This thesis deals with the fixation of lower jaw with bone tissue defect using commercially produced fixator. Large defects of bone tissue are mainly caused due to the removal of bone tissue affected by tumor. These topics have been researched on the basis of the literature. Subsequently, stress strain analysis of the lower jaw with the applied fixation plate was performed. This analysis was solved by using computational modeling with variational approach, ie the finite element method. The work also describes in detail the procedure of creating model of geometry, model of material, model of boundary conditions and loads with subsequent solution of several computational models. The stress strain analysis was done for lower jaw with varying size of the removed bone tissue with applied reconstruction plate made of CP-Ti Grade 4 and for the lower jaw with the plate, which is made of -Ti-Mo. Finally, the influence of the mechanical properties of the callus during formation of new bone tissue (callus healing) on the stress and deformation of the solved system was evaluated.

Linear time-invariant (LTI) dynamic networks are described by their dynamical structure function, and generally, they have many possible state space realizations. This work characterizes the necessary and sufficient conditions on a state transformation that preserves the dynamical structure function, thereby generating the entire set of realizations of a given order for a specific dynamic network.

Network-on-chip (NoC) based multi-processor systems-on-chip (MPSoCs) are promising candidates for future multi-processor embedded platforms, which are expected to be composed of hundreds of heterogeneous processing elements (PEs) to potentially provide high performances. However, together with the performances, the systems complexity will increase, and new high level design techniques will be needed to efficiently model, simulate, debug and synthesize them. System-level design (SLD) is considered to be the next frontier in electronic design automation (EDA). It enables the description of embedded systems in terms of abstract functions and interconnected blocks. A promising complementary approach to SLD is the use of models of computation (MoCs) to formally describe the execution semantics of functions and blocks through a set of rules. However, also when this formalization is used, there is no clear way to synthesize system-level models into software (SW) and hardware (HW) towards a NoC-based MPSoC implementation, i.e., there is a lack of system design automation (SDA) techniques to rapidly synthesize and prototype system-level models onto heterogeneous NoC-based MPSoCs. In addition, many of the proposed solutions require large overhead in terms of SW components and memory requirements, resulting in complex and customized multi-processor platforms. In order to tackle the problem, a novel model-based SDA flow has been developed as part of the thesis. It starts from a system-level specification, where functions execute according to the synchronous MoC, and then it can rapidly prototype the system onto an FPGA configured as an heterogeneous NoC-based MPSoC. In the first part of the thesis the HeartBeat model is proposed as a model-based technique which fills the abstraction gap between the abstract system-level representation and its implementation on the multiprocessor prototype. Then details are provided to describe how this technique is automated to rapidly prototype the modeled system on a flexible platform, permitting to adjust the system specification until the designer is satisfied with the results. Finally, the proposed SDA technique is improved defining a methodology to automatically explore possible design alternatives for the modeled system to be implemented on a heterogeneous NoC-based MPSoC. The goal of the exploration is to find an implementation satisfying the designer's requirements, which can be integrated in the proposed SDA flow. Through the proposed SDA flow, the designer is relieved from implementation details and the design time of systems targeting heterogeneous NoC-based MPSoCs on FPGA is significantly reduced. In addition, it reduces possible design errors proposing a completely automated technique for fast prototyping. Compared to other SDA flows, the proposed technique targets a bare-metal solution, avoiding the use of an operating system (OS). This reduces the memory requirements on the FPGA platform comparing to related work targeting MPSoC on FPGA. At the same time, the performance (throughput) of the modeled applications can be increased when the number of processors of the target platform is increased. This is shown through a wide set of case studies implemented on FPGA. / <p>QC 20140609</p>

No description available.

