While undergraduate enrollment of all racial groups in United States higher education institutions has increased, 6-year graduation rates of Blacks (39%) remain low compared to other races; Asians (69%), Whites (62%), and Hispanics (50%; NCES, 2010). Women’s graduation rate is higher than men’s; 58% compared to men’s at 53% in public institutions (IPEDS, 2011). Retention literature does not address the perceptions of Black ethnic groups’ experiences in college, particularly in Hispanic serving institutions. Informed by Tinto’s (1975, 1987, 1993) student academic and social integration model, Guiffrida’s (2003, 2004, 2005, 2006) model of relationships while at college, and ex-post facto research design, the study investigated personal and institutional factors that relate to Black students’ self-efficacy and persistence to the senior year in college. Data about Black ethnic undergraduate seniors’ (N = 236) academic and social experiences in college were collected using the Student Institutional Integration Survey (SIIS), an online questionnaire. Descriptive statistics were used to collect background information about the sample, correlation was calculated to indicate the degree of relationship between the variables, and multiple linear regressions were used to identify variables that are predictors of self-efficacy of persistence. Independent samples t-test and analyses of variance were computed to determine whether differences in perceptions of personal and institutional factors that relate to self-efficacy of persistence to the senior year in college could be identified between gender and ethnicity. Frequency was summarized to identify themes of participants’ primary motivation for finishing undergraduate degree programs. These themes were: (a) self-pride/personal goal, (b) professional aspiration/career (c) motivation to support family, (d) desire to have financial independence/better job, (e) to serve community, (f) opportunity to go to college, (g) being first-generation college student, and (h) prove to family the value of higher education. The research findings support the tenets of academic and social integration theories which suggest that students’ interaction with peer and faculty, relationships with family and friends, and involvement in institutional activities and organizations influence their persistence in college. Implications based on the findings affect institutional policy, curriculum, and program improvements that relate to Black undergraduate students’ academic and social support.

The first chapter relates the size of the present-day LGBT population to the discovery of gold during the nineteenth century gold rushes. Comparing the surroundings of gold rush counties to other mining counties, we find that there are currently 15% more same-sex couples in former gold rush counties and that residents of these counties have more favorable attitudes toward homosexuality. Gold rush counties were initially isolated, mostly uninhabited and lacked strong formal institutions, which helped shaping pro-LGBT attitudes. Examining channels of persistence, we provide empirical evidence for selective migration and the lack of strong religious institutions. The second chapter examines the impact of gender focused labor legislation on women’s labor force participation and economic empowerment. We rely on historical legislative acts passed by state legislatures and exploit whether or not states passed regulatory laws regulating overall and industry specific employment and work conditions for women, night work laws and labor laws requiring provision of seats for working women. We exploit the fact that not all states enacted these laws as well as the variation in the timing of enactment of such laws. Our results show that women in comparison to men in treated states are more likely to be in the labor force post introduction of night work laws in comparison to control states. We also document the effect of industry-specific labor policies on women’s likelihood to be employed in the affected industry and in higher-wage occupations within the industry of interest. Policy implications of our findings endorse the adoption of labor laws in favor of women to advocate their empowerment through a higher involvement in the labor market and financial independence. The third chapter tests the doctrine of first effective settlement by relating early settlers’ culture to within state variation in gender norms in the United States. In 1973, the cultural geographer Wilbur Zelinsky postulated that the distinctive traits of early settlers at initial stages of institutional development may be crucial for cultural formation. I capture settlers’ culture using past female labor force participation, women’s suffrage and financial rights at their place of origin. I document the distinctive characteristics of settlers’ populations and provide suggestive evidence in support of the spatial (across locations) and vertical (over time) transmission of gender norms. My results show that women’s labor supply is higher, in both the short and long run, in U.S. counties that historically hosted a larger settler population originating from places with favorable gender attitudes. My findings shed new light on the importance of immigrants’ characteristics and their countries/states of origin for cultural formation in hosting societies.

Cells are dynamic systems that generate and respond to forces through the complex interplay between biochemical and mechanical regulations. Since cellular processes often happen at the molecular level and are challenging to be observed under in vivo conditions due to limitations in optical microscopy, multiple analysis tools have been developed to gain insight into those processes. One of the ways to characterize these mechanical properties is by measuring their persistence length, the average length over which filaments stay straight. There are several approaches in the literature for measuring the persistence length of the filaments, including Fourier analysis of images obtained using fluorescence microscopy. Here, we show how curvature can be used to quantify local deformations of cell shape and cellular components. We develop a novel technique, called curvature analysis, to measure the stiffness of bio-filaments from fluorescent images. We test our predictions with Monte-Carlo generated filaments. We also apply our approach to microtubules and actin filaments obtained from in vitro gliding assay experiments with high densities of non-functional motors. The presented curvature analysis is significantly more accurate compared to existing approaches for small data sets. To study the effect of motors on filament deformations and velocities observed in gliding assays with functional and non-functional motors, we developed Langevin dynamics simulations of on glass and lipid surfaces. We found that generally the gliding velocity increases with an increase in motor density and a decrease in diffusion coefficient, and that motor density and diffusion coefficient have no clear effect on filament curvatures, except at a very low diffusion coefficients. Finally, we provide an ImageJ plugin to make curvature and persistence length measurements more accessible to everyone.

