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No / We present a series of iterative methods to examine the problems associated with summed probability functions (SPFs) based on archaeological radiocarbon data. As a case study we use an SPF generated from a substantial radiocarbon data-set from the Irish Later Bronze and Iron Ages. We use simple numerical methods to show that real patterns can be deciphered from SPFs that can be used to trace and evaluate patterns of change. However, our results suggest that SPFs should not be used as a simple index of past human activity. / This research forms part of the project ‘Mobility, Climate and Culture: Re-modelling the Irish Iron Age’, funded by the British Academy through their BARDA scheme. Preliminary data collection was conducted as part of a pilot project funded by the Heritage Council of Ireland.

Alveolar macrophages (AMs) are lung tissue-resident macrophages that can be expanded in culture, but it is unknown to what extent culture affects their in vivo identity. Here we show that mouse long-term ex vivo expanded AMs (exAMs) maintained a core AM gene expression program, but showed culture adaptations related to adhesion, metabolism and proliferation. Upon transplantation into the lung, exAMs reacquired full transcriptional and epigenetic AM identity, even after several months in culture and could self-maintain long-term in the alveolar niche. Changes in open chromatin regions observed in culture were fully reversible in transplanted exAMs and resulted in a gene expression profile indistinguishable from resident AMs. Our results indicate that long-term proliferation of AMs in culture did not compromise cellular identity in vivo. The robustness of exAM identity provides new opportunities for mechanistic analysis and highlights the therapeutic potential of exAMs.

A majority of underground coal mine disasters in the United States are due to explosions. Current atmospheric monitoring system (AMS) practices in the US could be enhanced to facilitate data sharing and learning of the entire work force. With the inclusion of additional atmospheric monitoring and data collecting, meaningful analysis can be realized and shared with the workforce. AMS data can be utilized to advance the understanding of underground atmospheres for the entire workforce along with adding to the knowledge base for preventative planning. An AMS interface ADAMAS is suggested to facilitate this conglomeration and sharing of the data visually, so that it can be quickly processed and applied in their daily decisions. An emerging sensor technology for underground mining, fiber optics is explored and tested in emergency, or fire and explosion situations. The fiber optic methane sensor performed well in smoke only showing a slow in response time due to soot on the filter. The ADAMAS interface was tested in a large population of underground coal miners. The population varied in age, job, classification, and experience. They all primarily found it to be easy to use and helpful to them. Concerns arose when asked how this will facilitate an improved relationship with regulatory agencies. There is trepidation when it comes to additional atmospheric information sharing, that it may not be used advance understanding of mine atmospheres. The AMS data collected is individual to each mine site but can assist in the understanding of underground atmosphere as a whole. Moving forward, regulatory bodies should use this as a stepping point to consider how this information can be used to advance the field of mine ventilation and also the health and safety of the miner. / Ph. D. / Many accidents in underground coal mines in the United States are due to explosions. Explosions occur when there is a spark created in an atmosphere that contains an explosive mixture of methane and oxygen. Current monitoring in the United States standardly follows what regulators stipulate. It is suggested and tested that we use additional atmospheric monitors, including fiber optic technology, to monitor the atmosphere, trend the data and share it with the mining workforce. Shown is current trends for atmospheric monitoring systems (AMS) and out suggestion for increased monitoring and using an interface called ADAMAS for trending and sharing data visually in graphs and locations on maps. A novel sensing technology a fiber optic methane sensor was also tested in smoke conditions for its applicability in underground mines during an emergency. Both the interface and the fiber optic sensor were successful in testing. Miners found the interface easy to use and informative. The fiber optic sensor was successful sensing methane even in smoke environments although the response time of the sensor decreased.

