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Acute Coronary Syndrome With Unprotected Left Main Coronary Artery Culprit ― An Observation From the AOI-LMCA Registry ― / 左冠動脈主幹部を責任病変とした急性冠症候群 -AOI-LMCAレジストリ後向き観察研究-Higami, Hirooki 24 September 2021 (has links)
京都大学 / 新制・論文博士 / 博士(医学) / 乙第13435号 / 論医博第2234号 / 新制||医||1054(附属図書館) / (主査)教授 石見 拓, 教授 佐藤 俊哉, 教授 湊谷 謙司 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM
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Syndecan-1 und Heparansulfat als Biomarker der endothelialen Glykokalyx im Infarkt-assoziierten kardiogenen SchockMünch, Phillip 20 October 2016 (has links)
Trotz enormer Fortschritte in der Therapie, bleibt der kardiogene Schock die führende Todesursache im akuten Myokardinfarkt. Die pathophysiologischen Veränderungen umfassen dabei unter anderem Störungen der Mikrozirkulation, endotheliale Dysfunktion mit vaskulärer Leckage, sowie vermehrte Thrombozyten- und Leukozytenadhäsion an die Gefäßwand. Die endotheliale Glykokalyx wurde als zentraler Regulator dieser Prozesse identifiziert. Das Glykosaminoglykan Heparansulfat repräsentiert dabei den Hauptbestandteil der Endothelzelloberfläche und Syndecan-1 das am weitesten verbreitete Proteoglykan. Diesbezüglich konnte in Studien eine Assoziation zwischen Schädigung der endothelialen Glykokalyx und den zirkulierenden Membranbestandteilen im Patientenblut beobachtet werden.
Ziel der Arbeit war die Analyse der Glykokalyxmarker bei 184 Patienten mit Infarkt-assoziiertem kardiogenen Schock. In den Serumproben zum Zeitpunkt der Aufnahme und nach einem Tag wurde mittels ELISA die Konzentration von Heparansulfat und Syndecan-1 bestimmt.
Dabei zeigte sich ein signifikanter Konzentrationsabfall von Syndecan-1 innerhalb des Analysezeitraums. Des Weiteren hatten die Überlebenden an beiden Tagen signifikant niedrigere Syndecan-1-Serumwerte. Durch eine schrittweise Multiregressionsanalyse wurde Syndecan-1 bei Patienten mit akutem Myokardinfarkt und assoziiertem kardiogenen Schock als unabhängiger Prädiktor der 30-Tage- Mortalität identifiziert.
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SAFETY AND EFFICACY OF BALLOON AORTIC VALVULOPLASTY STRATIFIED BY ACUITY OF PATIENT ILLNESSKumar, Anirudh 01 September 2021 (has links)
No description available.
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Prognostic Impact of Active Mechanical Circulatory Support in Cardiogenic Shock Complicating Acute Myocardial Infarction, Results from the Culprit-Shock TrialFeistritzer, Hans-Josef, Desch, Steffen, Freund, Anne, Poess, Janine, Zeymer, Uwe, Ouarrak, Taoufik, Schneider, Steffen, de Waha-Thiele, Suzanne, Fuernau, Georg, Eitel, Ingo, Noc, Marko, Stepinska, Janina, Huber, Kurt, Thiele, Holger 20 April 2023 (has links)
Objectives: To analyze the use and prognostic impact of active mechanical circulatory support (MCS) devices in a large prospective contemporary cohort of patients with cardiogenic shock (CS) complicating acute myocardial infarction (AMI). Background: Although increasingly used in clinical practice, data on the efficacy and safety of active MCS devices in patients with CS complicating AMI are limited. Methods: This is a predefined subanalysis of the CULPRIT-SHOCK randomized trial and prospective registry. Patients with CS, AMI and multivessel coronary artery disease were categorized in two groups: (1) use of at least one active MCS device vs. (2) no active MCS or use of intra-aortic balloon pump (IABP) only. The primary endpoint was a composite of all-cause death or renal replacement therapy at 30 days. Results: Two hundred of 1055 (19%) patients received at least one active MCS device (n = 112 Impella®; n = 95 extracorporeal membrane oxygenation (ECMO); n = 6 other devices). The primary endpoint occurred significantly more often in patients treated with active MCS devices compared with those without active MCS devices (142 of 197, 72% vs. 374 of 827, 45%; p < 0.001). All-cause mortality and bleeding rates were significantly higher in the active MCS group (all p < 0.001). After multivariable adjustment, the use of active MCS was significantly associated with the primary endpoint (odds ratio (OR) 4.0, 95% confidence interval (CI) 2.7–5.9; p < 0.001). Conclusions: In the CULPRIT-SHOCK trial, active MCS devices were used in approximately one fifth of patients. Patients treated with active MCS devices showed worse outcome at 30 days and 1 year.
