D.Litt. et. Phil. / Head injury is the major cause of death for individuals under 35 years old in the United States of America, and a similar picture exists in South Africa. A major cause of traumatic brain injury is motor vehicle accidents. In addition, the advances in modem medical technology increase the chances for survival, for example, sophisticated medical diagnostic techniques such as computerised tomography (CT), and magnetic resonance imaging (MRI). Advances in emergency trauma and neurosurgical procedures have also increased the number of survivors following a head injury. The symptoms resulting from head injury include disturbed physical, cognitive, psychological and behavioural functioning. Long-term management of these symptoms is usually required. A body of evidence exists that demonstrates the value of rehabilitation during the first year of recovery from traumatic brain injury. Head injury cases often result in litigation in that the injured person may be entitled to compensation for the injuries sustained. Considerable forensic debate exists around the issue of whether the victim's symptoms are attributable to organic brain damage, or whether they reflect a pre-existing functional psychological state of psychiatric illness, or personality disorder. Further still, the individual may be 'malingering' or faking postconcussion symptoms of headache, dizziness, fatigue, memory deficit, impaired concentration, irritability, anxiety, insomnia, concern about bodily functions, and hypersensitivity to light and noise. Alternatively, a common diagnosis is traumatic neurosis with a psychogenic basis, and in the context of litigation is referred to as "compensation neurosis". Specifically, the issue of contention revolves around concussion, and mild or minor head injuries. This study proposed that both neuropathophysiological and psychosocial symptoms occur in the event of a traumatic brain injury. This view supports the traditional model that pain or the sequelae of head injury are not affected by compensation. Therefore, the objective of the study was that follow-up assessment after compensation pay-outs should produce similar results to the assessment results obtained during the litigation process. The hypotheses of the study were essentially confirmed. The neuropsychological error scores produced in the assessments during litigation, and two-to-four years after the completion of litigation were similar. However, similar to other studies, variations were evident. Four exceptions were demonstrated in that significant improvement was evident with regard to shotterm verbal memory delayed recall for paragraphs, and for immediate recall (without and after interference) in verbal memory for a word list. These improvements therefore pertain to verbal memory. The fourth improvement occurred with respect to manual dexterity and visual-motor work speed, although the improvement may be peripheral or primary (neurological). Further findings included that no gender differences were evident in the neuropsychological posttest scores. It was confirmed that individuals with a good Glasgow Outcome Scale rating showed less posttraumatic amnesia, a shorter time since injury, less additional injuries, and a lower compensation sum. It was also supported that individuals with a good Glasgow Outcome Scale rating showed less impairment on neuropsychological indices. However, an exception was that individuals with a moderate Glasgow Outcome Scale rating showed improvement on the neuropsychological index measuring immediate concentration, visual scanning, and visual-motor work speed. The qualitative data or psychosocial measures of severity and outcome produced a similar picture that the majority of subjects maintained their pretest status although some exceptions were evident. Within the medico-legal domain it was shown that, in general, concordance of severity was high amongst the medical experts for the plaintiffs and the defendents. However, their prognoses were indicated to be less accurate, and whilst their consistency in documenting diagnoses in the reports of the subjects was adequate, they were found to be inconsistent in documenting severity ratings and prognoses. It was suggested that improvements may be attributed to neurophysiological differences, non-participation in a rehabilitation programme, the interference and delay of rehabilitation, increased psychological reactions associated with litigation, and mechanisms of secondary gain which may by attributed to the other players, such as the family, the attorneys, the medical experts, among others, and not only to the individual or victim.