The Alpha Magnetic Spectrometer (AMS-02) is a high-energy particle physics detector operating on the International Space Station (ISS) since May 2011. Since its launch, the AMS-02 provided a large amount of data whose precision was never before achieved, opening a new path for the study of cosmic rays (CRs). The first published results of AMS-021-3 show tension with the current understanding of the cosmic ray theory, particularly at higher energies. These tensions are directly linked to many fundamental questions like the dark matter nature, the CR origin and their propagation through the galaxy. This work presents the measurement of the electron flux and the positron flux in primary cosmic rays, based on the data collected between May 2011 and November 2016, an extended data set with respect to the published AMS-02 results.3 The results extend the energy range explored up to 1 TeV for electrons and up to 700 GeV for positrons, being consistent with the published results when using the same data set. A discrepancy between the new measurement and the published flux is observed in the low energy region of the electron flux, while the positron flux is in good agreement. This can be explained by a charge dependent solar modulation effect. This hypothesis was investigated by studying the time evolution of the fluxes, focusing on the energy region below 40 GeV, where an electron and positron flux is computed over 74 time bins of 27 days width, corresponding to the suns rotation period as seen from the Earth. The time dependent analysis confirms hints of charge dependent solar modulation, that are also observed by other independent analysis that have been carried out in parallel within the collaboration. / O Alpha Magnetic Spectrometer (AMS-02) é um experimento de física de partículas instalado na Estação Espacial Internacional (ISS) desde Maio de 2011. Desde seu lançamento, AMS-02 coleta uma quantidade de dados com tal precisão que até então nunca foram jamais vistos, abrindo o caminho para o estudo dos Raios Cósmicos (CRs). Os primeiros resultados publicados pelo AMS-021-3 apresentam tensões com o modelo atual da teoria de CRs, particularmente nas altas energias. Essas tensões são diretamente ligadas a diversas questões fundamentais como a natureza da Matéria Escura (DM), a origem dos CRs e suas propagações pela galáxia. Este trabalho apresenta a medição do fluxo de elétrons e pósitrons em CRs primários, baseando-se nos dados coletados entre Maio de 2011 e Novembro de 2016, período extendido com relação aos resultados públicados pelo AMS-02.3 Os resultados extendem o intervalo de energia explorado para 1 TeV para elétrons e 700 GeV ára pósitrons, consistentes com os resultados públicados usando o mesmo período. Discrepância entre a nova medição e o fluxo públicado é observada na região de baixas energias para o fluxo de elétrons, enquanto o fluxo de pósitrons continua em bom acordo. O resultado pode ser explicado por uma dependência na carga causada pela modulação solar. Tal hipótese é investigada estudando-se a evolução temporal dos fluxos, focando-se no intervao de energia abaixo de 40 GeV, onde um fluxo de elétrons e pósitrons é medido durante 74 intervalos temporais de 27 dias, correspondendo à rotação do sol vista da Terra. A análise dependente do tempo confirma a existência da dependência de carga da modulação solar, também observada por outras análises independentes que foram feitas dentro da colaboração.

The content of this thesis is focused on the performance evaluation of the DeLaval milking robot in the selected stable. For this work was chosen the family farm stable of Mr. Šítal in the village Mojné. Selected parameters of milking robotic were monitored from 19.9.2018 to 18.3.2019 and on the base of these parameters was evaluated efficiency of the equipment. In this time were followed numbers of milked cows per 24 hours, the average numbers of milking on one cow, the average milking time and daily milk utility. In the selected stable were in a half-year time milked averagely 44 cows with frequency 2,62 utilizations the milking robot per day. The milking took averagely 7 minutes and 40 seconds. Milking utilization was 30,70 liters on one cow per day and total milk herd was 1353,01 liters of milk per day.

