- About
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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 451 to 460 of 643 (0.029 seconds)| 451 |
Nitric oxide enhances transmitter release at the mammalian neuromuscular junction via a cGMP-mediated mechanismNickels, Travis John 24 April 2006 (has links)
No description available.
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| 452 |
MECHANISMS OF EXTRACELLULAR NUCLEOTIDE ACCUMULATION DURING REGULATED CELL DEATH IN TUMOR CELLSBoyd Tressler, Andrea Michelle 01 June 2016 (has links)
No description available.
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| 453 |
Modulation of the Arrhythmia Substrate in Cardiovascular DiseaseLong, Victor P., III 12 September 2016 (has links)
No description available.
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| 454 |
Purinergic neurogenic intestinal mucosal secretionHu, Hong-Zhen 22 December 2004 (has links)
No description available.
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| 455 |
An acrolein-derivatized cAMP antiserum to study cAMP signaling and visualization in the enteric nervous system-implications for gut inflammationGuzman, Jorge Enrique 22 December 2004 (has links)
No description available.
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| 456 |
Influenza A Virus Inhibits Alveolar Fluid Clearance in BALB/c MiceWolk, Kendra E. 22 June 2012 (has links)
No description available.
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| 457 |
ADENOSINE RECEPTOR MEDIATED PROTEIN KINASE C ACTIVATION IN THE HEARTYang, Zhaogang 25 June 2012 (has links)
No description available.
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| 458 |
Effects of exogenous ATP and phenothiazines on ion transport in isolated rat intestinal epithelial cells /Richards, Neil William January 1984 (has links)
No description available.
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| 459 |
Detailed analysis of Japanese patients with adenosine deaminase 2 deficiency reveals characteristic elevation of type II interferon signature and STAT1 hyperactivation / 日本人ADA2欠損症患者における詳細な発現解析によりII型インターフェロンシグネチャーの特異的上昇とSTAT1過剰活性化が明らかとなったNihira, Hiroshi 23 March 2022 (has links)
京都大学 / 新制・課程博士 / 博士(医学) / 甲第23796号 / 医博第4842号 / 新制||医||1058(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 森信 暁雄, 教授 椛島 健治, 教授 杉田 昌彦 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM
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| 460 |
Regulation of kinases by synthetic imidazoles, nucleotides and their deuterated analoguesNkosi, Thokozani Clement 19 April 2016 (has links)
Deuteration is the replacement of a hydrogen atom by deuterium atom in a molecule. The replacement begins at the most acidic hydrogen in the molecule. In ATP, the deshielded hydrogen is C8-H which is the first replaced during deuteration. During ATP deuteration some of the ATP is hydrolysed to ADP concurrently. Using kinetic analysis, it was confirmed that the ATP hydrolysis that occurs is 1st order in ATP concentration, while the hydrogen replacement is 2nd order. The ATP and its C8 deuterated analogue were tested against three enzymes shikimate kinase (SK), acetate kinase (AK) and glutamine synthetase (GS) to determine if a kinetic isotope effect (KIE) exists in these systems. With AK and GS, the KIED increased as the KIEH decreased, while with SK the KIED decreased as the KIEH increased as the concentration of the ATP or deuterated analogue increased. Deuteration of imidazole and purine compounds reduced the specific activity of AK or SK at low concentrations in an enzyme-catalysed reaction. From a library of imidazole-containing compounds that inhibited SK, three compounds were selected and their IC50 values were determined on the SK-catalysed reaction. These compounds show a differential potency and efficiency between their protonated and deuterated analogues when compared in a 1:1 mixture. Synthesized purines incorporating three different substituents at N-9 were tested against AK or SK for their ability to lower the specific activity of the enzymes used / Physics / M. Sc. (Physics)
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