>Magister Scientiae - MSc / We are fast moving into an era where data will be the primary driving factor for discovering new unknown astronomical objects and also improving our understanding of the current rare astronomical objects. Wide field survey telescopes such as the Square Kilometer Array (SKA) and Vera C. Rubin observatory will be producing enormous amounts of data over short timescales. The Rubin observatory is expected to record ∼ 15 terabytes of data every night during its ten-year Legacy Survey of Space and Time (LSST), while the SKA will collect ∼100 petabytes of data per day. Fast, automated, and datadriven techniques, such as machine learning, are required to search for anomalies in these enormous datasets, as traditional techniques such as manual inspection will take months to fully exploit such datasets.

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Microcantilever arrays have been shown to be promising label-free nanomechanical sensing devices with high sensitivity. Two factors that affect the usefulness of microcantilevers in sensing scenarios are the sensitivity of the transduction method for measuring changes in microcantilever properties and the ability to create large compact arrays of microcantilevers. In this dissertation, we demonstrate that microcantilevers with an in-plane photonic transduction method are attractive because they maintain the sensitivity of the traditional laser beam reflection method while being scalable to simultaneous readout of large microcantilever arrays. First I demonstrate the integration of a compact waveguide splitter network with in-plane photonic microcantilevers which have amorphous silicon strip loading differential splitter and simultaneous microcantilever readout with an InGaAs line scan camera. A 16-microcantilever array is fabricated and measured. Use of a scaled differential signal yields reasonable correspondence of the signals from 7 surviving released microcantilevers in the array. The average sensitivity is 0.23 µm-1. To improve the sensitivity and consistency, and reduce fabrication difficulties, a new differential splitter design with 4 µm long double-step multimode rib waveguide is introduced. Furthermore, a modified fabrication process is employed to enhance the performance of the device. A new 16-microcanitiler array is designed and fabricated. The sensitivity of a measured 16-microcantilever array is improved to approximately 1 µm-1, which is comparable to the best reported for the laser reflection read out method. Moreover, most of the microcantilevers show excellent uniformity. To demonstrate large scale microcantilever arrays with simultaneous readout using the in-plane photonic transduction method, a 64-microcantilver array is designed, fabricated and measured. Measurement results show that excellent signal uniformiy is obtained for the scaled differential signal of 56 measured microcantilevers in a 64-array. The average sensitivity of the microcantilevers is 0.7 µm-1, and matches simulation results very well.

The Nanoinjector Lance Array has been developed to inject foreign material into thousands of cells at once using electrophoresis to attract and repel particles to and from the electrically-charged lances. A mathematical computer model simulating the motion of attracted or repelled proteins informs the design of the nanoinjection lance array system. The model is validated by accurately predicting protein velocity in electrophoresis experiments. A complete analysis of parameters is conducted via simulations and specific research questions regarding the counter electrode of the nanoinjector lance array system are explored using the model. A novel technique for fabricating lance arrays from collapsed carbon nanotube forests is explored and detailed. Experiments are conducted using the Nanoinjector Lance Array, attempting to inject three different kinds of protein molecules into a culture of HeLa cells. The experimental results are encouraging and suggest possibilities for future success. Other recommendations are made for future research regarding the model, carbon nanotube fabrication, and experimental testing.

Mid-infrared (mid-IR) detection and imaging over atmospheric transparent 3-5 μm and 8-12 μm bands are increasingly becoming important for various space, defense and civilian applications. Various kinds of microbolometers offer uncooled detection of IR radiation. However, broadband absorption of microbolometers makes them less sensitive to spectrally resolved detection of infrared radiation and the fabrication is also very tedious involving multiple complex lithography steps. In this study, we designed an optical nano-antenna array based detector with narrow frequency band of operation. The structure consists of a two-element antenna array comprised of a perforated metallic hole array coupled with an underneath disk array which trap incident radiation as dipole currents. The energy is dissipated as electron plasma loss on the hole-disk system inducing close to ~100% absorption of the incident radiation. This near perfect absorption originates from simultaneous zero crossing of real component of permittivity and permeability due to the geometrical arrangement of the two antenna elements which nullifies overall charge and current distributions, prohibiting existence of any propagating electromagnetic modes at resonance. Moreover, the continuous perforated film allows probing of the induced "micro-current" plasma loss on each nano hole-disk pair via a weak bias current. Such optical antenna design enables flexible scaling of detector response over the entire mid-infrared regime by change in the antenna dimensions. Furthermore, the development of simple nanoimprint lithography based large area optical antenna array fabrication technique facilitates formation of low cost frequency selective infrared detectors.

