Syftet med föreliggande studie var att vidareutveckla en behandlingsspecifik följsamhetsskala för paniksyndrom vid internetförmedlad kognitiv beteendeterapi (IKBT). Studiens frågeställningar var 1) uppnår skalan tillräcklig interbedömarreliabilitet, 2) finns det ett samband mellan skalan och det tidigare använda följsamhetsmåttet antalet genomförda moduler, och 3) finns det ett samband mellan skalan och behandlingsutfallet. Interbedömarreliabiliteten mellan två bedömare testades genom två omgångar samskattning. 80 deltagare som behandlades med IKBT för paniksyndrom vid enheten för internetpsykiatri i Stockholm skattades sedan enligt den behandlingsspecifika följsamhetsskalan. Även antalet moduler deltagarna genomförde registrerades. Resultaten visade att skalan sammantaget hade en god interbedömarreliabilitet. Vidare korrelerade följsamhetsskalan positivt med både antalet genomförda moduler och behandlingsutfallet. Slutsats: Skattningsskalan vidareutvecklad i föreliggande studie visade indikationer på att vara ett tillförlitligt och användbart instrument för att mäta följsamheten till IKBT vid paniksyndrom. / The purpose of this study was to further develop a treatment-specific rating scale for adherence to internet-based cognitive behavioural therapy (ICBT) for panic disorder. The research questions for this study were 1) does the rating scale show satisfying inter-rater reliability, 2) is there an association between the rating scale and the commonly used measurement of adherence, module completion, and 3) is there an association between the rating scale and treatment outcome. The inter-rater reliability between two raters was assessed twice. 80 participants treated with ICBT for panic disorder at Internetpsykiatrin (the unit for internet-based cognitive behavioural therapy in Stockholm) were then assessed using the treatment-specific rating scale for adherence. Module completion was also registered. Results show that the rating scale had an overall satisfying inter-rater reliability. Furthermore, the rating scale correlated positively with both module completion and treatment outcome. Conclusion: The rating scale further developed in the present study showed indications of being a reliable and useful instrument for measuring adherence to ICBT for panic disorder.

Etude longitudinale comparative de l’efficacité d’un programme cognitivo-comportemental de groupe pour l’autogestion de la fibromyalgie : 112 patients suivis en ambulatoire à l’hôpital, âgés entre 18 et 66 ans, répartis au hasard dans un bras traitement GTCC (8 séances, 2 heures par semaine) ou dans un bras témoin GTEM (1 séance, 2 heures d’information d’éducation thérapeutique) organisés en groupes de 5 à 9 patients. Tous ont répondu à des questionnaires avant l’intervention et ont été réévalués avec des tests cliniques 3, 6 et 12 mois après le traitement. Les résultats montrent : il n’y pas de différences significatives entre GTCC et GTEM. Pour GTCC nous constatons des changements significatifs : amélioration de la motivation au maintien des acquis, de la qualité de vie spécifique à la fibromyalgie, de l’état de santé général ; et diminution du coping dramatisation, de l’intensité de la douleur, de l’anxiété et de la dépressivité. La sévérité de la douleur, reste inchangée. La dépressivité et la douleur peuvent jouer un rôle prédictif du développement de facteurs cliniques. Un programme TCC pour l’autogestion de la fibromyalgie est efficace à court et long terme / A longitudinally comparative study assessed a group self-management CBT program efficacy for 112 fibromyalgia hospital outpatients, aged 18 to 66. They were andomized in treatment group GTCC (8 weekly 2 hours sessions) and reference group GTEM (one 2 hours therapeutic patient education session), both organized with 5 to 9 patients. All patients were submitted a socio-demographic data and clinical questionnaire before intervention and a clinical re-evaluation at 3, 6 and 12 months after treatment. No significant differences between GTCC and GTEM groups were found. GTCC results shows significant short and long-term improvement in motivation to maintain the new strategies, quality of life and health status; and in decreased catastrophizing coping strategies, pain intensity, anxiety and depression propensity. No change in pain severity was found. Depression and pain can predict the development of psychological and clinical factors. A fibromyalgia self-management CBT program is efficient at short and long term.

