The scope of this diploma thesis is to evaluate the intention of the government of Slovak republic to initiate the unitary system of health insurance and thus form a sole health insurance company. The first section is focused on the opinions of economists on healthcare as a good, competition in healthcare and on the position of individual actors in healthcare. The second section provides the analysis of Slovak healthcare with the focus on insurance companies. The end of the thesis reviews the intention of forming the sole insurance company on the basis of information obtained from the literature research and from the analyses of current healthcare in Slovakia.

Theme of the Diploma Thesis " Systems and methods for street alley tending -- model object Brno" is focused on the given issue of terminology and related literature summarization. There are factors included which limits alley appearance in an urban environment, negative and positive woody plant effect in a city, but also requirements for planting and following care. Part of the methodology is a tree inventory and methods proposal, how to evaluate the prosperity of street alleys. The methodology includes habitat characteristics as the characteristics of the street itself, which together with the used taxons gives information about perspective landing or suitability selected woody plants to environmental conditions. The results of this work show that the model object contains as causal examples of inappropriate alleys as well as alleys very prospective. To summarize this work, these examples will be discussed against the gain literature information.

Thesis summarizes basic problems of working process of narrative in pioneer art - virtual reality.

No description available.

This thesis describes the topic of shooting a narrative film without the use of film lighting. The first part describes the topic in its general outlines and defines the various terms related to shooting in available light. Explores the motivation of other artists to choose this way of working and their subsequent style of work during the shooting. I also mention some film movements that are related to the topic. The second part is a description of the preproduction, shooting and postproduction of my graduation film "A Night Too Young" . In this project I used the method without the use of film lighting.

Made available in DSpace on 2018-08-01T20:28:06Z (GMT). No. of bitstreams: 1 tese_10964_Dissertação_AllinyBastos.pdf: 1478449 bytes, checksum: c80553159f9c8d359035662e8cb6ce77 (MD5) Previous issue date: 2017-02-23 / O carcinoma epidermóide de cabeça e pescoço (CECP) apresenta alta taxa de mortalidade e morbidade de indivíduos em todo o mundo. Apesar de diversos estudos apresentarem possíveis biomarcadores (BM) para o CECP, não há um BM específico estabelecido para esta doença. O objetivo deste trabalho foi avaliar o papel do VEGF- C, COX-2 e IL-17A como possíveis BM do CECP, uma vez que sua sobrexpressão tem sido relacionada com o pior prognóstico da doença. Foi realizado um estudo clínico transversal aprovado pelo Comitê de Ética CEP/UFES n° 99.242/2012. Dados clínicos-patológicos e amostras biológicas de 124 pacientes com CECP e 29 indivíduos saudáveis foram coletados. A detecção da expressão do mRNA de VEGF-C e COX-2 foi realizada por ensaio de qPCR em amostras de tumor e tecido normal. A avaliação da expressão proteica de VEGF-C e COX-2 foi realizada em soro de pacientes com CECP e controles por western blotting. O nível de IL-17A (pg/ml) foi mensurado por citometria de fluxo. A análise estatística dos dados mostrou aumento da expressão relativa do mRNA de VEGF-C em tecido tumoral foi observada em pacientes com metástase em linfonodos (p= 0,027), em relação ao grupo sem envolvimento linfonodal (0,043) e as amostras de tecido normal (0,031); Alteração da expressão proteica de VEGF-C em soro de pacientes com CECP em estágio avançado da doença (III/IV) (p=0,01) foi observado em comparação com grupo em estadiamento inicial (I/II) (p= 0,03) e controle (p= 0,003). COX-2 não apresentou diferença significante em nenhum dos parâmetros e tipos de amostras biológicas analisadas. O nível de IL-17A mostrou-se elevado nas amostras de soro de pacientes com CECP (p=0,04), no estadiamento incial da doença (I/II) (p= 0,03), em tabagistas (p= 0,04) e nos indivíduos sem metástase em linfonodos regionais quando comparados ao grupo controle (p= 0,04). VEGF-C e IL-17A se mostraram como potenciais BM do CECP em amostras de soro, sendo uma forma menos invasiva e mais viável para avaliação do estado do paciente, enquanto que para COX-2 são necessárias novas abordagens para avaliar seu papel no CECP. Palavras-chave: Carcinoma epidermóide de cabeça e pescoço; biomarcadores; VEGF- C; COX-2; IL-17A.

