Ce travail de thèse se donne pour objectif de mettre en évidence le fonctionnement des différents effets de sens produits en discours par le futur et le conditionnel à partir d’une valeur en langue unique de chacun de ces temps, dans une perspective contrastive entre l’espagnol et le français. La première partie interroge les notions de temporalité, d’aspectualité et de modalité, ainsi que les théories énonciatives qui sous-tendent toute recherche sur le temps verbal pour déterminer les cadres théoriques dans lesquels s’inscrit cette analyse et définir la valeur en langue du futur et celle du conditionnel sur lesquelles on s’appuie. Dans une seconde partie, on se propose de mettre en évidence le mécanisme d’actualisation de cette valeur aspectuo-temporelle dans la production de différents effets de sens de ces deux temps dont le fonctionnement est similaire en espagnol et en français. La troisième partie est consacrée quant à elle à l’analyse d’un fonctionnement différent dans les deux langues étudiées : l’effet de sens conjectural. / The purpose of this work is to show the various usages of future and conditionnal tenses in speech connected with the meaning in language of each tense. This is a contrastive approach between Spanish and French. In the first part, we explore the notions of temporality, aspectuality and modality. The enunciative theories that underlie every research on verbal tense are questionned too in order to define the theorical frameworks and the meaning of each analyzed tense. In the second part, we point out the actualization process of the aspectuo-temporal meaning of each tense that produces various usages in speech which works in a similar way in Spanish and French. In the third and last part, we focus on the analysis of a diferent functioning between these two languages : the conjectural usage.

This study explored the relationship between a new self-report measure built from justification mechanisms of aggression (i.e., the basis of conditional reasoning; James, 1998) with a traditional explicit measure and an implicit conditional reasoning measure of aggression. The construct validity and generalizability of the new measure were investigated by using non-work related criteria (violent acts, traffic violations, alcohol use, competitiveness, and agreeableness) in an undergraduate student sample. Correlations and moderated hierarchical multiple regressions were used to assess the relationships between variables. The results support the literature in that both explicit and implicit components of personality need to be examined. In conclusion, the newly developed measure fills a gap in the literature by operationalizing aggression as reasons for behaving aggressively. It is similar to the explicit aggression measure in that it is a self-report; however, the moderate correlation between the two suggests that each is measuring slightly different aspects of aggression.

Com o aumento progressivo do número de casos de infecção por diferentes arbovírus, por exemplo, dengue, zica e chikungunya, faz-se necessário o desenvolvimento de novas técnicas para o combate a esses arbovírus. A manipulação genética possibilitou a obtenção de mosquitos geneticamente modificados que sejam capazes de suprimir a população selvagem ou impedir a transmissão de agentes etiológicos gerando doenças. O estudo teve como objetivo o estabelecimento de linhagens para supressão populacional de Aedes aegypti. Esta construção apresenta esterilidade condicionada à presença ou ausência de antibiótico no meio em que esses mosquitos se desenvolvem durante a fase larval. Dessa forma, sem a necessidade de se utilizar radiação para obter insetos estéreis, é possível melhorar a qualidade dos machos adultos liberados e aumentar a competitividade dos mesmos em competir por fêmeas selvagens e adicionalmente gerar o desejado quadro de supressão populacional. / The increasing number of infection cases by arboviruses, for instance Dengue, Zika and Chikungunya, it is necessary to develop new techniques to fight against these arboviruses. Genetic manipulation allowed the production of genetically modified mosquitoes that are capable of suppressing the wild population or prevent pathogens transmission and avoid disease development. The project proposes to establish lines for population suppression of Aedes aegypti, one of the main vectors of those diseases. This construction presents the conditional sterility due to the presence or absence of antibiotics in the environment where these mosquitoes are developed during the larval stage. Thus, without the need to use radiation for sterile insects, it is possible to improve the quality of the released adult males and enhance the competitiveness thereof in competing with wild females and additionally generate population suppression.

