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<p>Platelets are the smallest cells in the blood. They are formed in the bone-marrow and are important for the blood coagulation. Platelet tranfusions are given to patients propyhlactically before an operation but also in therapeutical purpose in connection with bleeding. It’s importent that the quality controls of the platelet concentrates are reliable.</p><p>ADVIA®60 (Bayer HealthCare) is a fully automated cell counter which uses impedance principle to count platelets in blood samples. The purpose of the study was to evaluate this new instrument for use in the blood bank of Akademiska Sjukhuset in Uppsala. The instrument was bought to be used for quality control of platelet concentrates. 30 samples from platelet concentrates, from both apheresis and from buffy coats, were analyzed 10 times each on ADVIA®60 and the coefficient of variation (CV) was calculated for each sample. CV variated from 0,8 % to 2,9 % which is good considering that according to Bayer HealthCare the CV should be < 5 % for thrombocytes on ADVIA®60. The instrument was newly calibrated when the study was performed. Platelet count can also be performed by immunological or optical principles.</p>

<p>The study of high power fusion plasmas at the JET tokamak has been further enhanced through the development of instrumentation for neutron emission spectroscopy (NES) measurements. This has involved the upgrade of the magnetic proton recoil (MPR) spectrometer used for deuterium-tritium plasmas earlier so that the MPRu can now be also employed for deuterium (D) plasmas. A neutron time-of-flight (TOF) spectrometer designed for optimized rate (TOFOR) has been constructed and put into operation. The MPRu and TOFOR spectrometers were carried out as part of the JET enhanced performance program and represent the most advanced instrumentation for NES diagnosis of both D and DT tokamak plasmas setting a central platform for R&D direct to the next step in fusion research to be carried out with ITER.</p><p>The MPRu work presented in this thesis concerns the development of a new focal plane detector based on the phoswich scintillator technique. The main objective of this sub-project was to increase the signal-to-background ratio to permit measurement of the 2.5-MeV neutron emission from d+d-->3He+n reactions and, hence, allow NES diagnosis of D plasmas. The objective was achieved as demonstrated in preliminary measurements at JET. </p><p>The development of TOFOR from concept to construction is presented in the thesis including, in particular, the commissioning of the instrument at JET. The objective of the TOFOR project was to achieve the same high performance in the NES diagnosis of D plasmas as had earlier been demonstrated by the MPR for DT plasmas. TOFOR has been used in the first plasma physics experiments reported in this thesis. These demonstrate that the performance objectives have been achieved as tested, in particular, in the observation of auxiliary heating effects on velocity distribution of the deuterium population.</p>

This thesis contributes to the econometric literature in two ways. Firstly, it introduces a new multivariate count model that presents advances in several aspects. Our multivariate time series count model can deal with issues of discreteness, overdispersion (variance greater than the mean) and both cross- and serial correlation, all at the same time. We follow a fully parametric approach and specify a marginal distribution for the counts where, conditionally on past observations the means follow a vector autoregressive process (VAR). This enables to attain improved inference on coefficients of exogenous regressors relative to the static Poisson regression, while modelling the serial correlation in a flexible way. The method is also innovative in the use of copulas, which builds the dependence structure between variables with given marginal distributions. This makes it possible to model the contemporaneous correlation between individual series in a very flexible way. Secondly, this thesis introduces a new approach to estimate the multivariate reduced rank regressions when the normality assumption is not satisfied. We propose to use the copula tool to generate multivariate distributions and, we show that this method can be applied in multivariate settings. In terms of financial literature, this thesis provides two contributions. Firstly, with our multivariate count model we analyze diverse market microstructure issues about the submission of different types of orders by traders on stock markets. With this model, we can fully take into account the interactions between submissions of the various types of orders, which represent an advantage with respect to univariate models such as the autoregressive conditional duration model. Secondly, it contributes to portfolio research proposing a new dynamic optimal portfolio allocation model in a Value-at-Risk setup. This model allows for time varying skewness and kurtosis of portfolio distributions and the model parameters are estimated by weighted maximum likelihood in an increasing window setup. This last property allows us to have more accurate portfolio recommendations in terms of the amount to invest in the risk-free interest rate and in the risky portfolio.

