Esta dissertação trata dos Estudos Animais, área que se desenvolve como um rico campo de interdisciplinaridade já em sua origem. Mas para que não se julgue aprioristicamente um campo em suas particularidades, há que se esclarecer pontos em comum aos teóricos das mais diversas origens acadêmicas que compõem os Estudos animais e traçar planos para um futuro significativo. Após estabelecer os necessários diálogos entre teoria e campo social, passo à análise de certos pontos das obras Desonra e Elizabeth Costello, com o objetivo de evidenciar o potencial deste corpus para o desenvolvimento da crítica das categorias de humanidade e animalidade segundo os aportes do Pós-humanismo e inserindo-a no campo dos Estudos Animais. O teórico fundamental para este trabalho é Jacques Derrida, principalmente em sua obra O animal que logo sou. Após apresentar um panorama dos Estudos Animais, sobretudo sob a abordagem de Paul Waldau, trago ao encontro desses autores a pós-humanista Rosi Braidotti, de cuja obra The Post-human retiro as categorias do devir-planetário e devir-animal, as quais dão consequência às análises do corpus literário deste trabalho. Dialogo, ainda, com a Mitleidsethik, a ética da compaixão de Schopenhauer. Concluo que as tarefas dos Estudos Animais e do Pós-humanismo se assemelham no que toca à maior compreensão das interações interespecíficas, para a proposição consequente de novas formas de conviver num mundo mais-que-humano. / This dissertation deals with the Animal Studies, an area that develops as a rich field of interdisciplinarity already in its origin.. But in order not to make an aprioristic judgement of a field in its particularities, it is necessary to clarify points in common to the theoreticians of the most diverse academic origins that compose the Animal Studies and to draw up plans for a significant future. After establishing the necessary dialogues between theory and social field, I proceed to the analysis of certain points of the works Disgrace and Elizabeth Costello, with the objective of highlighting the potential of this corpus for the development of the critique of the categories of humanity and animality according to the contributions of Posthumanism and inserting it in the field of Animal Studies. The fundamental theorist for this work is Jacques Derrida, mainly in his work O animal que logo sou. After presenting an overview of the Animal Studies, especially under the approach of Paul Waldau, I bring to the meeting the post-humanist Rosi Braidotti, whose work The post-human retreat the categories of becoming-earth and becoming-animal, which give consequence to the analysis of the literary corpus of this work. I also dialogue with the Mitleidsethik, the ethic of compassion of Schopenhauer. I conclude that the tasks of Animal Studies and Post-humanism are similar in relation to the greater understanding of the inter-species interactions, for the consequent proposition of new ways of living in a more-than-human world.

Previous studies suggest that the IGF-I stimulates the elastin gene transcription through the unique responsive sequence on the elastin promoter, which is a putative retinoblastoma control element (RCE). This site interacts with (Sp)-family transcription factors whose delivery is mediated by the retinoblastoma protein (Rb). Since Rb (phosphorylated on serine 780) has been implicated in the initiation of the cell cycle, we speculated that a different phosphorylation of Rb might determine Rb involvement in elastogenesis. Obtained results demonstrated that, IGF-I-induced elastogenic signaling pathway in human dermal fibroblasts includes activation of cyclinE/cdk2 causing a site specific phosphorylation of Rb on threonine 821. This permits the sequestration of Sp1 by Rb before it could bind the elastin promoter, thereby allowing the elastin gene transcription. We also found that blocking of H-Ras in Costello syndrome fibroblasts (characterized by heightened proliferation and impaired elastogenesis), selectively down-regulated Rb phosphorylation on serine 780 and normalized impaired elastogenesis.

Previous studies suggest that the IGF-I stimulates the elastin gene transcription through the unique responsive sequence on the elastin promoter, which is a putative retinoblastoma control element (RCE). This site interacts with (Sp)-family transcription factors whose delivery is mediated by the retinoblastoma protein (Rb). Since Rb (phosphorylated on serine 780) has been implicated in the initiation of the cell cycle, we speculated that a different phosphorylation of Rb might determine Rb involvement in elastogenesis. Obtained results demonstrated that, IGF-I-induced elastogenic signaling pathway in human dermal fibroblasts includes activation of cyclinE/cdk2 causing a site specific phosphorylation of Rb on threonine 821. This permits the sequestration of Sp1 by Rb before it could bind the elastin promoter, thereby allowing the elastin gene transcription. We also found that blocking of H-Ras in Costello syndrome fibroblasts (characterized by heightened proliferation and impaired elastogenesis), selectively down-regulated Rb phosphorylation on serine 780 and normalized impaired elastogenesis.

