<p>The most frequently used radiopharmaceutical for treatment of thyroid diseases such as Thyroid Cancer and Hyperthyroidism is radioactive iodine 131I. It has a very high success rate in treatment of patients with thyroid diseases and also it has been proven to be safe and relatively inexpensive treatment modality. Whenever radiation is used in the treatment of the benign or cancer diseases dosimetry is essential. The main aim of this study is to perform external measurements of dose rate after administered activity and to simulate dosimetry of internal organs and risk assessment using MCNP 4b code, either for thyroid cancer and Hyperthyroid patients. To search safety optimization in this kind of therapy, it was recognized the necessity of more accurate knowledge of dose levels received by stomach and other organs. Of great importance is to know the effective dose that will be reached in gastric and other surrounding organs such as liver, lung, bladder etc. Additional aim was to provide information to be used in the improvement of radiation therapy, radiation safety practices and improvement of the fundamentals of radiation protection as defined by ICRP: justification, optimization and application of dose limits. The significance of this research is that the doses to internal organs can be determined and it worth to mention that such internal dosimetry calculation has been performed&nbsp;&nbsp; rare in the field of nuclear medicine. In accordance with the calculations carried out during this study and reference available in the literature that the therapy with radioiodine will be improved at the Institute of pathophysiology and nuclear medicine. Designed quality programs will be useful also for regulatory and accreditation bodies in the process of accreditation and radiation protection strategy. This work is divided into interconnected chapters. Chapter 2 to 4 contains the literature review and theoretical background of the study. Chapter 3 covers material and methods and aspect of Monte Carlo transport code focused on MCNP 4b code. Chapter 4 provides the results and discussion of the findings. Conclusions and recommendations are discussed in Chapter 5. Chapter 6 contains references used in this work.</p> / <p>Cilj terapije sa radiaoktivnim jodom 131I kod pacijenata koji boluju od nekih tipova tiroidnih carcinoma i hipertiroidizma je isporuka doze i apsorpcija doze u tiroidnoj žlezdi. Terapija sa radioaktivnim jodom sprovodi se u obliku rastvora Na131I (natrijum jodida) u tečnoj formi ili aplicira se u formi kapsule. Efektivna doza je rezultat apsorbovane doze u tiroidnom tkivu, ali i ostali unutra&scaron;nji organi prime izvesnu dozu. Kapsule koje sadrže natrijum jodid ostaju u stomaku oko 15 minuta pre nego &scaron;to započne apsorpcija, vreme dovoljno dugo za rizično izlaganje. Ova činjenica je jedan od ciljeva doktorske teze, odrediti efektivnu dozu u stomaku i nekoliko unutra&scaron;njih okolnih organa modelovanje transporta i interakcije gama zračenja i beta čestica emitovanih iz radionuklida 131I je kori&scaron;ćen Monte Karlo kod (MCNP4b). Radiojod je modelovan kao tačkasti izvor na dnu stomaka. Proračunavana je apsorbovana energija po jedinici transformacije u stomaku i okolnim organima. Ekvivalentna doza u tim organima je izračunata da bi se odredila efektivna doza primenom odgovarajućih težinskih faktora. Dobijeni rezultati imaju značaja za za&scaron;titu od zračenja, ali su važni i za ustanovljavanje novih kalibracionih procedura kao deo sigurnosne kontrole i kontrole kvaliteta u proizvodnji i kontroli radiofarmaceutika kao i procedure administriranja radiofarmaceutika i primene bolnčikih puteva. Smatramo da če rezultati ovog istraživanja pobolj&scaron;ati bezbednosnu kulturu u na&scaron;em sistemu zdravstvene za&scaron;tite kao i u državnim organima koji kreiraju i donose regulative.</p>

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

Micro-irradiation systems are used to analyse the effect of ionizing radiation at the cellular and tissue level, targeting individual cells within a population with a controlled low dose. Cell survival experiments using micro-irradiation systems are limited by factors including: 1) the radiation attenuation and optical properties of the chosen cell dish substrate, 2) the registration of the cell dish before and after irradiation or between multiple imaging modalities and 3) the analysis of the cell or colony growth after irradiation. In this thesis, a set of tools have been developed to improve micro-irradiation experiments and to increase the accuracy of information provided by the cell survival data. The first contribution, the substrate cell dish evaluation, provides a set of characteristics defining the substrates used for micro-irradiation experiments based on minimal energy loss and optical clarity using unstained cell imaging. The second contribution was the development of a novel and low cost fiducial marking device for micro-irradiation experiments using an 808 nm laser and providing marks suitable for imaging with multiple modalities. The minimum focused spot diameter was calculated as 22.9 urn and the device was used to create fiducial marks with diameters ranging from 20 urn to 130 urn. The third contribution, the development of a cell counting methodology for use with a lens-free imaging device, has been shown to accurately count thousands of cells suitable for immediate analysis. Approximately 1000 cell colonies, containing 17 729 cells on 11 cell dishes were used for testing and training for automatic cell counting. Validation of the cell counting method showed that 76% and 89% of the cell colonies were counted within a ± 20% and ± 30% error of the ground truth, respectively. Further development of the fiducial marking device, by modifying the choice of laser and making it suitable for multiple types of cell dish substrates, would increase the applications of the device. Development of the cell counting methodology for different cells line, and for cells grown on multiple types of substrates, would make the system suitable for analysis of a wide variety of cell survival studies. The cell counting methodology, applied to the CyMap lens-free imaging device, has the potential to be an extremely useful and cost effective tool for cell survival studies.