<pre><p>Difficulty understanding speech in background noise is the most common hearing complaint. Elucidating the neurophysiological mechanisms underlying speech intelligibility in everyday environments with multiple sound sources and distortions is hence important for any technology that aims to improve real-world listening. Using a combination of behavioral, electroencephalography (EEG), and computational modeling experiments, this dissertation provides insight into how the brain analyzes such complex scenes, and what roles different acoustic cues play in facilitating this process and in conveying phonetic content. Experiment #1 showed that brain oscillations selectively track the temporal envelopes (i.e., modulations) of attended speech in a mixture of competing talkers, and that the strength and pattern of this attention effect differs between individuals. Experiment #2 showed that the fidelity of neural tracking of attended-speech envelopes is strongly shaped by the modulations in interfering sounds as well as the temporal fine structure (TFS) conveyed by the cochlea, and predicts speech intelligibility in diverse listening environments. Results from Experiments #1 and #2 support the theory that temporal coherence of sound elements across envelopes and/or TFS shapes scene analysis and speech intelligibility. Experiment #3 tested this theory further by measuring and computationally modeling consonant categorization behavior in a range of background noises and distortions. We found that a physiologically plausible model that incorporated temporal-coherence effects predicted consonant confusions better than conventional speech-intelligibility models, providing independent evidence that temporal coherence influences scene analysis. Finally, results from Experiment #3 also showed that TFS is used to extract speech content (voicing) for consonant categorization even when intact envelope cues are available. Together, the novel insights provided by our results can guide future models of speech intelligibility and scene analysis, clinical diagnostics, improved assistive listening devices, and other audio technologies.</p></pre>

Linear time-invariant (LTI) dynamic networks are described by their dynamical structure function, and generally, they have many possible state space realizations. This work characterizes the necessary and sufficient conditions on a state transformation that preserves the dynamical structure function, thereby generating the entire set of realizations of a given order for a specific dynamic network.

