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Molecular dynamics simulation of the self-assembly of icosahedral virus / Simulations par dynamique moléculaire de l'auto-assemblage de virus icosaédriqueChen, Jingzhi 24 September 2019 (has links)
Les virus sont connus pour infecter toutes les classes d’organismes vivants sur Terre, qu’elles soient végétales ou animales. Les virions consistent en un génome d'acide nucléique protégé par une enveloppe protéique unique ou multicouche appelée capside et, dans certains cas, par une enveloppe de lipides. La capside virale est généralement composée de centaines ou de milliers de protéines formant des structures ordonnées. La moitié des virus connus présentent une symétrie icosaédrique, les autres étant hélicoïdaux, prolats ou de structure irrégulière complexe. Récemment, les particules virales ont attiré une attention croissante en raison de leur structure extrêmement régulière et de leur utilisation potentielle pour la fabrication de nanostructures ayant diverses fonctions. Par conséquent, la compréhension des mécanismes d'assemblage sous-jacents à la production de particules virales est non seulement utile au développement d'inhibiteurs à des fins thérapeutiques, mais elle devrait également ouvrir de nouvelles voies pour l'auto-assemblage de matériaux supramoléculaires complexes. À ce jour, de nombreuses études expérimentales et théoriques sur l'assemblage de virus ont été effectuées. Des recherches expérimentales ont permis d'obtenir de nombreuses informations sur l'assemblage du virus, y compris les conditions appropriées requises pour l'assemblage et les voies cinétiques. En combinant ces informations et méthodes théoriques, une première compréhension du mécanisme d'assemblage des virus a été élaborée. Cependant, les informations provenant uniquement d'expériences ne peuvent donner une image complète, en particulier à l'échelle microscopique. Par conséquent, dans cette thèse, nous avons utilisé des simulations informatiques, y compris des techniques de Monte Carlo et de la dynamique moléculaire, pour sonder l’assemblage du virus, dans l’espoir de mieux comprendre les mécanismes moléculaires en jeu. / Viruses are known for infecting all classes of living organisms on Earth, whether vegetal or animal. Virions consist of a nucleic acid genome protected by a single or multilayered protein shell called capsid, and in some cases by an envelope of lipids. The viral capsid is generally made of hundreds or thousands of proteins forming ordered structures. Half of all known viruses exhibit an icosahedral symmetry, the rest being helical, prolate or having a complex irregular structure. Recently, viral particles have attracted an increasing attention due to their extremely regular structure and their potential use for fabricating nanostructures with various functions. Therefore, understanding the assembly mechanisms underlying the production of viral particles is not only helpful to the development of inhibitors for therapeutic purpose, but it should also open new routes for the self-assembly of complex supramolecular materials. To date, numerous experimental and theoretical investigations on virus assembly have been performed. Through experimental investigations, a lot of information have been obtained on virus assembly, including the proper conditions required for the assembly and the kinetic pathways. Combining those information and theoretical methods, an initial understanding of the assembly mechanism of viruses has been worked out. However, information coming purely from experiments cannot give the whole picture, in particular at a microscopic scale. Therefore, in this thesis, we employed computer simulations, including Monte Carlo and molecular dynamics techniques, to probe the assembly of virus, with the expectation to gain new insights into the molecular mechanisms at play.
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The rhetoric of wolvesLukas, Michael 29 August 2018 (has links)
This interdisciplinary dissertation, The Rhetoric of Wolves, attempts to answer a simple, yet broad question: What do we talk about when we talk about wolves? While even the
“we” here is contentious, as there are many perspectives and positions through which the wolf is figured, there are also many kinds of wolves, but no “real” wolf. That is, this dissertation takes seriously the contention that has recently arisen in the environmental humanities and animal studies through the late work of Jacques Derrida and others that figurations of “the animal” matter, not only for multi-species relations and coexistence, but for how the subject and polity are constructed and normalized. As these discourses put “the animal” into question, that is, how the animal functions as a discursive resource in socio-political issues, so too does this dissertation question how “the wolf” functions discursively in contemporary socio-political issues in North America. To address these questions, this dissertation utilizes a Foucaultian-inspired genealogical analysis of the discourse around “the wolf” understand how rhetoric about wolves coalesces into what I call “rhetorical assemblages” that vie to become regimes of truth that are used to attempt to settle the identity of the wolf and human-“animal” relations through the productive capacity of various power/knowledges that are historically and materially grounded. To do so, this dissertation examines and analyzes the rhetoric of a series of case studies in North America where figurations of wolves produce “the wolf” variously as man-hunting machines, outlaws that disrupt the natural order, illegal immigrants threatening family and tradition, and always already potential terrorists who must be productively managed through a biopolitics that attempts to make good the expectations of the dominant neoliberal frame of contemporary social and political life. / Graduate / 2023-08-15
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The same but better: understanding ceramic variation in the Hebridean NeolithicCopper, Michael January 2015 (has links)
Over 22,000 sherds of pottery were recovered during the excavation of the
small islet of Eilean Dòmhnuill in North Uist in the late 1980s. Analysis of the
assemblage has demonstrated that all of the main vessel forms and
decorative motifs recognised at the site were already in place when settlement
began in the earlier 4th millennium BC and continued to be deposited at the
site until its abandonment over 800 years later. Statistically significant stylistic
variation is limited to slow drifts in the relative proportions of certain rim forms.