Purpose: The aim of the systematic review was to address whether psychological interventions were able to reduce fatigue severity or the impact of fatigue in individuals with Multiple Sclerosis. The empirical study aimed to evaluate the effectiveness of a CBT based self-help workbook at reducing perceived impact of fatigue in a clinical sample of MS patients. Methods: A systematic search of the literature was carried out between the years 1980 and February 2015 to review whether psychological interventions were effective for fatigue management in Multiple Sclerosis. A randomised controlled trial examined the effectiveness of a CBT-based self-help workbook for the reduction of fatigue impact in MS. Participants were randomly allocated to one of three groups treatment as usual (TAU), pure self-help (PSH) or guided self-help (GSH). Results: Eleven studies were included in the systematic review, which indicated that CBT based interventions aiming to reduce fatigue or depression were most effective at reducing the severity of fatigue. Impact of fatigue can be reduced through mindfulness, CBT, motivational interviewing and to a lesser extent acceptance and commitment therapy. The empirical study did not find any significant differences between groups, however satisfaction with the workbook was high. Conclusions: The review suggests that there is a clear role for psychological interventions in fatigue management in MS, although further robust research into different therapeutic modalities is needed. From the empirical study it appears that the low level CBT-based intervention for fatigue in MS was not effective at reducing the perceived impact of fatigue. This study reflects an inclusive, clinical sample, recruited from a specialist rehabilitation unit, with high levels of multidisciplinary input which may have diluted any potential effect of the workbook. Objectives: The aim of the systematic review was to address whether psychological interventions are able to reduce fatigue severity or the impact of fatigue in individuals with Multiple Sclerosis Data sources: A search was conducted of: Psychinfo, Medline, Embase, CINAHL between 1980 and February 2015. Review methods: All studies were evaluated against a set of quality criteria by author (KG) with a proportion of studies being independently reviewed by author (DP) to ensure reliability of ratings. Results: Eleven studies were included in the review. CBT based interventions with a focus on fatigue management and depression appear to significantly reduce fatigue severity with medium to large effect. Significant reductions in fatigue impact can be found from mindfulness groups, motivational interviewing and CBT. Effect sizes for CBT interventions ranged from negligible to medium. For the mindfulness and motivational interviewing interventions effect sizes were not able to be calculated. The acceptance and commitment therapy intervention did not find a significant reduction in fatigue but found a medium effect for the intervention. Conclusions: There is a clear role for psychological interventions in the reduction of fatigue management but more high quality research needs to be carried out.

Background: Group CBT approaches have been shown to be equally as effective as individual CBT for reducing depressive symptoms and preventing relapse; however, the predictors of response are poorly understood. The primary objective of the studies presented in this thesis was to further examine the formal and process factors within group CBT for depression that contribute to various treatment outcomes. The first study investigated the relationship between group CBT for depression and changes in interpersonal distress, as well as the process mechanisms that might influence this relationship. The second study assessed whether formal feedback provided to therapists and clients derived from the Outcome Questionnaire (OQ-45), a robust measure of client functioning, would enhance group processes and treatment outcomes. Method: Study 1: Secondary data from clients having received individual CBT for depression at a community-based mental health training centre constituted one condition (18 clients). Data for the group condition (12 clients) were collected from clients attending group CBT for depression at a tertiary care facility. Relationship distress, as measured by the OQ-45 relationship distress subscale score, was assessed at intake and termination. Group participants also completed process measures at the start and end of treatment. In study 2, participants were recruited from a tertiary care facility to participate in a CBT group for depression. Participation involved completing brief questionnaires assessing psychological and process variables before and after treatment, as well as the OQ-45 at every session. Three groups (21 clients) received standard CBT and two groups (12 clients) received enhanced CBT, which included feedback about their progress from the OQ-45. Results: Results of study 1 suggest that clients who participated in group CBT experienced a significantly greater reduction in relationship distress across time than clients who participated in individual CBT. Results also indicate that therapeutic alliance, and not group cohesion, mediates the relationship between pretreatment relationship distress on posttreatment relationship distress in group CBT. Results of study 2 indicate that participants in the enhanced condition experienced greater improvements in quality of life, dysfunctional beliefs, and therapeutic bond at termination, relative to participants in the standard condition. Trends also suggest a greater reduction in depressive symptoms. Conclusions: Group CBT for depression may be more effective than the individual modality for reducing interpersonal distress. Furthermore, therapeutic alliance plays a significant role in improving interpersonal distress within a structured group CBT protocol. Feedback from the OQ-45 may help improve client outcomes and enhance therapeutic bonding with facilitators in group CBT for depression.

