, while HDL–C levels were lower. TC, LDL–C, and TAG were higher in higher age goups while HDL–C levels were lower. Female subjects presented with higher mean triglycerides than males, probably due to higher prevalence of overweight and obesity. / Thesis (M.Sc. (Dietetics))--North-West University, Potchefstroom Campus, 2011.

Aim and objectives: This study set out to investigate the diet and blood lipid profiles of subjects in transition in the North West Province in South Africa. It looked specifically at how the diet differed between rural and urban areas, how the blood lipid profiles differed between rural and urban subjects, establishing an association between dietary fat, fatty acid and cholesterol intakes respectively and blood lipid profiles, as well as investigating the differences in blood lipid profiles at different ages, body mass index (BMI) and genders respectively in rural and urban areas. Design: The present study was a cross–sectional data analysis nested within the Prospective Urban and Rural Epidemiology (PURE) study that is currently undertaken in the North West Province of South Africa amongst other countries. Methods: Baseline data was obtained in 2005. A randomised paper selection was done of people between 35 - 70 years of age with no reported chronic diseases of lifestyle, TB or HIV of those enrolled into the PURE study if they had provided written consent. Eventually a paper selection was made of 2000 subjects, 500 people in each of the four communities (rural, urban–rural, urban, established urban). For the interpretation purposes of this study, data was stratified for rural (1000 subjects) and urban (1000 subjects) only, with no further sub–division into communities. Physical activity levels and habitual diets were obtained from these subjects. Demographic and dietary intake data in the PURE study was collected using validated, culture sensitive questionnaires. Anthropometric measures and lipid analysis were determined using standardised methodology. Descriptive statistics (means, standard deviations and proportions) were calculated. One–way analysis of variance (ANOVA) was used to determine differences between the different levels of urbanisation on blood lipid profiles and dietary intake. When a dietary intake variable proved to be significant for different levels of a factor (urbanisation, blood lipid profile), post–hoc tests were calculated to determine which levels for specific variables differed significantly. Bonferroni–type adjustments were made for the multiple comparisons. Spearman correlations were calculated to determine associations. Results: Mean fat intake was significantly higher in urban areas than in rural areas (67.16 ± 33.78 g vs. 32.56 ± 17.66 g, p<0.001); and the same was true for the individual fatty acid intakes. Fat and fatty acid intakes were still within recommendations even for urban areas, and low for rural areas. N–3 intake was very low in both rural and urban areas. Serum lipids did not differ significantly between rural and urban areas. Almost half of rural (43%) and urban (47%) subjects presented with elevated total cholesterol (5.0 mmol/L). In rural areas 52% and in urban areas 55% of subjects had elevated LDL–C (3.0 mmol/L). Amongst 23% of males in rural areas and 18% of males in urban areas HDL–C levels were decreased. Of the females living in rural areas 34.3% had decreased HDL–C levels and 39% of those who lived in urban areas presented with lowered HDL–C levels. In rural areas 16.3% of subjects and in urban areas 23% of subjects presented with high triglyceride levels. TC, LDL–C and triglyceride levels were higher in higher body mass index (BMI) classes, however, obese subjects did not differ significantly from overweight subjects in terms of blood lipids, suggesting that values stabilise after reaching overweight status. These blood lipids were also higher in higher age groups and higher in women than men, probably due to the high incidence of obesity in women. Conclusions: Associations between the diet and blood lipid profiles were weak, and diet is not likely to be the only factor responsible for high TC and LDL–C levels. Blood lipid profiles did not differ significantly between rural and urban areas due to the fact that the diet was prudent in terms of fat intake in both rural and urban areas. Higher prevalence of underweight was noted in males (32% in rural areas and 28% in urban areas), while overwieght was a bigger problem amongst women (48% in rural areas and 54% in urban areas). TC, LDL–C and TAG were higher with higher BMI’s, while HDL–C levels were lower. TC, LDL–C, and TAG were higher in higher age goups while HDL–C levels were lower. Female subjects presented with higher mean triglycerides than males, probably due to higher prevalence of overweight and obesity. / Thesis (M.Sc. (Dietetics))--North-West University, Potchefstroom Campus, 2011.

