"In 2001 after the 2000 election in Zanzibar, the Civic United Front (CUF) began planning a series of peaceful demonstrations to protest alleged fraud in the October 2000 presidential elections, calling for a rerun of the elections and constitutional reforms. The CUF notified the police of their intended routes, both the government officials and police immediately responded and announced that the demonstrations were banned. Police were ordered to use all force necessary to break up the demonstrations. The Tanzanian prime minister was recorded as stating that force would be used to break up the demonstration. According to him, "government has prepared itself in every way to confront whatever occurs ... any provocation will be met with all due forces of the state". CUF demonstrations, which were widely supported, took place on 27 January 2001 and as the unarmed demonstrators walked peacefully toward the four designated meeting grounds, security forces intercepted and opened fire without warning. They attacked the civilians, [and]ordered them to disperse [under] firing and beating. ... All these events occurred in the face of the fact that the Constitution of the United Republic of Tanzania (CURT) provides for freedom of assembly. The requirement of permits has been removed and section 40 of the Police Force Ordinance and 11(1) of the Political Parties Act were declared void on grounds that the requirement for a permit to hold an assembly infringed the freedom of peaceful assembly and procession enshrined in article 20(2) of the CURT. However the government limits these rights in practice, police have authority to deny permission to hold an assembly on public safety and security grounds. The relevant provision is section 41 of the Police Force Ordinance which permits any police officer to stop the holding of any assembly. The situation has not improved for opposition parties seeking to hold assemblies because of the way the police apply section 41. Rather than invoking this provision only in extraordinary situations as required, the police, once served with a notice of a planned meeting, issued prohibition orders claiming that they had information that the meeting was likely to cause chaos, but without giving evidence. ... These restrictions on the right to freedom of assembly and the excessive use of force by police officials as depicted in the above recounted incident and others of its kind, violate numerous provisions of international legal istruments to which Tanzania is a party. The Universal Declaration of Human Rights (UDHR) guarantees for the right to freedom of peaceful assembly and association, as does the International Covenant on Civil and Political Rights (ICCPR). The African Charter limits the right to assemble subject to necessary restrictions provided by law, in particular those enacted in the interest of national security and the safety, health, ethics and the rights to freedoms of other. But the African Commission has interpreted these claw back clauses to mean that the limitations must be in accordance with international law and thus the standards developed under the ICCPR, especially, would be relevant in determining when the rights to assemble may be limited. The exercise here is to examine the nature of the Tanzanian laws on the right to peaceful assembly and demonstration in the light of police practice having regards to the nature of the right as guaranteed under international human rights instruments." -- Introduction. / Thesis (LLM (Human Rights and Democratisation in Africa)) -- University of Pretoria, 2004. / Prepared under the supervision of Prof. K. Quashigah at the Faculty of Law, University of Ghana / http://www.chr.up.ac.za/academic_pro/llm1/dissertations.html / Centre for Human Rights / LLM

A set of elementary building blocks undergoes self-assembly if local interactions govern how this set forms intricate structures. Self-assembly has been widely observed in nature, ranging from the field of crystallography to the study of viruses and multicellular organisms. A natural question is whether a model of self-assembly can capture the hierarchical growth seen in nature or in other fields of mathematics. In this work, we consider hierarchical growth in substitution rules; informally, a substitution rule describes the iterated process by which the polygons of a given set are individually enlarged and dissected. We develop the Polygonal Two-Handed Assembly Model (p-2HAM) where building blocks, or tiles, are polygons and growth occurs when tiles bind to one another via matching, complementary bonds on adjacent sides; the resulting assemblies can then be used to construct new, larger structures. The p-2HAM is based on a handful of well-studied models, notably the Two-Handed Assembly Model and the polygonal free-body Tile Assembly Model. The primary focus of our work is to provide conditions which are either necessary or sufficient for the ``bordered simulation'' substitution rules. By this, we mean that a border made up of tiles is allowed to form around an assembly which then coordinates how the assembly interacts with other assemblies. In our main result, we provide a construction which gives a sufficient condition for bordered simulation. This condition is presented in graph theoretic terms and considers the adjacency of the polygons in the tilings associated to a given substitution rule. Alongside our results, we consider a collection of over one hundred substitution rules from various sources. We show that only the substitution rules in this collection which satisfy our sufficient condition admit bordered simulation. We conclude by considering open questions related to simulating substitution rules and to hierarchical growth in general.

