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Thesis (M.S. in mechanical engineering)--Washington State University, December 2006. / Includes bibliographical references (p. 87-91).

Kyoto University (京都大学) / 0048 / 新制・課程博士 / 博士(工学) / 甲第17600号 / 工博第3759号 / 新制||工||1573(附属図書館) / 30366 / 京都大学大学院工学研究科合成・生物化学専攻 / (主査)教授 濵地 格, 教授 松田 建児, 教授 秋吉 一成 / 学位規則第4条第1項該当

京都大学 / 新制・課程博士 / 博士(医学) / 甲第24495号 / 医博第4937号 / 新制||医||1063(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 生田 宏一, 教授 杉田 昌彦, 教授 鈴木 実 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

Peptide amphiphiles (PAs), peptides that self-assemble into hydrogels with a nanofibrous network, are interesting biomaterials due to their biocompatibility and biodegradability. Self-assembling peptide-based materials include a wide range of peptide motifs that form one-dimensional nanostructures in aqueous solution. Two different PAs are considered in this M.S. thesis work: lipidated peptides, and gas-releasing peptides (GRPs). These biomaterials have been developed to function as potential therapeutics that promote the growth of new blood vessels. The analyses conducted on the lipidated peptides, which were designed to include a peptide sequence that promotes angiogenesis, include cytotoxicity, viability, and tube formation assays. The GRPs were designed to release H2S, which is also capable of promoting angiogenesis. Several characteristic properties of the GRPs were analyzed, including morphology, mechanics, self-assembly, and gas release rates. Furthermore, cytotoxicity assays were conducted followed by the demonstration of gas uptake in endothelial cells. / Master of Science

The emergence of manufacturing automation to deal with decreased productivity and shorter product market-life is very evident in the area of assembly. Correspondingly, a wealth of researchers dedicate considerable efforts to advancing automated assembly technology. The purpose of this thesis is to provide a comprehensive monograph for the research. This thesis has categorized the current research efforts into eight research categories: rationalization techniques, design for assembly, representation, sequencing, system configuration, equipment, parts mating and joining, and a category for issues with a global impact. Each is described in terms of an explanation of the research in the category, the key researchers in the area, and suggestions for future research. Additionally, a database has been developed to capture characteristic research from each of these categories. This monograph coupled with the associated database, will assist automated assembly researchers in understanding the breadth of issues facing the research community. Additionally, it will provide researchers with a 'first-look' document and literature review for those interested in automated assembly. / M.S.

Thesis. 1976. M.S.--Massachusetts Institute of Technology. Dept. of Mechanical Engineering. / Microfiche copy available in Archives and Engineering. / Includes bibliographical references. / M.S.

Statics, dynamics, rheology and scission-recombination kinetics of self-assembling linear micelles are investigated at equlibrium state and under shear flow by computer simulations using a newly proposed mesoscopic model. We model the micelles as linear sequences of Brownian beads whose space-time evolution is governed by Langevin dynamics. A Monte Carlo algorithm controls the opening of a bond or the chain-end fusion. A kinetic parameter omega modelling the effect of a potential barrier along a kinetic path, is introduced in our model. For equilibrium state we focus on the analysis of short and long time behaviors of the scission and recombination mechanisms. Our results show that at time scales larger than the life time of the average chain length, the kinetics is in agreement with the mean-field kinetics model of Cates. By studying macroscopic relaxation phenomena such as the average micelle length evolution after a T-jump, the monomer diffusion, and the zero shear relaxation function, we confirm that the effective kinetic constants found are indeed the relevant parameters when macroscopic relaxation is coupled to the kinetics of micelles. For the non-equilibrium situation, we study the coupled effects of the shear flow and the scission-recombination kinetics, on the structural and rheological properties of this micellar system. Our study is performed in semi-dilute and dynamically unentangled regime conditions. The explored parameter omega range is chosen in order for the life time of the average size chain to remain shorter than its intrinsic (Rouse) longest relaxation time. Central to our analysis is the concept of dynamical unit of size Lambda, the chain fragment for which the life time tau_Lambda and the Rouse time are equal. Shear thinning, chain gyration tensor anisotropy, chain orientation and bond stretching are found to depend upon the reduced shear rate Beta_Lambda=gamma dot*tau_Lambda while the average micelle size is found to decrease with increasing shear rate, independently of the height of the barrier of the scission-recombination process.

The first chapter discusses the concept of macros: its definition, structure, usage, design goals, and the related prior work. This thesis principally concerns my work on OLMP (an On-Line Macro Processor for the Motorola 6800 Microprocessor), which is a macro processor which interacts with the user. It takes Motorola assembler source code and macro definitions as its input; after the appropriate editing and expansions, it outputs the expanded assembler source statements. The functional objectives, the design for implementation of OLMP, the basic macro format, and the macro definition construction are specified in Chapter Two. The software and the hardware environment of OLMP are discussed in the third chapter. The six modules of OLMP are the main spine of the fourth chapter. The comments on future improvement and how to link OLMP with the Motorola 6800 assembler are the major concern of the final chapter.

Thesis. 1978. Sc.D.--Massachusetts Institute of Technology. Dept. of Mechanical Engineering. / MICROFICHE COPY AVAILABLE IN ARCHIVES AND ENGINEERING. / Vita. / Bibliography: p. 85-89. / Sc.D.