- About
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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 81 to 90 of 1722 (0.031 seconds)| 81 |
Deciphering the consequences of polyploidy in an in vivo epitheliumCarmo Castilho Soares 13 November 2017 (has links)
No description available.
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| 82 |
Prevenção Quaternária e Saúde OcupacionalVera Lúcia da Rocha Teixeira 08 June 2016 (has links)
No description available.
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| 83 |
New Insights into the Role of Tissue Eosinophils in the Progression of Colorectal Cancer - A literature reviewAna Laura da Silva Santos Saraiva 30 May 2018 (has links)
No description available.
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| 84 |
Formação em Cuidados Paliativos. Influência na vida profissionalMariana Soares Lima 16 January 2018 (has links)
No description available.
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| 85 |
Optogenetic modulation of the corticostriatal circuitry in chronic painInês Costa Laranjeira 04 December 2017 (has links)
No description available.
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| 86 |
O papel da microbiota no cancro gástricoAna Filipa Torres Silva 05 June 2018 (has links)
No description available.
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| 87 |
Estimativa do sexo e da idade com base no esterno humanoInês da Cruz Gonçalves 27 November 2017 (has links)
No description available.
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| 88 |
Avaliação do Fluxo Aéreo e Resistência Nasais em Indivíduos Adultos com e sem Rinite. Contribuição para a Interpretação da RinomanometriaIvânia Martins Gonçalves 12 December 2017 (has links)
No description available.
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| 89 |
Can Adiponectin Help us to Target Diastolic Dysfunction?Catarina Domingues Francisco 15 June 2018 (has links)
No description available.
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| 90 |
Effect of tetrahydrocannabinol on COMT activity in mice prefrontal cortexAna Catarina Relvas do Novo 22 March 2019 (has links)
Tetrahydrocannabinol (THC) is the principal psychoactive constituent of cannabis and its effects are modulated by dopaminergic neurotransmission. Dopamine availability in prefrontal cortex is mostly controlled by catechol-o-methyltransferase (COMT) and it has been suggested that THC induced psychosis and cognitive impairment are dependent on COMT genotype. However the effect of THC in COMT activity is not known.This study aims to evaluate the effect of THC on COMT activity and monoamines tissue levels in mice prefrontal cortex. COMT activity in vitro and in vitro ex-vivo was evaluate in the pre-frontal cortex from C57BL/6J mice. For 10 days, mice were treated either with vehicle or THC (10 mg/Kg bw, total daily dose).In vitro, THC produced a concentration dependent inhibition in brain COMT activity with an IC 50 value of 232 µM. In vivo, THC treatment did not change monoamines or dopamine metabolites in prefrontal cortex. Nevertheless a significant decrease in 5-hydroxyindoleacetic acid (0.35±0.1, 0.54±0.02 pmol/mg tissue for control and THC respectively) was observed. In vitro-ex-vivo, COMT activity in the pre-frontal cortex showed no differences in the enzyme kinetics parameters when comparing THC to control animals. Analysis from the saturation curves found that the Vmax values (in nmol/mg prot/h) were 2.73 (2.4, 3.1) and 2.70 (2.3, 3.1) for CT and THC respectively.In conclusion, THC decreases COMT activity in vitro only in high concentrations (above 100 µM), however when administrated in vivo no significant effect was observed in enzyme activity or dopamine prefrontal cortex metabolism.
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