Yes / Direct oral anticoagulants (DOACs) uptake for stroke prevention in atrial fibrillation has been slow.[1] This study aimed to profile the prescribing of DOACs over three years to identify factors associated with DOAC prescribing in a Clinical Commissioning Group (CCG) without restrictions to DOACs use. The objectives were to identify: - Characteristics of patients prescribed oral anticoagulant (OAC) in a sample of general practices; - Who initiated the prescribing of OAC; - Recorded reasons for prescribing a DOAC rather than warfarin;

Yes / Background and Objective In England, the uptake of direct oral anticoagulants (DOACs) for stroke prevention in atrial fbrillation has been slow and varied across diferent Clinical Commissioning Groups (CCGs). This study aimed to profle the prescribing of oral anticoagulants for stroke prevention in patients with atrial fbrillation over 3 years in a CCG without restrictions to DOACs use to understand more about organisational and/or individual barriers to the early uptake of DOACs. Methods Data were collected from nine general practices between 1 April 2012 and 31 March 2015 of patients who were initiated on the oral anticoagulant therapy. Data were analysed descriptively and with independent Student’s t test and Chi square test to explore if there was an association between type of oral anticoagulant initiated and sex, age, type of prescriber and prior aspirin use. Results The early uptake of DOACs signifcantly increased over the study period (p<0.0001; medium size efect φc=0.372). There was no statistically signifcant diference between sex or age and type of oral anticoagulant initiated. Primary-care prescribers were responsible for initiating the majority of oral anticoagulants (71%; N=257) and driving the use of DOACs (72%, N=71). Patients switched from aspirin to an oral anticoagulant were more likely to be initiated on warfarin than a DOAC. Conclusions The early use of DOACs, in a CCG without restrictions to their use, was embraced by primary-care prescribers in this particular CCG. / Bayer Pharmaceuticals via an unrestricted educational grant.

The need for interacting with machines using spoken natural language is growing, along with the expectation that synthetic speech in this context sound natural. Such interaction includes answering questions, where prosody plays an important role in producing natural English synthetic speech by communicating the information structure of utterances. CCG is a theoretical framework that exploits the notion that, in English, information structure, prosodic structure and syntactic structure are isomorphic. This provides a way to convert a semantic representation of an utterance into a prosodically natural spoken utterance. GF is a framework for writing grammars, where abstract tree structures capture the semantic structure and concrete grammars render these structures in linearised strings. This research combines these frameworks to develop a system that converts semantic representations of utterances into linearised strings of natural language that are marked up to inform the prosody-generating component of a speech synthesis system. / Computing / M. Sc. (Computing)

Bedienstete Internationaler Organisationen stehen in einem speziellen Rechtsverhältnis zu ihrem Arbeitgeber, das ihnen ermöglicht, belastende Maßnahmen von speziell für Personalrechtsangelegenheiten errichteten internationalen Verwaltungsgerichten (Administrative Tribunals) überprüfen zu lassen. Anläßlich einer konkreten Streitigkeit (ESA) um Gehaltskürzungen befaßt sich der Beitrag sowohl mit prozeduralen als auch mit materiell-rechtlichen Fragenstellungen und erörtert, wie weit hier bereits allgemeine Rechtsgrundsätze existieren.

The goal of this thesis is to advance the use of recurrent neural network language models (RNNLMs) for large vocabulary continuous speech recognition (LVCSR). RNNLMs are currently state-of-the-art and shown to consistently reduce the word error rates (WERs) of LVCSR tasks when compared to other language models. In this thesis we propose various advances to RNNLMs. The advances are: improved learning procedures for RNNLMs, enhancing the context, and adaptation of RNNLMs. We learned better parameters by a novel pre-training approach and enhanced the context using prosody and syntactic features. We present a pre-training method for RNNLMs, in which the output weights of a feed-forward neural network language model (NNLM) are shared with the RNNLM. This is accomplished by first fine-tuning the weights of the NNLM, which are then used to initialise the output weights of an RNNLM with the same number of hidden units. To investigate the effectiveness of the proposed pre-training method, we have carried out text-based experiments on the Penn Treebank Wall Street Journal data, and ASR experiments on the TED lectures data. Across the experiments, we observe small but significant improvements in perplexity (PPL) and ASR WER. Next, we present unsupervised adaptation of RNNLMs. We adapted the RNNLMs to a target domain (topic or genre or television programme (show)) at test time using ASR transcripts from first pass recognition. We investigated two approaches to adapt the RNNLMs. In the first approach the forward propagating hidden activations are scaled - learning hidden unit contributions (LHUC). In the second approach we adapt all parameters of RNNLM.We evaluated the adapted RNNLMs by showing the WERs on multi genre broadcast speech data. We observe small (on an average 0.1% absolute) but significant improvements in WER compared to a strong unadapted RNNLM model. Finally, we present the context-enhancement of RNNLMs using prosody and syntactic features. The prosody features were computed from the acoustics of the context words and the syntactic features were from the surface form of the words in the context. We trained the RNNLMs with word duration, pause duration, final phone duration, syllable duration, syllable F0, part-of-speech tag and Combinatory Categorial Grammar (CCG) supertag features. The proposed context-enhanced RNNLMs were evaluated by reporting PPL and WER on two speech recognition tasks, Switchboard and TED lectures. We observed substantial improvements in PPL (5% to 15% relative) and small but significant improvements in WER (0.1% to 0.5% absolute).

