61 |
An Auditory profile of sclerosteosisPotgieter, Jenni-Marí January 2013 (has links)
Sclerosteosis is a rare genetic bone dysplasia disorder characterised by generalised
craniotubular bone modelling. Alongside many clinical appearances marked in
sclerosteosis, the auditory system is considerably compromised on several levels during
the disease progression. Extensive otolaryngological research on the history of
sclerosteosis, the clinical presentation of sclerosteosis, radiographic studies and the
gene causing the condition had been documented. No studies had been found describing
the audiological profiles, auditory functioning and abnormalities for subjects with
sclerosteosis. Thus the object of this study aimed to describe the auditory profile of
subjects with sclerosteosis.
A cross-sectional descriptive research design and quantitative research approach was
followed to investigate the auditory characteristics of subjects with sclerosteosis.
Subjects were selected from a database of patients with confirmed diagnoses of
sclerosteosis. Ten subjects responded and provided written informed consent. Test
procedures included otoscopy, tympanometry, acoustic reflexes, diagnostic pure-tone airand
bone-conduction audiometry, speech audiometry, distortion product otoacoustic
emissions (DPOAE), auditory brainstem responses (ABR) and computed tomographic
(CT) scans. The subjects were assessed with a comprehensive audiological test-battery
within a single test session lasting approximately two hours. A CT scan was conducted
on a separate occasion shortly after the audiological data were obtained.
Normal type A tympanograms were obtained in 50% (n=10/20) of ears. All subjects
presented with mixed hearing losses varying from moderate (5%; n=1), severe (55%;
n=11) and profound (40%; n=8) degrees across ears. Hearing loss configurations ranged
from rising (15%), sloping (35%) and air-conduction thresholds peaking at 2000 Hz
(50%). Air bone gaps (ABG) were larger in older subjects, although not statistically
significant (p>.05). The CT scans indicated anatomical abnormalities of the external
auditory canal, tympanic membrane, middle ear space, ossicles, oval window, round
window and the internal auditory canal. The progressive abnormal bone formation in sclerosteosis involved the middle ear, the
round and oval windows of the cochlea and internal auditory canal. The progressive
abnormal bony overgrowth, which is the hallmark of sclerosteosis, led to functional
impairment at various levels in the auditory system. The current findings provided a
comprehensive auditory profile for sclerosteosis. Results might be utilised alongside
future research findings to direct criteria and audiological indications for surgical and
audiological intervention. / Dissertation (MCommunication Pathology)--University of Pretoria, 2013. / gm2014 / Speech-Language Pathology and Audiology / Unrestricted
|
62 |
Construção de biossensores utilizando polímeros condutores eletrônicos / Construction of biosensors using electronic conductive polymersFiorito, Pablo Alejandro 27 July 2001 (has links)
Neste trabalho são elaborados biossensores para a detecção amperométrica de glicose. Para isso, imobilizou-se a enzima glicose oxidase em matrizes de polímeros condutores. Foram construídos sensores utilizando-se poli(pirrol) e poli(N-metilpirrol). Com o objetivo de substituir o oxigênio molecular na etapa de transdução do sinal, o ferroceno foi incorporado dentro do polímero condutor. Para isso, os polímeros foram elaborados utilizando misturas água-etanol como meio de polimerização. A inclusão do ferroceno no sensor resulta em maior sensibilidad à glicose (4,33 µA Mm-1 cm-2 para o biossensor preparado a partir da mistura água-etanol contendo o ferroceno e de 0,23 µA mM-1 cm-2 para o sensor sem ferroceno ). Por outro lado, permite o funcionamento do sensor a potenciais menores que no caso do sensor sem ferroceno (0,4 V para o sensor com ferroceno vs. 0,65 V para o caso sem ferroceno). O deslocamento do potencial de detecção para valores menos positivos não foi suficiente para evitar as interferências causadas pelos íons ascorbato e ureato. Para isto, mostrou-se 100% efetivo o recobrimento dos sensores com uma película de Nafion®. A sobreoxidação do poli(pirrol) também mostrou potencialidade para a eliminação de interferentes, embora o processo resulte na perda de sensibilidade, provavelmente causada pela desnaturação da enzima. Quando usado o poli(N-metilpirrol) como suporte para a enzima, obtiveram se melhores respostas, causadas pela possibilidade de se preparar filmes mais espessos, consequentemente de imobilizar maior quantidade de enzima, sem observar perda de resposta causada por problemas difusionais. / The present work describes the elaboration of a biosensor for glucose detection. The enzyme, glucose oxidase, was immobilized in different conducting polymers. Two different polymers were used: polypyrrole and poly(N-methilpyrrole ). With the aim of replacing the molecular oxygen in the transduction step, ferrocene has been immobilized within the conducting polymer. Once the ferrocenium was insoluble in water, in order to develop a different route, the electropolymerization was carried