Les tumeurs de Pancoast-Tobias ont été clairement décrites pour la première fois en 1932. Leur fréquence reste faible, 3% des cancers bronchiques. Le premier traitement efficace est rapporté en 1956 depuis, malgré le développement des traitements combinés il reste controversé. Cette étude rétrospective de 1992 à 2004 a évalué les traitements reçus par 71 patients porteurs de tumeur de Pancoast-Tobias dans le cadre du groupe d'oncologie thoracique clermontois. La comparaison des différents traitements permet de conclure que la chirurgie quand elle est possible reste le meilleur traitement à condition que l'exérèse soit complète. La radio-chimiothérapie concomitante d'induction par cisplatine, 5 fluoro-uracile et vinorelbine semble le meilleur traitement en induction ou chez les non opérés en comparaison à la radiochimiothérapie séquentielle ou à d'autres protocoles de chimiothérapie concomitante. A l'exception des patients métastatiques qui tirent plus de bénéfice en terme de survie et de tolérance d'un traitement séquentiel. La survie médiane tous stades confondus a été calculée à 9 mois avec une survie pour les stades IIb de 33 mois et 14 mois pour les stade IIIA et IIIB. Les principaux facteurs pronostics retrouvés ont été : l'age, le performans statu, le stade, le statu T, le taux de cyfra 21 initial, la présence d'une résection complète et le statu pN post opératoire. Le problème reste la fréquence élevée de rechutes cérébrales pour lesquelles des essais sont en cours pour savoir s'il faut s'orienter vers une chimiothérapie d'induction, une irradiation cérébrale prophylactique ou une chimiothérapie de consolidation.

La présente recherche traite des constructions participiales en –ing de l’anglais contemporain. Elle s’appuie sur un corpus de plus de 1700 occurrences de participiales issues de romans et d’articles de journaux, ainsi que sur le British National Corpus et le Corpus of Contemporary American English. Les participiales ont pour caractéristique majeure ne pas expliciter les liens syntaxiques et sémantiques qui les unissent à la proposition dont elles dépendent. Pour expliquer les fondements linguistiques de cette propriété, la recherche établit une typologie détaillée des participiales, étudie les relations qu’elles entretiennent avec leur sujet, ainsi que la nature de l’incidence et de la prédication qui les caractérisent, et détaille les interprétations sémantiques qu’elles peuvent recevoir. Elle montre que la valeur sémantique basique des participiales est la circonstance concomitante, soit un simple lien établi entre deux procès qui forment une unité dans l’esprit de l’énonciateur. Ce sont les traits spécifiques du co- et du contexte qui peuvent modifier cette valeur basique pour déboucher sur l’interprétation finale, adverbiale ou adjectivale, de la participiale. La recherche propose, dans le cadre de la psychosystématique de Gustave Guillaume, des hypothèses susceptibles d’expliquer le comportement syntaxique et sémantique des participiales ; elle montre qu’il est directement lié au sens du participe présent, dont il est postulé que l’incidence est interne et qu’il code la simultanéité et l’imperfectif dans tous ses emplois. / This research deals with –ing participle clauses in contemporary English. It is based on a corpus totalling over 1,700 participle clauses collected from novels and newspaper articles, and it also relies on data from electronic corpora – the British National Corpus and the Corpus of Contemporary American English. The main characteristic of –ing participle clauses is that they lack an explicit syntactic and semantic link to their superordinate clause: to shed light on the linguistic phenomena accounting for this specificity, the research establishes a detailed typology of –ing clauses, studies their relationship to their subjects, investigates the specific nature of their incidence and predication, and provides a detailed analysis of their semantic indeterminacy. It shows that their basic semantic value is one of attendant circumstance – a mere link between two events or states that form a unit in the speaker’s mind. The characteristics of the co- and context may alter this basic value to give the clause its final (adjectival or adverbial) meaning. The research puts forward hypotheses to account for the syntactic and semantic characteristics of –ing participle clauses within the framework of Gustave Guillaume’s psychosystematic theory: it shows the syntactic and semantic behaviour of –ing clauses can be directly traced back to the meaning of the –ing participle, which, it is hypothesised, has an internal incidence and expresses simultaneity and imperfectivity in all of its uses.