Esta dissertação trata dos Estudos Animais, área que se desenvolve como um rico campo de interdisciplinaridade já em sua origem. Mas para que não se julgue aprioristicamente um campo em suas particularidades, há que se esclarecer pontos em comum aos teóricos das mais diversas origens acadêmicas que compõem os Estudos animais e traçar planos para um futuro significativo. Após estabelecer os necessários diálogos entre teoria e campo social, passo à análise de certos pontos das obras Desonra e Elizabeth Costello, com o objetivo de evidenciar o potencial deste corpus para o desenvolvimento da crítica das categorias de humanidade e animalidade segundo os aportes do Pós-humanismo e inserindo-a no campo dos Estudos Animais. O teórico fundamental para este trabalho é Jacques Derrida, principalmente em sua obra O animal que logo sou. Após apresentar um panorama dos Estudos Animais, sobretudo sob a abordagem de Paul Waldau, trago ao encontro desses autores a pós-humanista Rosi Braidotti, de cuja obra The Post-human retiro as categorias do devir-planetário e devir-animal, as quais dão consequência às análises do corpus literário deste trabalho. Dialogo, ainda, com a Mitleidsethik, a ética da compaixão de Schopenhauer. Concluo que as tarefas dos Estudos Animais e do Pós-humanismo se assemelham no que toca à maior compreensão das interações interespecíficas, para a proposição consequente de novas formas de conviver num mundo mais-que-humano. / This dissertation deals with the Animal Studies, an area that develops as a rich field of interdisciplinarity already in its origin.. But in order not to make an aprioristic judgement of a field in its particularities, it is necessary to clarify points in common to the theoreticians of the most diverse academic origins that compose the Animal Studies and to draw up plans for a significant future. After establishing the necessary dialogues between theory and social field, I proceed to the analysis of certain points of the works Disgrace and Elizabeth Costello, with the objective of highlighting the potential of this corpus for the development of the critique of the categories of humanity and animality according to the contributions of Posthumanism and inserting it in the field of Animal Studies. The fundamental theorist for this work is Jacques Derrida, mainly in his work O animal que logo sou. After presenting an overview of the Animal Studies, especially under the approach of Paul Waldau, I bring to the meeting the post-humanist Rosi Braidotti, whose work The post-human retreat the categories of becoming-earth and becoming-animal, which give consequence to the analysis of the literary corpus of this work. I also dialogue with the Mitleidsethik, the ethic of compassion of Schopenhauer. I conclude that the tasks of Animal Studies and Post-humanism are similar in relation to the greater understanding of the inter-species interactions, for the consequent proposition of new ways of living in a more-than-human world.

Esta dissertação trata dos Estudos Animais, área que se desenvolve como um rico campo de interdisciplinaridade já em sua origem. Mas para que não se julgue aprioristicamente um campo em suas particularidades, há que se esclarecer pontos em comum aos teóricos das mais diversas origens acadêmicas que compõem os Estudos animais e traçar planos para um futuro significativo. Após estabelecer os necessários diálogos entre teoria e campo social, passo à análise de certos pontos das obras Desonra e Elizabeth Costello, com o objetivo de evidenciar o potencial deste corpus para o desenvolvimento da crítica das categorias de humanidade e animalidade segundo os aportes do Pós-humanismo e inserindo-a no campo dos Estudos Animais. O teórico fundamental para este trabalho é Jacques Derrida, principalmente em sua obra O animal que logo sou. Após apresentar um panorama dos Estudos Animais, sobretudo sob a abordagem de Paul Waldau, trago ao encontro desses autores a pós-humanista Rosi Braidotti, de cuja obra The Post-human retiro as categorias do devir-planetário e devir-animal, as quais dão consequência às análises do corpus literário deste trabalho. Dialogo, ainda, com a Mitleidsethik, a ética da compaixão de Schopenhauer. Concluo que as tarefas dos Estudos Animais e do Pós-humanismo se assemelham no que toca à maior compreensão das interações interespecíficas, para a proposição consequente de novas formas de conviver num mundo mais-que-humano. / This dissertation deals with the Animal Studies, an area that develops as a rich field of interdisciplinarity already in its origin.. But in order not to make an aprioristic judgement of a field in its particularities, it is necessary to clarify points in common to the theoreticians of the most diverse academic origins that compose the Animal Studies and to draw up plans for a significant future. After establishing the necessary dialogues between theory and social field, I proceed to the analysis of certain points of the works Disgrace and Elizabeth Costello, with the objective of highlighting the potential of this corpus for the development of the critique of the categories of humanity and animality according to the contributions of Posthumanism and inserting it in the field of Animal Studies. The fundamental theorist for this work is Jacques Derrida, mainly in his work O animal que logo sou. After presenting an overview of the Animal Studies, especially under the approach of Paul Waldau, I bring to the meeting the post-humanist Rosi Braidotti, whose work The post-human retreat the categories of becoming-earth and becoming-animal, which give consequence to the analysis of the literary corpus of this work. I also dialogue with the Mitleidsethik, the ethic of compassion of Schopenhauer. I conclude that the tasks of Animal Studies and Post-humanism are similar in relation to the greater understanding of the inter-species interactions, for the consequent proposition of new ways of living in a more-than-human world.

