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Resumo: A manutenção da vitalidade do ligamento periodontal cementário é de extrema importância para o sucesso do reimplante dentário. Minimizar o período de exposição do dente avulsionado ao meio seco ou mantê-lo em meio úmido, se constitui em importante conduta para o tratamento. Recentemente, o resveratrol tem sido bastante estudado, em razão das suas propriedades antioxidantes e da sua capacidade de prolongar a vida de diversos organismos desde as leveduras até os mamíferos. Portanto, o objetivo deste trabalho é avaliar a manutenção da vitalidade do ligamento periodontal cementário armazenado em resveratrol. Para isso foram empregados incisivos superiores e inferiores de sete macacos, totalizando 56 dentes. No grupo I os dentes foram extraídos e imediatamente imersos em solução fixadora. Nos grupos II a VI os dentes foram imersos em 50mL de solução de resveratrol em propilenoglicol (5 μM/L) durante 1, 2, 6, 12 e 24 horas, respectivamente. No grupo VII os dentes foram mantidos em meio seco por 6 horas. Parte dos cortes obtidos foi corada em H.E. para estudo histomorfológico e outra parte para análise imunoistoquímica utilizando anticorpos primários contra osteopontina e caspase. Os resultados demonstraram que nos grupos imediato e resveratrol 12 horas houve presença de moderado número de fibroblastos, alguns macrófagos e linfócitos. Nos grupos resveratrol 1, 2, 6 e 24 horas houve presença de pequeno número de fibroblastos e discreta vascularização. O grupo seco apresentou ausência de vasos sanguíneos e fibroblastos em degeneração. Houve imunomarcação moderada de osteopontina nos grupos imediato, resveratrol 12 e 24 horas. Nos demais grupos a imunomarcação variou de ausente a leve. Quanto à caspase, foi observada imunomarcação moderada nos grupos resveratrol... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The maintenance of vitality of the cement periodontal ligament is important for success of tooth reimplantation. It has been suggested to minimize the period of exposure of the avulsed tooth to dry environment or keep it in wet storage. Recently, resveratrol has been extensively studied due to its antioxidant properties and ability to prolong the lives of several organisms since yeast to mammals. The aim of this study is to evaluate the maintenance of vitality of the cement periodontal ligament stored in resveratrol. The analysis was conducted using maxillary and mandibular incisors of seven monkeys, total of 56 teeth. In group I, the teeth were extracted and immediately immersed in fixative solution. In groups II to VI, the teeth were immersed in 50ml of solution of resveratrol in propylene glycol (5 μM/L) for 1, 2, 6, 12 and 24 hours; respectively. In group VII, the teeth were maintained in dry environment for 6 hours. Some cuts were stained with HE for histomorphological analysis while some cuts were submitted to immunohistochemical analysis using primary antibody against osteopontin and caspase. The results demonstrated that in the groups immediate and resveratrol 12 hours showed presence of a moderate number of fibroblasts, some macrophages and lymphocytes. In the groups resveratrol 1, 2, 6 and 24 hours showed presence of small numbers of fibroblasts and mild vascularization. The dry group showed absence of blood vessels and fibroblasts in degeneration. There was moderate immunomarcation of osteopontin in the groups immediate, and resveratrol 12 and 24 hours. In the other groups, immunomarcation ranged from absent to light. Considering the caspase, it was observed moderate immunomarcation in the groups resveratrol 1, 2, 6 and 24 hours. In the remaining groups, immunomarcation ranged from absent to light... (Complete abstract click electronic access below) / Orientador: Wilson Roberto Poi / Coorientador: Roberta Okamoto / Banca: Mirian Marubayashi Hidalgo / Banca: Sônia Regina Panzarini Barioni / Mestre

Made available in DSpace on 2015-06-17T19:34:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-11-28. Added 1 bitstream(s) on 2015-06-18T12:48:40Z : No. of bitstreams: 1 000831501.pdf: 15772000 bytes, checksum: b98444e370d8c18b8d0c6664bf62447e (MD5) / O período mínimo de permanência extra-alveolar em meio seco ou o uso de um adequado meio de estocagem são determinantes para a manutenção da vitalidade do ligamento periodontal (LP). O soro do leite apresenta propriedades similares as do leite, tal condição despertou a atenção para investigar a sua utilização como meio de estocagem. O objetivo deste estudo foi avaliar o processo de reparo após o reimplante de dentes de rato previamente mantidos no soro do leite e leite integral. Foram empregados incisivos superiores direitos de 36 ratos divididos em 4 grupos de 9 animais. No grupo I os dentes foram extraídos e reimplantados imediatamente (controle positivo). No grupo II os dentes foram imersos em 50mL de soro do leite bovino doce, por 60 minutos. No grupo III os dentes foram mantidos, por 60 minutos, em 50mL de leite