out in a mixture of water and ethanol (1:1). This procedure leads to a polymer with a poor electroactivity, detected by Raman experiments. The ferrocene addition in the sensor increases the sensitivity to the glucose determination (4,33 µA mM-1 cm-2 for the biosensor with ferroecene and 0,23 µA mM-1 cm-2 for the sensor without ferrocene). Alternatively, the sensor containing ferrocene allows to operate at less positive potentials than that one without ferrocene (+ 0,40 V and + 0,65 V, respectively). This potential shift was not enough to inhibit the interference caused by ascorbate and ureate ions. One method to avoid the interference problem was to recover the sensor with a very thin layer of Nafion. Also poly(pyrrole) overoxidation is a very efficient method to eliminate this interference, but this process leads to a sensitivity decrease dueto enzyme denaturation. A better response was observed for sensor assembled using the poly(Nmethyl-pyrrole) as the support for enzyme immobilization. This behavior was provoked by the thicker of polymer film formed leading to higher amount of immobilized enzyme. Even though, no diminution in the response was caused by diffusion problems.
|
63 |
Conductive Stretchable and 3D Printable Nanocomposite for e-Skin ApplicationsAlsharif, Yasir 21 April 2021 (has links)
Electronic skin (e-skin) materials have gained a wide range of attention due to their multiple applications in different areas, including soft robotics, skin attachable electronics, prosthetics, and health care. These materials are required to emulate tactile perceptions and sense the surrounding environments while maintaining properties such as flexibility and stretchability. Current e-skin fabrication techniques, such as photolithography, screen printing, lamination, and laser reducing, have limitations in terms of costs and manufacturing scalability, which ultimately preventing e-skin widespread usage. In this work, we introduce conductive stretchable 3D printable skin-like nanocomposite material. Our nanocomposite is easily 3D printed, cost-effective, and actively senses physical stimuli, such as strain and pressure, which gave them the potential to be used in prosthetics, skin-attachable electronics, and soft robotics applications. Using the conductive properties of carbon nanofibers, alongside a polymeric matrix based on Smooth-on platinum cured silicone and crosslinked PDMS, we can obtain a flexible and stretchable material that resembles human skin and can conduct electricity. A great advantage in our composite is the ability to tune its mechanical properties to fit the desired application area through varying PDMS's chain lengths and composition ratios in the nanocomposite. Also, the interconnecting network of micrometer-long nanofibers allows the measurement of resistivity changes upon physical stimuli, granting the nanocomposite sensing abilities. Moreover, we explored and optimized 3D printing of the nanocomposite material, which offering simplicity and versatility for fabricating complex 3D structures at lower costs.
|
64 |
Novel Membrane-Based Approaches for Mitigating Biosensor InterferentsDeBrosse, Madeleine 24 May 2022 (has links)
No description available.
|
65 |
Coating of yarn with PEDOT-PSS : An examination of optimal manufacturing parameters in a dip coating production line for conductive yarn.Florén, Sandra, Pettersson, Alma January 2022 (has links)
Electrically conductive smart textiles are a very interesting area that could be important for the development of smart textiles. Today, conductive yarns and threads are often produced from coveted metals such as silver, copper and gold. These metals require large resources to be extracted and processed into yarns and threads and have a major impact on humans and the environment. One way to reduce the consumption of metals and save resources is to coat yarns of textile materials with electrically conductive polymers. In this study, we will investigate coating yarns with the conductive polymer blend PEDOT-PSS. PEDOT-PSS is extracted from oil, which is a non-renewable raw material, but coating with this polymer dispersion has many other advantages over metals and its production chain. Like coating yarn through a chemical bath produces very little waste, the yarn has a smaller mass, the yarn becomes more flexible, and it is easy to scale up production. However, previous studies have shown that there are some difficulties when it comes to coating yarns with PEDOT-PSS. The coating becomes fragile and brittle and to some extent affects the yarn that is coated in terms of mechanical properties. In this study, its investigated how the yarn is affected by various parameters in the production line, such as drying temperature, the viscosity of the PEDOT-PSS dispersion and the speed of the thread traveling through the production line, to find optimal production parameters that provide a balance between conductive and mechanical properties. We have produced a number of samples, all with different variations of parameters, and investigated how its conductive and mechanical properties are affected to see if there is a pattern and connection between parameters and conductive and mechanical properties