Thesis (MA (English))--University of Stellenbosch, 2009. / ENGLISH ABSTRACT: In its conversations with four texts by J.M. Coetzee – Age of Iron (1990), Life & Times of Michael K (1983), Elizabeth Costello: Eight Lessons (2003) as well as the critical essays published in Doubling the Point, “The Poetics of Reciprocity” (1992) – this thesis will demonstrate the manner in which the singularities of each of these texts prompt, expand and challenge the framework that sustains its reading of Coetzee’s fiction. Whereas some critical methodologies seek to eliminate the characteristic indeterminacy of Coetzee’s fiction, imprisoning his novels in a contextual cage, this thesis demonstrates an allegiance to the primacy of the literary text together with a concern with the ethics of reading. The thesis proposes – in both content and form – an inductive ‘style of reading’ concerned with the continuous modification of its own strategies according to the ‘internal logics of the text’. I first encountered the term, ‘confinement’, in relation to Coetzee in an unpublished conference paper by Lucy Graham, “‘It is hard to keep out of the camps’: Areas of confinement in the fiction of J.M. Coetzee”. Graham’s paper focuses on the different camps, the ‘different circles of hell’, in Life & Times of Michael K especially, mentioning that ‘images of the camp resonate throughout Coetzee’s most recent fiction’. Although this thesis considers a variety of concrete and conceptual camps as well, it rather places predominant emphasis on the relationship between reader and literary text, which is examined in terms of two forms of delimitation, confinement and containment. This study identifies its style of reading as a ‘containment’ rather than a ‘confinement’. The term is intended to evoke an adaptable, constructive delineation of Coetzee’s fiction that involves a reciprocal relationship between reader and/or critic and text. As the thesis’s primary conceptual tool, one that I will argue is both solicited and thematised in Coetzee’s fiction, containment refers not only to a style of reading, but also to any reciprocal relationship, any mutual exchange. It applies to the relationship between genres (realism and metafiction) and ‘reality’ in Age of Iron; between text and reader in Life & Times of Michael K; between self and other in Elizabeth Costello; and between text and critic in “The Poetics of Reciprocity”. The notion of containment accepts the critical challenge posed by Coetzee’s fiction to engage with what Derek Attridge would call each ‘singular event’ or ‘act of literature’ on its own terms. / AFRIKAANSE OPSOMMING: In die tesis se gesprek met vier tekste deur J.M. Coetzee – Age of Iron (1990), Life and Times of Michael K (1983), Elizabeth Costello: Eight Lessons (2003) asook die kritiese tekste wat in Doubling the Point, “The Poetics of Reciprocity” (1992) gepubliseer is – sal dit toon hoe die sonderlinghede van elk van hierdie tekste die raamwerk wat my interpretasie van Coetzee se fiksie ondersteun, uitbrei en uitdaag. Waar sekere kritiese metodologieë probeer om die kenmerkende onbepaaldheid van Coetzee se fiksie te elimineer en sy romans in ’n konstekstuele hok te beperk, demonstreer hierdie tesis ’n getrouheid aan die voorrang wat die literêre teks moet geniet, insluitend ’n gemoeidheid met die etiek van lees. Die tesis stel, ten opsigte van sowel inhoud as vorm, ’n induktiewe ‘leesstyl’ voor wat gemoeid is met die deurentydse aanpassing van sy eie strategieë volgens ‘die interne logikas van die teks’. Ek het die term ‘beperking’ vir die eerste keer teëgekom in ’n ongepubliseerde referaat deur Lucy Graham, “‘It is hard to keep out of the camps’: Areas of confinement in the fiction of J.M. Coetzee”. Hierdie voordrag fokus op die onderskeie kampe in spesifiek Life & Times of Michael K. Graham wys daarop dat ‘die kamp-beeld in resente Coetzee-werke resoneer’. Alhoewel hierdie tesis ook variante van konkrete en konsepsuele kampe bekyk, gaan dit verder om by voorkeur die klem te laat val op die verhouding tussen leser en literêre teks. Dit word ondersoek in terme van twee vorme van afbakening en ontperking, naamlik beperking en inperking. Hierdie studie definieer sy eie leesstyl as ‘inperking’, in teenstelling tot ‘beperking’. Die bedoeling met die term is om `n aanpasbare, konstruktiewe afbakening van Coetzee se fiksie te ontlok wat ’n wedersydse verhouding tussen leser en/of kritikus en teks behels. As die tesis se primêre konsepsuele instrument, waarvan ek sal aanvoer dat dit in Coetzee se fiksie aangevra en getematiseer word, verwys ‘inperking’ nie net na leesstyl nie, maar ook na enige wederkerige verhouding, enige wedersydse uitruiling. Dit geld vir die verhouding tussen genres (realisme en metafiksie) en realiteit in Age of Iron; tussen teks en leser in Life and Times of Michael K; tussen die self en die ander in Elizabeth Costello; en tussen teks en kritikus in “The Poetics of Reciprocity”. Die begrip ‘inperking’ aanvaar die kritiese uitdaging wat deur Coetzee se fiksie gestel word om wat Derek Attridge elke ‘sonderlinge geleentheid’ of ‘literatuurdaad’ sou noem, op sy eie terme te benader.