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No. of bitstreams: 1 chiapinotto_l_me_guara.pdf: 2025683 bytes, checksum: 06211c8bab58758df3a08535a4aa3f80 (MD5) Previous issue date: 2017-09-21 / Nesta pesquisa investiga-se a viabilidade do uso de misturas heterogêneas de combustíveis compostas por etanol e gás natural veicular (GNV) em motor flex fuel (Flex). Os motores Flex, no Brasil, são abastecidos com gasolina E27 (com até 27% de etanol anidro e 73% de gasolina), etanol, GNV ou qualquer mistura de etanol e gasolina. Ao funcionarem com o GNV apresentam vantagens pela menor emissão de dióxido de carbono (CO2), monóxido de carbono (CO) e óxidos de nitrogênio (NOX), mas são desvantajosos com relação às emissões de hidrocarbonetos (HC) em baixas rotações quando comparados ao utilizarem gasolina ou etanol, além da perda de potência variando de 10 a 20%. Esta pesquisa objetiva encontrar uma mistura de etanol-GNV, cuja combustão possa reduzir, as emissões de CO, HC e NOx do motor Flex em relação ao modo GNV. Os testes foram conduzidos num motor Flex de 2000 cilindradas, com duas válvulas por cilindro. No motor foi instalado um sistema de gerenciamento de injeção eletrônica de GNV funcionando concomitantemente com a injeção de combustível líquido. Fez-se inicialmente a medição da vazão de etanol (E100), do GNV (E0) e de diferentes misturas de etanol-GNV (E20, E40, E60, E80). Para a avaliação dos parâmetros das emissões de CO2, CO, O2, HC e NOx, das eficiências (térmica, volumétrica e mecânica), consumo específico de combustível e custo operacional, calibrou-se primeiramente o motor para o uso de E0 e de E100. Os testes foram realizados em modo estacionário e dinâmico, cujas emissões foram medidas através do analisador de gases. No modo estacionário mediram-se as emissões de gases de exaustão em velocidade angular de 1000 e 2500 RPM (rotações por minuto); no modo dinâmico mediram-se além das emissões, a potência e o consumo de combustível com o motor submetido a 25% de carga a 2000, 2500, 3000 RPM e à carga total num dinamômetro ativo para até 290 kW. Os melhores resultados obtiveram-se para a mistura E20. Comparando-se com E0, a mistura E20 resultou uma média de 55,33%, 31%, 29,86% e 57,41% na diminuição das emissões de CO, O2, HC e de NOx, respectivamente, com um aumento médio das emissões de CO2 em 5,81%; foi observado também perda de 2,45% de potência líquida, além do aumento de 2,35%, 1,25%, 1,41%, 16,94% e 18,85% para eficiência térmica, eficiência volumétrica, eficiência mecânica, consumo específico de combustível e do custo operacional, respectivamente / This research has investigated the feasibility of using heterogeneous fuel blends composed of ethanol and compressed natural gas (CNG) in flex-fuel engines. In Brazil, such vehicles are fueled by E27 gasoline (up to 27% anhydrous ethanol and 73% gasoline), ethanol, CNG or any ethanol and gasoline blend. When running on CNG, they offer advantages due to lower carbon dioxide (CO2), carbon monoxide (CO) and nitrogen oxide (NOX) emissions, although they are disadvantageous with respect to hydrocarbon emissions (HC) at low revolutions, especially if compared to being run on gasoline or ethanol, in addition to power loss ranging from 10 to 20%. Thus, it is aimed to find an ethanol-CNG blend whose combustion can reduce CO, HC and NOx emissions from flex-fuel engines in comparison with the CNG mode. Tests have been conducted on a 2000cc flex-fuel engine with two valves per cylinder. It was installed an electronic CNG injection system operating concomitantly with the liquid fuel injection system. Flows of ethanol (E100), CNG (E0) and different ethanol-CNG blends (E20, E40, E60, E80) were initially measured. In order to evaluate levels of CO2, CO, O2, HC and NOx emissions, efficiency (thermal, volumetric and mechanical), specific fuel consumption and operating cost, the engine was initially calibrated to run on E0 and E100. The emissions tests were performed in stationary and dynamic mode. In stationary mode, exhaust emissions were measured at 1000 and 2500 RPM (revolutions per minute); in dynamic mode, power and fuel consumption were measured while the engine was subjected to 25% load at 2000, 2500, and 3000 RPM, in addition to repeating exhaust gas and power tests at full load with an active dynamometer at up to 290 kW. Optimal results were obtained for blend E20. If compared to E0, E20 resulted in an average of 55.33%, 31%, 29.86% and 57.41% at reducing CO, O2, HC and NOX emissions, respectively, with increased CO2 emissions. It were also observed of 2.45% of gross power loss, besides an increase of 2.35%, 1.25%, 1.41%, 16.94% and 18.85% in thermal efficiency, volumetric efficiency, mechanical efficiency, specific fuel consumption and operating cost, respectively