Introdução: Os idosos representam um segmento demográfico crescente tanto nos países desenvolvidos como nos em desenvolvimento. A constipação intestinal é um sintoma relatado por 24 a 40% desses indivíduos, afetando 26% dos homens e 34% das mulheres. O consumo de uma dieta rica em fibras alimentares e líquidos ajuda na diminuição das queixas relacionadas à constipação intestinal funcional. Os idosos necessitam de atenção especial com intervenções dietéticas diferenciadas por meio de ações educativas específicas. Objetivo: Analisar os efeitos do aconselhamento nutricional centrado no cliente, em idosos com constipação intestinal funcional matriculados em ambulatório geriátrico. Métodos: O estudo foi experimental do tipo ensaio clínico aleatorizado realizado entre abril de 2002 e novembro de 2003. Os idosos foram alocados em grupo intervenção (n=19) e controle (n=21) e os dois grupos participaram de sete consultas mensais. O aconselhamento nutricional centrado no cliente foi o modelo educativo adotado nas consultas com o grupo intervenção. Esse modelo considera a educação como o processo de ensino, treinamento e facilitação, que permite a troca de informações entre o educador e o educando, por meio de uma linguagem entendível, dentro de um ambiente que conduz ao aprendizado. As variáveis analisadas foram: Índice de Massa Corporal (IMC), prática de atividade física, consumo alimentar (energia, carboidratos, lipídios, grupo das frutas, das leguminosas, ingestão de líquidos, grupo dos cereais, consumo de fibras alimentares), uso de medicamentos total e laxante e as queixas que caracterizam a constipação intestinal funcional. O consumo alimentar foi avaliado pelo recordatório de 24 horas em medidas caseiras e a atividade física pelo Questionário de Baecke. Os dados foram analisados por meio da Análise de Variância de Medidas Repetidas (paramétrica ou não paramétrica) e método de Bonferroni. O nível de significância adotado para os testes foi de 5%. Resultados: Os idosos mais jovens do grupo controle eram mais pesados que os mais velhos desde o início do acompanhamento (p=0,001) e os dois grupos não alteraram a prática de atividade física. O grupo intervenção aumentou o consumo de líquidos a partir da quarta consulta até o final do seguimento quando comparado à entrevista inicial (p=0,031) e, no que se refere à ingestão de leguminosas, observou-se aumento no consumo na quarta (p=0,028) e sexta (p=0,042) consultas na comparação intergrupos. Em relação ao uso de medicamentos total, tanto o grupo controle quanto o grupo intervenção não modificaram seu consumo (p=0,650), por outro lado, o grupo controle consumiu mais laxantes durante o acompanhamento quando comparado ao grupo intervenção (p=0,018). Os dois grupos apresentaram redução das queixas que caracterizam a constipação intestinal funcional durante o seguimento. Conclusões: Os resultados desse estudo indicam que o aconselhamento centrado no cliente é eficaz como uma abordagem educativa para a mudança de comportamento alimentar e conseqüente diminuição das queixas intestinais que caracterizam a constipação intestinal funcional. / Introduction: The elderly represent a growing demographic line not only in the developed countries but also the ones in developing. The bowel constipation is a related symptom for 24 to 40% of those persons, affecting 26% men e 34% women. The consumption of diet full in dietary fibers and liquids helps on decreasing of claims related to functional intestinal constipation. The elderly need to a special attention with diversified dietetics intervention through specific educated actions. Objective: Analyze the effects of client-centered nutritional counseling, in elderly with functional bowel constipation enrolled in geriatric ambulatory. Methods: The studying was experimental as a randomized clinic trial carried out between April 2002 and November 2003. Elderly were assigned in intervention group (n=19) and control (n=21) and both groups participated of seven consults, one per month. The client-centered nutritional counseling was the educating model adopted in consults with the intervention group. That model takes into account the education as the process of teaching, training and make it easy, that allows the changing of information between the educator and the student through understanding language inside of a place that lead to learning. The variables analyzed were: Body Mass Index (BMI), practice of physical activity, food intake (energy, carbohydrate, lipids, group of fruits, group of leguminous, ingestion of liquids, group of cereals, intake of dietary fibers), using of total drugs and laxatives and the claims that characterizes the functional bowel constipation. The food intake was evaluated with 24 hours recall on household measures and the physical activity by Baecke Questionnaire. The data were examined critically through Analyses of Variance With Repeated Measures (parametric and non-parametric) and Bonferroni's method. The significance level adopted to the tests was 5%. Results: The youngest elderly of control group were heavier than the oldest since the beginning of accompanying (p=0,001) and both group didn't change the practicing of physical activity. The intervention group increased the consumption of liquids since of fourth consult up the ending of segment when compared with initial interview (p=0,031) and, in what refers to ingestion of leguminous, it was observed an increasing in consumption in forth (p=0,028) and sixth (p=0,042) consults in the comparing between the groups. Relating the using of total drugs, not only the control group but also intervention group didn't change their consumption (p=0,650), on the other hand, the control group consumed more laxatives during the accompanying when compared to intervention group (p=0,018). Both groups presented reduction of claims that characteristic the functional bowel constipation during the segment. Conclusions: The results of that studying indicate that the client-centered counseling is efficient as an educative approach to the changing of alimentary behavior and consequent reduction of intestinal claims that characterize the functional bowel constipation.