Regeneration is a relatively widespread phenomenon in nature, although different organisms exhibit different abilities to reconstitute missing structures. Due to the diversity in the extent of damage the organisms can repair it has been debated for a long time whether those abilities are evolutionary traits that arose independently in multiple organisms or whether they represent a by-product of more basic processes. To date, due to constant increase in the amount of available genomic information this question can be approached by means of comparative genomics by comparing several taxa that have different regenerative capabilities. Two relatively closely related salamander species, newt, Notophthalmus viridescens, and the Mexican axolotl, Ambystoma mexicanum, offer a unique opportunity to compare two organisms with well-known regenerative capabilities. Despite their importance for regeneration research, relatively little sequence information was available until recently, owing mainly to the large sizes of the respective genomes. In this work I aimed to create a comprehensive transcriptome assembly of the axolotl by sequencing and then assembling the sequence data from a number of tissues and developmental stages. I also incorporated available sequence information that mostly comes from cDNA libraries sequenced previously. I assessed the completeness of the transcriptome by comparing it to a set of available axolotl sequences and found that 96% of those have homologs in the assembly. Additionally, I found that 7,568 of 7,695 protein families common to vertebrates are also represented in the transcriptome. In order to turn the assembly from a merely collection of sequences into a valuable and useful resource for the entire research community I first annotated the sequences, predicted the open reading frames and protein domains and additionally put together multiple bits of information available for each sequence including but not limited to time-course and tissue- specific expression data and in situ hybridization results. The assembly was thereafter made available for the entire axolotl research community through a web portal I developed. Not only does the web portal provide access to the transcriptome data, it is also equipped with an engine for automated data retrieval, which could facilitate automated cross-species bioinformatics analyses. The study crossed the boundary between pure bioinformatics and biology as the transcriptome allowed for computational comparison of the axolotl and the newt in order to identify salamander-specific genes possibly implicated in regeneration and subsequent functional analysis thereof in the lab. Since regeneration closely resembles embryonic development in terms of genes involved in both processes, I first identified approximately 200 homologous contigs in axolotl and newt, which had a predicted open reading frame, but did not have homologs in non-regenerating species. The expression profile of one of those candidate genes suggested that it had a role in regeneration. I studied the molecular function of that gene using CRISPR/Cas system to confirm that it was protein-coding and to create knock-out animals to study the effect of gene knock-down and knock-out. Knock-out animals exhibited significant delays in both, limb development and tail regeneration. The exact mechanism causing this delay is currently being investigated.

L’électronique de puissance est un domaine en mutation. Les environnements et les conditions de fonctionnement des modules de puissance sont de plus en plus sévères : hautes températures, tension et courant élevés. De plus, le frittage d’argent a été introduit dans les modules, en remplacement des joints brasés principalement composés de plomb. C’est la combinaison de ces évolutions qui ont motivés nos travaux. Dans l’objectif d’améliorer la conception des modules de puissance, ces travaux proposent d’augmenter la dissipation des modules grâce aux structures verticales-3D. Un onduleur triphasé vertical-3D a été conçut avec des puces Si reportées par frittage d’argent. Des caractérisations électriques et thermiques ont été réalisées et ont permis de montrer l’apport de cette technologie. Cette étude est couplée à des simulations numériques thermiques et électrostatiques permettant de mettre en lumière les enjeux de cette méthode d’assemblage. / Power electronics is a changing field. The environments and operating conditions of power modules are more severe: higher temperature, higher voltage and higher current. In addition, silver sintering was introduced in power modules to replace solders composed by lead. The combinations of these developments have motivated our work. In order to improve the design of the power modules our researches purpose to increase the dissipation of power modules with a3D-vertical structure. A three-phase inverter with3D-vertical structure has been designed with a Si dice sintered. Thermal and electrical characterizations were performed and allowed to show the contribution of this technology. This study is coupled to thermal and electrostatic Finite Element Method simulations to highlight and improve the possible issues of this assembly.

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Many conflicting issues exist between product design and manufacturing department. In the early design stage, designers often do not have enough expertise to successfully address all these issues. This results in a product design with a low level of assemblability and manufacturability. Hence, an intelligent decision support system is needed for early design stages to improve a design. This paper proposed a web-based intelligent decision support system, CBR-DFMA, connecting with a case base, database and knowledge base. Early experimental results indicate that potential design problems can be detected in advance, design expertise can be effectively disseminated and effective training is offered to designer by employing this system.

Surface self-assembly, the spontaneous aggregation of molecules into ordered, sta- ble, noncovalently joined structures in the presence of a surface, is of great importance to the bottom-up manufacturing of materials with desired functionality. As a bulk phenomenon informed by molecular-level interactions, surface self-assembly involves coupled processes spanning multiple length scales. Consequently, a computational ap- proach towards investigating surface self-assembled systems requires a combination of quantum-level electronic structure calculations and large-scale multi-body classical simulations. In this work we use a range of simulation approaches from quantum-based methods, to classical atomistic calculations, to mean-field approximations of bulk mixed phases, and explore the self-assembly strategies of simple dipoles and polyaromatic hydrocarbons on symmetric surfaces. / Graduate

京都大学 / 0048 / 新制・課程博士 / 博士(工学) / 甲第21778号 / 工博第4595号 / 新制||工||1716(附属図書館) / 京都大学大学院工学研究科材料化学専攻 / (主査)教授 木村 俊作, 教授 瀧川 敏算, 教授 大内 誠 / 学位規則第4条第1項該当 / Doctor of Philosophy (Engineering) / Kyoto University / DGAM

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