Il lavoro qui presentato analizza le pratiche di comunicazione tra pari mediate dalle nuove tecnologie. In particolare, è stato approfondito l’utilizzo di tali modalità comunicative in un gruppo di adolescenti di origine straniera residenti a Milano. Gli obiettivi della ricerca consistevano in: 1. individuare pratiche di comunicazione e socializzazione tecnologicamente mediate, specifiche dei giovani adolescenti di origine straniera; 2. evidenziare il ruolo di tali pratiche communicative innovative nell’orientare le tra il gruppo migrante e quello degli autoctoni, in termini di processi di acculturazione; 3. definire se e in che modo tali comportamenti consentono spazi di azione creativa e mediazione culturale tra le molteplici culture di appartenenza; 4. identificare possibili strategie di costruzione identitaria in termini transnazionali. / This article analyses peer to peer communication practices mediated by digital technologies. Particularly, the forms of this kind of communication have been in depth analysed within adolescents of foreigner origins living in Milan. Aims of the research were: 1) outlining communication and socialisation practices technologically mediated (such as the use of cellular phone to exchange photos, videos etc. or the participation in social network), typical of the target group; 2) highlighting the role of these new communication practices in shaping peculiar relationship between migrants and indigenous culture, in terms of integration/differentiation processes; 3) defining if and how such behaviours enable a space of creativity, selfdetermination and cultural mediation between multiple belongings; 4) identifying any strategy of identity constructing in transnational terms.

The present study, being part of a wide research program carried by the University of Bologna (Dipartimento di Scienze della Terra e Geo-Ambientali and Dipartimento di Archeologia) together with the Soprintendenze of Emilia-Romagna and Veneto, is aimed at examining the manufacturing and circulation of Greek Italic amphorae in the Adriatic area. This represents an essential step for the historical and archaeological reconstructions and in particular for: - the identification of local manufacturing though the archaeometric comparisons between ceramic samples and raw materials - the reconstruction of the ancient routes connecting different areas of the Roman world The examined archaeologic sites are representative of the main manufacturing areas in the Adriatic region both along the Italian and Albanian coasts: Adria, Cattolica, Rimini, Spina , Suasa and Phoinike. Notably, the Adriatic region not only represents the manufacturing area, but also coincides with the source area where the raw materials were collected. Archaeometric analyses of representative samples from the different areas of interests, were performed adapting the analytical tecniques used in mineralogy, petrography and geochemistry, to the study of ancient archaeological finds. These data were combined with the ones obtained from the analysis of clays, aimed at characterizing the nature of the raw materials. As a whole, an integration of these data with the available archaeologic observations led to significant advances in the scientific knowledge about of the main types of amphoric manufacturing and distribution in the Adriatic region. In particular, a local manufacturing is suggested for all the archaeological finds from Cattolica and for the main part of the archaeological finds from Suasa. Moreover, the occurrence of commercial routes between the sites of Rimini and Suasa and between Adria, Spina and Suasa is evidenced. On the contrary, for the amphorae from Phoinike a provenance from the examined sites is very unlikely.

La ricerca si propone di indagare sulle forme di cambiamento che stanno interessando l’agricoltura contadina contemporanea in Italia. In particolare, il proposito è quello di individuare le forme attraverso cui i contadini stanno cambiando il proprio rapporto con il mercato e con la società, proponendo stili di vita, di produzione e di consumo sostenibili. Le Teorie sulle Pratiche e gli studi sulla cultura materiale saranno utilizzati per comprendere il rapporto tra pratiche e reti sociali. / The research aims to investigate the forms of change that are affecting contemporary farming in Italy. In particular, the purpose is to identify the forms through which farmers are changing their relationship with the market and with society. Practice Theories and studies on material culture will be used to understand the relationships between practices and social networks.