bovino longa vida integral, Leite UHT (Parmalat®). No grupo IV os dentes foram mantidos em meio seco pelo mesmo período (controle negativo). Em seguida, os dentes dos animais dos Grupos II, III e IV foram reimplantados em seus alvéolos. Os animais foram submetidos à eutanásia 60 dias após o reimplante. Os espécimes foram corados pela Hematoxilina e eosina para avaliação histomorfométrica. Em relação a organização do LP e a extensão e profundidade da reabsorção inflamatória, houve diferença estatisticamente significante entre os grupos I (Imediato) e IV (Tardio) (p<0,05). O soro do leite e o leite UHT apresentaram resultados semelhantes, sendo assim o soro do leite pode ser indicado como meio de estocagem para dentes avulsionados / Minimal extra-alveolar dry storage period or uses of a suitable storage media are crucial to maintaining the vitality of the periodontal ligament (PDL). Whey has similar properties to milk, such a condition attracted attention for investigating its use as a storage medium. The aim of this study was to evaluate the repair process after replantation of rat teeth previously kept in whey and whole milk. To this, 36 male rats were used, under general anesthesia upper right incisor were extracted and reimplanted. Treatment was performed, dividing in four groups, of 9 animals each. Group I without any treatment the teeth were immediately reimplanted (positive control). Group II teeth were immersed in 50mL sweet whey, for 60 minutes. Group III teeth were kept for 60 minutes in 50mL long shelf-life whole milk, UHT (Parmalat ®). Group IV teeth were kept in dry for the same period (negative control). Then, animals tooth in Groups II, III and IV were reimplanted in their sockets. The animals were subjected euthanasia 60 days after replantation. The specimens were stained in Hematoxylin and eosin for histomorphometric analysis. Regarding the organization of the periodontal ligament and the extent and depth of inflammatory resorption, there was a statistically significant difference between groups I (Immediate) and IV (Late). The whey milk and whole milk showed similar results and therefore the whey can be indicated as the storage medium for avulsed teeth

Made available in DSpace on 2014-06-11T19:23:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-02-08Bitstream added on 2014-06-13T20:30:43Z : No. of bitstreams: 1 sedlacek_p_me_araca.pdf: 366259 bytes, checksum: 78c436fdbcc840d9d7a56a5855d49a61 (MD5) / A avulsão dentária é causa frequente de perda de dente em crianças, adolescentes e adultos jovens. O dente avulsionado deve ser imediatamente reimplantado em seu alvéolo por qualquer pessoa no local do acidente e não apenas pelo cirurgião-dentista. Porém, a falta de conhecimento sobre trauma dentário é significante. Há a necessidade de um programa especial objetivando educar escolares em relação a procedimentos emergenciais nos casos de trauma dentário. Por esta razão, foram produzidos 134 cadernos escolares com capas contendo figuras e textos sobre avulsão e reimplante dentários, que foram distribuídos a 134 estudantes da sexta série do ensino fundamental (grupo experimental). Outro grupo semelhante (grupo controle), com 108 integrantes, recebeu cadernos escolares com capas sem informações relacionadas ao trauma dentário. A pesquisa foi desenvolvida em 2 escolas estaduais de Aaçatuba, SP, Brasil e, para prevenir interferências nos resultados, os grupos não foram desenvolvidos numa mesma escola. Após utilizarem os cadernos por 9 meses em sala de aula, os estudantes dos dois grupos responderam um questionário padronizado pela Teoria de Resposta ao Item, específico para avaliar conhecimento de escolares da sexta série do ensino fundamental de Araçatuba, SP, Brasil. Os Dados foram coletados e processados, usando-se o programa EPIINFO 2010. Setenta e sete por cento dos estudantes tinham idades em torno de 12 anos e 95% relataram praticar algum tipo de atividade física. Os resultados demonstraram que a utilização dos cadernos com as capas relacionadas à avulsão e ao trauma dentários, por 9 meses, proporcionou o conhecimento a esses estudantes sobre a chance do reimplante dentário, após avulsão. Também... / Tooth avulsion is a common cause of tooth loss in children, adolescents and young adults. The avulsed tooth should be immediately reimplanted into its socket, a procedure that can be performed by anyone at the accident site and not only by dental surgeons. However, the lack of knowledge about dental trauma is significant. It is necessary to increase the number of programs designed to educate school-aged students about emergency procedures to handle cases of dental trauma. For this reason, the educational effect of a printed notebook cover with information on tooth avulsion and replantation was evaluated in this study, after using them for 9 months by students of the sixth grade in a public school from Araçatuba city, SP , Brazil. To this purpose, 134 of these students (experimental group) received notebooks, whose cover was printed with illustrations and explanatory texts related to tooth avulsion and replantation. Another group received notebooks, whose covers were not related to dental trauma (control group). To avoid interferences in this etudy, each group was developed in a different school. An evaluation of the educational effects on students was performed at the end of the school year, through a specific questionnaire standatized... (Complete abstract click electronic access below)