The Alpha Magnetic Spectrometer (AMS-02) is a high-energy particle physics detector operating on the International Space Station (ISS) since May 2011. Since its launch, the AMS-02 provided a large amount of data whose precision was never before achieved, opening a new path for the study of cosmic rays (CRs). The first published results of AMS-021-3 show tension with the current understanding of the cosmic ray theory, particularly at higher energies. These tensions are directly linked to many fundamental questions like the dark matter nature, the CR origin and their propagation through the galaxy. This work presents the measurement of the electron flux and the positron flux in primary cosmic rays, based on the data collected between May 2011 and November 2016, an extended data set with respect to the published AMS-02 results.3 The results extend the energy range explored up to 1 TeV for electrons and up to 700 GeV for positrons, being consistent with the published results when using the same data set. A discrepancy between the new measurement and the published flux is observed in the low energy region of the electron flux, while the positron flux is in good agreement. This can be explained by a charge dependent solar modulation effect. This hypothesis was investigated by studying the time evolution of the fluxes, focusing on the energy region below 40 GeV, where an electron and positron flux is computed over 74 time bins of 27 days width, corresponding to the suns rotation period as seen from the Earth. The time dependent analysis confirms hints of charge dependent solar modulation, that are also observed by other independent analysis that have been carried out in parallel within the collaboration. / O Alpha Magnetic Spectrometer (AMS-02) é um experimento de física de partículas instalado na Estação Espacial Internacional (ISS) desde Maio de 2011. Desde seu lançamento, AMS-02 coleta uma quantidade de dados com tal precisão que até então nunca foram jamais vistos, abrindo o caminho para o estudo dos Raios Cósmicos (CRs). Os primeiros resultados publicados pelo AMS-021-3 apresentam tensões com o modelo atual da teoria de CRs, particularmente nas altas energias. Essas tensões são diretamente ligadas a diversas questões fundamentais como a natureza da Matéria Escura (DM), a origem dos CRs e suas propagações pela galáxia. Este trabalho apresenta a medição do fluxo de elétrons e pósitrons em CRs primários, baseando-se nos dados coletados entre Maio de 2011 e Novembro de 2016, período extendido com relação aos resultados públicados pelo AMS-02.3 Os resultados extendem o intervalo de energia explorado para 1 TeV para elétrons e 700 GeV ára pósitrons, consistentes com os resultados públicados usando o mesmo período. Discrepância entre a nova medição e o fluxo públicado é observada na região de baixas energias para o fluxo de elétrons, enquanto o fluxo de pósitrons continua em bom acordo. O resultado pode ser explicado por uma dependência na carga causada pela modulação solar. Tal hipótese é investigada estudando-se a evolução temporal dos fluxos, focando-se no intervao de energia abaixo de 40 GeV, onde um fluxo de elétrons e pósitrons é medido durante 74 intervalos temporais de 27 dias, correspondendo à rotação do sol vista da Terra. A análise dependente do tempo confirma a existência da dependência de carga da modulação solar, também observada por outras análises independentes que foram feitas dentro da colaboração.

Die Dissertationsschrift stellt eine Toolkette zum abstrakten Entwurf von Mikrosystemen vor. Mikrosysteme können aus Elementen verschiedener physikalischer Domänen bestehen und zusätzlich digitale Hardware sowie Software enthalten. Die Erfassung und Formalisierung dieser heterogenen Systeme stellt den ersten Schritt im Entwurfsprozess dar, die damit verbundene neue Methodik des Designs von Mikrosystemen bildet den Kern der vorliegenden Arbeit. Zur Erfassung der analogen Spezifikationsteile enthält die Arbeit die Schilderung und Implementierung neuer Datenstrukturen, die ausgehend von einer ausführlichen Anforderungsanalyse geschaffen wurden. Das abstrakte Systemverhalten wird mit Hilfe hybrider Automaten modelliert, die sowohl mit speziellen hybriden Werkzeugen als auch mit SystemC-AMS simulierbar sind. Darüber hinaus beschäftigt sich die Arbeit mit der Erfassung von Signalverläufen und Schaltplaninformationen. Die formalisierten Anforderungen ermöglichen erste Prüfungen der Spezifikation auf Konsistenz. Zur Unterstützung niedriger Abstraktionsebenen wie der Differentialgleichungsebene steht ein Wandler von SystemC-AMS nach VHDL-AMS bereit. In die Systembeschreibung mit SystemC-AMS ist die Definition und Verknüpfung von Kostenparametern integrierbar. Das daraus entstehende globale Gütemaß hilft dem Entwerferteam, die optimale Systemrealisierung zu finden. / The PhD thesis proposes a toolflow for the design of microsystems on higher abstraction levels. Microsystems may consist of components using effects in different physical domains plus additional digital hardware and software. The collection and formalization of these heterogeneous systems is a first step in the design process, the associated design method ist the key point of this work. The system behavior is modeled using hybrid automata, which are checkable using hybrid modelcheckers and simulable using SystemC-AMS. Furthermore the work deals with signal forms and circuit parameters. To support modeling on lower abstraction levels like differential algebraic equations a syntax conversion from SystemC-AMS to VHDL-AMS was included. The integration of cost factors into SystemC-AMS allows design space exploration during system simulation.