The thesis analyses dance as artistic profession and bodily work. The aim is to explore the social foundations of a performative, bodily and kin(aesth)etic doing, the purpose being to untie some of the knots that, in manifold ways, link together corporeal experience, (sense of) society, knowledge and identity. The considered dance, thus, is first of all a performative art, to be (re)presented on stage during particular social occasions. The work of dance professionals can be defined as artistic doing. In this sense, the thesis aims to contribute to arts sociology and creativity studies, through, first, the analysis of the process bringing from 'nothing' to the artwork, considering the choreographic creative process and the continuum improvisation-composition, the everyday collective work practices, and the collaboration and negotiation characterizing them. Secondly, I present an analysis of the relations between different entities – institutional, commercial, cultural, etc. – that inhabit Italian dance field. Finally, I propose an analysis of artistic, and particularly dancer's, identity. Focusing on a performative art also means to focus on the body, and the impermanence of its doing. Dance, indeed, is a profession based on corporeal practices and embodied knowledge; it's a bodily doing. From this point of view, the thesis represents a contribution to sociology of the body and embodiment, as well as to sociology of knowledge, as an analysis of a case of teaching/learning process of bodily and performative expertise. Such a case enlights some dimensions of teaching/learning-to-perform activity, and could be usefully compared with other practical (artistic or 'simply' human) activities. Finally, I focus on dance as a professional doing. In this sense, the thesis contributes to the sociology of prefessions and semiprofessions, because it analyses the processes of socialization to the culture, knowledge and knowhow of the considered occupational community; the training paths and trajectories undertaken in the field; the social organization of everyday work and the ways in which dance professionals coordinate with one each other as well as with other kind of professionals; the recruitment mechanisms; the master and alternative narratives that sustain and (re)produce the community, and that dancers exploit in their biographies and identies construction.

Establishment of the independent Republic of Armenia in 1991 has been a turning point in the Armenian history; except for the existence of an independent Armenian republic between 1918 and 1920, by the dissolution of the USSR, Armenians gained an independent state after more than six hundred years. The transition of the Soviet Armenia to an independent republic stimulated not only the radical dislocation of the established economic, political and socio-cultural structures in Armenia, but also transformed the routine in the Armenian diaspora communities. In this process, aiding the frail and infant independent Armenian republic became a paramount ethno-national cause among the diaspora communities and, by extension, one of the principal ethno-national binders, as well as a chief cause of controversies. Overall, the post-1991 era has witnessed the re-territorialization of the de-territorialized Armenian political imagination in the diaspora. This facilitated the post-1991 trans-state Armenian ethno-national re-construction along the Armenia-diaspora nexus. A parallel process to that has been the construction of the social reality of the post-1991 Armenia. This dissertation examines the construction of the Armenian ethno-national social reality of the post-1991 Armenia through the discursive social practices of the Armenian state, new generation diaspora organizations and the diasporic individuals within the communicative space formed along the Armenia-diaspora nexus. The examination demonstrates that concerns over the physical and cultural survival of the Armenian ethno-nation expressed in different ways are the main considerations that eventually result in the construction of the post-1991 Armenia as the guardian and the soil of the Armenianness. From an abstract point of view, the actual agent of discourses that speaks through the Armenian state, new generation diaspora organizations and the diasporic individuals is the “anxious Armenian” who searches stability and security, reclaims her ethno-national identity, and is concerned about the cultural survival of the Armenian ethno-nation. Besides all, she is the one who “remembers” the genocide. This “anxious Armenian”, instead, is the person that the social memory of the genocide speaks itself through. As such, genocide is not only the “defining and founding moment” of the contemporary Armenian identity, but also the “defining and founding moment” of the post-1991 Armenia.

This dissertation studies the relationship existing between youth political organizations, music and national identity in contemporary Russia. In particular, it focuses on some of the most representative youth political organizations present in the city of St. Petersburg and aims at describing their contribution to the conceptualization of post-Soviet Russian national identity(ies), as captured through an analysis of their music.