Orientador: Wilson Roberto Poi / Banca: Idelmo Rangel Garcia Júnior / Banca: Nikeila Chacon de Oliveira Conde / Resumo: O período mínimo de permanência extra-alveolar em meio seco ou o uso de um adequado meio de estocagem são determinantes para a manutenção da vitalidade do ligamento periodontal (LP). O soro do leite apresenta propriedades similares as do leite, tal condição despertou a atenção para investigar a sua utilização como meio de estocagem. O objetivo deste estudo foi avaliar o processo de reparo após o reimplante de dentes de rato previamente mantidos no soro do leite e leite integral. Foram empregados incisivos superiores direitos de 36 ratos divididos em 4 grupos de 9 animais. No grupo I os dentes foram extraídos e reimplantados imediatamente (controle positivo). No grupo II os dentes foram imersos em 50mL de soro do leite bovino doce, por 60 minutos. No grupo III os dentes foram mantidos, por 60 minutos, em 50mL de leite bovino longa vida integral, Leite UHT (Parmalat®). No grupo IV os dentes foram mantidos em meio seco pelo mesmo período (controle negativo). Em seguida, os dentes dos animais dos Grupos II, III e IV foram reimplantados em seus alvéolos. Os animais foram submetidos à eutanásia 60 dias após o reimplante. Os espécimes foram corados pela Hematoxilina e eosina para avaliação histomorfométrica. Em relação a organização do LP e a extensão e profundidade da reabsorção inflamatória, houve diferença estatisticamente significante entre os grupos I (Imediato) e IV (Tardio) (p<0,05). O soro do leite e o leite UHT apresentaram resultados semelhantes, sendo assim o soro do leite pode ser indicado como meio de estocagem para dentes avulsionados / Abstract: Minimal extra-alveolar dry storage period or uses of a suitable storage media are crucial to maintaining the vitality of the periodontal ligament (PDL). Whey has similar properties to milk, such a condition attracted attention for investigating its use as a storage medium. The aim of this study was to evaluate the repair process after replantation of rat teeth previously kept in whey and whole milk. To this, 36 male rats were used, under general anesthesia upper right incisor were extracted and reimplanted. Treatment was performed, dividing in four groups, of 9 animals each. Group I without any treatment the teeth were immediately reimplanted (positive control). Group II teeth were immersed in 50mL sweet whey, for 60 minutes. Group III teeth were kept for 60 minutes in 50mL long shelf-life whole milk, UHT (Parmalat ®). Group IV teeth were kept in dry for the same period (negative control). Then, animals tooth in Groups II, III and IV were reimplanted in their sockets. The animals were subjected euthanasia 60 days after replantation. The specimens were stained in Hematoxylin and eosin for histomorphometric analysis. Regarding the organization of the periodontal ligament and the extent and depth of inflammatory resorption, there was a statistically significant difference between groups I (Immediate) and IV (Late). The whey milk and whole milk showed similar results and therefore the whey can be indicated as the storage medium for avulsed teeth / Mestre

Orientador: Wilson Roberto Poi / Banca: Sônia Regina Panzarini Barioni / Banca: Liliana Vicente Melo de Lucas / Resumo: A avulsão dentária é causa frequente de perda de dente em crianças, adolescentes e adultos jovens. O dente avulsionado deve ser imediatamente reimplantado em seu alvéolo por qualquer pessoa no local do acidente e não apenas pelo cirurgião-dentista. Porém, a falta de conhecimento sobre trauma dentário é significante. Há a necessidade de um programa especial objetivando educar escolares em relação a procedimentos emergenciais nos casos de trauma dentário. Por esta razão, foram produzidos 134 cadernos escolares com capas contendo figuras e textos sobre avulsão e reimplante dentários, que foram distribuídos a 134 estudantes da sexta série do ensino fundamental (grupo experimental). Outro grupo semelhante (grupo controle), com 108 integrantes, recebeu cadernos escolares com capas sem informações relacionadas ao trauma dentário. A pesquisa foi desenvolvida em 2 escolas estaduais de Aaçatuba, SP, Brasil e, para prevenir interferências nos resultados, os grupos não foram desenvolvidos numa mesma escola. Após utilizarem os cadernos por 9 meses em sala de aula, os estudantes dos dois grupos responderam um questionário padronizado pela Teoria de Resposta ao Item, específico para avaliar conhecimento de escolares da sexta série do ensino fundamental de Araçatuba, SP, Brasil. Os Dados foram coletados e processados, usando-se o programa EPIINFO 2010. Setenta e sete por cento dos estudantes tinham idades em torno de 12 anos e 95% relataram praticar algum tipo de atividade física. Os resultados demonstraram que a utilização dos cadernos com as capas relacionadas à avulsão e ao trauma dentários, por 9 meses, proporcionou o conhecimento a esses estudantes sobre a chance do reimplante dentário, após avulsão. Também... