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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 11 to 20 of 136 (0.023 seconds)Spelling suggestions: "subject:"xenobiotics"" "subject:"xenobioticos""
| 11 |
Human arylamine N-acetyltransferase type 1Ward, Alison January 1995 (has links)
No description available.
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| 12 |
Developmental and dietary regulation of flavin-containing monooxygenaseSu, Shelley A. Larsen 08 May 1998 (has links)
Graduation date: 1998
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| 13 |
Formation and fate of chlorophenol glycosides in an aquatic plant environmentDay, James A., III 12 1900 (has links)
No description available.
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| 14 |
The relevance of prostanoid metabolism in the development of drug-induced nephrotoxicityCockburn, Elinor M. January 1990 (has links)
The enzymes prostaglandin synthetase (PGS) and lipoxygenase can cooxidise a variety of xenobiotics to reactive intermediates during the metabolism of arachidonic acid (AA). PGS exhibited a gradient of activity within the kidney which was greatest in the papilla and least in the cortex. Rabbit and rat renal microsomes metabolised the model compound, tetramethylphenylenediamine (TMPD), in the presence of AA by pathways which were predominantly PGS and lipoxygenase-dependent, respectively. Therefore, both enxymes may play a role in the development of site-specific nephrotoxicity within the kidney. The model papillotoxin 2-bromoethanamine (2-BEA) which exhibits target selective toxicity for the renal papilla, was found to be significantly more toxic to medullary interstitial cells than to proximal tubule cells in culture. Toxicity was enhanced significantly by AA whereas inhibitors of cyclooxygenase (indomethacin, aspirin), prostaglandin hydroperoxidase (propylthiouracyl) and lipoxygenase (nordihydrogauaretic acid) all significantly decreased 2-BEA toxicity. This suggests that toxicity is mediated either by the hydroperoxidase component of PGS or by lipoxygenase. Thromboxane A<sub>2</sub> (TxA<sub>2</sub>) is thought to play a pivotal role in cyclosporin A (CsA) induced nephrotoxicity. Administration of a thromboxane synthetase inhibitor (TSI) normalised TxB<sub>2</sub> excretion but only partially protected against other factors involved. However, treatment with angiotensin converting enzyme inhibitor either alone or in combination with TSI did not affect CsA nephrotoxicity. Tubular toxicity, manifest as N-acetyl-β-D-glucosaminidase (NAG) enzymuria, glycosuria, vacuolation, calcification and chronic tubule damage, may contribute to the CsA-induced reduction in renal function. In addition to protecting against CsA-induced nephrotoxicity, the administration of TSI to CsA-treated rats also partially reversed pre-existing renal damage.
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| 15 |
Interaction of xenobiotics with the glucocorticoid hormone system in vitro /Johansson, Maria. January 1900 (has links)
Diss. (sammanfattning) Uppsala : Univ., 2002. / Härtill 5 uppsatser.
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| 16 |
The effects of a chemical stressor on amphibian larvae : individual, population, and species level responses /Bridges, Christine M. January 1999 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 1999. / Typescript. Vita. Includes bibliographical references. Also available on the Internet.
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| 17 |
The effects of a chemical stressor on amphibian larvae individual, population, and species level responses /Bridges, Christine M. January 1999 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 1999. / Typescript. Vita. Includes bibliographical references. Also available on the Internet.
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| 18 |
Evaluation of Immune Responses and Cytological Changes in Lumbricus Terrestris and Eisenia Foetida as Assays for XenobioticsHariri, Abdolrahman Sadeghi 12 1900 (has links)
The earthworms, Lubricus terrestris and Eisenia foetida, were used as non mammalian surrogate models to assess the immunotoxicpotential of xenobiotic to mammals. Assays were developed and optimized for detecting spreading activity and phagocytosis of rabbit red blood cell (RRBC), bacteria, and yeasts by macrophage-like coelomocytes of L. terrestris.
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| 19 |
Molecular aspects of xenobiotic toxicity : role of bioactivation and bioinactivationPowell, Helen January 1999 (has links)
No description available.
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| 20 |
The interactions of toluic acid with indigenous microbial populations in a model Gravel Bed Hydroponic systemFuller, Robert A. January 1996 (has links)
No description available.
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