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Optimisation des thérapeutiques du choc cardiogénique : conséquences métaboliques, microcirculatoires et inflammatoires d’une assistance circulatoire à objectif de débit d’ECMO bas versus standard dans un modèle porcin d’arrêt cardiaque réfractaire réanimé / Optimization of cardiogenic shock therapeutics : mrtabolic, microcirculatory and inflammatory consequences of circulatory support with low or standard ECMO blood flow in a porcine model of resuscitated refrattory cardiac arrestLuo, Yun 12 October 2018 (has links)
Introduction : L’arrêt cardiaque réfractaire est défini par l’absence du retour à l’activité circulatoire spontané (RACS) après 30 minutes de réanimation cardiopulmonaire médicalisé. ExtraCorporeal Membrane Oxygenation (ECMO) représente une thérapie alternative urgente dans cette population. L’hémodynamique post la réanimation cardiopulmonaire extracorporel (E-CRP) est un entité complexe et le pris en charge dans les premières heures suivant l’implantation d’ECMO n’est pas bien décrit. L’objectif de cette étude est d’évaluer l’effet de deux stratégie de débit d’ECMO dans un modèle porcin d’arrêt cardiaque réfractaire sur les conséquences métaboliques, microcirculatoires et inflammatoires.Matériels et Méthodes : l’arrêt cardiaque a été induit par la ligature l’artère intraventriculaire antérieure (IVA) chez 18 cochons. E-RCP a été initié après 40 minutes de low-flow avec un débit d’ECMO bas de 30-35 ml.kg-1.min-1 ou un débit d’ECMO standard de 65-70 ml.kg-1.min-1, avec la même pression artérielle moyenne (PAM) au niveau de 65 mmHg. Les paramètres hémodynamiques et métaboliques ont été évalués avec la clairance de lactate et le débit sanguin carotidien. Les paramètres microcirculatoires ont été évalués par la microcirculation sublinguale avec l’imagerie de SDF et NIRS. Cytokines inflammatoires ont été mesurés avec un plateforme de ELISA multiplexe. Résultats : Pas de différence entre les deux groups à H basale et à l’initiation d’ECMO (H0). La clairance de lactate était plus faible dans le groupe débit bas comparé au groupe débit standard (6.67[-10.43-18.78] vs. 47.41[19.54, 70.69] %, p=0.04). Le débit carotidien était plus bas significativement (p<0.005) dans le groupe débit bas pendant les dernières quatre heures malgré le même niveau de la pression artérielle moyenne. Pour les paramètres microcirculatoires, le flux microcirculatoire sublingual évalué par SDF et le StO2 par NIRS ont été altéré transitoirement à H3 dans le groupe débit bas. Le niveau de cytokine IL-6 était plus élevé significativement dans le groupe débit bas à la fin d’expérimentation. Conclusions : Une réanimation à objectif de débit d’ECMO bas 35 ml.kg-1.min-1 versus standard 70ml.kg-1.min-1dans les six premières heures d’un ACR réfractaire n’est pas associé à une meilleure réversion des conséquences métaboliques, microcirculatoire et inflammatoire avec un objectif de PAM à 65 mmHg dans un modèle porcin / Introduction : Refractory cardiac arrest is defined by the absence of the return of spontaneous circulation (ROCS) within 30 minutes of cardiopulmonary resuscitation (CRP) under medical supervision. ExtraCorporeal membrane oxygenation (ECMO) is an emerging alternative therapy in this population. The post extracorporeal cardiopulmonary resuscitation (ECPR) hemodynamic state is a complex entity and the critical care management in the first hours following ECMO implantation is not well defined. This study was designed to assess the effect of two veno-arterial Extracorporeal Membrane Oxygenation (ECMO) blood-flow strategies in an experimental model of ECPR (extracorporeal cardio-pulmonary resuscitation) on macrocirculatory, metabolic and microcirculatory parameters in the first six hours of ECMO initiation. Material and methods : Cardiac arrest was induced in 18 pigs by surgical ligature of the left descending coronary artery. ECPR was initiated after 40 minutes of low-flow with an ECMO blood-flow of 30-35 ml.kg-1.min-1 (low-blood-flow group, LBF) or 65-70 ml.kg-1.min-1 (standard-blood-flow group, SBF), with the same mean arterial pressure target (65 mmHg). Macrocirculatory and metabolic parameters were assessed by lactate clearance and carotid blood-flow. Microcirculatory parameters were assessed by sublingual microcirculation with Sidestream Dark Field (SDF) imaging and peripheral Near-InfraRed Spectrometry (NIRS). Inflammatory cytokine levels were measured with a multiplexed ELISA-based array platform. Results : There was no between-group difference at baseline and at ECMO initiation (H0). Lactate clearance at H6 was lower in LBF compared to SBF (6.67[-10.43-18.78] vs. 47.41[19.54, 70.69] %, p=0.04). carotid blood flow was significantly lower (p<0.005) during the last four hours despite similar mean arterial pressure levels. For microcirculatory parameters, SDF and NIRS parameters were transitorily impaired at H3 in LBF. IL-6 cytokine level was significantly higher in LBF at the end of the experiment. Conclusion: In an experimental porcine model of refractory cardiac arrest treated by ECMO, a low-blood-flow strategy during the first six hours of resuscitation was associated with lower lactate clearance and lower cerebral blood-flow with no benefits on ischemia-reperfusion parameters