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Tooth avulsion is a common cause of tooth loss in children, adolescents and young adults. The avulsed tooth should be immediately reimplanted into its socket, a procedure that can be performed by anyone at the accident site and not only by dental surgeons. However, the lack of knowledge about dental trauma is significant. It is necessary to increase the number of programs designed to educate school-aged students about emergency procedures to handle cases of dental trauma. For this reason, the educational effect of a printed notebook cover with information on tooth avulsion and replantation was evaluated in this study, after using them for 9 months by students of the sixth grade in a public school from Araçatuba city, SP , Brazil. To this purpose, 134 of these students (experimental group) received notebooks, whose cover was printed with illustrations and explanatory texts related to tooth avulsion and replantation. Another group received notebooks, whose covers were not related to dental trauma (control group). To avoid interferences in this etudy, each group was developed in a different school. An evaluation of the educational effects on students was performed at the end of the school year, through a specific questionnaire standatized... (Complete abstract click electronic access below) / Mestre

The study of fluvial geomorphology is one of the critical sciences in the 21st Century. The previous century witnessed a virtual disregard of the hydro and morphodynamic processes occurring in rivers when it came to design of transportation, flood control, and water resources infrastructure. This disregard, along with urbanization, industrialization, and other land uses has imperiled many waterways. New technologies including geospatially referenced data collection, laser-based measurement tools, and increasing computational powers by personal computers are significantly improving our ability to represent these complex and diverse systems. We can accomplish this through both the building of more sophisticated models and our ability to calibrate those models with more detailed data sets. The effort put forth in this dissertation is to first introduce the accomplishments and challenges in fluvial geomorphology and then to illustrate two specific efforts to add to the growing body of knowledge in this exciting field.First, we explore a dramatic phenomenon occurring in the Middle Rio Grande River. The San Marcial Reach of the Rio Grande River has experienced four events that completely filled the main channel with sediment over the past 20 years. This sediment plug has cost the nation millions of dollars in both costs to dredge and rebuild main channels and levees, along with detailed studies by engineering consultants. Previous efforts focused on empirical relations developed with historical data and very simple one dimensional representation of river hydrodynamics. This effort uses the state-of-the-art three-dimensional hydro and morphodynamic model Delft3D. We were able to use this model8to test those hypotheses put forth in previous empirical studies. We were also able to use this model to test theories associated with channel avulsion. Testing found that channel avulsions thresholds do exist and can be predicted based on channel bathymetric changes.The second effort included is a simple yet sophisticated model of river meander evolution. Prediction of river meandering planform evolution has proven to be one of the most difficult problems in all of geosciences. The limitations of using detailed three dimensional hydro and morphodynamic models is that the computational intensity precludes the modeling of large spatial or temporal scale phenomenon. Therefore, analytical solutions to the standard Navier-Stokes equations with simplifications made for hydrostatic pressure among others, along with sediment transport functions still have a place in our toolbox to understand and predict this phenomenon. One of the most widely used models of meander propagation is the Linear Bend Model that employs a bank erosion coefficient. Due to the various simplifications required to find analytical solutions to these sets of equations, efforts to build the stochasticity seen in nature into the models have proven useful and successful. This effort builds upon this commonly used meander propogation model by introducing stochasticity to the known variability in outer bank erodibility, resulting in a more realistic representation of model results.