The need for interacting with machines using spoken natural language is growing, along with the expectation that synthetic speech in this context sound natural. Such interaction includes answering questions, where prosody plays an important role in producing natural English synthetic speech by communicating the information structure of utterances. CCG is a theoretical framework that exploits the notion that, in English, information structure, prosodic structure and syntactic structure are isomorphic. This provides a way to convert a semantic representation of an utterance into a prosodically natural spoken utterance. GF is a framework for writing grammars, where abstract tree structures capture the semantic structure and concrete grammars render these structures in linearised strings. This research combines these frameworks to develop a system that converts semantic representations of utterances into linearised strings of natural language that are marked up to inform the prosody-generating component of a speech synthesis system. / Computing / M. Sc. (Computing)

Bedienstete Internationaler Organisationen stehen in einem speziellen Rechtsverhältnis zu ihrem Arbeitgeber, das ihnen ermöglicht, belastende Maßnahmen von speziell für Personalrechtsangelegenheiten errichteten internationalen Verwaltungsgerichten (Administrative Tribunals) überprüfen zu lassen. Anläßlich einer konkreten Streitigkeit (ESA) um Gehaltskürzungen befaßt sich der Beitrag sowohl mit prozeduralen als auch mit materiell-rechtlichen Fragenstellungen und erörtert, wie weit hier bereits allgemeine Rechtsgrundsätze existieren.

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Les trois monothéismes conçoivent un Dieu créateur et ordonnateur du monde, révélé dans l’histoire, garant de toute justice et de tout équilibre, et déterminant l’autorité et les systèmes d’autorités. La théologie a informé le droit et les lois, l’économie et l’éthique des personnes et des États. L’islam, loin d’être homogénéisé dans ses approches économiques, financières et réglementaires, révèle par le biais d’un exemple concret, par l’industrie des services financiers islamiques, les différentes facettes de ce qu’est l’autorité dans un contexte musulman, international et en pleine évolution. Prenant en compte la dynamique des questions sectaires, géographiques et interprétatives, la thèse analyse cette force déterminante que sont les « autorités » en finance islamique. Ces dernières semblent déterminer la finance islamique dans ses formes les plus tangibles, en structurant des produits financiers islamiques. L’analyse comporte d’abord une approche théorique, ensuite une étude comparée des facteurs qui déterminent les décisions prises lors de la structuration de produits financiers islamiques. Ces structures sont en effet fondées sur des contrats financiers conformes aux principes de la sharia. Leur approbation par des membres de conseils de la sharia est-elle déterminée par une autorité régionale, par des autorités internationales ou par des autorités de régulation ? Ces autorités sont-elles conventionnelles ou religieuses ? Afin de bien évaluer la problématique non seulement de l’autorité en tant que telle mais aussi de l’équilibre complexe entre les différentes autorités, nous développons une analyse comparée du système de structuration des produits financiers islamiques par les autorités concernées, en fonction des zones géographiques, au moyen d’un échantillon de 121 membres de conseils de la sharia couvrant l’approbation de produits financiers islamiques au sein de 243 institutions financières islamiques sur 35 pays. / The three monotheistic religions refer to a God who is the all-powerful creator of all that exists, revealed throughout history, guarantor of justice and fairness, who is the ultimate moral authority. Theology advises some of the laws, economics and ethics of individuals and of states. Islam is not homogeneous in its economic, financial and regulatory approaches. However, through the financial services industry, it reveals in a tangible manner various facets of authority across Muslim contexts. These include contexts that are international and highly dynamic. Taking into account the delicate balance between sectarian, geographic and interpretive facets, the thesis analyses the determining forces that we refer to as authorities in Islamic finance. These contribute to the Islamic finance industry in its most tangible form in the structuring of Islamic financial products. Analysis is carried out initially theoretically. It is followed by a comparative study of factors affecting decisions pertaining to the structuring of Islamic financial products. These structures are based on financial contracts that conform to the principles of the Sharia. Is approval by Sharia board members fashioned by a regional authority, by international authorities, or by regulatory authorities? Are these authorities conventional or religious? We address the question as it pertains to the dynamics between various types of authority. We develop a comparative analysis of the approach taken in structuring Islamic financial products, according to geographical areas related to a sample of 121 Sharia board members covering Islamic financial products for 243 Islamic financial institutions in 35 countries.