Magister Educationis (Adult Learning and Global Change) - MEd(AL) / The notion of student persistence is one that remains a topic for lifelong learning. Many scholars pursue an understanding of this phenomenon yet it remains an unsaturated subject for further studies. Furthermore, many countries embrace international students in their universities and colleges for various reasons. South Africa is no different. The intake of international students at this particular institution of interest is mainly faith-based; many of these students are associated with the same faith or have some religious background. Combining the two phenomena (persistence and international studentship) seems an area that could open doors to new knowledge. So I ask the question: “Do foreign students persist more consistently than local students/nationals? And if so, why?” This then formed the basis for my key question in this study: “What are the relationships between social integration and student persistence?”

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In this paper I will look at two common theories about persistence and their views on parthood. The two theories are Endurantism and Perdurantism, but I will also mention exdurantism which is a theory closely related to perdurantism. Endurantism is a three-dimensional theory which states that persisting objects are at every moment “wholly present” and have no temporal extent. Perdurantism and exdurantism on the other hand are four-dimensional theories which states that objects have temporal as well as spatial extent. The four-dimensional theories apply an atemporal parthood relation between a persisting object and its temporal parts, this means that a persisting object has its parts simpliciter. Three dimensionalists usually do not talk about a thing having temporal parts, but some philosophers think that there is nothing that restricts a three-dimensionalist from applying a similar understanding of parthood as the four-dimensionalist does. I will begin by taking a look at the different theories and their solutions to two common problems associated with persistence. Later on, I will look at the atemporal parthood relation that perdurantists apply to their theory and see if it really is something an endurantist could accept as well. I will make my conclusion based on what would logically follow from accepting the concept of atemporal parthood. I will argue that, while endurantists could accept path inclusion, they can in fact not apply an atemporal parthood relation between a persisting object and its temporal parts without their view collapsing into four-dimensionalism. I will also show that path inclusion cannot do the same job in solving these two problems that will be discussed. Besides this, my point will also be to argue that it is unmotivated (or even a mistake) for a three-dimensionalist to apply any three-dimensional version of atemporal parthood to their theory.

Cells are dynamic systems that generate and respond to forces through the complex interplay between biochemical and mechanical regulations. Since cellular processes often happen at the molecular level and are challenging to be observed under in vivo conditions due to limitations in optical microscopy, multiple analysis tools have been developed to gain insight into those processes. One of the ways to characterize these mechanical properties is by measuring their persistence length, the average length over which filaments stay straight. There are several approaches in the literature for measuring the persistence length of the filaments, including Fourier analysis of images obtained using fluorescence microscopy. Here, we show how curvature can be used to quantify local deformations of cell shape and cellular components. We develop a novel technique, called curvature analysis, to measure the stiffness of bio-filaments from fluorescent images. We test our predictions with Monte-Carlo generated filaments. We also apply our approach to microtubules and actin filaments obtained from in vitro gliding assay experiments with high densities of non-functional motors. The presented curvature analysis is significantly more accurate compared to existing approaches for small data sets. To study the effect of motors on filament deformations and velocities observed in gliding assays with functional and non-functional motors, we developed Langevin dynamics simulations of on glass and lipid surfaces. We found that generally the gliding velocity increases with an increase in motor density and a decrease in diffusion coefficient, and that motor density and diffusion coefficient have no clear effect on filament curvatures, except at a very low diffusion coefficients. Finally, we provide an ImageJ plugin to make curvature and persistence length measurements more accessible to everyone.

