A Esclerose Múltipla (EM) é uma doença inflamatória autoimune caracterizada por desmielinização e degeneração do sistema nervoso central (SNC) duas a três vezes mais frequente em mulheres. A etiologia da EM é dividida em dois subtipos principais: o tipo remitente-recorrente (EMRR) mais comum, caracterizado por dois ou mais episódios de agravamento dos sintomas que envolvem diferentes locais do SNC, separados por pelo menos 1 mês e remisão dos sintomas e o tipo progressivo é a forma menos comum, caracterizada por um contínuo agravamento dos sintomas desde o início geralmente sem recaídas claras ou remissões. A presente pesquisa teve por objetivo avaliar o comprometimento da visão de cores e de sua relação com perdas de atenção, memória visual imediata, memória visual tardia, memória operacional e funções executivas dos portadores de esclerose múltipla tipo remitente recorrente. Método: participaram 41 pacientes com esclerose múltipla de idades entre 20 e 58 anos (35,4±12,2) e 37 controles com idade (34,7±12,1) e escolaridade semelhante. A discriminação de cores foi avaliada com o Cambridge Colour Test (CCT) e a avaliação de funções neuropsicológicas foram utilizados subtestes da bateria Cambridge Neuropsychological Testing Automated Battery (CANTAB) - Pattern Recognition Memory, Spatial Span, Spatial Recognition Memory, Information Sampling Task, Stop Signal Task e Rapid Information Processing; Escalas de Depressão e Ansiedade de Beck e Escala de Determinação Funcional da Qualidade de vida (DEFU). Resultados: A visão de cores está prejudicada de forma difusa em 24% dos pacientes com esclerose múltipla, tanto em pacientes com histórico de neurite óptica quando em pacientes que não tiveram neurite óptica. Na parte cognitiva, os pacientes demonstraram lentidão em executar as tarefas, comprometimento na atenção, na memória visual de curto e longo prazo, na memória operacional, na memória visuoespacial, além de lentidão no processamento de informações. Há uma relação entre alterações na visão de cores e alterações de memória visual somente em testes em que os estímulos são complexos e com inúmeros detalhes / Multiple sclerosis (MS) is an autoimmune inflammatory disease characterized by demyelination and central nervous system (CNS) degeneration. It is two times more frequent in women. It can be presented in two subtypes: the relapsing-remitting (RR), most common type, characterized by two or more episodes of focal disorders in different sites of the CNS, and remission of the symptoms; and the progressive subtype, less common, characterized by a continuous worsening of the symptoms, since the beginning, usually with no remissions. The present research evaluated color vision impairment and its relationship to attention loss, short-term memory, long-term memory, working memory and executive function in patients with the relapsing-remitting MS type. Methods: 41 patients with multiple sclerosis (20 to 58 years, 35.4 ± 12.2 in average) and 37 controls matched to age (34.7 ± 12.1 in average) and years of education participated of the study. Color vision was tested using the Cambridge Colour Test (CCT) and the neuropsychological assessment was performed using tests of the Cambridge Neuropsychological Testing Automated Battery (CANTAB) - Pattern Recognition Memory, Spatial Span, Spatial Recognition Memory, Information Sampling Task, Stop Signal Task, Rapid Information Processing the Beck Depression and Anxiety Inventories and the Functional Assessment of Multiple Sclerosis quality of life instrument. Results: Color vision was diffusely impaired in 24% of the MS patients, with or with no history of optic neuritis. Patients also showed a delay during the tasks execution, impairment in attention, short and long-term visual memory and working memory, and slowness in the information processing. There was a relationship between color vision loss and visual memory impairment, but only in tests with complex and highly detailed stimuli