Les métamodèles statistiques sont régulièrement confrontés au manque de données qui engendre des difficultés à estimer les paramètres. Le paradigme bayésien fournit un moyen élégant de contourner le problème en décrivant la connaissance que nous avons des paramètres par une loi de probabilité a posteriori au lieu de la résumer par une estimation ponctuelle. Cependant, ce paradigme nécessite de définir une loi a priori adéquate, ce qui est un exercice difficile en l'absence de jugement d'expert. L'école bayésienne objective propose des priors par défaut dans ce genre de situation telle que le prior de référence de Berger-Bernardo. Un tel prior a été calculé par Berger, De Oliveira and Sansó [2001] pour le modèle de krigeage avec noyau de covariance isotrope. Une extension directe au cas des noyaux anisotropes poserait des problèmes théoriques aussi bien que pratiques car la théorie de Berger-Bernardo ne peut s'appliquer qu'à un jeu de paramètres ordonnés. Or dans ce cas de figure, tout ordre serait nécessairement arbitraire. Nous y substituons une solution bayésienne objective fondée sur les posteriors de référence conditionnels. Cette solution est rendue possible par une théorie du compromis entre lois conditionnelles incompatibles. Nous montrons en outre qu'elle est compatible avec le krigeage trans-gaussien. Elle est appliquée à un cas industriel avec des données non-stationnaires afin de calculer des Probabilités de Détection de défauts (POD de l'anglais Probability Of Detection) par tests non-destructifs dans les tubes de générateur de vapeur de centrales nucléaires. / A recurring problem in surrogate modelling is the scarcity of available data which hinders efforts to estimate model parameters. The Bayesian paradigm offers an elegant way to circumvent the problem by describing knowledge of the parameters by a posterior probability distribution instead of a pointwise estimate. However, it involves defining a prior distribution on the parameter. In the absence of expert opinion, finding an adequate prior can be a trying exercise. The Objective Bayesian school proposes default priors for such can be a trying exercise. The Objective Bayesian school proposes default priors for such situations, like the Berger-Bernardo reference prior. Such a prior was derived by Berger, De Oliveira and Sansó [2001] for the Kriging surrogate model with isotropic covariance kernel. Directly extending it to anisotropic kernels poses theoretical as well as practical problems because the reference prior framework requires ordering the parameters. Any ordering would in this case be arbitrary. Instead, we propose an Objective Bayesian solution for Kriging models with anisotropic covariance kernels based on conditional reference posterior distributions. This solution is made possible by a theory of compromise between incompatible conditional distributions. The work is then shown to be compatible with Trans-Gaussian Kriging. It is applied to an industrial case with nonstationary data in order to derive Probability Of defect Detection (POD) by non-destructive tests in steam generator tubes of nuclear power plants.

L’objectif de cette thèse est de mettre en évidence le fonctionnement des différents emplois marqués par le potentiel et le conditionnel à partir d’une valeur en langue unique de chacune de ces formes verbales, dans une perspective contrastive entre le serbe et le français. La première partie interroge les notions et les théories qui sous-tendent toute recherche sur une forme verbale participant à la définition du potentiel et du conditionnel et pointant les convergences et les divergences entre ces deux formes verbales. Dans la deuxième partie, on se propose de déterminer et d’analyser les emplois modaux et temporels du potentiel et du conditionnel inscrits dans les cadres théoriques définissant la valeur unique de ces formes verbales et de proposer une nouvelle approche du traitement des formes en question. La troisième partie vise à saisir et à expliciter les équivalents sémantiques du conditionnel en serbe et du potentiel en français, dans le but de faire ressortir les difficultés possibles dans la compréhension de ces deux formes verbales et ainsi participer à l’avancement de la didactique franco-serbe. / The objective of this work is to show the various usages of the French conditional and the Serbian potential connected with the meaning in language of each verbal form. This is a contrastive approach between Serbian and French. In the first part, we explore the notions and theories that underlie every research on verbal form in order to define the potential and the conditional and to point out the convergences and the divergences between these two forms. In the second part, we aim to identify and analyze modal and temporal usages of the potential and the conditional in the theoretical frameworks defining the meaning in language of these forms and to propose a new approach to the treatment of the forms in question. In the third and last part, we focus on determining and explaining the semantic equivalents of the conditional in Serbian and the potential in French in order to highlight the possible comprehension problems of these two forms and thus to participate in the development of Didactics of languages (French and Serbian).