Thesis advisor: Douglas A. Edmonds / Delta morphology is traditionally explained by differences in fluvial energy and wave and tidal energy. However, deltas influenced by similar ratios of river to marine energy can display strikingly different morphologies. Other variables, such as grain size of the sediment load delivered to the delta, influence delta morphology, but these models are largely qualitative leaving many questions unanswered. To better understand how grain size modifies deltaic processes and morphologies I conducted 33 numerical modeling experiments and quantified the effects produced by different grain sizes. In these 33 runs I change the median (0.01 - 1 mm), standard deviation (0.1 - 3 φ), and skewness (-0.7 - 0.7) of the incoming grain-size distribution. The model setup includes a river carrying constant discharge entering a standing body of water devoid of tides, waves, and sea-level change. The results show that delta morphology undergoes a transition as median grain size and standard deviation increase while changing skewness has little effect. At small median grain size and standard deviation, deltas have elongate planform morphologies with sinuous shorelines characterized by shallow topset gradients ranging from 1 x 10<super>-4</super> to 3 x 10<super>-4</super>, and by 1 - 8 stable active channels. At large median grain size and standard deviation, deltas transition to semi-circular planform morphologies with smooth shorelines characterized by steeper topset gradients ranging from 1 x 10<super>-3</super> to 2 x 10<super>-3</super>, and by 14 - 16 mobile channels. The change in delta morphology can be morphodynamically linked to changes in grain size. As grain size increases delta morphology transitions from elongate to semi-circular because the average topset gradient increases. For a given set of flow conditions, larger grain sizes require a steeper topset gradient to mobilize and transport. The average topset gradient reaches a dynamic equilibrium through time. This requires that, per unit length of seaward progradation, deltas with steeper gradients have higher vertical sedimentation rates. Higher sedimentation rates, in turn, perch the channel above the surrounding floodplain (so-called `super-elevation'), resulting in unstable channels that frequently avulse and create periods of overbank flow. The overbank flow is more erosive because the steeper gradient causes higher shear stresses on the floodplain, which creates more channels. More channels reduce the average water and sediment discharge at a given channel mouth, which creates time scales for mouth bar formation in coarse-grained deltas that are longer than the avulsion time scale. This effectively suppresses the process of bifurcation around river mouth bars in coarse-grained deltas, which in turn creates semi-circular morphologies with smooth shorelines as channels avulse across the topset. On the other hand, the finest-grained (i.e. mud) deltas have low topset gradients and fewer channels. The high water and sediment discharge per channel, coupled with the slow settling velocity of mud, advects the sediment far from channel mouths, which in turn creates mouth bar growth and avulsion time scales that are longer than the delta life. This creates an elongate delta as stable channels prograde basinward. Deltas with intermediate grain sizes have nearly equal avulsion and bifurcation time scales, creating roughly semi-circular shapes but with significant shoreline roughness where mouth bars form. / Thesis (MS) — Boston College, 2013. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Earth and Environmental Sciences.