No description available.

I compared the utility of two continuous time-series data measures for applied conservation biology by investigating how well each could predict future local persistence of a diverse set of bird species. I used 37 years of data from the North American Breeding Bird Survey to calculate abundance from yearly point-counts and permanence (i.e., consistent occupancy over time) from yearly presence-absence data in the early portion of the study period, then used the later portion of data to empirically evaluate how well each measure predicted persistence two decades into the future. I found that permanence could only match the ability of abundance to accurately predict local species persistence if multiple within-year repeated observations contributed to its calculation. Neither measure was effective at predicting persistence for regionally rarer species. I suggest the yearly and within-year repeated collection of abundance estimating data for use in applied conservation biology to best ensure biodiversity persistence.

Platelets are the smallest cells in the blood. They are formed in the bone-marrow and are important for the blood coagulation. Platelet tranfusions are given to patients propyhlactically before an operation but also in therapeutical purpose in connection with bleeding. It’s importent that the quality controls of the platelet concentrates are reliable. ADVIA®60 (Bayer HealthCare) is a fully automated cell counter which uses impedance principle to count platelets in blood samples. The purpose of the study was to evaluate this new instrument for use in the blood bank of Akademiska Sjukhuset in Uppsala. The instrument was bought to be used for quality control of platelet concentrates. 30 samples from platelet concentrates, from both apheresis and from buffy coats, were analyzed 10 times each on ADVIA®60 and the coefficient of variation (CV) was calculated for each sample. CV variated from 0,8 % to 2,9 % which is good considering that according to Bayer HealthCare the CV should be &lt; 5 % for thrombocytes on ADVIA®60. The instrument was newly calibrated when the study was performed. Platelet count can also be performed by immunological or optical principles.

I compared the utility of two continuous time-series data measures for applied conservation biology by investigating how well each could predict future local persistence of a diverse set of bird species. I used 37 years of data from the North American Breeding Bird Survey to calculate abundance from yearly point-counts and permanence (i.e., consistent occupancy over time) from yearly presence-absence data in the early portion of the study period, then used the later portion of data to empirically evaluate how well each measure predicted persistence two decades into the future. I found that permanence could only match the ability of abundance to accurately predict local species persistence if multiple within-year repeated observations contributed to its calculation. Neither measure was effective at predicting persistence for regionally rarer species. I suggest the yearly and within-year repeated collection of abundance estimating data for use in applied conservation biology to best ensure biodiversity persistence.

