The primary goal of this work is to validate the visual analog screening scale Emotion Thermometer (ET) in patients with chronic non-cancer lower back pain. In addition, the work aimed to verify the presumed relationships of clinically significant anxiety, its related concepts and depression with chronic pain and to explore which factors predict decrease in level of function and presence of psychiatric diagnosis according to MINI in patients with chronic pain. In the first chapter, the theoretical part of the thesis deals with the description of the ET tool and a systematic overview of validation and empirical studies. The second chapter focuses on mapping the relationships between stable affective components of ET (distress, anxiety, depression, anger) and chronic pain. The empirical part of the work has a quantitative design and is realized in the form of observational analytical cross-sectional study, in which two hundred and eighty-one patients hospitalized at the Department of Rehabilitation and Sports Medicine of the 2nd Faculty of Medicine at Charles University and at the University Hospital in Motol participated. Participants of the study underwent a clinical examination in the form of an interview and a questionnaire survey. 16 % of the participants met the MINI criteria for major...

Introduction: The current study examined the psychosocial predictors (Type D personality, anxiety, depression & social support) in patients following MI. It further assessed the influence of these psychosocial predictors on quality of life of MI patients. Methods: In this prospective cohort study, 300 patients with definite myocardial infarction were recruited and assessed at baseline (2 -8 weeks) post MI (time 1). Out of 300 participants 191 completed assessments at 9 months follow up (time 2). Type D personality was evaluated with Distress scale 14(DS-14). Depression and anxiety were assessed with Hospital anxiety and depression scale (HADS). Social support was measured with Social support scale (SSS), while quality of Life was assessed with WHO quality of life scale (WHOQOL-BREF) at time 1 and time 2. Results: Analysis revealed that a significantly high percentage of MI patients had Type D personality characteristics, high levels of anxiety, depression and low level of social support. Type D personality and depression emerged as most significant predictors of quality of life after controlling for sociodemographic and clinical variables at time 1 and time 2 assessments. Discussion & Conclusion: This research emphasized the importance of Type D personality, anxiety, depression, and lack of social support in risk stratification for adverse outcomes such as impaired quality of life. This research highlighted the need for a more personalized approach to therapeutic interventions along with medical treatment for the management and rehabilitation of MI patients. / Fatima Jinnah Women University of Pakistan and The Higher Education Commission

Pain catastrophizing (PC) and fear of pain (FOP) are understudied across different race/ethnicity minorities. The association between these constructs and psychological disorders with relation to chronic pain are understudied as well. Prior research indicates that racial/ethnic minority populations may engage in more PC and FOP than white, non-Hispanic populations. These studies, however, have only examined macro-level differences between white, non-Hispanic and minority populations. Less is known about the nuanced differences in PC and FOP across individual racial/ethnic groups (i.e., white vs. Asian vs. Black/African American). The current study explores between-group differences in PC and FOP across diverse racial/ethnic groups of youth with chronic pain while also observing the association between anxiety/depression and PC/FOP in these populations. Youth (ages 11-17) with chronic pain presenting for treatment to a tertiary pediatric pain clinic completed the Pain Catastrophizing Scale (PCS), which includes a total score and subscales (i.e., rumination, magnification, and helplessness) and the Fear of Pain Questionnaire. Racial/ethnic group sizes were as follows: Black/non-Hispanic (N = 29), Hispanic (N = 58), Asian (N = 17), another race/non-Hispanic (N = 37), and Multiracial (N = 15). One-way ANOVAs were conducted to test differences in the PCS total score and subscales as well as FOP among racial/ethnic groups, and Chi-square analyses were conducted to test the association between binary codes of anxiety/depression diagnoses provided in the data repository and the race/ethnicity minorities, respectively. Results revealed non-significant differences in total PCS and PCS subscales across race/ethnicity minority groups. In addition, there were no statistically significant differences in FOP across race/ethnicity minority groups. However, there were some clinically significant differences between mean PCS and FOP scores across certain racial/ethnic minority groups. Finally, no significant associations emerged between anxiety and race/ethnicities or between depression and race/ethnicities. Findings suggest that youth with chronic pain may experience PC and FOP similarly regardless of their racial/ethnic backgrounds. However, these findings were limited by small sample sizes across groups, and future research with larger sample sizes is warranted. These results can inform continued exploration and sensitivity to diversity, equity, and inclusivity issues in healthcare for pediatric chronic pain patients.

