People with psychosocial disabilities and mental health conditions are commonly exposed to human rights violations within the mental health care system and the general community. The negative consequences of such violations have been widely documented but attempts to change the status quo have met with little success. The present dissertation aims to challenge this situation and advance the human rights-based global agenda for mental health by promoting a change within the mental health care system and the general community. Chapter 2 is a scoping review that comprehensively examines the literature on interventions that apply a human rights-based approach to promote the rights of persons with psychosocial disabilities and mental health conditions in health settings and the general community. Chapter 3 is an empirical paper that evaluates the psychometric properties of three instruments that can be used to assess the effect of future interventions aiming to promote the rights of persons with psychosocial disabilities and mental health conditions. Chapter 4 is an empirical paper that assesses the efficacy of the WHO QualityRights e-training, a new intervention to promote the human rights of persons with psychosocial disabilities and mental health conditions. The scoping review indicated that there is a growing body of literature on interventions that apply a human rights-based approach to promote the rights of people with psychosocial disabilities and mental health conditions. However, many of the studies evaluating these interventions are currently low-quality and there is urgent need for additional and methodologically robust research on this topic. Additionally, our findings showed that worldwide there are many promising practices and interventions that are currently unexamined or insufficiently evaluated. The psychometric analyses in Chapter 3 indicated that the three instruments developed to assess the knowledge about the rights of persons with mental health conditions and psychosocial disabilities (WHO QualityRights Knowledge), the attitudes towards them and their role as rights holders (WHO QualityRights Attitudes), and mental health professionals’ practices related to substitute decision-making and coercion (WHO QualityRights Practices) are sufficiently valid and reliable and could be used in future research. Finally, the data analyzed in Chapter 4 demonstrated that the WHO QualityRights e-training, compared with a placebo intervention, is effective in improving mental health professionals’ knowledge about human rights and attitudes towards people with psychosocial disabilities and mental health conditions and their role as rights-holders. Furthermore, these improvements are maintained over time. The WHO QualityRights e-training was also effective in reducing self-reported practices related to substitute-decision making and restraint both at 3 and 6 months. Given the impact that human rights violations have on the health and wellbeing of persons with psychosocial disabilities and mental health conditions, more efforts are needed to develop new interventions and carry out methodologically strong research in this area. This dissertation is a right step in this direction.

(1) Background: Low rates of hepatitis C virus (HCV) diagnosis and sub-optimal linkage to care constitute barriers toward eliminating the infection. In 2012/2013, we showed that HCV screening in primary care detects unknown cases. However, hepatitis C patients may not receive further diagnostics and therapy because they drop out during the referral pathway to secondary care. Thus, we used an existing network of primary care physicians and a practice of gastroenterology to investigate the pathway from screening to therapy. (2) Methods: HCV screening was prospectively included in a routine check-up of primary care physicians who cooperated regularly with a private gastroenterology practice. Anti-HCV-positive patients were referred for further specialized diagnostics and treatment if indicated. (3) Results: Seventeen primary care practices screened 1875 patients. Twelve individuals were anti-HCV-positive (0.6%), six of them reported previous antiviral HCV therapy, and one untreated patient was HCV-RNA-positive (0.05% of the population). None of the 12 anti-HCV-positive cases showed up at the private gastroenterology practice. Further clinical details of the pathway from screening to therapy could not be analyzed. (4) Conclusions: The linkage between primary and secondary care appears to be problematic in the HCV setting even among cooperating partners, but robust conclusions require larger datasets.

Linkage to care presents one obstacle toward eliminating HCV, and the current two-step pathway (anti-HCV, followed by HCV-RNA testing) results in the loss of patients. HCV screening was tested in the primary care setting with the fingerstick Xpert HCV viral load point-of-care assay to analyze the practicability of immediate diagnosis. Anti-HCV (Cobas) and HCV-RNA (Cobas Amplicor version 2.0, only performed if anti-HCV was positive) were analyzed centrally as the gold standard. The Xpert assay was performed by 10 primary care private practices. In total, 622 patients were recruited. Five individuals (0.8%) were anti-HCV positive, and one was HCV-RNA positive. The Xpert test was valid in 546/622 (87.8%) patients. It was negative in 544 and positive in 2 cases, both of whom were anti-HCV negative. The HCV-RNA PCR and the Xpert test were both negative in 4/5 anti-HCV-positive cases, and the individual with HCV-RNA 4.5 × 106 IU/mL was not detected by the Xpert test. Primary care physicians rated the Xpert test practicability as bad, satisfactory, or good in 6%, 13%, and 81%, respectively, though 14/29 (48%) bad test ratings were assigned by a single practice. Despite adequate acceptance, interpretability and diagnostic performance in primary care settings should be further evaluated before its use in HCV screening can be recommended.