Proteins are one of the most studied biological molecules of the last decades. A great amount of experimental techniques provide to researchers direct or indirect informations on proteins structure and function. In silico simulations can be used as a “computational microscope” giving the possibility to observe protein dynamic properties at atomistic resolution. In this work, various applications of computational methods to biological systems are presented. In particular, all-atom Molecular Dynamics (MD) simulations were employed to investigate the behaviour of proteins at atomstic resolution. The term “Molecular Dynamics” is usually referred to computational methods used for the simulation of classical many-body systems. These techniques are applied to microscopic systems and they represent a powerful approach for the study of physical processes, providing a tool for their interpretation. They have been widely used in the past decades to elucidate a large variety of molecular processes in different fields such as solid state physics, material science, chemistry, biochemistry and biophysics. Here, all-atom MD simulations were employed to observe equilibrium properties of several biologically relevant proteins. This allowed us to direct perform a comparison of molecular mechanisms occurring at the atomistic level as obtained from in silico studies with experimental data, which usually describe processes at larger length and time scales. These MD simulations were also meant as a starting point for the construction of simplified models, as they were processed through coarse-graining procedures to extrapolate crucial systems features, such as informative protein sites, on the basis of information theory approaches. Specifically we studied the dynamics of pembrolizumab, a humanized immunoglobulin of type G4 (IgG4) used as a therapeutic antibody. It is employed for the treatment of lung cancer, melanoma, stomach and head cancer and Hodgkin’s lymphoma. This antibody interacts with the programmed cell death protein 1 (PD-1) receptor, blocking the suppression of the immune response during cancer development. The studied systems are three: the apo state of pembrolizumab, the holo state (i.e. pembrolizumab bound to PD-1) and the glycosylated apo configuration. Each configuration was simulated for 2μs, for a total of 6μs. The analysis of the trajectories was carried out by combining standard structural analysis techniques and information theory-based measures of correlation. From MD trajectories we could extract valuable informations on the connectivity that exists among the structural domains that compose the antibody structure. Moreover, it was possible to infer which regions are involved in the structural rearrangement in the case of the antigen binding. We could observe that the presence of the antigen reduces the conformational variability of the molecule giving a greater stability to it. The second studied system is the P53 protein complex. In this case we focused on the tetramerization domain (TD) region that is composed by 2 identical dimers and has the function of bringing together the four monomers of the p53 complex. Starting from the observation that in case of the mutation of residue R337 several pathologies are developed in humans, we constructed computational models to reproduce the dynamics of the mutants and investigate their behaviour in silico. We performed simulations for a total of 16 μs divided in 8 different cases. In the first part of the study the wild type (WT) protein was compared to the R337C and the R337H mutant in three different protonation states: delta protonated Histidine, epsilon protonated Histidine ad double protonated Histidine. In the second part of the study we highlighted the differences between the WT configuration and three rationally designed mutants: R337D-352D, 337R-D352R, R337D-D352R. In this part of the investigation, the importance of the electrostatic interaction between residues R337 and D352 in the stability of the tetramerization do- main was discussed. Furthermore, we matched the obtained computational results of p53 tetramerization domain with functional experiments in yeasts (performed in collaboration with the CIBIO department) of all the simulated forms. The third simulated protein is the zinc sensing transcriptional repressor (CzrA), an homodimeric protein that binds DNA in Staphylococcus aureus. All-atom MD simulations of two different configurations were performed for a total of 4μs, the first one is the WT apo protein while the second is the WT holo system, where the protein is complexed with two Zn ions. In this case, in addition to standard analysis techniques, we applied the mapping entropy minimization protocol to highlight the most informative protein regions, from the perspective of information theory. Finally, our in silico results were compared to available NMR data of the protein itself.

The research lies at the intersection of two large social research areas—highly skilled migration and return migration—and aims to provide a contribution to the studies of sending countries by focusing on post-return experiences of highly skilled professionals in the Belarusian context. Thus, I explore public attitudes toward migration issues in Belarus; investigate the dynamics of return migration among highly skilled migrants; analyse the complexities of highly skilled people’s lifestyles; and study in which ways they apply socio-cultural remittances to different spheres of their lives. Among the main results of this research are the following. This study has conceptualised return in relation to the transnational involvement of returnees, by introducing the concepts of ‘locally oriented’- and ‘transnationally oriented style of life’. These ideal types of post-return lifestyle differ in degree of mobility, attitudes toward home, consumption practices, and type of employment. International experience of living abroad seems to have had a substantial effect on individual styles of life in terms of transnational orientation. However, it appears to be quite heterogeneous and has evident gender differences in its manifestations. Moreover, I argue that formation and transmission of socio-cultural remittances are strongly heterogeneous and selective processes, which manifest themselves to varying degrees not only in different people, but also in different aspects of people’s lives. The analysis of several socio-cultural remittances in private and public spheres showed that under certain conditions, the formation of ‘reactive’ socio-cultural remittances occurred. What is more, in some cases the socio-cultural remittances appeared to have strong gender differences. The results draw on qualitative content analysis of three online discussions (almost 19 thousand posts) and 43 in-depth interviews with highly skilled Belarusian returnees.