Thesis advisor: Julie H. Mortimer / The unifying theme of this dissertation is the growing importance of pharmaceutical products in health care and in society more broadly. The first two chapters use structural and reduced-form models to study the effects of various policies on the choice and utilization of prescription drugs. The third chapter surveys the empirical literature on the competitive effects of a class of pricing arrangements used in the pharmaceutical and many other industries. Chapter 1. One of the criticisms leveled against direct-to-consumer advertising of prescription drugs is that it overemphasizes the use of pharmaceuticals at the expense of other forms of treatment. In “Choice of Depression Treatment: Advertising Spillovers in a Model with Complementarity,” I study how antidepressant TV ads affect demand for psychotherapy. Antidepressant advertising can increase demand for therapy if the products are complements or if advertising has spillover effects. To disentangle the different channels, I develop a discrete-choice demand model that allows for complementarity between products, advertising spillovers, and flexible unobserved preference heterogeneity. Individual-level panel data on treatment choices and price variation allow me to separately identify complementarity and correlated preferences, whereas the average price of TV advertising, used as an instrument, identifies the causal effect of antidepressant ads on demand for each product. The results indicate that even though antidepressants and psychotherapy are substitutes, drug advertising increases demand for therapy through a spillover effect. Allowing for time-invariant and time-varying unobservables that can be correlated across products critically affects the estimated degree of complementarity and advertising elasticities. Chapter 2. While prescription drugs have enabled the cost-effective treatment of a myriad of diseases, many pharmaceuticals come with potential for abuse. The growing use of opioid medications for chronic pain led to widespread misuse, addiction, and skyrocketing overdose death rates. In “Did Plain-Vanilla Prescription Drug Monitoring Programs Reduce Opioid Use? Evidence from Privately Insured Patients,” I explore whether prescription drug monitoring programs (PDMPs) with no registration or use mandates were effective in reducing the utilization of opioid prescription drugs. Exploiting the staggered introduction of such programs between 2008 and 2010, I use difference-in-differences to estimate their causal effect on the number of prescriptions, days supply, and dosage per capita. Based on data from privately insured adults, the estimation results reveal that PDMPs successfully reduced opioid utilization, especially of high-dosage prescriptions. A battery of robustness checks suggests that the estimated effects are caused by the PDMPs and not by confounding factors such as broader trends in health care, attrition, out-of-state purchases, or other anti-opioid policies. Chapter 3. The assumption that buyers pay the same price for each unit of the good they purchase underlies many economic analyses. However, linear pricing is one of many pricing arrangements used in practice. In “Empirical Evidence on Conditional Pricing Practices: A Review,” Julie Holland Mortimer and I review the existing empirical studies on the competitive impact of conditional pricing practices (CPPs), under which the price of a product may depend on a quantity, share, bundling, or other requirement. Examples of CPPs include all-units and loyalty discounts, full-line forcing contracts, and exclusivity arrangements. A common thread unifying the empirical literature is that CPPs often have both procompetitive and anticompetitive effects and that their net effect may depend on the details of the arrangements and the characteristics of the markets in which they are used. / Thesis (PhD) — Boston College, 2020. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Economics.

Sidman's (2000) theory of stimulus equivalence predicts an interaction between the development of analytic units and the development of equivalence relations. Previous research has documented these interactions (stewart, Barnes-Holmes, Roche, & Smeets, 2002; Vaidya & Brackney, 2014), therefore the current study attempted to replicate the effects seen in Vaidya & Brackney, 2014 (Experiment 2). Baseline conditional discriminations were trained for two sets of three, three-member classes, while participants simply observed stimuli in the third set which was arranged identical to those of Sets 1 and 2. Following equivalence tests where performance met the accuracy criterion of 85% for Sets 1 and 2, participants then entered a simple successive discrimination training phase where common responses were then trained with an equivalence class (pressing the Q key in the presence of A1, B1, or C1), cross equivalence classes (pressing the R key in the presence of A4, A5, or A6), or for stimuli where the participants had experience with them, but the contingencies were never arranged to facilitate equivalence class formation. Results showed a facilitative effect for common responses drawn from within equivalence classes (Set 1), and a retardation effect for common responses drawn from across equivalence classes (Set 2), for three of the five participants. Results for Set 3 showed an acquisition that fell intermediate to that of Sets 1 and 2, respectively, suggesting an interaction occurring between existing equivalence relations and the development of analytic units.

京都大学 / 0048 / 新制・課程博士 / 博士(生命科学) / 甲第22133号 / 生博第420号 / 新制||生||55(附属図書館) / 京都大学大学院生命科学研究科高次生命科学専攻 / (主査)教授 渡邊 直樹, 教授 千坂 修, 教授 原田 浩 / 学位規則第4条第1項該当 / Doctor of Philosophy in Life Sciences / Kyoto University / DFAM

Conditional discontinuance of criminal prosecution is a method for alternative dispute resolution of criminal cases, also labelled "diversions" by the professional public. It is a criminal procedural measure allowed to be used for case settlement by the court and at the pre-trial stage by the public prosecutor on conditions laid down in the Criminal Code. If the accused committed minor offence and afterwards pleaded guilty; compensated for damages; returned unjust enrichment, or concluded a contract to compensate for damages or to return the unjust enrichment; or he has taken other necessary measures to do so, the determining authority can - with consideration of the accused's character - thereafter decide to conditionally discontinue criminal prosecution. If the accused has committed a serious offense, the public prosecutor or the court may take such decision only if the accused fulfills additional and stricter condition. That is, a probationary period must be determined in the resolution phase, obligating the accused to behave in an orderly way for its duration. If this condition is met, the determining authority will rule that the accused proved himself and then subsequently discontinue criminal prosecution. Otherwise, prosecution will continue, which can potentially lead to indictment and...

The aim of this work is to find out which algorithm is the best at recognizing named entities in e-mail messages. The theoretical part explains the existing tools in this field. The practical part describes the design of two tools specifically designed to create new models capable of recognizing named entities in e-mail messages. The first tool is based on a neural network and the second tool uses a CRF graph model. The existing and newly created tools and their ability to generalize are compared on a subset of e-mail messages provided by Kiwi.com.