Widespread critical shortages of high-quality teachers in the United States (Sutcher, Darling-Hammond, Carver-Thomas, 2016) has prompted considerable research on staffing trends within the teaching profession. Research suggests both an increase in the demand for teachers and a "chronic and relatively high annual turnover compared with many other occupations" (Ingersoll & Smith, 2003, p. 31). Recent studies have highlighted the negative effects that high teacher turnover has on financial costs, school climate, and student performance. Since attrition rates appear to be higher for beginning teachers (Ingersoll & Smith, 2003; Ingersoll, 2012), it is important to understand why beginning teacher attrition occurs and what factors influence beginning teachers to stay in the profession, move to another school, or return to the profession. While several studies suggest multiple factors influence teacher attrition, having a better understanding of how these factors correlate with each other and how the impact of these factors changes over time will provide additional information into how time influences teacher attrition. Exploring where teaching go after they leave teaching and why some teachers decide to return to the profession will provide additional insight into the complex nature of teacher attrition patterns in the United States. The purpose of this study was to examine attrition patterns among K-12 teachers who began teaching in a public school in the United States during the 2007-2008 academic year and factors that influenced teachers decisions to move from their initial school to another school, discontinue teaching, or return to the position of a K-12 teacher. This study used data collected as part of the Beginning Teacher Longitudinal Study (BTLS) and explores the effect that various predictor variables have on the probability that BTLS teachers will either leave teaching or move to another school. Using a structural equation modeling (SEM) approach to discrete-time survival analysis made it possible to simultaneously model systems of equations that included both latent and observed variables, allow for the effect of mediators, and analyze how the effect of each predictor variable changed over time. Results suggest the higher the teachers' base salary during their first three years of teaching, the less likely they were to leave the profession during their second through fourth years of teaching. Teachers who supplement their base salaries by working extra jobs are more likely to leave the profession after their fourth year of teaching. Teachers who participated in an induction program during their first year of teaching were less likely to leave the profession in Wave 2 of the study and teachers who had taken more courses on teaching methods and strategies before they started teaching were less likely to leave teaching in all waves of the study than teachers who had taken fewer courses on teaching methods or strategies. Teachers who reported higher levels of positive school climate during their first year of teaching were less likely to leave the profession in Wave 2 and 4. Teachers who indicated higher levels of satisfaction with being a teacher in their school were less likely to move schools than teachers with lower levels of satisfaction and teachers who taught in schools with higher percentages of students who were approved for free or reduced prices lunches were more likely to move schools than teachers with lower percentages of students who were approved for free or reduced price lunches. However, due to convergence issues, these results should be interpreted with caution. Weighted item response descriptive analyses suggest teachers' most important reason for moving schools was to work in a school more convenient to their home. Teachers who leave teaching are more likely to enter professions or occupations in education-related fields than occupations outside the field of education. Results also suggest teachers who leave the profession of teaching are more likely to be working in a job, either full-time or part-time, than not working in job. Finally, the majority of teachers who return to the profession of teaching do so because they missed being a K-12 teacher or they want to make a difference in the lives of others. This study contributes to the existing literature on teacher attrition by testing whether multiple relationships exist between various predictor variables and beginning teacher attrition and examines how the influence of each of these predictor variables changes over time. The study also investigates topics that have been relatively unexplored in the literature, including where teachers go when they leave the profession and factors that influence teachers' decisions to return to the profession. The results of this study may benefit researchers, teachers, educators, administrators, and policy makers interested in and/or studying teacher attrition in the United States.

Charles University, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Author: Eliška Voříšková Supervisor: PharmDr. Kateřina Malá, Ph.D. Consultant: Mgr. Barbora Košťálová Title of thesis: CONSENSUS OF CZECH TERMINOLOGY IN THE FIELD OF MEDICATION ADHERENCE BACKGROUND: The terminology of medication adherence has undergone a vast change over the last 50 years. As individual terms have not become established, they are often misused and interchanged between each other. The aim of this work was to analyze the Czech literature and to establish a consensus in the field of terminology of medication adherence using Delphi round survey. METHODS: For Czech language, a search of literature released before January 6th, 2021 in databases Solen, ProLékaře.cz, BMČ and PubMed was reviewed. There were 122 articles published between 1998-2020, themed on the medication adherence. Based on the review, a questionnaire for three-round Delphi survey was created as well as a list of panelists invited in the survey. The survey was online, anonymous and contained questions about translation of 7 terms and their definitions established by the English document so-called ABC Taxonomy. RESULTS: In the 1st round of the Delphi survey, 106 panelists were contacted, 46 of whom responded. A consensus on...

Immune homeostasis is a host characteristic that maintains biological balance within a host. Humans have evolved many host defence mechanisms that ensure the survival of individuals upon encountering a pathogenic infection, with recovery or persistence from a viral infection being determined by both viral factors and host immunity. Chronic viral infections, such as hepatitis B virus, hepatitis C virus and HIV, often result in chronic fluctuating viraemia in the face of host cellular and humoral immune responses, which are dysregulated by multi-faceted mechanisms that are incompletely understood. This review attempts to illuminate the mechanisms involved in this process, focusing on immune homeostasis in the setting of persistent viral infection from the aspects of host defence mechanism, including interferon-stimulated genes, apolipoprotein B mRNA editing enzyme catalytic polypeptide 3 (APOBEC3), autophagy and interactions of various immune cells, cytokines and regulatory molecules.