Le Spectromètre Magnétique Alpha (AMS) est un détecteur de particules installé à bord de la Station Spatiale Internationale ; il enregistre des données depuis mai 2011. L'expérience a pour objectif d'identifier la nature des rayons cosmiques chargés et des photons et de mesurer leur flux dans la gamme d'énergie du GeV au TeV. Ces mesures permettent d'affiner les modèles de propagation de rayons cosmiques, d'effectuer une recherche indirecte de matière noire, et de chercher l'antimatière primordiale (anti-hélium). Dans ce mémoire, les données des premières années ont été utilisées pour mesurer les flux d'électrons et de leptons (électrons + positons) dans la gamme d'énergie de 0.5 GeV à 700 GeV. L'identification d'électrons nécessite une séparation électrons/protons de l'ordre de 104, obtenue par l'utilisation conjointe des estimateurs de différents sous-détecteurs d'AMS, en particulier du calorimètre électromagnétique (ECAL), du trajectomètre et du détecteur à radiation de transition (TRD). Dans cette analyse, les nombres d'électrons et de leptons sont estimés par un ajustement des distributions de l'estimateur du calorimètre et vérifiés en utilisant l'estimateur du TRD : 11 millions leptons ont été sélectionnés et analysés. Les incertitudes systématiques sont déterminées en variant les coupures de sélection et la procédure d'ajustement. L'acceptance géométrique du détecteur et les efficacités de sélection sont estimées grâce aux données de simulation. Les différences observées sur les échantillons de contrôle issus des données permettent de corriger la simulation. Les incertitudes systématiques associées à ces corrections sont établies en variant les échantillons de contrôle. Au total, à 100 GeV (resp. 700 GeV), l'incertitude statistique du flux de leptons est 2% (30%) et l'incertitude systématique est 3% (40%). Comme les flux se comportent globalement en loi de puissance en fonction de l'énergie, il est important de maitriser la calibration en énergie. Nous avons contrôlé in situ la mesure en énergie du calorimètre en comparant les électrons des données de vol et les données de tests en faisceaux, en utilisant en particulier la variable E/p ou p est la quantité de mouvement mesurée par le trajectomètre. Une deuxième méthode de calibration absolue à basse énergie, indépendante du trajectomètre, basée sur l'effet de la coupure géomagnétique a été développée. Deux modèles de prédiction de la coupure géomagnétique, l'approximation Störmer et le modèle IGRF, ont été testés et comparés. Ces deux méthodes ont permis de contrôler la calibration en énergie à 2% et de vérifier la stabilité des performances du calorimètre dans le temps. / The Alpha Magnetic Spectrometer (AMS) is a particle detector installed on the International Space Station; it starts to record data since May 2011. The experiment aims to identify the nature of charged cosmic rays and photons and measure their fluxes in the energy range of GeV to TeV. These measurements enable us to refine the cosmic ray propagation models, to perform indirect research of dark matter and to search for primordial antimatter (anti-helium). In this context, the data of the first years have been utilized to measure the electron flux and lepton flux (electron + positron) in the energy range of 0.5 GeV to 700 GeV. Identification of electrons requires an electrons / protons separation power of the order of 104, which is acquired by combining the information from different sub-detectors of AMS, in particular the electromagnetic calorimeter (ECAL), the tracker and the transition radiation detector (TRD). In this analysis, the numbers of electrons and leptons are estimated by fitting the distribution of the ECAL estimator and are verified using the TRD estimator: 11 million leptons are selected and analyzed. The systematic uncertainties are determined by changing the selection cuts and the fit procedure. The geometric acceptance of the detector and the selection efficiency are estimated thanks to simulated data. The