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Ergebnisse der notfallmäßigen Koronarrevaskularisation bei Patienten mit akutem Myokardinfarkt und komplizierendem kardiogenem SchockMohr, Matthias 05 March 2013 (has links)
Die koronare Herzkrankheit ist trotz wachsendem Lebensstandard und aller präventiven medizinischen Maßnahmen nach wie vor von hoher medizinischer und ökonomischer Bedeutung. Die Akutform stellt das akute Koronarsyndrom dar. Komplizierend kann sich im Rahmen eines akuten Koronarsyndroms ein kardiogener Schock manifestieren, welcher die häufigste Todesursache für Patienten mit akutem Myokardinfarkt nach Aufnahme ins Krankenhaus darstellt.
Ziel dieser Arbeit war die Identifizierung von Risikofaktoren für die Krankenhaus- sowie Langzeitmortalität bei der chirurgischen Revaskularisation von Patienten mit akutem Koronarsyndrom und komplizierendem kardiogenen Schock.
Wir führten hierfür eine retrospektive Datenanalyse an 302 konsekutiven Patienten durch, welche im akuten Koronarsyndrom und kardiogenen Schock mittels aortokoronarer Bypassoperation therapiert wurden.
Insgesamt wurden 44 präoperative, 18 intraoperative und 28 postoperative binäre Items analysiert.
Wir konnten zeigen, dass bei den Höchstrisiko-Patienten die Letalität stark vom präoperativen Risikoprofil und dem Ausmaß des kardiogenen Schocks abhängt. Insbesondere der präoperative Einsatz einer IABP sowie die Verwendung der linken Arteria mammaria als Bypassgefäß wirkten sich positiv aus.
Das gute Langzeit-Ergebnis demonstriert den Benefit einer chirurgischen Revaskularisation bei den Patienten mit akutem Koronarsyndrom und kardiogenen Schock mit anderenfalls schlechter Prognose.
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Percutaneous Mechanical Right Ventricular SupportCecchini, Arthur, Othman, Ahmad, Cecchini, Amanda, Jbara, Manar 07 April 2022 (has links)
Ventricular assist devices are used in patients with heart failure refractory to standard management. Though left ventricular assist devices are more often used, patients with severe right ventricular dysfunction may also be treated with mechanical support. This case presents a patient with mixed cardiogenic and septic shock requiring placement of a percutaneous right ventricular assist device. A 38-year-old obese male with a medical history of alcoholism presented to the hospital with a complaint of dyspnea. He was found to have volume overload and was given intravenous diuretics. However, he had progressive renal insufficiency, hypotension requiring vasopressor support, and worsening respiratory status requiring mechanical ventilation. An echocardiogram showed a severely enlarged right ventricle, reduced RV function, normal RV wall thickness, moderate to severe tricuspid regurgitation, a severely dilated right atrium, ventricular septal flattening, and mild pulmonary hypertension. Left ventricular ejection fraction was 65-70%, LV diastolic function was normal, and there were no other significant valvular abnormalities. Troponin levels, ECG, and CT pulmonary angiography were unrevealing. Right heart catheterization showed a right atrial pressure of 29 mmHg (2 – 6 mmHg), right ventricular pressures of 50/24 mmHg (15-25/0-8 mmHg), pulmonary artery pressures of 56/35/43 mmHg (15-25/8-15/10-20 mmHg), a pulmonary capillary wedge pressure of 22 mmHg (6-12 mmHg), and a Prognostic Impact of Pulmonary Artery Pulsatility Index (PAPi) score of 0.3 to 0.6 (>1). Cardiac chamber oxygen saturations did not demonstrate intracardiac shunting. A right-sided mechanical circulatory support device was placed. The hospital course was complicated by sepsis due to pneumonia and presumed central line-associated bloodstream infection requiring antibiotic therapy, anemia secondary to device-related hemolysis requiring blood transfusions, renal failure requiring renal replacement therapy, and candidemia requiring antifungal therapy. Due to concern for device-associated infection, his central lines were replaced. The mechanical circulatory support device was able to be removed after ten days. Subsequent cardiac imaging did not reveal any other structural abnormalities, and a definitive cause for the right heart failure was not determined. Etiologies of right-sided heart failure include left-sided heart failure, pulmonary hypertension, chronic pulmonary disease, myocardial infarction, pulmonary embolism, myocarditis, valvular dysfunction, and congenital anomalies. Mechanical circulatory support may be used to support cardiac function, to allow the ventricular function to improve. Potential complications of mechanical circulatory support include infection, hemolysis, bleeding, device migration, and malfunction. RVAD therapy should be considered for patients with isolated right ventricular failure refractory to less invasive therapy.