Background: Autism and other neurodevelopmental disorders (NDD) are common in low- and middle-income countries (LMIC). However, services to address the needs of this group in LMIC are almost non-existent. The World Health Organization (WHO) developed the Caregiver Skills Training (CST) programme to be suitable for delivery in diverse global contexts. Ethiopia, the country of focus in this study, has a largely rural population and a lack of specialist service providers. Additional contextual challenges, including poverty, low literacy, limited access to healthcare and a lack of specialist child mental health services, may undermine the delivery of CST in this setting. This thesis, therefore, seeks to explore the acceptability and feasibility of non-specialist delivery of the WHO-CST from the perspective of providers and caregivers in rural Ethiopia. Methods: In Chapter one, a general literature review of neurodevelopmental disability and caregiver skills training is presented, with a focus on sub-Saharan Africa, to help contextualise the main qualitative study, outlined in chapter two. In-depth interviews were conducted with caregivers (n=19) who were all participants in two rural pilot studies of the WHO-CST programme. In addition, three focus group interviews were conducted with non-specialist facilitators (n=8), who facilitated the CST programme in two rural pilot tests. Data were analysed using the framework approach. Results: Findings were mapped onto the three framework themes created for this analysis: 1) Programme content: caregivers and facilitators uniformly indicated that the adapted programme addressed a need and was relevant for their context; caregivers emphasised how the programme helped them understand their child's problems and improve their skills to support their children; facilitators highlighted having acquired new knowledge and skills relating to NDD; 2) Programme facilitation: caregiver responses suggested that programme facilitation by non-specialists was acceptable; non-specialist facilitators emphasised the importance of support and supervision for the facilitators and simplification and modification of some concepts, such as the concept of play, and 3) CST training approach and delivery: participants indicated that the training modalities, including home visits and group training, were acceptable and feasible in the local context. Conclusions: This study suggested that, with some contextually appropriate modifications of programme content and delivery and continuing supervision of facilitators, the WHO-CST programme facilitated by non-specialists would be acceptable and feasible in rural Ethiopia. Results from this study may be useful to fine-tune the implementation of non-specialist delivery of the CST programme in Ethiopia, as well as other LMIC.

Infectious diseases attract a lot of mediatic, cultural and political attention. But are those diseases like Ebola, or ‘disease x’ actually what kills us? Since 1946, the WHO is the most authoritative figure in the fights against infectious disease outbreaks. So how does the WHO maintain this power and authority after tremendous budget cuts, competition for authority, and a shift to non-communicable disease epidemiology? This thesis uses a mixed-methods approach of quantitative analysis of ‘Disease Outbreak News’ reports, and qualitative analysis of key WHO literature, to develop the alternative narrative answering those questions. This thesis found that the WHO activities surrounding the collection and distribution of data create a political and institutional environment in which the WHO seems to be the only logical solution to prevent them. Additionally, the narrative put forth by the WHO prioritizes the ‘alert and response’ and operational capabilities of the organization to further expand authority in outbreak response. This study concludes that the WHO, through the collection and distribution of knowledge, and efforts to increase operational capability as seen through the Global Outbreak Alert and Response Network (GOARN), seeks to maintain normative authority and power as an international organization. / M.A. / Globalization of trade and travel has only increased the fear of infectious disease transmission. There is a great demand for a global health security system that is alert and capable. Based on this ‘threat’ the WHO justifies their role as global health leader. The Global Outbreak Alert and Response Network (GOARN) is the system that currently acts as the operational arm of the WHO, monitoring and coordinating response to infectious disease outbreaks globally. Despite the critical role of GOARN, its day-to-day endeavors remain unexplored by the public health field. This thesis analyzes how the WHO uses GOARN and its surveillance capabilities to collect and transform data as a method to maintain normative authority, and projects a powerful narrative as the leader of ‘alert and response’. In a competitive environment with limited financial resources, the WHO has adapted in terms of surveillance and operational capability to maintain its leadership and authority in the global public health field.