[ES] En la actualidad, uno de los principales desafíos a los que se enfrentan las grandes áreas metropolitanas es la congestión provocada por el tráfico, la cual se ha convertido en un problema importante al que se enfrentan las autoridades de cada ciudad. Para abordar este problema es necesario implementar una solución eficiente para controlar el tráfico que genere beneficios para los ciudadanos, como reducir los tiempos de viaje de los vehículos y, en consecuencia, el consumo de combustible, el ruido, y la contaminación ambiental. De hecho, al analizar adecuadamente la demanda de tráfico, es posible predecir las condiciones futuras del tráfico, y utilizar esa información para la optimización de las rutas tomadas por los vehículos. Este enfoque puede ser especialmente efectivo si se aplica en el contexto de los vehículos autónomos, que tienen un comportamiento más predecible, lo cual permite a los administradores de la ciudad mitigar los efectos de la congestión, como es la contaminación, al mejorar el flujo de tráfico de manera totalmente centralizada. La validación de este enfoque generalmente requiere el uso de simulaciones que deberían ser lo más realistas posible. Sin embargo, lograr altos grados de realismo puede ser complejo cuando los patrones de tráfico reales, definidos a través de una matriz de Origen/Destino (O-D) para los vehículos en una ciudad, son desconocidos, como ocurre la mayoría de las veces. Por lo tanto, la primera contribución de esta tesis es desarrollar una heurística iterativa para mejorar el modelado de la congestión de tráfico; a partir de las mediciones de bucle de inducción reales hechas por el Ayuntamiento de Valencia (España), pudimos generar una matriz O-D para la simulación de tráfico que se asemeja a la distribución de tráfico real. Si fuera posible caracterizar el estado del tráfico prediciendo las condiciones futuras del tráfico para optimizar la ruta de los vehículos automatizados, y si se pudieran tomar estas medidas para mitigar de manera preventiva los efectos de la congestión con sus problemas relacionados, se podría mejorar el flujo de tráfico en general. Por lo tanto, la segunda contribución de esta tesis es desarrollar una Ecuación de Predicción de Tráfico para caracterizar el comportamiento en las diferentes calles de la ciudad en términos de tiempo de viaje con respecto al volumen de tráfico, y aplicar una regresión logística a esos datos para predecir las condiciones futuras del tráfico. La tercera y última contribución de esta tesis apunta directamente al nuevo paradigma de gestión de tráfico previsto, tratándose de un servidor de rutas capaz de manejar todo el tráfico en una ciudad, y equilibrar los flujos de tráfico teniendo en cuenta las condiciones de congestión del tráfico presentes y futuras. Por lo tanto, realizamos un estudio de simulación con datos reales de congestión de tráfico en la ciudad de Valencia (España), para demostrar cómo se puede mejorar el flujo de tráfico en un día típico mediante la solución propuesta. Los resultados experimentales muestran que nuestra solución, combinada con una actualización frecuente de las condiciones del tráfico en el servidor de rutas, es capaz de lograr mejoras sustanciales en términos de velocidad promedio y tiempo de trayecto, ambos indicadores de un menor grado de congestión y de una mejor fluidez del tráfico. / [CA] En l'actualitat, un dels principals desafiaments als quals s'enfronten les grans àrees metropolitanes és la congestió provocada pel trànsit, que s'ha convertit en un problema important al qual s'enfronten les autoritats de cada ciutat. Per a abordar aquest problema és necessari implementar una solució eficient per a controlar el trànsit que genere beneficis per als ciutadans, com reduir els temps de viatge dels vehicles i, en conseqüència, el consum de combustible, el soroll, i la contaminació ambiental. De fet, en analitzar adequadament la demanda de trànsit, és possible predir les condicions futures del trànsit, i utilitzar aqueixa informació per a l'optimització de les rutes preses pels vehicles. Aquest enfocament pot ser especialment efectiu si s'aplica en el context dels vehicles autònoms, que tenen un comportament més predictible, i això permet als administradors de la ciutat mitigar els efectes de la congestió, com és la contaminació, en millorar el flux de trànsit de manera totalment centralitzada. La validació d'aquest enfocament generalment requereix l'ús de simulacions que haurien de ser el més realistes possible. No obstant això, aconseguir alts graus de realisme pot ser complex quan els patrons de trànsit reals, definits a través d'una matriu d'Origen/Destinació (O-D) per als vehicles en una ciutat, són desconeguts, com ocorre la majoria de les vegades. Per tant, la primera contribució d'aquesta tesi és desenvolupar una heurística iterativa per a millorar el modelatge de la congestió de trànsit; a partir dels mesuraments de bucle d'inducció reals fetes per l'Ajuntament de València (Espanya), vam poder generar una matriu O-D per a la simulació de trànsit que s'assembla a la distribució de trànsit real. Si fóra possible caracteritzar l'estat del trànsit predient les condicions futures del trànsit per a optimitzar la ruta dels vehicles automatitzats, i si es pogueren prendre aquestes mesures per a mitigar de manera preventiva els efectes de la congestió amb els seus problemes relacionats, es podria millorar el flux de trànsit en general. Per tant, la segona contribució d'aquesta tesi és desenvolupar una Equació de Predicció de Trànsit per a caracteritzar el comportament en els diferents carrers de la ciutat en termes de temps de viatge respecte al volum de trànsit, i aplicar una regressió logística a aqueixes dades per a predir les condicions futures del trànsit. La tercera i última contribució d'aquesta tesi apunta directament al nou paradigma de gestió de trànsit previst. Es tracta d'un servidor de rutes capaç de manejar tot el trànsit en una ciutat, i equilibrar els fluxos de trànsit tenint en compte les condicions de congestió del trànsit presents i futures. Per tant, realitzem un estudi de simulació amb dades reals de congestió de trànsit a la ciutat de València (Espanya), per a demostrar com es pot millorar el flux de trànsit en un dia típic mitjançant la solució proposada. Els resultats experimentals mostren que la nostra solució, combinada amb una actualització freqüent de les condicions del trànsit en el servidor de rutes, és capaç d'aconseguir millores substancials en termes de velocitat faig una mitjana i de temps de trajecte, tots dos indicadors d'un grau menor de congestió i d'una fluïdesa millor del trànsit. / [EN] Currently, one of the main challenges that large metropolitan areas have to face is traffic congestion, which has become an important problem faced by city authorities. To address this problem, it becomes necessary to implement an efficient solution to control traffic that generates benefits for citizens, such as reducing vehicle journey times and, consequently, use of fuel, noise and environmental pollution. In fact, by properly analyzing traffic demand, it becomes possible to predict future traffic conditions, and to use that information for the optimization of the routes taken by vehicles. Such an approach becomes especially effective if applied in the context of autonomous vehicles, which have a more predictable behavior, thus enabling city management entities to mitigate the effects of traffic congestion and pollution by improving the traffic flow in a city in a fully centralized manner. Validating this approach typically requires the use of simulations, which should be as realistic as possible. However, achieving high degrees of realism can be complex when the actual traffic patterns, defined through an Origin/Destination (O-D) matrix for the vehicles in a city, are unknown, as occurs most of the times. Thus, the first contribution of this thesis is to develop an iterative heuristic for improving traffic congestion modeling; starting from real induction loop measurements made available by the City Hall of Valencia, Spain, we were able to generate an O-D matrix for traffic simulation that resembles the real traffic distribution. If it were possible to characterize the state of traffic by predicting future traffic conditions for optimizing the route of automated vehicles, and if these measures could be taken to preventively mitigate the effects of congestion with its related problems, the overall traffic flow could be improved. Thereby, the second contribution of this thesis was to develop a Traffic Prediction Equation to characterize the different streets of a city in terms of travel time with respect to the vehicle load, and applying logistic regression to those data to predict future traffic conditions. The third and last contribution of this thesis towards our envisioned traffic management paradigm was a route server capable of handling all the traffic in a city, and balancing traffic flows by accounting for present and future traffic congestion conditions. Thus, we perform a simulation study using real data of traffic congestion in the city of Valencia, Spain, to demonstrate how the traffic flow in a typical day can be improved using our proposed solution. Experimental results show that our proposed solution, combined with frequent updating of traffic conditions on the route server, is able to achieve substantial improvements in terms of average travel speeds and travel times, both indicators of lower degrees of congestion and improved traffic fluidity. / Finally, I want to thank the Ecuatorian Republic through the "Secretaría de Educación Superior, Ciencia, Tecnología e Innovación" (SENESCYT), for granting me the scholarship to finance my studies. / Zambrano Martínez, JL. (2019). Efficient Traffic Management in Urban Environments [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/129865

