Thesis (PH. D.)--Johns Hopkins University, 1923. / Biography. Description based on print version record. Includes bibliographical references.

Reproduction de : Thèse d'exercice : Pharmacie : Nantes : 2008. / Bibliogr.

Thesis (Ph. D.)--School of Electrical and Computer Engineering, Georgia Institute of Technology, 2004. Directed by Spyros G. Pavlostathis. / Vita. Includes bibliographical references (leaves 332-345).

Thesis (Ph. D.)--Georgia State University, 2008. / Title from file title page. Thomas L. Netzel, Dabney W. Dixon, committee co-chairs; David Boykin, Jerry Smith, committee members. Electronic text (250 p. : ill. (some col.)) : digital, PDF file. Description based on contents viewed Nov. 20, 2008. Includes bibliographical references.

Thesis (Ph. D.)--Johns Hopkins University, 1920. / Biography.

No description available.

No description available.

Thesis (M.S.)--Wildlife and Fisheries Sciences Dept., South Dakota State University, 2009. / Includes bibliographical references (leaves 49-53). Also available via the World Wide Web.

M.Tech. (Biomedical Technology) / The uncontrolled growth of cells in the body is often associated with cancer. It constitutes a major health problem and is one of the leading causes of death in the world. Cancers of the lung, breast, colon/rectum and prostate are no longer only associated with developed countries but are the most common occurring cancers worldwide. Breast cancer is the leading cancer faced by women in South Africa as well as in the world. Conventional cancer therapies often result in uncertain outcomes with numerous side effects and may be associated with limited therapeutic advantage. This has led to the development of safer and better treatment regimes with improved therapeutic outcomes. Photodynamic therapy (PDT) is a treatment used for a wide range of conditions, including cancer. This treatment utilises a photosensitiser (PS), a light activated chemotherapeutic agent, and light of a specific wavelength and power density. It is based on the selective tumour localisation of the PS and the ability to generate high levels of reactive oxygen species (ROS) in the presence of light. The generation of ROS causes permanent damage to the tumour cells resulting in cancer cell death. The distinctive criteria when comparing different PDT modalities is the choice of PS as the treatment outcomes are greatly influenced by the light dependent properties of the chemotherapeutic agent. Phthalocyanines are second generation PSs used in PDT. Effects of members of this PS family have been studied and they exhibited good photosensitising properties including lack of cytotoxicity in the absence of light, extended retention times in the tumour and high triplet lifetime of singlet oxygen species.

Nous assistons durant ces trente dernières années à une croissance de la fréquence d’apparition des bactéries résistantes aux antibiotiques. Face à la récurrence des infections difficiles à traiter dues à ces bactéries pathogènes multi-résistantes, le renforcement de l’arsenal des antimicrobiens fait partir des préoccupations majeures de santé publique. À ce titre, une approche ethno-pharmacologique a été initiée dans le cadre d’une coopération entre le laboratoire de pharmacodynamie biochimique (Université Félix Houphouët-Boigny, Côte d’Ivoire) et le laboratoire universitaire de biodiversité et d’écologie microbienne(Université de Bretagne Occidentale, France). Dans cette approche, les habitudes traditionnelles d’automédication par les plantes médicinales ont été exploitées pour identifier de nouvelles sources de composés antimicrobiens. Dans une première partie de cette présente étude, une investigation sur les résistances bactériennes en Côte d’Ivoire a montré non seulement une évolution de la fréquence d’apparition des bactéries résistantes aux antibiotiques dans le temps, mais aussi une évolution de ces souches résistantes vers des différents types de multi-résistances. Dans la seconde partie, Morinda morindoides, une plante médicinale ivoirienne, a suscité notre attention pour la recherche de substances antimicrobiennes. À partir de 18 extraits des différents organes de cette plante, des tests d’activité antimicrobienne ont permis de justifier son utilisation en médecine traditionnelle. L’extrait à l’acétonitrile de la racine qui affiche l’activité la plus intéressante a servi pour isoler et caractériser 12 phytomolécules antimicrobiennes dont une se distingue par sa structure chimique originale, la morindoïdine. En plus de leurs paramètres antimicrobiens, d’autres propriétés biologiques de ces substances ont été évaluées telles que, leur pouvoir antioxydant, leur cytotoxicité, leur activité hémolytique et leur cible moléculaire. Cette évaluation a révélé un mode d’action sans doute proche de celui des quinolones. / We are witnessing over these last thirty years a growing frequency of occurrence of antibiotic-resistant bacteria. This observation is coupled with a reduction in discovery of new antimicrobials. Given the recurrence of difficult to treat infections caused by these pathogens become multidrug resistant, strengthening the antimicrobial arsenal is one of the main public health concerns. To this end, an ethnopharmacological approach has been developed. Within the framework of cooperation between the laboratory of Biochemical pharmacodynamics (University of Cocody, Côte d'Ivoire) and the laboratory of microbial biodiversity and ecology (LUBEM EA 3882, University of Brest, France), traditional self-medication habits affecting more than 70% of the population of Cote d'Ivoire were analyzed to identify new sources of antimicrobial compounds. In the first part of this study, an investigation of bacterial resistance in Côte d'Ivoire has revealed not just an increase in the frequency of occurrence of antibiotic-resistant bacteria in time, but also an evolution of resistant strains toward different types of antibiotics. In the second part, Morinda morindoides, an Ivorian medicinal plant aroused our attention for the research of antimicrobial substances. From 18 extracts from different organs of this plant the antimicrobial activity tests were performed. The acetonitrile extract of the root which exhibit the most interesting activity was used to isolate and characterize 12 antimicrobial phytomolecules. One of these compounds exhibits an original chemical structure named morindoidine. In addition to their antimicrobial activity, other biological properties of these substances have been evaluated such as their antioxidant potency, their cytotoxicity, their hemolytic activity and their molecular target. This assessment revealed a mode of action probably close to that of quinolones.