Trata-se de uma pesquisa teórica que verifica as relações existentes entre saúde mental e saúde pública a partir da identificação dos principais problemas referentes à infância em recomendações divulgadas pela Organização Mundial da Saúde nos seguintes momentos históricos: início da década de 1950, meados da década de 1970 e primeiros anos do século XXI. Apresenta a diversidade presente na construção do campo da saúde mental, as principais perspectivas teóricas e o lugar da clínica psiquiátrica e psicanalítica nesse processo. Ações dirigidas à infância pelo movimento da Higiene Mental, nas primeiras décadas do século XX, também são analisadas. Verifica-se que a prevenção se instaura como principal modelo de assistência. A saúde materno-infantil, a escola e a família são os principais componentes das medidas preventivas propostas. Nestas recomendações, evidencia-se uma relação de quase equivalência entre psiquiatria e saúde mental. A diversidade deste campo é substituída por um discurso relativamente hegemônico, no qual a noção de adaptação ocupa lugar central. Nas recomendações da OMS, deste início de século, observa-se a influência das neurociências, da psiquiatria biológica e das terapias cognitivo-comportamentais. / This is a theoretical research aiming at detecting the main problems concerning children on the intersection of mental and public health, and based upon the World Health Organization’s commendations at the following historical moments: the 1950s and 1970s, as well as the early 21st century. The foundations of such commendations were checked, keeping in mind the diversity of orientations in the field of mental health. The theoretical frame presents the origins of psychiatric and psychoanalytical clinics with children, and their fundamentals. Actions aiming at children by the Mental Hygiene Movement in the early 20th century were also analyzed. It can be observed that prevention imposes itself as the main assistance pattern. The health of both mothers and children, schools and families are the main components of the proposed prevention measures. In these commendations it can also be noticed an almost equivalent relationship between psychiatrist and mental health. Diversity in this field is substituted for a relatively hegemonic speech, in which the notion of adaptation plays a crucial role. In the World Health Organization’s commendations in this early century, it can be detected the influence of neurosciences, biological psychiatry, and behaviorist-cognitive therapies.

Trata-se de uma pesquisa teórica que verifica as relações existentes entre saúde mental e saúde pública a partir da identificação dos principais problemas referentes à infância em recomendações divulgadas pela Organização Mundial da Saúde nos seguintes momentos históricos: início da década de 1950, meados da década de 1970 e primeiros anos do século XXI. Apresenta a diversidade presente na construção do campo da saúde mental, as principais perspectivas teóricas e o lugar da clínica psiquiátrica e psicanalítica nesse processo. Ações dirigidas à infância pelo movimento da Higiene Mental, nas primeiras décadas do século XX, também são analisadas. Verifica-se que a prevenção se instaura como principal modelo de assistência. A saúde materno-infantil, a escola e a família são os principais componentes das medidas preventivas propostas. Nestas recomendações, evidencia-se uma relação de quase equivalência entre psiquiatria e saúde mental. A diversidade deste campo é substituída por um discurso relativamente hegemônico, no qual a noção de adaptação ocupa lugar central. Nas recomendações da OMS, deste início de século, observa-se a influência das neurociências, da psiquiatria biológica e das terapias cognitivo-comportamentais. / This is a theoretical research aiming at detecting the main problems concerning children on the intersection of mental and public health, and based upon the World Health Organization’s commendations at the following historical moments: the 1950s and 1970s, as well as the early 21st century. The foundations of such commendations were checked, keeping in mind the diversity of orientations in the field of mental health. The theoretical frame presents the origins of psychiatric and psychoanalytical clinics with children, and their fundamentals. Actions aiming at children by the Mental Hygiene Movement in the early 20th century were also analyzed. It can be observed that prevention imposes itself as the main assistance pattern. The health of both mothers and children, schools and families are the main components of the proposed prevention measures. In these commendations it can also be noticed an almost equivalent relationship between psychiatrist and mental health. Diversity in this field is substituted for a relatively hegemonic speech, in which the notion of adaptation plays a crucial role. In the World Health Organization’s commendations in this early century, it can be detected the influence of neurosciences, biological psychiatry, and behaviorist-cognitive therapies.