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Derived from the ancient mind-body practice and congruent with western scientific studies, the 8-Week Program to Support Undergraduate Academic Aptitude draws specific modalities from the 5,000-year-old Yoga tradition for helping lower undergraduate anxiety, depression, and stress. The program emphasizes use of physical postures, breathing exercises, basic mediation, and philosophy. Selectively chosen, the clinically researched techniques create physiological shifts for offsetting anxiety and depression in undergraduates, two factors known for adversely affecting students’ health and academic readiness. The main goal of the program is to educate a student to use Yogic tools intelligently and effectively for emotional, mental, and physical health to support quality of life and flourishing academically. A student’s health, wellness, and happiness are key contributing factors to staying engaged with an institution and student attainment.

Paradoxen är tydlig: äldre är mest oroliga över att utsättas för brott trots att de löper minst risk att faktiskt utsättas för brott. Denna oro är speciellt hög hos äldre kvinnor. Denna studie ämnar att undersöka om ångestbenägenhet och sociala nätverk har en påverkan på oro för brott. Frågeställningen lyder enligt följande: Vilken påverkan har ångestbenägenhet och sociala nätverk på oron att utsättas för brott hos kvinnor äldre kvinnor? Studiens resultat fann ett positivt samband mellan oro övergående i ångest och oro för brott. Sociala nätverk hade även en positiv effekt på oro för brott. Slutsatsen av denna studie är att det finns ett samband mellan oro för brott och ångestbenägenhet men att den sistnämnda existerar i högre grad. Ytterligare studier måste tillämpas kring sambandet mellan sociala nätverk och oro för brott. / The paradox is clear: elderly have the highest fear of crime even though they have the lowest risk to actually get exposed to crime. Especially women report high fear of crime. This study aims to explore the affect of trait anxiety and social relationships on fear of crime. The problem statement is: what affect has trait anxiety and social networks on fear of crime among older women? The result of this study found a positive association between anxiety and fear of crime. Social network had also an positive affect on fear of crime. The conclusion of this study is that there is a association between fear of crime and anxiety but that anxiety is more frequent. More studies on the association between social network and fear of crime needs to be made.

The present meta-analytic study examined the overall effectiveness of child-centered play therapy (CCPT) and child-parent relationship therapy (CPRT) for children experiencing internalizing problems. After conducting a comprehensive literature search and review, 25 studies published between 2000 and 2023 met the following inclusion criteria: (a) published and peer-reviewed; (b) used CCPT or CPRT as an intervention; (c) participants were ages 3 to 13 or parents of children ages 3 to 13; (d) study outcomes related to children's internalizing problems, such as anxiety, depression, or withdrawal; (e) used single group within study or between study design, including randomized controlled trials and non-randomized controlled trials; (f) published between January 2000 and April 2023; (g) published in English; (h) used standardized measurements; and (i) reported effect sizes, or means and standard deviations, or the author disclosed the means and standard deviations upon request. Final analysis included 28 individual effect sizes using a random effects model to determine the overall effect size for 6 analyses that included CCPT/CPRT combined between, CCPT/CPRT combined within, CCPT between, CCPT within, CPRT between, CPRT within. Moderating variables included gender, age, ethnicity, and number of CCPT sessions. CCPT and CPRT effect sizes were statistically significant and ranged from small to large effects. Results support the use of CCPT and CPRT with children for the reduction of internalizing problems. Procedures and results, including the coding process, limitations, and implications are discussed.