Indiana University-Purdue University Indianapolis (IUPUI) / In three of J. M. Coetzee’s recent novels, Disgrace (1999), Elizabeth Costello (2003), and Slow Man (2005), the South African author explores notions of authorship and challenges the possibilities of the sympathetic imagination. The notion of the sympathetic imagination has roots in Romanticism, and it connotes inhabiting another in order to understand or interpret. Romantic poet John Keats described the poet as “continually in for [sic] and filling some other body” (Letter to Richard Woodhouse), and Coetzee addresses the notion of the sympathetic imagination in his work. There are two facets of the sympathetic imagination: that which governs social relations and that which authors and creative minds attempt to claim as a driving force behind their work. It is important not to conflate the two separate facets of the sympathetic imagination. The social facet encourages good citizenship and allows humankind to behave in humane ways. It counters one’s private desire for mastery and balances self-interest with self-sacrifice; the sympathetic imagination helps others attain their goals and places others’ needs alongside one’s own selfishness. A sympathetic imagination is an essential quality in society, yet it will always yield only partial success. It cannot achieve complete success because truly inhabiting and embodying another living person is simply impossible, but in fiction, Coetzee explores the possibilities and limits of the sympathetic imagination at the level of language and metaphor. The other facet of the sympathetic imagination is often claimed by authors, poets, and artists to allow them to inhabit the subjects of their creativity. Coetzee tests the limits of authorial claims that writing is accomplished by applying a sympathetic imagination. In doing so, he creates metaphysical frames in which his own author-characters interact with other characters to reveal that some characters resist being written. In these metaphysical frames of fiction, Coetzee suggests that an author’s sympathetic imagination will never have total success; he sets forth a notion of partial success that helps address what is gained when the sympathetic imagination runs up against limits. My argument is that the authors and characters in these three novels attempt acts of sympathetic imagination and recurrently encounter limits. Coetzee questions perceived notions of authorship and the possibilities of the sympathetic imagination without offering alternatives. He critiques common notions of authorship and character writing but offers no real solutions.

This thesis explores solo performance in New Zealand. That solo performance has been widely used in New Zealand's relatively brief theatre history is usually ascribed to the economy, manoeuvrability and adaptability of the form - common reasons for the popularity of solo performance elsewhere as well. But this thesis considers solo performance as a kind of theatre that has been suited to New Zealand in a distinctive way. In particular, I argue that solo performance has emerged on the margins of mainstream theatre in New Zealand as a means of actively engaging with a sense of isolation that typifies the post-colonial New Zealand experience. The ability of the solo performance to move between remote rural settlements and urban centres has connected these New Zealand communities in a way that is unusual for theatre in New Zealand. Furthermore, a solo performer speaking directly to an audience about the experience of living in New Zealand allows for an intimate interaction with a traditionally stoic and laconic masculine society. In this thesis, I make a case for three solo performances where it is possible to see, in the representation of a search for what it means to be a New Zealander, a theatrical contribution to nation-building: The End of the Golden Weather (1959), Coaltown Blues (1984) and Michael James Manaia (1991). However, in a subsequent chapter, I look at solo performances in New Zealand that might better be understood within global movements such as feminism and multiculturalism. I argue that this shift has depleted the power that the form once held to comment upon New Zealand identity and to assist in the search for national identity. I conclude the thesis by considering how ongoing theatre practice may be informed by the experience of solo performance in New Zealand.