Infrared (IR) dipole antenna-coupled metal-oxide-metal (MOM) tunnel diodes provide a unique detection mechanism that allows for determination of the polarization and wavelength of an optical field. By integrating the MOM diode into a phased-array antenna, the angle of arrival and degree of coherence of received IR radiation can be determined. The angular response characteristics of IR dipole antennas are determined by boundary conditions imposed by the surrounding dielectric or conductive environment on the radiated fields. To explore the influence of the substrate configuration, single dipole antennas are fabricated on both planar and hemispherical lens substrates. Measurements demonstrate that the angular response can be tailored by the thickness of the electrical isolation stand-off layer on which the detector is fabricated and/or the inclusion of a ground plane. Directional detection of IR radiation is achieved with a pair of dipole antennas coupled to a MOM diode through a coplanar strip transmission line. The direction of maximum angular response is altered by varying the position of the diode along the transmission line connecting the antenna elements. By fabricating the devices on a quarter wave layer above a ground plane, narrow beam widths of 35° full width at half maximum and reception angles of ± 50° are achievable with minimal side-lobe contributions. Phased-array antennas can also be used to assess the degree of coherence of a partially coherent field. For a two-element array, the degree of coherence is a measure of the correlation of electric fields received by the antennas as a function of the element separation.

Yes / This paper presents the results of a study on developing an effective technique to increase the performance characteristics of antenna arrays for sub-THz integrated circuit applications. This is essential to compensate the limited power available from sub-THz sources. Although conventional array structures can provide a solution to enhance the radiation-gain performance however in the case of small-sized array structures the radiation properties can be adversely affected by mutual coupling that exists between the radiating elements. It is demonstrated here the effectiveness of using SIW technology to suppress surface wave propagations and near field mutual coupling effects. Prototype of 2 × 3 antenna arrays were designed and constructed on a polyimide dielectric substrate with thickness of 125 μm for operation across 0.19-0.20 THz. The dimensions of the array were 20 × 13.5 × 0.125 mm3. Metallization of the antenna was coated with 500 nm layer of Graphene. With the proposed technique the isolation between the radiating elements was improved on average by 22.5 dB compared to a reference array antenna with no SIW isolation. The performance of the array was enhanced by transforming the patch to exhibit metamaterial characteristics. This was achieved by embedding the patch antennas in the array with sub-wavelength slots. Compared to the reference array the metamaterial inspired structure exhibits improvement in isolation, radiation gain and efficiency on average by 28 dB, 6.3 dBi, and 34%, respectively. These results show the viability of proposed approach in developing antenna arrays for application in sub-THz integrated circuits. / Ministerio de Ciencia, Innovación y Universidades, Gobierno de España (MCIU/AEI/FEDER, UE) under Grant RTI2018-095499-B-C31, in part by the Innovation Programme under Grant H2020-MSCA-ITN-2016 SECRET-722424, and in part by the U.K. Engineering and Physical Sciences Research Council (EPSRC) under Grant EP/E022936/1.

Arrays of silicon lances were made using photolithographic and STS DRIE Bosch techniques. Arrays consist of a 10 mm square grid pattern of lances measuring 100 m tall and having a 3 mm diameter, each lance being spaced 30 mm apart. The tips of lances are pointed, allowing easier penetration through plant cell walls. A nanoinjector device was also made to accept the silicon lance arrays and perform nanoinjections. A nanoinjection consisted of 2 silicon lance arrays, with lances oriented towards each other, being moved into and out of a plant cotyledon placed between them. Prior to the nanoinjection, polar molecules in solution can be attracted to the lances through a process utilizing the nanoinjector device’s ability to control the electrical current between the 2 lance arrays. During the nanoinjection the displacement between the lances, the force exerted on the plant cotyledon and the electrical current between the lance arrays are controlled. Once the lances are inserted into the cells, the electrical current between the lance arrays is reversed, repelling the molecular load from the lance array. Propidium iodide (PI) and Cotton Leaf Crumple Virus (CLCrV) were used as molecular loads in nanoinjections. The nanoinjector also records and outputs data from the nanoinjection for analysis. Nanoinjections were performed on Arabidopsis and Cotton cotyledons. Changes in the force applied during a nanoinjection and varying the number of repeated nanoinjections on the same cotyledon were observed. Too much force or too many repeated injections causes physical damage to the cotyledon. An optimal force and number of repeated injections can be performed without causing physical damage to the cotyledon. Successful transfection of PI and CLCrV was not observed in a relatively small number of performed nanoinjection procedures on either Arabidopsis or Cotton cotyledons. Possible interacting variables and recommendations for further work are discussed.