The aim of this thesis was to develop stable-isotope steady-state metabolic flux analysis (MFA) based on ¹³C labeling to quantify intracellular fluxes of central carbon metabolism in plants. The experiments focus on the analysis of a heterotrophic cell suspension culture of Arabidopsis thaliana (L) Heynh. (ecotype Landsberg erecta). The first objective was to develop a robust methodology based on combining high quality steady-state stable labeling data, metabolic modeling and computational analysis. A comprehensive analysis of the factors that influence the outcome of MFA was undertaken and best practice established. This allowed a critical analysis of the subcellular compartmentation of carbohydrate oxidation in the cell culture. The second objective was to apply the methodology to nutritional perturbations of the cell suspension. A comparison of growth on different nitrogen sources revealed that transfer to an ammonium-free medium: (i) increased flux through the oxidative pentose phosphate pathway (oxPPP) by 10% relative to glucose utilisation; (ii) caused a substantial decrease in entry of carbon into the tricarboxylic acid cycle (TCA); and (iii) increased the carbon conversion efficiency from 55% to 69%. Although growth on nitrate alone might be expected to increase the demand for reductant, the cells responded by decreasing the assimilation of inorganic N. Cells were also grown in media containing different levels of inorganic phosphate (Pi). Comparison of the flux maps showed that decreasing Pi availability: (i) decreased flux through the oxPPP; (ii) increased the proportion of substrate fully oxidised by the TCA cycle; and (iii) decreased carbon conversion efficiency. These changes are consistent with redirection of metabolism away from biosynthesis towards cell maintenance as Pi is depleted. Although published genome-wide transcriptomic and metabolomic studies suggest that Pi starvation leads to the restructuring of carbon and nitrogen metabolism, the current analysis suggests that the impact on metabolic organisation is much less extreme.

Presented work deals with Biomechanical study of the facial skeleton. This work is focused on the fixation of the mandible after removal of a tumor from affected bone tissue. The aim of the work is to perform biomechanical study of the facial skeleton with subsequent detailed stress strain analysis of two mandible implants designed and manufactured for specific patients. The geometry model of mandible used for design of mandible implants and used for computational modelling has been obtained on the basis of CT data of two patients. A Theoretical-Clinical sub-study that deals with the comparison the CT data processing which is necessary for creating the model of geometry is a part of the thesis. Two models of mandible with applied mandible implant have been created for two specific patients with tumorous mandible bone tissue. Stress strain analysis has been performed for these two models. Results of the stress strain analysis of two models of mandibles with mandible implants are presented in the final chapters of the thesis. Findings of the biomechanical study have been published and applied in clinical practice.

Presented work deals with Biomechanical study of the facial skeleton. This work is focused on the fixation of the mandible after removal of a tumor from affected bone tissue. The aim of the work is to perform biomechanical study of the facial skeleton with subsequent detailed stress strain analysis of two mandible implants designed and manufactured for specific patients. The geometry model of mandible used for design of mandible implants and used for computational modelling has been obtained on the basis of CT data of two patients. A Theoretical-Clinical sub-study that deals with the comparison the CT data processing which is necessary for creating the model of geometry is a part of the thesis. Two models of mandible with applied mandible implant have been created for two specific patients with tumorous mandible bone tissue. Stress strain analysis has been performed for these two models. Results of the stress strain analysis of two models of mandibles with mandible implants are presented in the final chapters of the thesis. Findings of the biomechanical study have been published and applied in clinical practice.