I chose the theme of obsessive-compulsive disorder as a topic of my thesis. The main reason was that it is a disorder I have worked as a therapist in individual or group therapy frequently. Also I have participated in several studies as evaluator in Psychiatric Centre, and I collected data from dozens of patients. In the first part the thesis deals with the symptoms, clinical picture, prevalence, aetiology and treatment of OCD. Thesis is focuses on behavioural and cognitive models of the disorder in detail, because the treatment used in the present group of patients was CBT. Various models of cognitive behavioural therapy I discuss in more detail, because they allow different views of what happens to the patient and how to change it. The practical part has two parts. The first deals with the effectiveness of group cognitive behavioral approach for OCD patients, who use antidepressants but were resistant to previous treatment and were attended a daycare center at the Prague Psychiatric Center. The second part of the thesis deals with finding a predictor of successful cognitive behavioral therapy in these patients. The aim was to determine whether certain demographic or clinical factors that we evaluated before treatment may predict success outcome. The result is the finding that severity of the...

Anxiety disorders share the feature of excessive fear, anxiety and related behavioural disturbances. Fear is defined as the emotional response to a real or a perceived imminent threat and anxiety is the anticipation of a future threat. The anxiety disorders covered in this thesis are panic disorder with or without agoraphobia, social phobia, post-traumatic stress disorder, generalized anxiety disorder and anxiety disorder not otherwise specified. Cognitive behavioural treatment protocols are typically designed to target one specific disorder and falls under the definition of disorder-specific cognitive behavioural therapy. It is however unclear if this is the most optimal approach in regards to the high comorbidity between anxiety disorders and depressive disorders. Internet-based cognitive behavioural therapy has in the past generally been disorder-specific and from above mentioned predicament two alternative treatment approaches emerged, the tailored and the transdiagnostic approach that aims to simultaneously treat both principal and comorbid disorders. Previous trials on internet-based cognitive behavioural therapy have targeted adults in general and relatively few target adolescents, young adults and older adults. The aims of this thesis were to further develop and test the effects of tailored internet-based cognitive behavioural therapy on the basis of age, for adolescents, young adults and older adults. Specifically by developing and testing the effects of individually tailored internet-based cognitive behavioural therapy for adolescents with anxiety and comorbid depressive symptoms and by adapting and testing the effects of individually tailored internet-based cognitive behavioural therapy for young adults and older adults with anxiety and comorbid depressive symptoms. These aims were tested in two pilot effectiveness studies (Paper I and III) and two efficacy randomised controlled trials (Paper II and IV). The results from these four trials showed significant results across all outcome measures with overall moderate to large effect sizes. The tentative conclusion based on these results is that tailoring internet-based cognitive behavioural therapy can be a feasible approach in the treatment of anxiety symptoms and comorbid depressive symptoms for adolescents, young adults and older adults. Despite the positive findings of the studies in this thesis, there is a need for more research examining the acceptability and effectiveness of internet-based cognitive behavioural therapy for adolescents, young adults and older adults with anxiety and depression before implementation on a larger scale.