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Orientador: Elizete Aparecida Lomazi da Costa Pinto / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-08-07T13:04:46Z (GMT). No. of bitstreams: 1 VerasNeto_MagnoCardoso_M.pdf: 1277080 bytes, checksum: 79819f766291c884cad1299f8efb29ef (MD5) Previous issue date: 2006 / Resumo: A constipação intestinal é um problema freqüente na população pediátrica e sua apresentação clínica expressa grande heterogeneidade. Um grupo de pacientes constipados apresenta constipação refratária ao tratamento habitual e os conceitos fisiopatológicos clássicos pouco contribuíram para os avanços terapêuticos desejáveis a esses pacientes. O reconhecimento de distúrbios da motilidade gastrointestinal pode contribuir para o entendimento da fisiopatologia da constipação intestinal em crianças. Assim, o objetivo deste trabalho foi comparar os valores dos índices de contratilidade da vesícula biliar em crianças com constipação intestinal crônica funcional com aqueles de crianças sadias. Foi realizado estudo observacional, analítico e transversal, sendo selecionados como casos todos os pacientes com diagnóstico de constipação intestinal funcional, na faixa etária de 2 a 16 anos, em acompanhamento no ambulatório de Gastroenterologia Pediátrica do Hospital das Clínicas da UNICAMP no período de janeiro de 2004 a agosto de 2005. Os controles foram selecionados a partir de Unidades Básicas de Saúde de Campinas e região e pareados por sexo e idade. Casos e controles foram incluídos num protocolo de estudo e em seguida, foi realizado exame ultra-sonográfico pelo mesmo observador, mascarado e com registro dos índices de contratilidade. Foi considerado alterado o índice de contratilidade menor que 25%. Foram avaliados 132 casos e o mesmo número de controles. O índice de contratilidade da vesícula biliar apresentou diferença estatisticamente significativa entre os grupos, sendo menor nos pacientes constipados (31,5 ± 16,9 vs. 41,6 ± 12,7; p<0,001). Não houve diferença significativa no índice de contratilidade da vesícula biliar dos pacientes constipados de acordo com a idade de início da constipação, hábito intestinal, presença de escape fecal ou impactação, sintomas digestivos e uso de laxativos. Concluímos que, para o grupo de pacientes estudados, a contratilidade da vesícula biliar mostrou-se menor. Deste modo, a constipação intestinal pode representar um distúrbio mais amplo da motilidade do trato gastrintestinal / Abstract: Intestinal constipation is a frequent condition in pediatric population. Clinical presentation is heterogeneous. A group of children has a refractory outcome despite habitual therapy. Clinical picture in these children may result from physiopathologic mechanisms related to gastrointestinal motility disorders. Gastrointestinal motility investigation in children with functional constipation may add useful information for managing refractory patients. The objective of this study was to evaluate gallbladder motility in constipated children. An observational, cross-sectional study design was conducted. Research period included patients seen from January, 2004 to August, 2005 in a pediatric outclinic of a School Hospital. All patients with functional constipation assisted in the period were included (age range: 2 - 16 years). The control group was selected from Pediatrics Outclinics which usually sent patients to the School Hospital. The control group was matched for sex and age. Patients were interviewed for filling a study protocol. Gallbladder contractility index, calculated from fast and post-prandial area, was calculated in children with refractory functional constipation, using an ultrassonographic method. Data were compared with results obtained in healthy children. Ultrassonography studies were performed by the same physician in a blinded way. One-hundred-thirty-two constipated children and the same number of healthy children were included. Contractility index from constipated children was inferior than index from healthy children (31,5 ± 16,9 vs. 41,6 ± 12,7, p<0,001). There was no significant difference in contractility index from constipated children analyzed for constipation duration, evacuation frequency, and occurrence of soiling or fecal impaction, laxatives use and clinical symptoms. In a group of children with refractory intestinal constipation the gallbladder motility is reduced when compared with healthy children. This phenomenon may light up the understanding about functional constipation in children / Mestrado / Saude da Criança e do Adolescente / Mestre em Saude da Criança e do Adolescente