L’objectif de la présente étude visait à évaluer les effets différentiels de la privation de sommeil (PS) sur le fonctionnement cognitif sous-tendu par les substrats cérébraux distincts, impliqués dans le réseau fronto-pariétal attentionnel, lors de l’administration d’une tâche simple et de courte durée. Les potentiels évoqués cognitifs, avec sites d’enregistrement multiples, ont été prévilégiés afin d’apprécier les effets de la PS sur l’activité cognitive rapide et ses corrélats topographiques. Le matin suivant une PS totale d’une durée de 24 heures et suivant une nuit de sommeil normale, vingt participants ont exécuté une tâche oddball visuelle à 3 stimuli. L’amplitude et la latence ont été analysées pour la P200 et la N200 à titre d’indices frontaux, tandis que la P300 a été analysée, à titre de composante à contribution à la fois frontale et pariétale. Suite à la PS, une augmentation non spécifique de l’amplitude de la P200 frontale à l’hémisphère gauche, ainsi qu’une perte de latéralisation spécifique à la présentation des stimuli cibles, ont été observées. À l’opposé, l’amplitude de la P300 était réduite de façon prédominante dans la région pariétale pour les stimuli cibles. Enfin, un délai de latence non spécifique pour la N200 et la P300, ainsi qu’une atteinte de la performance (temps de réaction ralentis et nombre d’erreurs plus élevé) ont également été objectivées. Les résultats confirment qu’une PS de durée modérée entraîne une altération des processus attentionnels pouvant être objectivée à la fois par les mesures comportementales et électrophysiologiques. Ces modifications sont présentes à toutes les étapes de traitement, tel que démontré par les effets touchant la P200, la N200 et la P300. Qui plus est, la PS affecte différemment les composantes à prédominance frontale et pariétale. / The objective of the present study was to assess the differential effects of sleep deprivation (SD) on cognitive functions relying on distinct cerebral networks, involved in the fronto-parietal attentional network, during a relatively simple and short cognitive task. Multi-sites recording event-related-potentials (ERP) were used in order to evaluate the effect of SD on rapid cognitive activity and its topographical correlates. The morning following a night of total SD and a night of sleep, 20 participants were administered a 3-stimuli visual oddball paradigm. Amplitudes and latencies of the P200 and N200 ERP components were analyzed as frontal indexes, whereas P300 was analyzed as a mixed frontal and parietal component. Following TSD, a non specific increase in P200 amplitude for the left hemisphere, as well as a loss of lateralisation in response to target stimuli, were observed. Contrarily, P300 amplitude was predominantly reduced in the parietal region in response to target stimuli. Moreover, N200 and P300 latencies were delayed non specific to the type of stimuli and performance (reaction time and accuracy) was altered. These results confirm the deleterious effect of a moderate duration SD on attention processes that can be objectified by means of behavioural and electrophysiological measures. Each stages of information processing was altered by SD, as shown by its effect on P2, N2 and P3 components. Moreover, SD affected differently components caracterized by a predominant frontal or parietal distribution.

It is imperative to prepare South African learners to participate and function confidently within the context of a rapidly changing world. The curriculum of the South African Education System emphasises the significance of optimising learners‟ cognitive development as early as pre-school age to enable them to become creative and critical citizens who lead purposeful lives in a safe and prejudice-free environment. Despite continuous efforts by educators to optimise cognitive development, recently executed research studies indicate that cognitive development has not been adequately optimised in South African schools. This study was undertaken to establish the cognitive development level (cognitive and meta-cognitive skills and strategies, cognitive functions and non-intellective factors) of Grade R-learners and to determine the effect of an intervention programme, the Cognitive Enhancement Programme for Pre-schoolers (CEPP), on their cognitive development. By means of a literature study, I investigated whether, to what extent the cognitive development of Grade R-learners was taking place, and established which cognitive and meta-cognitive thinking skills and strategies, cognitive functions and non-intellective factors are required for effective cognitive development among Grade R-learners. In addition to this, the role of mediation for optimising cognitive development was investigated. A concurrent embedded mixed methods design was conducted in the implementation of the research. Intervention research within a quasi-experimental research design was applied. The data collection by means of a quantitative strategy (quasi-experimental research) and qualitative strategy (observation study) was executed simultaneously. By means of convenient sampling, one Grade R-class with twenty learners was subjected to a pre-test to establish their cognitive developmental level. The test results as well as the observations conducted during the pre-test revealed that the learners experienced problems related to their cognitive development. Ten of the twenty learners were then divided purposively based on their test performance into two experimental groups, Experimental Group A and Experimental Group B consisting of five participants each. Experimental group A and Experimental Group B took part in the CEPP intervention based on the principles of mediation on a rotational basis over a period of twelve weeks, during which intentional attempts were made to optimise their cognitive development. Both groups completed a post-test and delayed post-test (retention) to determine the effect of the CEPP intervention on their cognitive development. In addition to the test results, observations in the form of structured running and anecdotal records and reflective notes were utilised to understand the nature and quality of the cognitive development of the learners better. Furthermore, the effect of the intervention on their cognitive development was established. The cognitive development of Grade R-learners who participated in this study was optimised, which is a clear indication that cognitive capacity can be optimised when instruction is based on the principles of mediation / PhD, Teaching and Learning, North-West University, Vaal Triangle Campus, 2012