Cílem práce je podat co nejširší přehled o způsobech a metodách výběru a hodnocení dodavatelů a posoudit tuto problematiku ve vybraném podniku. Dále pak shrnout požadavky na dodavatele, zhodnotit dosavadní přístupy a při zjištění nedostatků navrhnout racionalizační opatření.

Cílem práce je podat co nejširší přehled o způsobech a metodách výběru a hodnocení dodavatelů a posoudit tuto problematiku ve vybraném podniku. Dále pak shrnout požadavky na dodavatele, zhodnotit dosavadní přístupy a při zjištění nedostatků navrhnout racionalizační opatření.

The topic of my diploma thesis is Changes of microbiologic parameters of packaged mineral waters during non-starndard manipulation.Firstly is clarify what mineral water actually is and what is its dividing. Other chapters of literary summary are focused onpacked water from ordinance number 275/2004. After that it focuses on microbilogy of packaged water where are the microbiological contaminants and also impacts that growth and microbiological reproduction impact. There was made an experiment at the end of diploma thesis at chosen packaged water. In this experiment was made total number of microorganism which was in the process cultivated on 36 °C and 22 °C. Everything was done after its verification and after that were consumed. All the samples were kept in condition as is defined. This research was completed with questionnaire focused on consumation of packaged water and its further storing.

L'endothelium vasculaire constitue la principale barrière entre le sang et les tissus régulant le passage de macromolécules et de cellules circulantes. Longtemps considéré comme une monocouche passive, l'endothélium joue d'importants rôles dans la régulation de la pression sanguine, de l'hémostase, des réponses immunitaires et inflammatoires. L'adhérence cellule/cellule est initiée dans l'endothélium vasculaire par des interactions homophiliques entre molécules de VE-cadhérine (= jonctions adhérentes). La dynamique de la jonction et du cytosquelette est importante pour le remodelage des jonctions intercellulaires qui a lieu au cours l'angiogenèse, de la vasculogenèse et lors de la réparation de l'endothélium. C'est pourquoi la détermination des mécanismes moléculaires sous-jacents est indispensable à la comprehension de phénomènes physiopathologiques (angiogenèse et progression tumorales, inflammation...). D'après la littérature, la protéine EPLIN intervient dans la formation du complexe E-cadhérine/alpha-caténine/EPLIN et stabilise l'actine corticale. Actuellement décrite comme spécifique des modèles épithéliaux, EPLIN peut-elle intervenir dans la liaison du complexe à base de VE-cadhérine au cytosquelette d'actine? De plus, il paraît essentiel de comprendre le rôle de cette protéine dans les cellules car son expression est fortement diminuée dans la plupart des cancers alors qu'à l'inverse sa surexpression bloque la prolifération cellulaire. / The endothelium forms the main barrier regulating the passage of macromolecules and circulating cells between the blood and tissue. Historically viewed as a passive vascular lining, vascular endothelium plays important roles in the regulation of vascular pressure, hemostasis, immune and inflammatory responses. In vascular endothelium, cell/cell adhesion is mediated by homophilic interactions of VE-cadherin molecules (= adherens junctions). Cytoskeleton and junction dynamics are important for intercellular junctions remodelling that occurs during angiogenesis, vasculogenesis and endothelium repair. So, determining the underlying molecular mechanisms is essential for the comprehension of pathologic phenomena such as angiogenesis, tumor progression or inflammation. We learn from the literature that EPLIN is involved in E-cadherin/α-catenin/EPLIN complex formation and cortical actin stabilization. Usually described as a protein specific of epithelial models, we wondered if EPLIN is able to link VE-cadherin complex to actin cytoskeleton. Furthermore, it seems essential to understand its cellular role since it is downregulated in many cancers while in contrast its overexpression blocks cell proliferation.