Title: The path(way) to a clean colon: Improving the management of functional constipation Authors: Sarah Nichols, D.O. Pediatrics Resident, Nathan Justice, M.D. Pediatrics Hospital Medicine, Anjali Malkani, M.D. Pediatric Gastroenterology, David Wood, M.D., MPH General Pediatrics and Adolescent Medicine Purpose / Objectives: Hospitalization for the treatment of functional constipation is a leading cause among encounters that incur a financial loss at our institution. There are few resources that describe best practices or quality improvement efforts in the management of children who are hospitalized with functional constipation. A clinical pathway was implemented to promote interventions that improve hospital resource utilization for this group of children. Design / Methods: A clinical pathway was developed by a multidisciplinary team of stakeholders. The pathway emphasized interventions known to improve resource utilization and believed to facilitate a more effective and efficient cleanout. The inpatient arm of the pathway was implemented on a 24-bed medical/surgical unit; members of the medical and clinical staff of this unit received education with dissemination of the pathway. An electronic order set was implemented concurrently to facilitate practitioners’ application of pathway recommendations. Plan-Do-Study-Act (PDSA) cycles were used to monitor process measures and outcomes. Inpatient utilization was selected as the primary outcome for this effort’s first iteration; length of stay and frequency of readmissions were monitored as a secondary outcome and balancing measure, respectively. Results: Pathway utilization reached 65% within two periods of implementation. Adherence to selected process measures exceeded 80% within two periods. Inpatient utilization demonstrated initial improvement, increasing from 20% at baseline to 50% post-implementation; however, it subsequently fell below baseline performance after third-party payers revised admission criteria during period 6. Length of stay and frequency of readmissions remained unchanged post-intervention. Conclusion / Discussion: A clinical pathway for the treatment of functional constipation was quickly adopted by clinicians within two periods of implementation (spanning two months). The pathway was effective at promoting interventions that improved inpatient utilization; however, these improvements could not be sustained in the face of an unanticipated, external force. Future improvement cycles will be directed at reducing the length of stay to improve hospital resource utilization.

Chronic constipation is a very common problem that negatively affects the quality of life of patients, especially the elderly population. It can also lead to significant health care expenditure. Careful assessment by obtaining a thorough history and physical examination with limited indicated diagnostic testing is important to identify potential underlying etiologies and to treat effectively.

The U.S. health care system is evolving from medical centric to patient centered, augmenting the importance for patients to comprehend and process medical information. The Department of Education indicated that 77 million Americans have a basic or below basic health literacy proficiency and 12% register as health literacy proficient. Animation is a time-tested device for improving health by enhancing comprehension. Chronic constipation (CC) complexity entails physiological, anatomical, and environmental mechanisms. Using the cognitive theory of multimedia learning and dual-channel auditory and visual processing, the primary research question addressed whether an animated educational video improved health literacy for CC more than a traditional written educational pamphlet. A secondary dataset of 100 CC subjects from the University of Michigan was collected using a cross-sectional study design with a convenience sampling strategy of CC patients who underwent anorectal functional testing. Dependent variables were CC Pretest Quiz and CC Posttest Quiz scores, and independent variables included CC education intervention, demographics, health literacy proficiency, and environmental learning variables. Descriptive and analytical statistical methods were employed for data summarization and comparison. The animated educational video had minimal impact (p = 0.20) on improving health literacy; however, pretest scores (p -?¤ 0.001), age (p = 0.03) and highest level of education achievement (p = 0.03) influenced the largest variance between quiz scores. Enhancing health literacy influences social change by empowering individuals with CC to improve quality of life metrics, increase work productivity, and decrease health care utilization costs.