Background: Accrual of continuing medical education credits is part of licensure in family medicine but opinions are mixed as to whether the training has an impact on clinical practice. Literature does suggest that practice change is most likely when training involves multiple interactive exposures, and when the benefit to patients is apparent. Aim: To determine whether an interactive peer-lead educational intervention for General Practitioners in British Columbia, the Practice Support Program Mental Health Module, resulted in measureable change in clinical practice of the Vancouver Island participants. Method: Administrative information from British Columbia Ministry of Health databases was obtained for analysis regarding physician billing and prescribing, and hospitalizations on Vancouver Island. Paired t-tests were used to compare physician-patient interactions among module participants before and after the training regarding a) initiation of antidepressants and anti-anxiety medication, and b) use of the mental health plan billing code, used to support patients who struggle with activities of daily living. In addition, mental health hospitalizations among participants' patients before and after training were used to measure its impact on patient outcomes. Results: One-hundred and ninety-seven General Practitioners on Vancouver Island completed the mental health module between 2008 and 2011. While no significant difference was found in the numbers of mental health patients seen during the pre- and post- periods (M=142.06, SD=97.45) and (M=144.44, SD=103.00); t(196)=-0.679, p=0.498, α=.05, the change in the proportion of new prescriptions between pre-period mean (M=0.0796, SD=.06527) and post-period means (M=.0530, SD=.03877); t(195)=6.668, p<0.001 was found to be significant and indicative of a relative decrease between 31.2 and 33.4%. The change in the proportion of mental health plans was also found to be significant between pre-period (M=0.1142, SD=.018598) and post-period means (M=.1674, SD=.23973); t(180)=-3.586, p<0.001. This indicated a relative increase between 42.0 and 46.6%. No significant change in patient hospitalizations was found between the pre- and post-period means: (M=0.039, SD=.0612) and (M=.0392, SD=.0978); t(192)=-0.055, p=0.956. Conclusion: This educational intervention appears to have resulted in significant changes in the practice patterns of the physician participants. Future research using better indicators may reveal more about the impact of physician training on patient outcomes. / Graduate

Introduction: Chronic orofacial pain (COFP) is distressing and disabling to sufferers and can be costly to patients, health services and society. Frequently, no underlying medical pathology can be found to account for the condition. Despite this, patients are treated according to a biomedical model, often by mechanistic and invasive procedures, which tend to be unsuccessful and not evidence based. Evidence suggests that cognitive behavioural therapy (CBT) based management may produce improved outcomes for patients. However, published studies can tell us little about which intervention components are effective, or recommend an optimum way for these components to be applied. Aim: To develop an evidence based intervention for the management of COFP that is feasible and acceptable to patients and practitioners. Method: The Medical Research Council’s guidelines for developing complex interventions were used as a framework for the research. Evidence from multiple sources was synthesised to produce the draft components of an intervention to manage COFP. An exploratory trial investigated preliminary outcomes, acceptability, feasibility and explored parameters for a full scale randomised control trial. Results: The intervention was acceptable to participants and could be feasibly implemented. No conclusions could be drawn relating to the effectiveness of the intervention. Participants were not affected at baseline for a number of outcomes, which implies that cut off points should be introduced into the inclusion and exclusion criteria of any future studies. Conclusion: The study produced an intervention which is acceptable and feasible to participants, however it is not known if it is effective. A number of recommendations are made for progression to a larger, definitive trial.