In this paper, top-down and bottom-up processing were studied regarding their effect on speech-in-noise. Three cognitive functions were also studied (divided attention, executive functioning, and semantic comprehension), and the effect they have on the speech processing and on each other. The research questions asked were if a difference in speech-in noise perception can be observed regarding the different levels of top-down and bottom-up support, if speech-in-noise is related to any of the researched cognitive abilities, and if there exists any correlation between these abilities. The method is a within-subject experimental design, consisting of four different tests: PASAT, to measure attention, LIT, to measure semantic comprehension, TMT, to measure executive functioning and SIN, to measure speech-in noise. The results showed a significant difference between top-down and bottom-up processing, a significant difference between top-down processing in decreasing and increasing conditions could also be seen. A negative correlation between the benefit of top-down support and the semantic comprehension task was found. Regarding the cognitive abilities a few correlations were found; the semantic comprehension task had a positive correlation to both the central executive task and the attentional task, the attentional task had a negative correlation to the central executive task, and both of the central executive subtasks had a positive correlation to each other. Most of the findings were expected, built on earlier cognitive hearing theories and studies.

A Esclerose Múltipla (EM) é uma doença inflamatória autoimune caracterizada por desmielinização e degeneração do sistema nervoso central (SNC) duas a três vezes mais frequente em mulheres. A etiologia da EM é dividida em dois subtipos principais: o tipo remitente-recorrente (EMRR) mais comum, caracterizado por dois ou mais episódios de agravamento dos sintomas que envolvem diferentes locais do SNC, separados por pelo menos 1 mês e remisão dos sintomas e o tipo progressivo é a forma menos comum, caracterizada por um contínuo agravamento dos sintomas desde o início geralmente sem recaídas claras ou remissões. A presente pesquisa teve por objetivo avaliar o comprometimento da visão de cores e de sua relação com perdas de atenção, memória visual imediata, memória visual tardia, memória operacional e funções executivas dos portadores de esclerose múltipla tipo remitente recorrente. Método: participaram 41 pacientes com esclerose múltipla de idades entre 20 e 58 anos (35,4±12,2) e 37 controles com idade (34,7±12,1) e escolaridade semelhante. A discriminação de cores foi avaliada com o Cambridge Colour Test (CCT) e a avaliação de funções neuropsicológicas foram utilizados subtestes da bateria Cambridge Neuropsychological Testing Automated Battery (CANTAB) - Pattern Recognition Memory, Spatial Span, Spatial Recognition Memory, Information Sampling Task, Stop Signal Task e Rapid Information Processing; Escalas de Depressão e Ansiedade de Beck e Escala de Determinação Funcional da Qualidade de vida (DEFU). Resultados: A visão de cores está prejudicada de forma difusa em 24% dos pacientes com esclerose múltipla, tanto em pacientes com histórico de neurite óptica quando em pacientes que não tiveram neurite óptica. Na parte cognitiva, os pacientes demonstraram lentidão em executar as tarefas, comprometimento na atenção, na memória visual de curto e longo prazo, na memória operacional, na memória visuoespacial, além de lentidão no processamento de informações. Há uma relação entre alterações na visão de cores e alterações de memória visual somente em testes em que os estímulos são complexos e com inúmeros detalhes / Multiple sclerosis (MS) is an autoimmune inflammatory disease characterized by demyelination and central nervous system (CNS) degeneration. It is two times more frequent in women. It can be presented in two subtypes: the relapsing-remitting (RR), most common type, characterized by two or more episodes of focal disorders in different sites of the CNS, and remission of the symptoms; and the progressive subtype, less common, characterized by a continuous worsening of the symptoms, since the beginning, usually with no remissions. The present research evaluated color vision impairment and its relationship to attention loss, short-term memory, long-term memory, working memory and executive function in patients with the relapsing-remitting MS type. Methods: 41 patients with multiple sclerosis (20 to 58 years, 35.4 ± 12.2 in average) and 37 controls matched to age (34.7 ± 12.1 in average) and years of education participated of the study. Color vision was tested using the Cambridge Colour Test (CCT) and the neuropsychological assessment was performed using tests of the Cambridge Neuropsychological Testing Automated Battery (CANTAB) - Pattern Recognition Memory, Spatial Span, Spatial Recognition Memory, Information Sampling Task, Stop Signal Task, Rapid Information Processing the Beck Depression and Anxiety Inventories and the Functional Assessment of Multiple Sclerosis quality of life instrument. Results: Color vision was diffusely impaired in 24% of the MS patients, with or with no history of optic neuritis. Patients also showed a delay during the tasks execution, impairment in attention, short and long-term visual memory and working memory, and slowness in the information processing. There was a relationship between color vision loss and visual memory impairment, but only in tests with complex and highly detailed stimuli

