Global ETD Search

441	CHO-human hybrid cells as models for human chromosome non-disjunction Evans, Elizabeth Balconi 02 May 2009 (has links) We have used Chinese hamster ovary (CHO)-human hybrid cells containing chromosomes 16, 18, X, and 21 to test the ability of human kinetochores to successfully bind to spindle microtubules and to be distributed to the daughter cells. We have established the intrinsic rate of non-disjunction among these human chromosomes noted above and compared these rates with those in cells presented with mitotic challenges such as taxol, nocodazole, and mitosis with unreplicated genomes (MUG). Cells were grown on culture slides, fixed and processed for immunofluorescence and fluorescence in situ hybridization (FISH). Daughter pairs were identified by staining with anti-á-tubulin to identify midbodies. Human centromere DNA probes were used for FISH in order to test for the successful passage of human kinetochores to daughter cells during anaphase. Our data indicate that different human kinetochores vary in their ability to properly engage the spindle and to be successfully distributed. In addition, mitotic challenges have been shown to affect the rate of non-disjunction. The mechanism of this effect is not yet known. CHO-Human Hybrid Chromosome Instability FISH Kinetochore Centromere
442	The Mammalian Process of Meiotic Synapsis Brown, Petrice Wynaka January 2007 (has links) No description available. Synapsis chromosome synaptic initiation Meiotic recombination Sites of synaptic initiation
443	Transgenerational Genetic Effects In Mouse Models Of Complex Traits Nelson, Vicki R. January 2010 (has links) No description available. Genetics transgenerational effects genetic chromosome substitution strains complex traits
444	X Chromosome Aneuploidy: A Look at the Effects of X Inactivation Sprong, Amy Nicole 26 April 2008 (has links) No description available. Genetics Genetics X Chromosome Aneuploidy Turner Klinefelter triple X
445	Evaluation of Soybean Germplasm for Additional Sources of Resistance and Characterization of Resistance towards Fusarium graminearum. Acharya, Bhupendra 03 November 2014 (has links) No description available. Plant Pathology Fusarium graminearum soybean resistance Quantitative Trait Loci chromosome
446	THE REGULATION OF BubR1 EXPRESSION BY p53: A ROLE FOR p53 IN THE MITOTIC SPINDLE CHECKPOINT AND CHROMOSOME INSTABILITY STUABACH, AMY ELIZABETH January 2004 (has links) No description available. BubR1 p53 mitotic spindle checkpoint chromosome instability aneuploidy cancer
447	Immune Defects in Chromosome 22q11.2 Deletion Syndromes Bobey, Nicola A. 08 April 2010 (has links) No description available. Immunology DiGeorge syndrome chromosome 22q11.2 deletion syndrome immunodeficiency
448	Chromosomal abnormalities identified in infants with congenital heart disease Connor, Jessica 04 August 2011 (has links) No description available. Genetics cytogenetic testing chromosome microarray congenital heart disease
449	Molecular and Integrated Systems Physiology of Prolactin Christensen, Heather R. 23 September 2011 (has links) No description available. Physiological Psychology prolactin bacterial artificial chromosome GIRK reproduction
450	Genomic signatures of population history in a pair of recently diverged Australian teal support strong selection on the Z - sex chromosome Hawkins, Kevin Kyle 30 August 2016 (has links) No description available. Biology biology population genetics evolutionary biology speciation sex chromosome

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