Indiana University-Purdue University Indianapolis (IUPUI) / Cyclobutane pyrimidine dimers (CPD) are the predominant DNA lesions formed upon exposure of this biopolymer to sunlight. Given the potentially dire biological consequences of DNA lesions, there is a need to fully characterize their behavior, with an eye towards understanding their complete reactivity and as a possible means to detect and quantify their presence in the genome. The work described in this dissertation describes studies of the alkaline reactivity of CPD lesions generated within dinucleotide & polynucleotide strands. It was found that CPD-TpT is generally inert under alkaline conditions at room temperature, which is in agreement with earlier studies on alkaline hydrolysis of CPD-thymine and CPD-thymidine. However, a re-evaluation of the same reaction in the presence of 18O labelled water demonstrated that, similar to other UV-induced DNA lesions containing a saturated pyrimidine ring, CPD undergoes a water addition at the C4=O group of the nucleobase leading to the formation of a hemiaminal intermediate. This intermediate, however, does not lead to hydrolysis products and completely reverts to starting material under those same conditions. Moreover, the two C4=O groups present on 3′ and 5′-thymines in a CPD molecule show different chemical reactivities, with the 3′ C4=O group having greater affinity towards water addition as compared to the one on 5′ end, a fact reflected in different rates of exchange with the incoming nucleophile leading to the hemiaminal intermediate. The 18O labelling reaction was also investigated in CPD lesions generated within oligonucleotides to probe the cause of asymmetry between the 3′ vs 5′ C4=O groups; ultimately, it was determined that the asymmetric reactivity observed to occur between the two C4=O groups was an intrinsic property of the CPD molecule and did not arise as a result of asymmetry in a dinucleotide setting. In addition to the above studies, during the course of the investigation of the nucleophilic reactivity of CPD, a chemical reaction was observed leading to what appeared to be the rapid and total chemical reversal of CPD lesions to the original TpT (thymine-thymine dinucleotide)! This “repair” reaction occurred when CPD reacted with hydrazine, and appears facilitated by an inert atmosphere under which it rapidly proceeds to completion at room temperature.

in English This diploma thesis deals with the manner and extent of compensation for damage in civil law, which is systematically included in the fourth part of the Civil Code, entitled Relative property rights and in section named Obligations arising from torts. Specifically, the manner and extent of compensation for damage is defined in articles from 2951 to 2971. The thesis contains basic comparison of the conceptions of the manner and extent of compensation in the former Civil Code and in the new one, with emphasis on the most important reforms. It clarifies new terminology and describes the background of the newly established rules of law. It contains an analysis of the Czech legislation and its comparison with legislation of the neighboring states. It also mentions the European conception of the manner and extent of compensation for damage. The system of the thesis follows the organisation of the provisions on the manner and extent of compensation in the new Civil Code and is also divided into three chapters. The first one deals with compensation for material damage. Its main issue is the manner and extent of the material compensation and the conditions for its reduction. It also contains a provision on compensation for damage caused by an intentional criminal offence and rules for determining...

Thesis (Ph. D.)--University of Newcastle, 2004. / School of Social Sciences. Includes bibliographical references (leaves 269-292). Also available online.

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Doctor of Philosophy / Department of Civil Engineering / Asadollah Esmaeily / Civil structures are susceptible to damages over their service lives due to aging, environmental loading, fatigue and excessive response. Such deterioration significantly affects the performance and safety of structure. Therefore, it is necessary to monitor the structural performance, detect and assess damages at the earliest possible stage in order to reduce the life-cycle cost of structure and improve its reliability. Over the last two decades, extensive research has been conducted on structural health monitoring and damage detection. In this study, a signal-based pattern-recognition method was applied to detect structural damages with a single or limited number of input/output signals. This method is based on the extraction of sensitive features of the structural response under a known excitation that present a unique pattern for any particular damage scenario. Frequency-based features and time-frequency-based features of the acceleration response were extracted from the measured vibration signals by Fast Fourier Transform (FFT) and Continuous Wavelet Transform (CWT) to form one-dimensional or two-dimensional patterns, respectively. Three pattern recognition algorithms were investigated when performing pattern-matching: (1) correlation, (2) least square distance, and (3) Cosh spectral distance. To demonstrate the validity and accuracy of the method, numerical and experimental studies were conducted on a simple small-scale three-story steel building. In addition, the efficiency of the features extracted by Wavelet Packet Transform (WPT) was examined in the experimental study. The results show that the features of the signal for different damage scenarios can be uniquely identified by these transformations. Suitable correlation algorithm can then be used to identify the most probable damage scenario. The proposed method is suitable for structural health monitoring, especially for the online monitoring applications. Meanwhile, the choice of wavelet function affects the resolution of the detection process and is discussed in the “experimental study part” of this report.