(in English): This thesis introduces the issue of reliability and validity of the dynamic assessment methods. In the theoretical part, the author briefly presents specifics of the dynamic assessment and various ways of verifying reliability and validity in the context of dynamic assessment. The text then summarizes ways of verifying reliability and validity for specific methods of the dynamic assessment based on experience from mostly foreign studies. The empirical part of the thesis aims to examine the relationship between the outputs of the ACFS method and characteristics of the assessors and subsequently to propose an optimal approach to the examination of the dynamic assessment methods. The results showed that the assessor was a statistically significant factor to the magnitude of the change in all ACFS scales. However, a more detailed analysis showed that the difference between the assessors varied across subtests. The qualitative analysis did not signify any relevance of specific characteristics to the differences between the assessors.

Attention is one of the key competencies which has to be adequately developed in preschool children to support their good school adaptation and acceptation of school demands. This work describes current approaches to assessment of attention and related cognitive functions in children at preschool and early school years. On the basis of the methods which are accessible we introduce a new assessment tool, which could serve as screening of attention and other necessary competencies of children aged 5-7 years. The empirical part of this work shows results of a validization study of our method (Coloured trail making test for children), and its reliability the tool. Results proved strong correlations among our method and three other assessment tools from larger batteries of tests (Woodcock - Johnson Tests of Cognitive Abilities, IDS and CAS II). However, the outcomes of the tests are also different enough to conclude that each of four methods which we used can be important in the process of attention assessment in preschool children; and each of these methods can bring valid information about children's abilities. The work also includes normative data for Coloured trail making test for children, which can be used as a screening tool to detect minor difficulties of children's attention or it can help to...

The "Activation of Older People as a Professional Qualification" diploma thesis deals with the activation of older people and with the professionalization and professionalism of activation staff as professional workers. The thesis also focuses on the designing of activation methods as a professional tool that is to be beneficial to any pre-defined objectives of the activation and also successfully finalized. A key element in the process is the emphasis placed on the professional knowledge of activation, its principles, the possibility of designing the procedures from a holistic point of view, and the subsequent planning of activation collectively, with respect to a team, as well as individually, in a manner that is tailored to the client. In this thesis, I define the profession of an activation worker as highly professional, requiring an active dialogue between the activation worker as the guarantor of activation and the activated, as a person who needs to achieve predetermined goals through activation. This work also addresses the demographic development of the population in the Czech Republic (as a factor which confirms the need to professionally elevate this profession). It also defines the health, psychological and social aspects of old age in practice. However, this thesis focuses in...

Les patients coronariens (PC) sont plus à risque de présenter des déficits cognitifs et certains types démence. Les fonctions cognitives des PC ont été étudiées au repos, mais jamais au cours d’une séance d’exercice aigu. L’exercice aigu à haute intensité peut affecter négativement la performance cognitive chez des personnes saines. Bien que les PC soient plus à risque de dysfonctions cérébrales et cardiovasculaires, cette relation n’a jamais été étudiée au sein de cette population clinique et peut permettre de mieux comprendre l’axe coeur-cerveau. Il était postulé que la performance cognitive sera affectée par l’exercice à haute intensité due à une diminution de l’apport en oxygène seulement chez les patients coronariens. Trente-huit PC et 16 participants sains ont été recrutés. Les participants ont complété les mesures suivantes : (1) des tests neuropsychologiques et une familiarisation à la tâche de Stroop modifiée informatisée (2) un test mesurant la consommation d’oxygène jusqu’au pic de l’effort (VO2pic) et (3) la tâche de Stroop à 30% et 70% de leur puissance maximale atteinte au VO2pic tout en pédalant sur un ergomètre. L’oxygénation cérébrale a été mesurée grâce à la spectroscopie proche infrarouge. Les résultats ont démontré que la performance cognitive est restée stable entre les deux intensités pour les deux groupes. Chez les PC, le volume sanguin cérébral était affecté négativement par l’effort physique à haute intensité comparativement à l’intensité modérée et aux participants sains. La maladie coronarienne affecte négativement l’oxygénation cérébrale pendant un effort à haute intensité. D’autres études sont nécessaires afin de déterminer si un test cognitif administré pendant un effort physique pourrait permettre d’identifier les patients coronariens à risque de déclin cognitif. / Coronary heart disease (CHD) patients are at higher risk for developing cognitive deficits and certain types of dementia. The cognitive functions of coronary patients have been studied at rest, but never during an acute exercise session. Acute high intensity exercise negatively affects cognitive performance in healthy people. Although coronary patients are at higher risk of cerebral and cardiovascular dysfunction, this relationship has never been studied in this clinical population and could help better understanding of the heart-brain axis. The aim of this study was to measure the effects of an acute exercise at two different intensities on cognitive performance and cerebrovascular response in CHD patients. It was hypothesized that higher exercise intensity will impair executive performance and cerebrovascular response only in CHD patients. Thirty-eight CHD patients and 16 healthy controls completed neuropsychological assessments, maximal cardiopulmonary exercise testing and two exercise bouts at 30% and 70% of their individualized maximum capacity on an ergocycle while performing a cognitive test including non-executive and executive conditions. Cerebral oxygenation and perfusion were measured during both intensities in all participants with near-infrared spectroscopy. The results demonstrated that the cognitive performance remained stable between the two intensities for both groups. In CHD patients only, cerebral blood volume was negatively affected by high intensity exercise compared with moderate intensity. Coronary heart disease negatively affects cerebral oxygenation during high intensity exercise. Further studies are needed to determine whether a cognitive test administered during physical exertion could identify coronary patients at risk of cognitive decline.