Across the Outer Hebrides, decorative elaboration and the presence of large
numbers of distinctive vessel forms would appear to mark out certain
assemblages seemingly associated with communal gathering and feasting
events at key locales within which a distinctive Hebridean Neolithic identity
was forged.
Throughout, this study takes a relational approach to the issue of variation in
material culture, viewing all archaeological entities as dynamic assemblages
that themselves form attributes of higher-level assemblages. It is argued that
the various constraints and affordances that arise within such assemblages
constitute significant structuring principles that give rise to commonly held
expectations and dispositions, resulting in the kind of constrained temporal
and spatial variation that we observe in the archaeological record and which in
turn gives rise to the concept of the archaeological culture. / Faculty of Life Sciences at the University of Bradford / Erratum:
Vol. 1: 196 and Vol. II: xii and 383 It should be noted that the Unstan-type bowl recorded as being from Loch Mor is actually from Loch Arnish (Chris Murray pers. comm.).
The appendices including 'An Doirlinn Report and Illustrations' and 'St Kilda Report and Illustrations' are not available online due to copyright.
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“It’s the machine’s fault” : An ethnographic study of the domestication of Swedish production forestsArleskär, Albin January 2022 (has links)
This thesis explores different ways of relating to forests, and thus also different types of forestry. Starting with the Swedish forest industry one which is characterized by the planting of forests at the expense of natural regeneration, thus making Sweden the fifth country in the world in terms of planted area the study then examines different forests. This study is conducted with qualitative methods and by “following the seed” looks at various actors’ interests and potential flaws in the venture of planting forests. Different possibilities of doing forestry are explored in the thesis through letting modern forestry meet local forest-owners as well as a seed-collecting practice in central Sweden. These processes are explored by understanding the forest as an assemblage of historical decisions, species and human interests, tracing relations and powers within and beyond forestsfrom a more-than-human perspective. Forestry emerges as an attempt at domestication of the forest and the thesis explores how it goes wild, as well as the meeting of modern industrialism and science with other world views, values and practices. This allows for an alternative understanding of forests, forestry beyond industrialism and modernity, and what sort of futures we might have living together with forests.
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Geology, Petrology and Geochemistry of the Potterdoal CuZn Deposit, Kidd-Munro Assemblage, Munro Township, OntarioEpp, Mark 09 1900 (has links)
<p> The Potterdoal volcanogenic massive sulphide deposit is hosted by a tholeiitic/komatiitic succession located in northern Munro Township, Ontario. An integrated surface and drill core study of this property was undertaken to document the three dimensional structure and stratigraphy of the deposit. Petrography focused on mineralogical changes associated with the hydrothermal alteration within specific units. Several geochemical methods were used to determine the effects of hydrothemal alteration (as quantified by elemental mobility) as well as source magma affinities and tectonic setting. Based on this information, a model for ore genesis was developed. </p> <p> The Potterdoal deposit is hosted by volcanic rock of an iron tholeiite affinity, emplaced within an ocean floor rifting environment. The chemistry of the tholeiites shows similarities to that of large deposits like Kidd Creek, but lacks the felsic component of bimodal volcanism. It is suggested that felsic volcanics are absent because the local crust did not achieve sufficient thickness to allow partial melting of lower crustal material. </p> <p> The deposit consists of a stockwork zone overlain by an extensive massive sulphide lens which lies along a scarp structure defmed in the paleosurface. Stockwork mineralization is narrowly confined to conduits within a fault breccia in the footwall Ore Flow. gabbro, and widens into an overlying tectonic breccia. Sulphide paragenesis appears to be controlled by the thermal solubilities ofthe sulphide minerals, and consists of pyrite, sphalerite, pyrrhotite and chalcopyrite in both stockworks and the massive sulphide lens. The lens occurs at the top of the tectonic breccia near the paleo-seawater interface, and formed by direct replacement of the tectonic breccia. The lens locally exhibits ore grade