O presente trabalho investigou microscopicamente o efeito da equistatina sobre o processo reabsortivo de dentes incisivos superiores de ratos, extraídos e reimplantados. Foram utilizados 42 animais, divididos em grupos com e sem equistatina. Os tempos extra-alveolares dos dentes foram de 30 e 60 minutos e os períodos experimentais pós-cirúrgicos foram 15, 60 e 90 dias. Os espécimes obtidos foram processados e corados em H.E. para observar os processos biológicos presentes. Os eventos microscópicos foram avaliados por dois examinadores, de modo quantitativo histomorfométrico e descritivo, de acordo com o tipo de infiltrado e intensidade da reação inflamatória; com o tipo, extensão e localização de reabsorção dentária; e presença de anquilose alveolodentária. O nível de concordância entre examinadores, determinado pelo índice Kappa, revelou-se quase perfeito para todas as variáveis avaliadas. A comparação entre os grupos testes e controle para as variáveis apresentadas foi feita por meio do teste Mann-Whitney e mostrou não haver diferença estatística entre a administração de equistatina e tempo extra-alveolar em relação à intensidade inflamatória nas diferentes porções radiculares. Quanto ao tipo de reabsorção estabelecida, notou-se que a presença de reabsorção inflamatória foi significativamente maior (p<0,05) no grupo controle nos tempos de 30 e 60 minutos no período pós-cirúrgico de 15 dias. A anquilose alveolodentária também esteve significativamente mais presente no grupo tratado com equistatina com 30 minutos extra-alveolar e 15 dias de período experimental. Houve, ainda, mais anquilose alveolodentária no grupo controle de 60 minutos extra-alveolar, com o período experimental de 60 dias. No período experimental de 90 dias todos os espécimes avaliados apresentaram processos reabsortivos inflamatórios e ausência de anquilose alveolodentária. O teste Kruskall-Wallis avaliou as diferenças significantes entre grupos, em relação à intensidade inflamatória por terço radicular, tipo de reabsorção e anquilose alveolodentária. As comparações individuais foram realizadas com teste Dunn e mostrou diferenças significantes entre grupos teste em relação ao período experimental. As variáveis testadas também foram avaliadas pelo teste de correlação de Spearman, que demonstrou haver correlações positivas substanciais ou muito fortes entre as variáveis: intensidade inflamatória no 1/3 cervical e no 1/3 médio, intensidade inflamatória no 1/3 cervical e no 1/3 apical e intensidade inflamatória no 1/3 médio e no 1/3 apical. Destacou-se ainda a correlação negativa substancial entre tipo de reabsorção e a intensidade inflamatória do 1/3 médio radicular. O uso de implantes de ELVAX com equistatina demonstrou possuir um potencial terapêutico na prevenção de processos reabsortivos inflamatórios no modelo experimental de reimplante de incisivos superiores murinos. / This study aimed to microscopically investigate the effect on the dental resorptive process of subgingival implants of ELVAX polymer with peptide echistatin in reimplantation of upper incisors in rats. For this purpose, 42 animals were used and divided into groups with and without echistatin. Extra alveolar socket period was 30 and 60 minutes and post-surgical experimental periods were 15, 60 and 90 days. Specimens were processed and stained with H.E. to observe the biological processes in the area. The microscopic events were evaluated by two examiners. Quantitative histomorphometric and descriptive evaluation of the events were performed according to the presence, type and location of the inflammatory response, incidence of resorptions or dental ankylosis. The level of agreement between examiners determined by the Kappa index, proved to be almost perfect for all variables. The comparison between the experimental and control groups for the variables presented was performed using the Mann-Whitney test and showed no statistical difference between the administration of echistatin and extra alveolar socket period relative to the inflammatory intensity in different portions of the root. Regarding the type of resorption established, it was noted that the presence of inflammatory resorption was significantly higher (p<0.05) in the control group on days 30 and 60 minutes in the postoperative period of 15 days. Dental ankylosis was also significantly more prevalent in the group treated with echistatin in extra alveolar socket period of 30 minutes and 15-day trial period. There was even more dental ankylosis in control group with 60 minutes of extra alveolar socket, with the trial period of 60 days. In the trial period of 90 days all specimens studied featured inflammatory resorptives processes and absence of dental ankylosis. The Kruskal-Wallis test assessed significant differences between groups in relation to the intensity of inflammation by root third, resorption type of and dental. Individual comparisons were performed with Dunn test and showed significant differences between groups in relation to the test observation period. The variables tested were also evaluated by Spearman correlation test, which showed that there are substantial or very strong positive correlations among the variables: intensity of inflammation in the cervical third and the medium third, intensity of inflammation in the cervical 1/3 and apical 1/3 inflammatory intensity in the middle 1/3 and apical 1/3. It also highlighted the significant negative correlation between type and intensity of inflammatory resorption of middle 1/3 root. The use of subgingival ELVAX implants with echistatin shown to have therapeutic potential in preventing the inflammatory resorptive process in the experimental model of reimplantation of upper incisors in rats.