Worldwide degradation and conversion of tropical forests affects many species and their provided ecosystem services. Among them are birds, responsible for pollination, seed dispersal, pest control and scavenging. This study, conducted in southwest Ethiopia, compares species composition and bird functional diversity between forest and homegardens close to and far from forest, both in terms of species numbers and bird abundances. Point counts and mist netting were used to obtain data. While the former method detected more species, abundance data from the latter revealed patterns not observed by just comparing species numbers. I found that species diversity was lower in forest compared to gardens and that the species composition of both communities was significantly distinct. Whereas forest had more forest specialists, gardens held more forest visitors and species of open country. Close and far gardens did not differ in any aspect, except that abundances of forest generalist birds were somewhat higher close to forest. Regarding bird feeding guilds, I found that granivores and nectarivores were more numerous in gardens, while frugivores were more common in forest. Carnivores and omnivores showed no effect. Insectivore proportions were the same for forest and farmland, but their numbers (including those of all sub-guilds) were higher in gardens. The Ethiopian forest avifauna is poor in comparison with other Afromontane regions, lacking several, mostly insectivorous genera. This could be the result of an extinction after which its geographic isolation made recolonization difficult, especially for dispersal-limited understory species. Nonetheless, and despite their impoverished state, the results suggest that forest remnants are important for forest-dependent species, being a stronghold for forest specialists and supporting higher numbers of forest generalists in nearby gardens. However, future forest regrowth might be at stake with ongoing agricultural encroachment, because gardens hold fewer frugivores, especially forest specialists, which might affect seed dispersal. / Många arter påverkas negativt av avskogning och annan mänsklig påverkan på tropiska skogar, vilket också kan få konsekvenser för de ekosystemtjänster dessa arter levererar. En viktig artgrupp i detta avseende är fåglar, som kan ha betydelse för pollination, fröspridning, naturlig skadedjurskontroll och som asätare. Denna studie, utförd i sydvästra Etiopien, jämför artsammansättning och funktionell diversitet hos fåglar i skogar och trädgårdar både nära och långt ifrån skogen. Både antal arter och antal individer har undersökts. Data materialet bygger både på observationer från punktinventering och fåglar fångade med slöjnät. Med den första metoden noterade jag fler arter, medan abundansvärden från den andra metoden gjorde att jag såg mönster som inte syntes vid endast jämförelser av artrikedom. Jag fann att artrikedomen var lägre i skogen i jämförelse med trädgårdarna, men att artsammansättningen var signifikant skiljd däremellan. Skogarna hade fler skogsspecialister medan trädgårdarna hade fler arter från öppna marker och tillfälliga skogsbesökande arter. Trädgårdar som låg nära eller långt ifrån skogen skiljde sig inte på något sätt utom att individtätheten av skogsgeneralister var något högre i trädgårdar nära skogen. När det gäller uppdelningen av fåglarna utifrån vad de äter så fann jag att fröätande och nektarätande arter var vanligare i trädgårdar medan fruktätande arter var vanligare i skogen. Rovfåglar och allätare uppvisade inget tydligt mönster. Proportionen insektsätande fåglelarter var samma i skogen och trädgårdarna, men det absoluta antalet arter (inklusive alla olika underkategorier) var högre i trädgårdarna. Den etiopiska skogsfågelfaunan är artfattig i förhållande till andra bergstrakter i Afrika och saknar flera släkten av framförallt insektsätande fåglar. Detta skulle kunna bero på ett tidigare utdöende varefter en senare återkolonisering varit svår på grund av den geografiska isoleringen, speciellt för insektsätande fåglar som huvudsakligen finns i undervegetationen. Trots den relativa artfattigdomen så visar resultatet från min studie hursomhelst på att skogarna är viktiga för skogsberoende fåglar. Den största betydelsen har de för skogsspecialister där, men även genom en positiv effekt på abundansen av skogsgeneralister i närliggande trädgårdar. Dock kan framtida återväxt av skogar bli problematisk på grund av en pågående omvandling av skogar till trädgårdar, eftersom trädgårdar hyser färre fruktätande fåglar, vilket kan påverka fröspridning över landskapet. / Examining mismatches between management and the supply of ecosystem services in Ethiopian agroecosystems across scales in space and time

The land around Herrevad Abbey consists mostly of pastures with a lot of old coarse oaks, a touch of broad-leaved decidous forest andmixed deciduous and coniferous forest. In the year 2010 the Swedish Environmental Protection Agency became owner of the area around Herrevad Abbey, previously owned by the Swedish National Fortification Administration. A high pressure from hunting occurred during the Swedish National Fortification Administration ownership. This resulted in a decrease of the roe deer (Capreolus capreolus L.) population. A pellet-group count is a reliable, indirect inventory method that is used with high frequence within wildlife management since the 1930s. Pellet-group count is used in Swedish Wildlife research since the 1977 at Grimsö Research Station and today an increasing interest for this method is seen both in nature management, among hunters and  in the Swedish Association for Hunters. Through a pellet-group count of a roe deer population, an underestimated index of the total density is shown, which means that the investigated population can be larger than the survey shows. The pellet-group count in this study covered 3,20 km-2 with a total of 315 plots. The plot had a circular shape and covered 10m2, which is recommended for roe deer surveys. Each plot was investigated twice, one round clockwise and one round counter clock-wise to increase the precision of the survey. The calculation showed 10,76 roe deer per 1,00 km-2 in winter population during 2010; with a 10% set-off for winter mortality and 8,22 roe deer per 1,00 km-2 in winter population with a 30% set-off. The density with 10,76 roe deer /km-2 is low compared to experimental plots at Bogesund, Ekenäs, where the population is estimated to around 17-23 roe deer/ 1,00 km-2. A calculation for carrying capacity shows that the population will reach the density limit within four years at Herrevad Abbey.