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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Using Neural Networks to Predict Cell Specific Productivity in Bioreactors

Nordström, Frida January 2021 (has links)
During production of certain biopharamaceutical drugs, cells are grown in a liquid mediainside bioreactors with the goal of producing a specic biomaterial that can be rened intoa drug. This project investigates whether the use of Neural Networks (NN) can decreasethe prediction error, in terms of Mean Squared Error (MSE), for 2 metabolic processes incells compared to current methods. The rst experiment tests predictions of cell-SpecicConsumption Rate (SCR) of 5 dierent metabolites and the second experiment testspredictions of cell-Specic Production Rate (SPR) of titer. Fully connected feed-forwardneural networks were trained and cross-validation was used to obtain MSE betweenpredictions and measured values. The SCR predictions made by the NN was better thanthe original model predictions for all 5 metabolites. The predictions of SPR from the NNcannot with certainty be said to be better than the original model, with a p-value of 0.13.These results indicate that using NNs when modeling cell metabolism in bioreactors candecrease its prediction error, leading to better control of the bioreactor environment andmore ecient production.

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