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Circulating Monocyte Chemoattractant Protein-1 in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction Treated with Mild Hypothermia: A Biomarker Substudy of SHOCK-COOL TrialCheng, Wenke, Fuernau, Georg, Desch, Steffen, Freund, Anne, Feistritzer, Hans-Josef, Pöss, Janine, Buettner, Petra, Thiele, Holger 05 December 2023 (has links)
Background: There is evidence that monocyte chemoattractant protein-1 (MCP-1) levels
reflect the intensity of the inflammatory response in patients with cardiogenic shock (CS) complicating
acute myocardial infarction (AMI) and have a predictive value for clinical outcomes. However, little
is known about the effect of mild therapeutic hypothermia (MTH) on the inflammatory response in
patients with CS complicating AMI. Therefore, we conducted a biomarker study to investigate the
effect of MTH on MCP-1 levels in patients with CS complicating AMI. Methods: In the randomized
mild hypothermia in cardiogenic shock (SHOCK-COOL) trial, 40 patients with CS complicating
AMI were enrolled and assigned to MTH (33 ◦C) for 24 h or normothermia at a 1:1 ratio. Blood
samples were collected at predefined time points at the day of admission/day 1, day 2 and day 3.
Differences in MCP-1 levels between and within the MTH and normothermia groups were assessed.
Additionally, the association of MCP-1 levels with the risk of all-cause mortality at 30 days was
analyzed. Missing data were accounted for by multiple imputation as sensitivity analyses. Results:
There were differences in MCP-1 levels over time between patients in MTH and normothermia groups
(P for interaction = 0.013). MCP-1 levels on day 3 were higher than on day 1 in the MTH group
(day 1 vs day 3: 21.2 [interquartile range, 0.25–79.9] vs. 125.7 [interquartile range, 87.3–165.4] pg/mL;
p = 0.006) and higher than in the normothermia group at day 3 (MTH 125.7 [interquartile range,
87.3–165.4] vs. normothermia 12.3 [interquartile range, 0–63.9] pg/mL; p = 0.011). Irrespective of
therapy, patients with higher levels of MCP-1 at hospitalization tended to have a decreased risk of
all-cause mortality at 30 days (HR, 2.61; 95% CI 0.997–6.83; p = 0.051). Conclusions: The cooling
phase of MTH had no significant effect on MCP-1 levels in patients with CS complicating AMI
compared to normothermic control, whereas MCP-1 levels significantly increased after rewarming.
Trial registration: NCT01890317.
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Extracorporeal Membrane Oxygenation in Infarct-Related Cardiogenic ShockFreund, Anne, Desch, Steffen, Pöss, Janine, Sulimov, Dmitry, Sandri, Marcus, Majunke, Nicolas, Thiele, Holger 02 June 2023 (has links)
Mortality in infarct-related cardiogenic shock (CS) remains high, reaching 40–50%. In refractory CS, active mechanical circulatory support devices including veno-arterial extracorporeal membrane oxygenation (VA-ECMO) are rapidly evolving. However, supporting evidence of VA-ECMO therapy in infarct-related CS is low. The current review aims to give an overview on the basics of VA-ECMO therapy, current evidence, ongoing trials, patient selection and potential complications.
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Effects of Mild Hypothermia on Inflammation in Acute Myocardial Infarction Complicated by Cardiogenic Shock: A Biomarker Analysis Based on the SHOCK-COOL TrialCheng, Wenke 02 October 2024 (has links)
In the framework of this thesis, we focused on two inflammatory markers, MCP-1, and galectin-3, to evaluate the impact of MTH on inflammation levels in patients suffering from AMI complicated by CS. Furthermore, the relationship between MCP-1 and galectin-3 levels within the first three days of post-admission and the risk of 30-day all-cause mortality was also investigated.
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