differences observed on the control samples from data allow to correct the simulation. The systematic uncertainty associated to this correction is estimated by varying the control samples. In total, at 100 GeV (resp. 700 GeV), the statistic uncertainty of the lepton flux is 2% (30%) and the systematic uncertainty is 3% (40%). As the flux generally follows a power law as a function of energy, it is important to control the energy calibration. We have controlled in-situ the measurement of energy in the ECAL by comparing the electrons from flight data and from test beams, using in particular the E/p variable where p is momentum measured by the tracker. A second method of absolute calibration at low energy, independent from the tracker, is developed based on the geomagnetic cutoff effect. Two models of geomagnetic cutoff prediction, the Störmer approximation and the IGRF model, have been tested and compared. These two methods allow to control the energy calibration to a precision of 2% and to verify the stability of the ECAL performance with time.

Le rayonnement cosmique, mis en évidence par Viktor Hess en 1912, est composé de particules chargées, créées et possiblement accélérées dans les restes de supernova, et qui se propagent dans la Galaxie. La mesure des flux du rayonnement cosmique permet de mettre des contraintes sur leurs sources et leur transport, mais aussi de se pencher sur le problème de la matière sombre.C'est pour répondre à ces questions qu'a été construit le détecteur AMS-02, mis en place sur la station spatiale internationale depuis mai 2011. Ce détecteur de haute précision mesure l'ensemble des flux de particules du rayonnement cosmique.Le travail proposé dans cette thèse consiste à estimer le flux de protons avec le détecteur AMS-02. L'accent est mis sur la déconvolution des effets de la réponse en énergie du détecteur sur les flux et sur la caractérisation du flux obtenu à haute énergie (au-dessus de 200 GeV/n) avec la mise en évidence d'une cassure spectrale.D'autre part, le soleil émet un plasma qui interagit avec les particules du rayonnement cosmique, modifiant les flux issus de la propagation dans la Galaxie. Cette modification évolue dans le temps en suivant le cycle d'activité solaire et est appelée modulation solaire. Dans ce cadre, nous avons obtenu une nouvelle détermination robuste des flux interstellaires de protons et d'hélium en nous basant sur les données récentes du rayonnement cosmique (incluant AMS-02). Les niveaux de modulation solaire obtenus sont validés avec une seconde analyse réalisée à partir des données des moniteurs à neutrons, détecteurs au sol, qui permettent d'établir des séries en temps du paramètre de modulation depuis les années 50. / Cosmic rays (CR) were discovered by Viktor Hess in 1912. Charged CR are synthesized and supposedly accelerated in supernova remnants, then propagate through the Galaxy. CR flux measurement set constraints on CR sources and propagation, but may also bring answers to the dark matter problem.AMS-02 is a high precision particle physics detector placed on the international space station since may 2011. It measures the CR fluxes of many species.This thesis deals with the proton flux estimation measured by the AMS-02 instrument. The focus is set on the unfolding of the instrument energy response impacting the flux, and on the caracterisation of the high-energy spectral break.The Sun produces a plasma which interacts with CR particles, modifying the flux obtained from galactic propagation. This modification evolves through time following the solar activity cycle, and is denoted solar modulation. In this framework, decolving from this effect, a robust determination of the proton and helium interstellar fluxes is obtained using recent high precision CR data including AMS-02. The associated solar modulation levels are cross-checked with a second estimation taken from neutron monitors (ground based detectors) data, allowing solar modulation time series reconstruction from the 50s.