Объектом исследования явилось развитие нейрокогнитивных функций у детей 6-8 лет. Предметом исследования стало влияние цифровой среды на нейрокогнитивное развитие детей. Магистерская диссертация состоит из введения, трех глав, заключения, списка литературы (63 источника) и приложений, включающих в себя примеры выполнения детьми нейропсихологических проб. Объем магистерской диссертации 80 страниц, на которых размещены 16 рисунков и 3 таблицы. Во введении раскрывается актуальность проблемы исследования, разработанность проблематики, ставятся цель и задачи исследования, определяются объект и предмет исследования, формулируется основная гипотеза, указываются методы и эмпирическая база, а также этапы проведения исследования, научная новизна, теоретическая и практическая значимость работы. Первая глава включает в себя обзор иностранной и отечественной литературы по теме влияние цифровой среды на нейрокогнитивное развитие детей. Представлены разделы, посвященные непосредственно исследованию влияния цифровой среды и обзору современных тенденций в образовательном процессе в России. Вторая глава посвящена рассмотрению нейропсихологического подхода к оценке состояния высших психических функций у детей. В ней представлено описание теории системной динамической локализации в аспекте детской нейропсихологии и особенностей нейропсихологической диагностики в детском возрасте. Третья глава – это экспериментальная часть исследования. Она включает описание нейропсихологической методики, выборки для исследования, а также факторный анализ результатов исследования. Выводы по главе 3 включают в себя основные результаты эмпирического исследования. В заключении в обобщенном виде изложены результаты теоретической и эмпирической частей работы, а также выводы по выдвинутой гипотезе, обоснована практическая значимость исследования и описаны возможные перспективы дальнейшей разработки данной проблематики. / The object matter of the study is development of cognitive functions in children 6-8 years old. The subject of the study is the impact of the digital environment on the cognitive development of children. The master's thesis consists of the introduction, three chapters, the conclusion, the list of literature (63 sources) and the appendix, which includes the examples of children performing neuropsychological tests. The volume of the master's thesis is 80 pages, on which are placed 16 figures and 3 tables. The introduction reveals the relevance of the research problem, the development of the problematics, the purpose and objectives of the research are set, the object and the subject of research are determined, the basic hypotheses is formulated, the methods and the empirical base are specified, as well as the stages of the research, the scientific novelty, the theoretical and practical significance of the work are described. The first chapter includes an overview of the Russian and foreign literature on the subject of the impact of the digital environment on the cognitive development of children. The sections devoted to the study of the impact of the digital environment and an overview of the modern trends in the educational process in Russia are presented. The second chapter is devoted to the description of the neuropsychological approach to assessing the status of cognitive functions in children. It provides a description of the theory of system dynamic localization in the aspect of child neuropsychology and the characteristics of neuropsychological diagnostics in childhood. The third chapter is the experimental part of the study. It includes the description of neuropsychological tests, sample for the research and also the factor analysis of the results of the study. The findings of Chapter 3 are the main results of the empirical study. In conclusion, brief results of the theoretical and empirical parts of the work are presented, as well as conclusions on the hypotheses. The practical significance of the study is substantiated and possible prospects for further development of the problematics are described.