base metal values (i.e. combined Cu and Zn content of at least 3% ), and shows an upward and outward gradation from chalcopyrite to sphalerite-dominated ore. These features suggest that exhalation of the hydrothermal system was focused into local vent sites. </p> <p> Mass change associated with the hydrothermal alteration envelopes surrounding Ore Flow fault breccia conduits involve loss of Si, Ca, Na and Sr, and gain of Fe, Mg, K, Cu and Zn. These changes are attributed to fluid-rock reactions which are consistent with hydrothermal alteration associated with other VMS deposits, The genetic model suggested for the Potterdoal deposit involves a hydrothermal system driven by heat from the intrusion ofthe Munro-Warden Sill at a high stratigraphic level. The relatively small size of the deposit is probably due to the rapid cooling of the sill, which shortened the life-span of the hydrothermal system. The primary source of metals was the upper portion of the Munro-Warden Sill, as indicated by the high degree of pervasive hydrothermal alteration of this part of the gabbro. </p> <p> Drill core information has also revealed the importance of the Buster Fault in the construction of the currently exposed Potterdoal stratigraphy. Thrusting subparallel to bedding along the Buster Fault during the Kenoran compressional event(~2.6 Ga) was responsible for the local repetition of tholeiitic flows, and has effectively removed the deep footwall rocks originally associated with the Potterdoal mineralization. </p> / Thesis / Master of Science (MSc)
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Critical Evaluation of Techniques for the Identification of Archaeological Bast Fibres: Flax, Hemp and NettleWaudby, Denis B. January 2019 (has links)
Fibre plants favour different growth conditions and require different levels of
husbandry. However, the fibres share some physical and material properties,
which make them difficult to distinguish in the archaeological record. This
thesis evaluates the effectiveness of methods for characterising bast fibres
including; fibre chemical analysis, mechanical testing and fibre morphology, to
propose that longitudinal microfibrillar angle (MFA) and cross-sectional
circularity (Ct) used in a two-step procedure to analyse selected modern fibres
of nettle (Urtica dioica L.), flax (Linum usitatissimum L.) and hemp (Cannabis
sativa L.) could offer an alternative approach.
The reliability of MFA and Ct, as diagnostic features, was evaluated under a
temperature accelerated degradation 48week trial with eight fibre types from
three deposition soils Post deposition, surviving fibres were subjected to
evaluation of changes in MFA and Ct. An additional check on the diagnostic
efficacy was conducted within a blind-test protocol.
Finally, the research programme employs MFA and Ct in the diagnosis of a
range of archaeological textile fibres from museum collections and fibres from
the Kasr el Yahud mass burial. The thesis includes recommendations to
address future post thesis research programmes.
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What Lies Within or BeneathMasters, David Michael, II January 2013 (has links)
No description available.
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Milieu: An Architectural Foray Into West-Indian Migrant CultureGarcia, Stefan 19 September 2017 (has links)
No description available.
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SPATIAL AND TEMPORAL FIDELITY OF SUBFOSSIL MOLLUSCAN ASSEMBLAGES IN A MODERN, SHALLOW MARINE CARBONATE SETTINGFERGUSON, CHAD ALLEN January 2003 (has links)
No description available.
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Dinoflagellate biostratigraphy of the Cretaceous-Tertiary boundary, Round Bay, MarylandBenson, Don Gehr 07 July 2010 (has links)
The Monmouth and Brightseat Formations contain a rich and diverse dinoflagellate assemblage. Thirty-five genera and sixty-six species, of which two genera and eight species are new, are described in this study. The stratigraphic distribution of the taxa is summarized in Figure 4. The content of the assemblage changes suddenly at the Cretaceous-Tertiary boundary with thirteen species making the~r first appearance at or just above the boundary. Nineteen species cross the boundary and thirty-five species are restricted to the Cretaceous. The rather sudden change in the nature of the dinoflagellate assemblage at the boundary is interpreted by the author to indicate a paraconformable relationship between the Cretaceous and Paleocene sediments. The term paraconformity is used since there is little field evidence (a few pebbles, some lignite, and evidence of boring) indicating any extensive period of erosion at the boundary. / Master of Science
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