Published Article / Direct feeding damage to head lettuce (Lactuca sativa L.) by varying aphid populations in two differently constructed shadehouse structures (fully- and partially covered) was examined. Fresh lettuce head weight, the number of lettuce leaves formed, and the number of lettuce leaves infested with aphids were compared between the two structures. Warmer months showed a significant lower fresh lettuce head weight in the fully covered structure with more aphid-infested leaves. During June/September, the mean number of aphid-infested leaves and aphid infestation levels were significantly higher in the partially covered structure. Visible feeding damage to the lettuce crop was restricted, but asymptomatic damage in terms of a decrease in head weight did occur under severe infestation levels.

Early events occurring during induction of the SOS response in Escherichia coli are poorly understood. In order to understand the early steps in SOS induction more fully, we have isolated several mutations which constitutively express the SOS regulon. Using a Mud(Apᴿ,lac) fusion to the SOS regulated gene sulA, we isolated Lac⁺ colonies as mutants in which RecA protein is constitutively activated for repressor cleavage. The mutations map to four loci: dam, lig, uvrD and recA. The extent of constitutive SOS induction in these mutants varied greatly, indicating different levels or types of signal in the cell. The mutations isolated demonstrate two early steps in SOS induction. The first step in SOS induction is signal generation and includes mutations found in dam, lig and uvrD genes. The mutant gene products presumably alter DNA metabolism to produce an inducing signal. These non-lethal mutations lead to sub-induction and probably generate very specific signals, such as abnormally unwound DNA in the case of DNA helicase II mutants or unsealed DNA nicks that result from deficient ligation in lig mutants. Greater induction may require quantitatively more signal or different types of signal generated by severe defects leading to cell death. These mutations also show that signal is a variable quantity, allowing the cell to fine tune the levels of SOS repair activity according to the amount or type of signal (damage) perceived. In some cases (such as dam mutations), blocking the SOS response by lexA(Ind⁻) alleles leads to cell death. In this type of constitutively activated strain, the increased level of repair from SOS induction is required to allow the cell to tolerate potentially lethal DNA structures generated by the mutant gene product. The second step in induction is the interaction of signal with RecA protein and is shown by isolating 8 recA mutants. Mutant recA alleles caused the strongest SOS induction in any mutants obtained, similar to the level found in strains lacking repressor (lexA(Def) mutants). This full induction in the absence of lethal DNA damage underscores the pivotal role of RecA protein in regulating the SOS response.

Molecular dynamics techniques are used to explore metals at an atomic level. The focus of the studies is the effects of irradiation on a metallic system. Ion surface bombardment effects, bulk cascades and interaction with voids and bubbles in bulk are studied. In the first section a study of a copper <110> surface being bombarded by low energy argon ions is conducted. Molecular dynamics simulations were used to study the surface impact crater formation and the damage caused in the surrounding area. Another group had previously performed experimental measurements on the same system. The simulation data is compared to experiment, in order to validate the molecular dynamics technique. Additionally, information about the formation of the craters at time scales inaccessible to experiment can be gained. In the next section bulk radiation induced cascades in BCC iron are considered. Cascades of energy 1 keV, 2 keV, and 5 keV are initiated in the bulk of the material and the damage yields studied. Cascades are also studied in proximity to voids and helium bubbles in the bulk. The damage formation processes and damage yields in these cascades is analysed. A mechanism that allowed voids to be ballistically moved by the cascade was observed. To further explore this an object kinetic Monte Carlo model was written to simulate the effects of this motion on the diffusion of the voids. The final section is a study of transition metals as alloying elements in BCC iron. This system is of interest as it would be a model for various steels used in construction and shielding. A set of potentials describing iron with low concentrations of transition metals has previously been developed by a different group. These potentials were implemented in the molecular dynamics code. The equilibrium properties of various alloys are explored by implementing a Metropolis algorithm to minimise the Gibbs free energy of the system. Various binary and tertiary alloys are analysed and compared with experimental values in the literature. The attraction of the elements to voids present in the system is also studied.

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