The present dissertation examines whether the heterogeneity of co-residence experiences and the nest-leaving process have consequences for later parent-adult child relationships in Italy and Sweden. Three aspects of intergenerational linkages are analyzed: residential proximity, the frequency of parent-child contact, and the downward flow of economic resources from parents to their adult children. By devoting particular attention to these three dimensions of intergenerational solidarity, the first chapter presents an overview of the literature on parent-adult child relationships and describes long-standing cultural differences between Italy and Sweden. In the second chapter, I ask whether in Italy the time spent in the parental home promotes the frequency of contacts between generations, and whether violating social norms regarding the socially accepted time for leaving home is related to less frequent interactions with parents in later life. The findings show that the longer the time adult children spent in their parents’ home, the higher the propensity to reside near, and maintain frequent interaction with parents in later life is. In addition, spending longer time in the parental home appears to provide much less benefit for Italian daughters than for sons. Age norms appear to prescribe the socially accepted ‘age deadline’ for fulfilling expectations for normal adult development. Considering the reasons for leaving home, marriage continues to be the normative occasion to leave the parental family, particularly among adult daughters, who are subject to greater cultural expectations about family ties. The third chapter devotes particular attention to union dissolution and family conflict during childhood and adolescence as possible mechanisms behind the relationship between nest-leaving processes and later parent-child relationships. The findings reveal that the duration of co-residence is likely to foster family interactions also in Sweden, and this positive relationship is only marginally explained by childhood family experiences. However, late home leavers tend to maintain frequent contacts with parents in part owing to having moved shorter geographical distances, and this is more evident for adult daughters than for sons. In addition, adult daughters who stay at home for longer have more opportunities to form binding relationships with mothers than with fathers. The fourth study aims to extend the findings of the previous two chapters, by analyzing intergenerational financial transfers and using a within-family approach (or a sibling design). The findings show that in Italy and other southern European countries late home leavers are more likely to receive economic support from their parents, compared to their siblings who move out of the family nest at an earlier age. But this effect is completely mediated by the time since leaving the parental home, indicating that parents tend to facilitate the transition to independence of their young adult children. The last chapter discusses the findings in the light of previous research. The results of the present dissertation supports the idea that family members’ life courses are deeply interconnected, and that previous family history has important long-term consequences for later intergenerational relationships. I provide new insights into how co-residence experiences and events in early adulthood shape later family relations throughout the life course.

MACPF/CDCs proteins are a huge family of pore-forming proteins present from the bacteria to the human genera. Cholesterol-dependent cytolysins (CDCs) are a family of toxins that participate in bacterial infection pathway at the membrane level. Great interest in this family is due to their similarity, in structure and in pore-forming mechanism, with some human immune system proteins (MACPF). We focused our attention particularly on two bacterial CDCs, Perfringolysin O and Listeriolysin O, and on the human protein Perforin, which is involved in the apoptotic pathway facilitating Granzyme release. In the literature, two possible configurations of CDCs and Perforin pores are proposed: ring and arc structures that could have different implications on the biological mechanism of action of these pore-forming proteins. By electrophysiological measurements and atomic force microscopy technique on different artificial membrane, we are able to enrich the ring and the arc fraction and demonstrate that both kinds of pore are active, i.e. conduct ions. Thus, my PhD work underlines two physiological structures which are involved in several ways, more than merely by disrupting membrane integrity, in pathogenic attack (bacterial CDCs proteins) as well as in immune response (human Perforin proteins).