Computerised Cognitive Behavioural Therapy (CCBT) has been recommended for patients in the National Health Service (NHS) Primary Care across the United Kingdom for management of mild to moderate anxiety and depression. This approach also promises financial savings, and may fill the gap between demand and supply of face-to-face therapy. Studies have shown that CCBT is feasible and effective. However, dropout rates can be as high as 86%, but the reasons remain unclear and the information available is limited. This thesis explores factors that may impact on the usability and user experience of this computer-mediated therapy. Espousing the “real world” research philosophy and widely used methods in the Human-Computer Interaction (HCI) field for usability evaluations, four studies using a mixed-methods design were conducted. Study I was an online usability survey, which investigated if usability evaluations had been conducted for CCBT applications. Two versions of questionnaires were sent to four CCBT software developers and ten authors of randomised controlled trials. The categories and responses of the questionnaires gathered from five respondents were reviewed and summarised. The findings suggested that usability evaluations for CCBT were still in their infancy when compared to other healthcare interventions to which HCI approaches have been widely applied. Study II was a usability Heuristic Evaluation (HE) conducted with four expert evaluators to assess two different CCBT applications’ interfaces (MoodGYM and Living Life to the Full) against the self-designed usability heuristics for their compliance. The findings revealed numerous usability issues. Major problems related to navigation and inconsistency of the interfaces were identified. These could be rectified to enhance the user experience. Study III focused on other factors besides usability that might have an influence on the effective use of CCBT. Perceptions of service providers who were involved in both decision-making about CCBT availability and supporting its use were gathered. Nine service providers at different NHS organisations were interviewed. The interviews were analysed using techniques from Grounded Theory (GT). The findings suggested that the practitioners’ attitudes towards CCBT might have affected its service delivery. Four categories from the data analysis were identified: (1) shaping behaviour, (2) implementing and delivering, (3) making an appropriate referral, and (4) technology/CCBT packages - advancing with time. A conceptual model was also generated, “building support around CCBT”: a road-map that could address some of these issues. Study IV examined patients’ perceptions and acceptance of a CCBT application (Beating the Blues), its usability and the user experience, and also whether the user characteristics (e.g. computer experience (CE) and computer self-efficacy (CSE)) had any influence on patients’ use of this technology. A mixed-methods approach was utilised with a sample of 33 participants. Face-to-face and email interviews were conducted. Feedback was also gathered from a usability questionnaire and think-aloud protocol with seven participants selected from the sample. The data were analysed using Thematic and Saliency Analysis to uncover themes. Descriptive statistics were used to describe data from questionnaires. Two overarching themes from the interviews were identified: (1) access to CCBT services, and (2) perceptions and attitudes towards CCBT. Both themes revealed issues which might have significantly impacted on patients’ engagement with CCBT. Numerous flaws were also discovered in the application’s design and functionality (e.g. navigation, aesthetics, relevance of content, and inflexibility). However, the results from CE and CSE questionnaires suggested that participants were confident in using this technology. The four studies provided an in-depth understanding of factors that affect the usability and user experience of CCBT and possible reasons for the high attrition rates. The implications of this research point to the need for health policymakers to focus on the current implementation issues and on how best to deploy this treatment therapy to patients. Further development of CCBT is pivotal to its success, in particular, expanding contexts of use and increasing usability evaluations. Keeping users interested and engaged will improve treatment efficiency, completion rates and will achieve better clinical outcomes.

A manualised trauma-focused cognitive behavioural therapy (TF-CBT) programme was developed for multiply-abused children diagnosed with posttraumatic stress disorder (PTSD; Feather & Ronan, 2004) referred to the specialist clinic of the statutory child protection agency in New Zealand. The TF-CBT protocol was based on: (1) a review of the history of child abuse (CA) and child protection in New Zealand and internationally, with particular reference to professional developments and the role of psychologists in ameliorating CA; (2) a conceptualisation of the clinical presentation of CA in children; (3) a review of the field of psychotraumatology and theoretical models, including locally developed, relevant to the development of a treatment programme for traumatised abused children in a child protection setting in New Zealand; and (4) a review of evidence-based practice, treatment outcome models, and current empirical research related to developing an effective treatment model in this area. The locally developed TF-CBT programme built on efficacious treatments for child anxiety and PTSD as a result of sexual abuse. It encompasses psychosocial strengthening, coping skills training, gradual exposure using expressive modalities, and special issues relevant to trauma and abuse. A “scientist-practitioner” approach to local clinical research was used to evaluate the programme. A single-case multiple-baseline design demonstrated the controlling effects of the treatment across four studies; each comprising four typically-referred multiply-abused children aged 9-15 years who met diagnostic criteria for PTSD. Parent/caregivers were involved in treatment sessions. Study 1 was a pilot with four Pakeha/New Zealand European children; Study 2 trialled the protocol with two Maori and two Samoan children; Study 3 was an evaluation of the developed protocol with a multicultural group of typically-referred children; and Study 4 was an evaluation with other therapists delivering the manualised programme. Despite some methodological difficulties related to conducting research in a setting of this nature, the overall results indicate a good deal of promise. Across the four studies, for the majority of children treated, PTSD symptoms decreased and child coping increased. Where follow-up data was available, gains generally maintained or improved over 3-, 6-, and 12-month intervals. Recommendations are made about further applications of this TF-CBT programme, including the interweaving of cultural models with TF-CBT, and development and evaluation of the protocol in other settings. Implications of the current research are discussed in terms of recognition of the crucial importance of evidence-based practice in CA/child protection settings, and the contribution psychologists and therapists can make to ensure quality outcomes for this most vulnerable population of children and families.