Uma nutrição maternal rica em lipídios pode causar prejuízos no desenvolvimento e na vida adulta dos descendentes, como elevado risco de desenvolver alterações metabólicas e obesidade, e também parece alterar a sinalização central por opióides. Porém, estudos realizados a fim de investigar a influência da dieta hiperlipídica (HF) materna sobre o comportamento materno e o desenvolvimento da prole não são conclusivos. Este trabalho investigou a influência da dieta HF sobre a interação mãe-filhote, em duas gerações, e os efeitos imediatos e tardios sobre a prole, relacionando-os ao sistema opióide. As mães HF apresentaram prejuízos na ejeção do leite e maior expressão dos receptores opióides no hipotálamo. No geral, os descendentes HF apresentaram elevados níveis de colesterol, baixa leptina plasmática, maior expressão de peptídeos relacionados à ingestão alimentar, e menor peso. Portanto, o consumo materno de dieta HF causou alterações metabólicas, comportamentais e na expressão gênica na mãe e nos descendentes, mesmo que esses animais não tenham se tornado obesos. / A maternal nutrition high in fat may impair offspring development and adulthood, increasing the risk to develop metabolic alterations and obesity, and may modify the opioids central signaling. However, studies investigating maternal high fat (HF) diet influences on maternal behavior and offspring development are inconclusive. This study aimed to evaluate the influences of a diet high in fat on mother-pup interaction, in two generations, and its early and late effects in the offspring, connecting them to the opioid system. HF dams show decreased milk ejections and higher expression of opioid receptors in the hypothalamus. Overall, HF offspring had higher cholesterol levels, less serum leptin, higher expression of peptides related to food intake, and were lighter. Therefore, maternal intake of HF diet promoted metabolic, behavioral and gene expression alterations in the mother and her offspring, even though these animals did not become obese.

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Uma nutrição maternal rica em lipídios pode causar prejuízos no desenvolvimento e na vida adulta dos descendentes, como elevado risco de desenvolver alterações metabólicas e obesidade, e também parece alterar a sinalização central por opióides. Porém, estudos realizados a fim de investigar a influência da dieta hiperlipídica (HF) materna sobre o comportamento materno e o desenvolvimento da prole não são conclusivos. Este trabalho investigou a influência da dieta HF sobre a interação mãe-filhote, em duas gerações, e os efeitos imediatos e tardios sobre a prole, relacionando-os ao sistema opióide. As mães HF apresentaram prejuízos na ejeção do leite e maior expressão dos receptores opióides no hipotálamo. No geral, os descendentes HF apresentaram elevados níveis de colesterol, baixa leptina plasmática, maior expressão de peptídeos relacionados à ingestão alimentar, e menor peso. Portanto, o consumo materno de dieta HF causou alterações metabólicas, comportamentais e na expressão gênica na mãe e nos descendentes, mesmo que esses animais não tenham se tornado obesos. / A maternal nutrition high in fat may impair offspring development and adulthood, increasing the risk to develop metabolic alterations and obesity, and may modify the opioids central signaling. However, studies investigating maternal high fat (HF) diet influences on maternal behavior and offspring development are inconclusive. This study aimed to evaluate the influences of a diet high in fat on mother-pup interaction, in two generations, and its early and late effects in the offspring, connecting them to the opioid system. HF dams show decreased milk ejections and higher expression of opioid receptors in the hypothalamus. Overall, HF offspring had higher cholesterol levels, less serum leptin, higher expression of peptides related to food intake, and were lighter. Therefore, maternal intake of HF diet promoted metabolic, behavioral and gene expression alterations in the mother and her offspring, even though these animals did not become obese.

Insufficient sleep may be associated with obesity via increased energy intake and/or decreased energy expenditure. The present study therefore aimed to investigate effects of sleep restriction on energy balance in healthy young adults. Participants (14 men, 13 women) aged 35.3 ± 1.0 y with 23.6 ± 0.2 kg/m2 BMI completed a randomized, crossover study exposed to short and habitual sleep with 4 wk washout. Controlled diets were provided during the first 4 d, followed by 2 d of ad libitum eating. Ad libitum energy intake, energy expenditure and physical activity level were determined as well as energy balance and body weight. Results showed that ad libitum energy intake (p = 0.031), as well as total fat (p = 0.018) increased after short compared with habitual sleep, but physical activity level, energy expenditure, energy balance, and body weight remained unaffected by sleep duration. In conclusion, sleep deprivation elevates energy intake, which may lead to positive energy balance over time and increase the risk of weight gain and/or obesity.