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Osmotic laxatives produce the best results. Fiber and behavior modification may have a role. Increased fiber and behavior modification are the most often recommended first steps in managing chronic functional constipation (CFC) in children, but only limited evidence supports this approach. For pharmacologic management, the best evidence supports osmotic laxatives.

Major Depressive Disorder (MDD) is a common and debilitating mental illness primarily characterized by depressed mood and anhedonia, as well as a heterogenous mixture of other somatic symptoms. Existing therapies for MDD act primarily on monoamine transporters and receptors, with only partial success. A more recent advancement in depression treatment is the identification of the N-methyl-d-aspartate receptor (NMDAR) antagonist (R,S)-ketamine, which has shown efficacy in individuals with treatment resistant depression. Studies have raised the possibility of a mu opioid receptor (MOR)-dependent component to the actions of (R,S)- ketamine, through direct activation of MOR or indirect effects of NMDAR antagonism on endogenous opioids. Considering the ongoing global opioid epidemic, in which over prescribing of opioid painkillers and greater availability of illicit opioids has caused significant morbidity and mortality, studies suggesting an opioid component to ketamine’s actions have caused concern. We undertook the current experiments to better understand 1) the contribution of MORs to the behavioral effects of ketamine, and 2) how very low efficacy agonism of MOR may lead to a better separation between the desirable and undesirable effects of opioid drugs. Previous work from collaborators had established that a single dose of (R,S)-ketamine, specific hydroxynorketamine (HNK) metabolites, and the memantine derivative fluoroethylnormemantine (FENM), given one week before a contextual fear conditioning stressor could prevent the development of learned fear and behavioral despair. Moreover, some of these drugs also prevented the development of learned fear and behavioral despair when given shortly after the contextual fear conditioning stressor. We were interested in how (R,S)- ketamine’s reported MOR activity may contribute to these behavioral effects. We began by testing these compounds in cell-based signaling assays to determine their ability to directly activate MORs. We found that the parent (R)- and (S)-ketamine enantiomers could activate MORs with low potency in a high amplification G protein activation assay. In contrast, in low amplification miniG-based assays, the compounds tested showed little to no activation of MOR, suggesting that (R,S)-ketamine activates MOR with low potency and low efficacy. We moved to experiments in mice with the pseudo-irreversible MOR antagonist methocinnamox (MCAM) and attempted to block various behavioral effects of (R,S)-ketamine and the more selective NMDAR antagonist (FENM). We found that MCAM pretreatment blocked effects of (R,S)-ketamine on antinociception, behavioral despair, and learned fear, while other effects such as anesthesia and changes in hippocampal electrophysiology were not prevented by MCAM. With FENM the antinociceptive effects were less potent and less impacted by MCAM; however, the effects on behavioral despair and learned fear were still MORdependent. These results suggest that the protective effects of (R,S)-ketamine and FENM against stress may be an indirect effect of NMDAR antagonism on endogenous opioids. In a separate line of experiments, we used a range of doses of MCAM to antagonize the behavioral effects of morphine, the MOR agonist antidepressant tianeptine, and the MOR partial agonist 7-OH mitragynine. 7-OH mitragynine is a metabolite of mitragynine, the major alkaloid in kratom, which some reports suggest may have antidepressant and anxiolytic properties. Based on fundamentals of pharmacology, we hypothesized that inherent differences in the presence of “spare receptors” or receptor reserve between brain circuits could be revealed by differential inhibition by MCAM across behaviors and agonists. We assessed the inhibitory potency of MCAM against these drugs in tests of antinociception, hyperlocomotion, behavioral despair, respiration, and gastrointestinal motility. We found that MCAM pretreatment more potently inhibited the low efficacy agonist 7-OH mitragynine in the tests of antinociception, behavioral despair, and constipation. These data suggest that in circuits modulating antinociception, behavioral despair, and constipation, differences in receptor reserve likely facilitate the response to low efficacy agonists. However, our data also argue that the wider therapeutic window of G protein biased, low intrinsic efficacy MOR agonists is not solely a result of differences in the number of “spare” MORs regulating the effects of opioids in different circuits.

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