Child and adolescent mood and anxiety symptoms are common and debilitating, with long-term effects on well-being. Research presented in this thesis examines interpersonal cognitive factors in the emergence of anxious and depressive symptoms in late childhood through to early adulthood. The thesis considers this issue using three main approaches. For the first, data are presented showing that biases in the appraisals of social situations are the aspects of interpersonal cognition most closely associated with emotional symptoms. For the second, longitudinal twin data are used to examine genetic and environmental origins of these interpersonal cognitive biases and their temporal prediction of symptoms across a 2-year period. Data show that interpersonal cognitive factors are strongly influenced by non-shared environmental factors, and moreover, predict symptoms across time. The final section of the thesis comprises four studies using Cognitive Bias Modification of Interpretations (CBM-I) training methodology to show that both positive and negative interpretive biases for interpersonal information can be induced in adolescents. Positive biases are shown to persist for at least 24 hours after training, and induced positive and negative biases are shown to differentially predict anxious responses to an experimental stressor. Evidence is also provided to suggest that effects following training positive interpretive biases may transfer to other cognitive measures, namely appraisals of ambiguous emotional faces. Finally, data tentatively show that CBM-I training may be useful in reducing negative interpretations of interpersonal information made by 11-year-old children undergoing the transition to secondary school. In summary, studies in this thesis support the contribution of cognitive biases to mood and anxiety symptoms in childhood and adolescence. They further extend this knowledge by suggesting that these reflect individual-specific (non-shared) environmental risks to predict symptoms across time. These biases may also be amenable to change through training interventions, with some - albeit weak - effects on other cognitive outcomes.

La vasopressine (AVP) et la corticolibérine (CRF) agissent de manière synergique lors de la réponse aux stimuli stressants. Elles régulent de manière concertée la sécrétion d'adrénocorticotrophine hypophysaire et la libération de catécholamines surrénalienne. Dans ces deux structures, les isoformes de récepteurs présents sont les récepteurs V1B et CRF1. Nous avons démontré que deux mécanismes moléculaires sous-tendent la synergie fonctionnelle de l'AVP et du CRF : un croisement des voies de seconds messagers propres à chacun des récepteurs d'une part, et une modification de leurs propriétés pharmacologiques résultant de leur interaction (hétérodimérisation) d'autre part. Pour valider ce dernier mécanisme, nous avons recherché des formes naturelles ou mutées de récepteurs à l'AVP et au CRF conservant leurs propriétés de couplage aux protéines G, mais incapables d'hétérodimériser, et avons analysé les conséquences de cette rupture d'hétérodimérisation sur leur aptitude à agir en synergie. Grâce à une approche de mutagénèse dirigée, nous avons commencé à résoudre la question des portions de récepteurs engagées dans l'hétérodimérisation. Les résultats obtenus apportent les premières évidences permettant de comprendre la synergie AVP/CRF au niveau moléculaire, et particulièrement le rôle de l'hétérodimérisation. L'hétérodimère V1B/CRF1 pourrait être impliqué dans le stress et ses états pathologiques que sont l'anxiété et la dépression. Nous montrons que les récepteurs V1B et CRF1 sont co-exprimés dans les neurones de certaines structures cérébrales régulant ces phénomènes comportementaux. Démontrer l'existence de l'hétérodimère V1B/CRF1 dans des tissus natifs sera la prochaine étape de ce travail. Si elle est validée, le complexe V1B/CRF1 pourra être considéré comme une cible pharmacologique de première importance dans le traitement de l'anxiété et de la dépression. Travail soutenu par l'Institut de Recherches SERVIER et la Fondation pour la Recherche Médicale. / Vasopressin (AVP) and Corticotropin-Releasing Factor (CRF) are involved in the stress response, mainly by regulating ACTH secretion from the pituitary and by increasing catecholamine and corticosteroids secretion from the adrenal medulla. In these two structures, AVP and CRF have been shown to act in synergism via V1B and CRF1 receptors. Recently, our group demonstrated that such synergism operates via both second messenger crosstalk and putative mechanism involving receptors heterodimerization. To further validate this last original mechanism, we monitored the influence of receptor heterodimerization selectivity and of receptor heterodimerization disruption on functional synergism. We also deciphered receptor dimers interface by synthesizing receptor mutants that do not heterodimerize anymore.These results give clues to the comprehension of AVP/CRF synergism at the molecular level and trigger the potential role of receptors heterodimerization in stress-related behaviours. Indeed both V1B and CRF1 are also co-expressed in neurons of relevant brain area. Establishing the physical association of V1B/CRF1 as heterodimers in native tissue, the next step of our project, would be of considerable importance.Work supported by SERVIER (France) an d the FRM.