on the yarn. The results show that yarn samples made with high viscosity of the PEDOT-PSS dispersion are among the lower range of resistance (with some exceptions), with average values of about 2990 O up to 10300 O, while lower viscosity shows uneven results with average values of about 92,000 O and all the way up to about 6,500,000 O. Most samples with lower measured O values are made with a high drying temperature, but no clear connection could be detected between temperature and end result, nor did the different speeds show any clear connection to the result. For the mechanical properties, it turns out that there is a relationship between result and viscosity as well as result and drying temperature. Samples made with low viscosity and low drying temperature perform best in the mechanical tests, 59.7% to 52.9% elongation and 25 cN / tex to 21 cN / tex. While speeds in this category could not show any connection between the results either. Overall, the results can be summarized as the results of tests show that there are some correlations between the parameters and the properties of the yarn samples and that the viscosity of the PEDOT-PSS dispersion and drying temperature are the most influential parameters. For conductive properties, viscosity has the greatest effect and for mechanical properties, viscosity and temperature have the greatest effect. For conductive properties, high viscosity is good, and for mechanical properties, low temperature and low viscosity are best. The sample with the best combination of test results was tested in a knitting machine but the variant chosen for knitting did not have good enough mechanical properties for the knitting machine used and broke when exposed to the stress from the knitting process. Therefore, the knitting test was not successful, but it was possible to sift out what parameter of the production line that had the greatest impact on the coated yarn properties.
|
66 |
The Radiative and Conductive Heat Exchange of a Cold DesertMartinez, Luis R. 01 May 1975 (has links)
The heat exchange during dry conditions in Curlew Valley for selected clear days is determined from recordings in 10 minute intervals . The two heat budget components , radiative exchange and heat flow in the soil, are studied in detail.
Maximum surface temperature due to radiative exchange above, assuming no heat loss by other components, is determined.
Reduction of surface temperature by heat conduction into the ground was calculated as a second step to solve the heat budget equation.
Substantial heat flow throughout a day is restricted to the upper 10 em of the soil. Diffusivity of the soil was determined from soil temperature using phase and amplitude equations, of which the first gave better results.
|
67 |
Processing of Generic Circuits by Conductive Adhesives: Geometrical and Rheological ConsiderationsZhou, Jianguo 02 October 2007 (has links)
No description available.
|
68 |
Resistive Switching Behavior in Low-K Dielectric Compatible with CMOS Back End ProcessFan, Ye 16 January 2017 (has links)
In an effort to lower interconnect time delays and power dissipation in highly integrated logic and memory nanoelectronic products, numerous changes in the materials and processes utilized to fabricate the interconnect have been made in the past decade. Chief among these changes has been the replacement of aluminum (Al) by copper (Cu) as the interconnect metal and the replacement of silicon dioxide (SiO2) by so called low dielectric constant (low-k) materials as the insulating interlayer dielectric (ILD). Cu/low-k structure significantly decreases the RC delay compared with the traditional interconnect (Al/SiO₂). Therefore, the implementation of low-k dielectric in Cu interconnect structures has become one of the key subjects in the microelectronics industry. Incorporation of pores into the existing low-k dielectric is a favorable approach to achieve ultra low-k ILD materials.
To bring memory and logic closer together is an effective approach to remove the latency constraints in metal interconnects. The resistive random access memories (RRAM) technology can be integrated into a complementary metal-oxide-semiconductor (CMOS) metal interconnect structure using standard processes employed in back-end-of-line (BEOL) interconnect fabrication. Based on this premise, the study of this thesis aims at assessing a possible co-integration of resistive switching (RS) cells with current BEOL technology. In particular, the issue is whether RS can be realized with porous dielectrics, and if so, what is the electrical characterization of porous low-k/Cu interconnect-RS devices with varying percentages of porosity, and the diffusive and drift transport mechanism of Cu across the porous dielectric under high electric fields.
This work addresses following three areas:
1. Suitability of porous dielectrics for resistive switching memory cells. The porous dielectrics of various porosity levels have been supplied for this work by Intel Inc. In course of the study, it has been found that Cu diffusion and Cu+ ion drift in porous materials can be significantly different from the corresponding properties in non-porous materials with the same material matrix.