Masters of Public Health - see Magister Public Health / The World Health Organization (WHO) considers violence to be a global public health problem. It is estimated that 1.6 million people worldwide lost their lives to violence in 2000. This translates to a global rate of 28.8 deaths per 100 000 population. The end of Apartheid in South Africa in 1994 brought about various economic, social and political transitions within the country, resulting in rapid urbanization, increasing unemployment and deepening inequalities. Consequently, these conditions also brought about increased incidences of crime and violence. The South African Police Service (SAPS) recorded approximately 2.58 million crimes in 2000. The SAPS faced many challenges in transforming the eleven South African Police Forces to a combined South African Police Service in 1994. Literature has indicated that while serious crimes increased, the chances of an offender being caught and punished declined between 1994 and 2000. During the 2002-2003 financial year the SAPS recorded a national homicide rate of 47.4 per 100 000 population. The Western Cape and Limpopo province had the highest and lowest provincial homicide rate of 84.8 and 12.1 per 100 000 population respectively. Other studies indicated that city-specific homicide rates for Cape Town increased from 84 to 88 per 100 000 population between 1999 and 2001. A pilot study conducted in Cape Town during 2003 to determine victim-perpetrator relationships and motives for homicide that occurred in 1999 was hampered by difficulties in tracing police dockets, inconsistencies in data capturing, and the absence of perpetrator information due to some court cases not being finalized. It was therefore decided to conduct a qualitative, descriptive, comparative study between two police stations in Cape Town. Semi-structured interviews were conducted with police officers at different ranks to document the procedures and route of reported crimes and to explore the factors impacting on the criminal investigation process. The interviews were audio-recorded, transcribed and analysed using thematic content analysis. The interviews provided an insight to the contextual environment and the attitudes of police officers regarding the transformation of the SAPS, and identified the factors impacting on the criminal investigation process at the two selected police stations. Issues discussed are discipline, restructuring and motivational factors regarding the transformation process, as well as training courses, the court impact and the relationship between the detectives and prosecutors. The main constraints identified at both police stations were human resources, training courses and vehicles. Social support and community factors are also discussed. The interviews with police officers revealed that there are various issues of management at national and provincial level that need to be addressed, such as detective recruitment standards, training courses and the management of different crime types to reduce the workload of detectives. The need for closer collaboration with the courts to avoid the misplacement of dockets and to minimise delays in the finalisation of court cases was also identified. Previous studies have also identified blockages within the South African criminal justice system and it is hoped that this study could highlight those issues that still need to be addressed.

<p>Background: The Baby Friendly Hospital Initiative (BFHI) is considered one of the most successful international efforts to protect, promote and support breastfeeding. The initiative has proven impact, increasing the likelihood of babies being exclusively breastfed for six months. Official designation as Baby Friendly requires careful assessment completed by a trained external team to confirm that the institution is truly carrying out all Ten Steps of successful breastfeeding and conforming to the International Code of Marketing of Breastmilk Substitutes (BMS).The implementation of these principles are however challenging for facilities as it requires &ldquo / strategic planning, implementation and maintaining change&rdquo / within the facilities. Aim: To assess the factors influencing the implementation of BFHI principles in non accredited MOU` s in the Metropole region of the Western Cape.</p>

The CIDI is a fully standardised diagnostic interview designed for assessing mental disorders based on the definitions and criteria of ICD-1Oand DSM-IlI-R. Field trials with the CIDI have been conducted in 18 centres around the world, to test the feasibility and reliability of the CIDI in different cultures and settings, as well as to test the inter-rater agreement for the different types of questions used. Of 590 subjects interviewed across all sites and rated by an interviewer and observer, 575 were eligible for analysis. The CIDI was judged to be acceptable for most subjects and was appropriate for use in different kinds of settings. Many subjects fulfilled criteria for more than one diagnosis (lifetime and six-month). The most frequent lifetime disorders were generalised anxiety, major depression, tobacco use disorders, and agoraphobia. Percentage agreements for all diagnoses were above 90% and the kappa values were all highly significant. No significant numbers of diagnostic disconcordances were found with lifetime, six-month, and four-week time frames.