This work introduces new binaural beamforming algorithms for hearing aids, with a robustness to errors in the estimate of the target speaker direction of arrival (DOA) and a good trade-off between noise reduction and preservation of the noise/interferers spatial impression. Three robust designs are proposed, and their robustness is confirmed by simulation results. These robust designs are a combination of binaural and monaural beamformers using two different microphone configurations: one for low frequency components and one for high frequency components. The robust designs are also found to be robust to mismatch between the anechoic propagation models used for the beamformers designs and the reverberant propagation models used to generate the signals at the microphones in the simulations. To preserve the binaural cues of the noise/interferers in the binaural beamformer outputs, a method based on a mixing/selection of different available binaural signals is proposed, using a classification from the phase and magnitude of a complex coherence function. This method is added as a post processor to the beamforming designs robust to target DOA mismatch. Simulation results show that the resulting mixed binaural output signals have a good binaural cues preservation level that outperform the benchmark design, with significant noise reduction and low target distortion. Since knowledge of source DOAs is important for beamforming noise reduction, a beamformer-based broadband multi-source DOA detection system is also developed in the thesis, using information from different frequencies or sub‐bands to obtain global estimates of sources DOAs. Simulation results shows that using one beamformer on each side is capable of detecting the DOAs of active sources under several acoustic scenarios, including scenarios with one, two, or three sources, and with or without the presence of some level of diffuse noise.

Phased array antennas with small size and light weight are proposed to make signal transmitting more efficiently and accurately. These antennas have such advantages that they can realize beam scanning over a large range, accurately track and identify targets within the observation range. In beam scanning, the scan loss which is the difference between the scanned gain and broadside gain has a great impact on the performance of phased array antennas. This thesis aims to study how to reduce the scan loss while the beam is scanned over a wide range. One of the methods to reduce the scan loss is to widen the beam-width of the embedded radiation pattern. With the wide beam-width, the gain reduction due to beam scanning would be small. We propose a method to replace a conventional half-wavelength unit-cell in an array with a sub-array composed of 5 miniaturized elements with special phase/amplitude distribution. The size of the sub-array is finely tuned in this thesis to achieve the goal of wide beam-width without any grating lobe. Then, in order to further expand the beam-width, the ideal power divider is utilized to apply specific weight to the sub-array. The simulation result shows that the maximum scan loss for the considered case is 3.67dB over ±80° scan range with an voltage amplitude distribution of [0.234, 0.64, 0.26, 0.64, 0.234] (1) and a phase of 88° between the 5 sub-array elements, which can be realized by the ideal power divider. If the allowed gain reduction is relaxed to 5dB, the scan coverage can be extended to ±89°. / Fasstyrda antenner med eu liten storlek och låg vikt har förslegits för att göra signalöverföring effektivt och korrekt. Dessa antenner har stora fördelar i att de kan realisera stort område. De kan också följa och identifiera mål inom observationsområdet. Vid strålskanning är skanningsförlusten, som är skillnaden mellan den skannade förstärkningen och förstärkningen vid den breda sidan, följande har stor inverkan på prestandan hos fasstyrda antenner. Denna avhandling syftar till att studera hur man minskar skanningsförlusten när strålen skannar inom ett brett skanningsområde. En av metoderna för att minska skanningsförlusten är att bredda strålbredden i det inbyggda strålningsmönstret. Med en bred strålbredd blir förstärkningsminskningen på grund av strålskanning liten. Vi föreslår en metod för att ersätta en konventionell halvvågig enhetscell i en matris med en delmatris som består av 5 miniatyriserade element med speciell fas/amplitudfördelning. Storleken på delarrayen är finjusterad i denna avhandling för att uppnå målet med bred strålbredd utan någon gitterlob. För att ytterligare utöka strålbredden används sedan den ideala effektdelaren för att ge subarrayet en särskild vikt. Simuleringsresultatet visar att den maximala skanningsförlusten för det undersökta fallet är 3,67dB inom ±80° täckningsvinkel med amplitudfördelning av [0.234, 0.64, 0.26, 0.64, 0.234] (2) och fas av 88°, som kan realiseras av den idealiska effektdelaren. Om kravet på minskningen av förstårluing sänks till 5dB, kan täckningen breddas till ±89°.