Saskatchewan is the only province in Canada to have routinely tested the antimicrobial susceptibility of all provincially reported human cases of campylobacteriosis. From 1999 to 2006, 1378 human Campylobacter species infections were tested for susceptibility at the Saskatchewan Disease Control Laboratory using the Canadian Integrated Program for Antimicrobial Resistance Surveillance panel and minimum inhibitory concentration (MIC) breakpoints. Of these, 1200 were C. jejuni, 129 were C. coli, with the remaining made up of C. lari, C. laridis, C. upsaliensis and undifferentiated Campylobacter species. Campylobacter coli had significantly higher prevalences of ciprofloxacin resistance (CIPr), erythromycin resistance (ERYr), combined CIPr-ERYr resistance and multidrug resistance (to three or greater drug classes) than C. jejuni. Logistic regression models indicated that CIPr in C. jejuni decreased from 1999 to 2004 and subsequently increased in 2005 and 2006. The risk of CIPr was significantly increased in the winter months (January to March) compared to other seasons. A comparison of logistic regression and Cox proportional hazard survival models found that the latter were better able to detect significant temporal trends in CIPr and tetracycline resistance by directly modeling MICs, but that these trends were more difficult to interpret. Scan statistics detected significant spatial clusters of CIPr C. jejuni infections in urban centers (Saskatoon and Regina) and temporal clusters in the winter months; the space-time permutation model did not detect any space-time clusters. Bernoulli scan tests were computationally the fastest for cluster detection, compared to ordinal MIC and multinomial antibiogram models. eBURST analysis of antibiogram patterns showed a marked distinction between case and non-case isolates from the scan statistic clusters. Multilevel logistic regression models detected significant individual and regional contextual risk factors for infection with CIPr C. jejuni. Patients infected in the winter, that were between the ages of 40-45 years of age, that lived in urban regions and that lived in regions of moderately high poultry density had higher risks of a resistant infection. These results advance the epidemiologic knowledge of CIPr C. jejuni in Saskatchewan and provide novel analytical methods for antimicrobial resistance surveillance data in Canada. / Saskatchewan Disease Control Laboratory (Saskatchewan Ministry of Health); Laboratory for Foodborne Zoonoses (Public Health Agency of Canada); Centre for Foodborne, Environmental and Zoonotic Infectious Diseases (Public Health Agency of Canada); Ontario Veterinary College Blake Graham Fellowship

L'amélioration des performances des chaînes de conversion dédiées à la récupération d'énergie par les hydroliennes est un point particulièrement important pour rendre cette ressource économiquement attractive. La minimisation du coût de l'énergie produite passe nécessairement par une amélioration des performances de la chaîne de conversion électromécanique et une réduction des coûts de maintenance et de production des éléments la constituant. Dans ce contexte particulier, les génératrices à aimants permanents apparaissent particulièrement intéressantes dans la mesure où elles sont bien adaptées à un fonctionnement à basse vitesse et à fort couple. Ceci permet d'éliminer des systèmes mécaniques très complexes, encombrants et exigeants en maintenance, tels que le multiplicateur de vitesse et/ou le système d'orientation des pales. L'objectif de cette thèse est d’explorer un certain nombre de pistes concernant les outils, les concepts et les règles de conception à mettre en oeuvre pour dimensionner une génératrice associée en entraînement direct à une turbine hydrolienne à pas fixe. Les outils mis au point dans ces travaux englobent des modèles multi-physiques intégrés dans une démarche de conception qui se veut la plus globale possible. Cette méthodologie tient compte de la caractéristique de la ressource (courants de marées), de celle de la turbine (hélice), des spécifications de la génératrice à aimants permanents, de la mise en oeuvre d’une stratégie de pilotage associant MPPT et limitation de puissance par défluxage à fort courants de marées, en plus des contraintes liées au convertisseur. L'environnement de conception développé est basé sur un couplage des modèles dans une procédure d'optimisation. Les résultats obtenus mettent en lumière les points clés associés au développement d’une telle génératrice pour un contexte hydrolien. / The improvements of marine current turbines drive train are key features to ensure safe operation and to make tidal energy resource cost-attractive. In this context, eliminating mechanical systems that demand high-level of maintenance can be an interesting way to improve the global behavior of tidal turbines. For that purposes, the presented studies focus on design methodologies and concepts of direct-driven generators associated with fixed-pitch turbines. The proposed designs are based on multiphysics models of the generator that are integrated in an optimization process taking into account the drive train environment. For these reasons, several models have been integrated into a global design strategy in order to find solutions that improve marine current turbines performances. This strategy is based on the use of an optimization process that combines electromagnetic model, thermal model, turbine performances model, and tidal resource velocity profile. This methodology integrates also an efficient control strategy based on a maximum power point tracking (MPPT) approach at low tidal speed and a flux-weakening power limitation control at high tidal speed. This control at high tidal velocities is in this work achieved by considering only the generator electrical control without using blade pitching systems. The obtained results highlight trends that could lead to an improvement of the design and they help designers to set relevant technological choices in order to ensure significant cost reduction and highly improve the reliability of marine current turbines.