2. Suitability of ruthenium as an inert electrode in resistive switching memory cells. Current state-of-the-art thin Cobalt (Co)/Tantalum Nitride (TaN) bilayer liner with physical vapor deposited (PVD) Cu-seed layer has been implemented for BEOL Cu/low-k interconnects. TaN is used for the barrier and Co is used to form the liner as well as promoting continuity for the Cu seed. Also, the feasibility of depositing thin CVD ruthenium (Ru) liners in BEOL metallization schemes has been evaluated. For this study, Ru is used as a liner instead of Ta or Co in BEOL interconnects to demonstrate whether it can be a potential candidate for replacing PVD-based TaN/Ta(Co)/Cu low-k technology. In this context, it is of interest to investigate how Ru would perform in well-characterized RS cell, like Cu/TaOx/Ru, given the fact that Cu/TaOx/Pt device have been proven to be good CBRAM device due to its excellent unipolar and bipolar switching characteristics, device performance, retention, reliability. If Cu/TaOx/Ru device displays satisfactory resistive switching behavior, Cu/porous low-k dielectric/Ru structure could be an excellent candidate as resistive switching memory above the logic circuits in the CMOS back-end.
3. Potential of so-called covalent dielectric materials for BEOL deployment and possibly as dielectric layer in the resistive switching cells. The BEOL reliability is tied to time dependent failure that occurs inside dielectric between metal lines. Assessing the suitability of covalent dielectrics for back-end metallization is therefore an interesting topic. TDDB measurements have been performed on pure covalent materials, low-k dielectric MIM and MI-semiconductor (MIS) devices supplied by Intel Inc. / Master of Science
|
69 |
Development of sensing concrete: principles, properties and its applicationsDing, S., Dong, S., Ashour, Ashraf, Han, B. 14 November 2019 (has links)
Yes / Sensing concrete has the capability to sense its condition and environmental changes, including stress (or force),
strain (or deformation), crack, damage, temperature and humidity through incorporating functional fillers. Sensing
concrete has recently attracted major research interests, aiming to produce smart infrastructures with elegantly
integrated health monitoring abilities. In addition to having highly improved mechanical properties, sensing concrete
has multifunctional properties, such as improved ductility, durability, resistance to impact, and most importantly self-health monitoring due to its electrical conductivity capability, allowing damage detection without the need of an
external grid of sensors. This tutorial will provide an overview of sensing concrete, with attentions to its principles,
properties, and applications. It concludes with an outline of some future opportunities and challenges in the application
of sensing concrete in construction industry. / National Science Foundation of China (51978127 and 51908103), the China Postdoctoral Science Fundation (2019M651116) and the Fundamental Research Funds for the Central Universities in China (DUT18GJ203). / National Science Foundation of China (NSFC) (Nos. 51978127 and 51908103), the China Postdoctoral Science Foundation (No. 2019M651116), and the Fundamental Research Funds for the Central Universities in China (No. DUT18GJ203).
|
70 |
Oligoaniline-based conductive biomaterials for tissue engineeringZarrintaj, P., Bakhshandeh, B., Saeb, M.R., Sefat, Farshid, Rezaeian, I., Ganjali, M.R., Ramakrishna, S., Mozafari, M. 04 April 2018 (has links)
No / The science and engineering of biomaterials have improved the human life expectancy. Tissue engineering
is one of the nascent strategies with an aim to fulfill this target. Tissue engineering scaffolds are one of the
most significant aspects of the recent tissue repair strategies; hence, it is imperative to design biomimetic substrates with suitable features. Conductive substrates can ameliorate the cellular activity through enhancement of cellular signaling. Biocompatible polymers with conductivity can mimic the cells’ niche in an appropriate manner. Bioconductive polymers based on aniline oligomers can potentially actualize this purpose because of their unique and tailoring properties. The aniline oligomers can be positioned within the molecular structure of other polymers, thus painter acting with the side groups of the main polymer or acting as a comonomer in their backbone. The conductivity of oligoaniline-based conductive biomaterials can be tailored to mimic the electrical and mechanical properties of targeted tissues/organs.
These bioconductive substrates can be designed with high mechanical strength for hard tissues such as the bone and with high elasticity to be used for the cardiac tissue or can be synthesized in the form of injectable hydrogels, particles, and nanofibers for noninvasive implantation; these structures can be used for applications such as drug/gene delivery and extracellular biomimetic structures. It is expected that with progress in the fields of biomaterials and tissue engineering, more innovative constructs will be proposed in the near future. This review discusses the recent advancements in the use of oligoaniline-based conductive biomaterials for tissue engineering and regenerative medicine applications.
|
Page generated in 0.049 seconds