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This thesis focuses on the development of housing policy in Písek after 1989 and its impact on residential differentiation and segregation. To do this it was necessary to carry out interviews with key stakeholders and to link the findings with quantitative analysis. From the research, it was found that the city primarily established rules of allocation and sale of city apartments and also tried to address the issue of social housing, especially in the context of an aging population. Also important was the development of residential development, which the town supported the various tools. Influence of the housing policy in Písek created several locations which became attractive for housing. In the city, however, also located 2 socially excluded localities incurred controlled migration socially maladjusted people. As an endangered locality by segregation and social exclusion is denoted housing estate Portyč where is but rather a residential differentiation. It is also possible to observe the cooperation of the city with local actors, as well as disputes between the leaders of housing policy. Contribution of the thesis also focuses on analyzing the implications of municipal housing policy of the city and its inhabitants. Key words: housing policy, Písek, residential differentiation, segregation

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This final thesis gives an overview of possibilities given to Member states by European law to differentiate the legislature the way it fits their national needs. It might be difficult for all Member states to participate in all European policies as it is stated in Treaties, directives or regulations as the Member state cannot or does not want to follow the mainstream of integration. European law then provides the means how to differentiate from the provisions to secure that any harm will be caused to a Member state. In the first part of the thesis, some basic terms to understand the subject are introduced such as differentiation, harmonisation, flexibility and integration itself. In the second chapter you can find the process of harmonization and the power within that the institutions of European Union can operate. Some disputes about how the powers are exercised are also introduced here. The differentiated integration had some development which laid the foundations to the current situation and therefore the development is described in this chapter. There are more ways how to differentiate within the European law, chapter number 3 gives a basic overview of these possibilities. It mentions multiple-speed Europe, variable geometry and integration á la carte, and gives some practical examples to understand...

Obsahem této práce je analýza ekonomického vývoje Vietnamské socialistické republiky za pomoci indikátorů, které jsou z tohoto pohledu nejdůležitější. Analýza sleduje vývoj hrubého domácího produktu, zahraničního obchodu, přímých zahraničních investic, vývoj indexu lidského rozvoje a vývoj indexu lidské chudoby. Tato analýza je využita ke zhodnocení vývoje jednotlivých vietnamských regionů a vyslovení závěrů o regionální diferenciaci. Část práce je věnována ekonomickým vztahům České republiky a Vietnamu.

Diplomová práce se ve své první části věnuje charakteristice trhu nábytku v České republice a představuje společnost IKEA. Druhá aplikační část se zaměřuje na celosvětový projekt IKEA pro segment malých podnikatelů, jehož smyslem je rozšířéní portfolia zázníků, růst tržeb společnosti a její mezinárodní rozvoj. Práce popisuje podstatu projektu, jeho realizaci a přínos jak pro společnost tak pro její zákazníky.

Tato práce se zabývá problematikou regionální diferenciace cen nemovitostí a její dopad na reálnou ekonomickou situaci regionů, která bývá obvykle analyzována pomocí standardních ekonomických ukazatelů jako je HDP na obyvatele, výše mezd nebo úroveň nezaměstnanosti. Důležité je však si uvědomit, že nemovitosti hrají ve spotřebním koši domácností významnou úlohu a jejich zahrnutím získáme pravdivější obraz o ekonomické úrovni krajů ČR. Ceny nemovitostí mají značný vliv nejen na osídlení, ale i na lokalizaci firem. To se pak odráží na dalším rozvoji regionu. Přínosem práce je prokázat, že v krajích, které vykazují větší ekonomickou výkonnost, jsou nemovitostí finančně hůře dostupné než v krajích, které jsou z ekonomického hlediska méně výkonné. Tato cenová diferenciace výrazně snižuje a často i neguje meziregionální rozdíly, kterých jsme svědky při standardní komparativní analýze. Celá práce je doplněna o grafy, obrázky a kartogramy, jenž slouží k vizuálnímu vyjádření jednotlivých ukazatelů a podílů. V diplomové práci je tato problematika řešena i na mezinárodní úrovni, kde je předmětem zkoumání Praha, Hamburk a Vídeň.

The aim of the thesis is the regional differentiation analysis in the European Union territory. Thesis is focused on the EU Regional policy (its origin, development, objectives and instruments) and mainly on the demographic and economic differentiation in the EU. The demographic differentiation is qualified through the use of natural population increase, net migration and settlement structure. For the economic differentiation there have been used indicators such as GDP per inhabitant, employment and unemployment rate.

PU.1 downregulation within haematopoietic stem and progenitor cells (HSPCs) is the primary mechanism for the development of acute myeloid leukaemia (AML) in mice with homozygous deletion of the upstream regulatory element (URE) of PU.1 gene. p53 is a well known tumor suppressor that is often mutated in human haematologic malignancies including AML and adds to their aggressiveness; however its genetic deletion does not cause AML in mouse. Deletion of p53 in the PU.1ure/ure mice (PU.1ure/ure p53-/- ) results in more aggressive AML with shortened overall survival. PU.1ure/ure p53-/- progenitors express significantly lower PU.1 levels. In addition to URE deletion we searched for other mechanisms that in absence of p53 contribute to decreased PU.1 levels in PU.1ure/ure p53-/- mice. We found involvement of Myb and miR-155 in downregulation of PU.1 in aggressive murine AML. Upon inhibition of either Myb or miR-155 in vitro the AML progenitors restore PU.1 levels and lose leukaemic cell growth similarly to PU.1 rescue. The MYB/miR-155/PU.1 axis is a target of p53 and is activated early after p53 loss as indicated by transient p53 knockdown. Furthermore, deregulation of both MYB and miR-155 coupled with PU.1 downregulation was observed in human AML, suggesting that MYB/miR-155/PU.1 mechanism may be involved...

The thesis deals with evolutionary and ecological consequences of edaphic speciation (adaptation to different soil types) and genome duplication (polyploidization), acting in concert. Using a wide range of ecological, karyological and molecular approaches, several hypotheses of general importance have been examined in three model angiosperm systems (ploidy variable species or species aggregates occurring both on and off specific substrates, including serpentines and calcareous soils). In the Knautia arvensis group (Caprifoliaceae) a unique cryptic diploid lineage in central Europe was identified to be restricted to serpentine and limestone outcrops, which served as refugia during environmental changes (forest spread, human impact) in the Holocene. These refugial populations exhibited strong evolutionary potential because they were able to polyploidize and escape beyond the borders of their original edaphically-conditioned refugia owing to hybridization with surrounding widespread homoploid genotypes. Survival of both Knautia cytotypes on serpentine soils was facilitated by their high tolerance to chemical stress factors such as high Ni concentrations and low Ca/Mg ratios. In the Galium pusillum group (Rubiaceae), a striking cytological, ecological, and taxonomic, diversity was revealed in northern and...