Traditionally, uncertainties are handled by expanding the irradiated volume to ensure target dose coverage to a certain probability. The uncertainties arise from e.g. the uncertainty in positioning of the patient at every fraction, organ motion and in defining the region of interests on the acquired images. The applied margins are inherently population based and do not exploit the geometry of the individual patient. Probabilistic planning on the other hand incorporates the uncertainties directly into the treatment optimization and therefore has more degrees of freedom to tailor the dose distribution to the individual patient. The aim of this thesis is to create a framework for probabilistic evaluation and optimization based on the concept of dose coverage probabilities. Several computational challenges for this purpose are addressed in this thesis. The accuracy of the fraction by fraction accumulated dose depends directly on the accuracy of the deformable image registration (DIR). Using the simulation framework, we could quantify the requirements on the DIR to 2 mm or less for a 3% uncertainty in the target dose coverage. Probabilistic planning is computationally intensive since many hundred treatments must be simulated for sufficient statistical accuracy in the calculated treatment outcome. A fast dose calculation algorithm was developed based on the perturbation of a pre-calculated dose distribution with the local ratio of the simulated treatment’s fluence and the fluence of the pre-calculated dose. A speedup factor of ~1000 compared to full dose calculation was achieved with near identical dose coverage probabilities for a prostate treatment. For some body sites, such as the cervix dataset in this work, organ motion must be included for realistic treatment simulation. A statistical shape model (SSM) based on principal component analysis (PCA) provided the samples of deformation. Seven eigenmodes from the PCA was sufficient to model the dosimetric impact of the interfraction deformation. A probabilistic optimization method was developed using constructs from risk management of stock portfolios that enabled the dose planner to request a target dose coverage probability. Probabilistic optimization was for the first time applied to dataset from cervical cancer patients where the SSM provided samples of deformation. The average dose coverage probability of all patients in the dataset was within 1% of the requested.

<p>X-ray mammography has been the gold standard for breast imaging for decades, despite the significant limitations posed by the two dimensional (2D) image acquisitions. Difficulty in diagnosing lesions close to the chest wall and axilla, high amount of structural overlap and patient discomfort due to compression are only some of these limitations. To overcome these drawbacks, three dimensional (3D) breast imaging modalities have been developed including dual modality single photon emission computed tomography (SPECT) and computed tomography (CT) systems. This thesis focuses on the development and integration of the next generation of such a device for dedicated breast imaging. The goals of this dissertation work are to: [1] understand and characterize any effects of fully 3-D trajectories on reconstructed image scatter correction, absorbed dose and Hounsifeld Unit accuracy, and [2] design, develop and implement the fully flexible, third generation hybrid SPECT-CT system capable of traversing complex 3D orbits about a pendant breast volume, without interference from the other. Such a system would overcome artifacts resulting from incompletely sampled divergent cone beam imaging schemes and allow imaging closer to the chest wall, which other systems currently under research and development elsewhere cannot achieve. </p><p>The dependence of x-ray scatter radiation on object shape, size, material composition and the CT acquisition trajectory, was investigated with a well-established beam stop array (BSA) scatter correction method. While the 2D scatter to primary ratio (SPR) was the main metric used to characterize total system scatter, a new metric called ‘normalized scatter contribution’ was developed to compare the results of scatter correction on 3D reconstructed volumes. Scatter estimation studies were undertaken with a sinusoidal saddle (±15° polar tilt) orbit and a traditional circular (AZOR) orbit. Clinical studies to acquire data for scatter correction were used to evaluate the 2D SPR on a small set of patients scanned with the AZOR orbit. Clinical SPR results showed clear dependence of scatter on breast composition and glandular tissue distribution, otherwise consistent with the overall phantom-based size and density measurements. Additionally, SPR dependence was also observed on the acquisition trajectory where 2D scatter increased with an increase in the polar tilt angle of the system. </p><p>The dose delivered by any imaging system is of primary importance from the patient’s point of view, and therefore trajectory related differences in the dose distribution in a target volume were evaluated. Monte Carlo simulations as well as physical measurements using radiochromic film were undertaken using saddle and AZOR orbits. Results illustrated that both orbits deliver comparable dose to the target volume, and only slightly differ in distribution within the volume. Simulations and measurements showed similar results, and all measured dose values were within the standard screening mammography-specific, 6 mGy dose limit, which is used as a benchmark for dose comparisons.</p><p>Hounsfield Units (HU) are used clinically in differentiating tissue types in a reconstructed CT image, and therefore the HU accuracy of a system is very important, especially when using non-traditional trajectories. Uniform phantoms filled with various uniform density fluids were used to investigate differences in HU accuracy between saddle and AZOR orbits. Results illustrate the considerably better performance of the saddle orbit, especially close to the chest and nipple region of what would clinically be a pedant breast volume. The AZOR orbit causes shading artifacts near the nipple, due to insufficient sampling, rendering a major portion of the scanned phantom unusable, whereas the saddle orbit performs exceptionally well and provides a tighter distribution of HU values in reconstructed volumes. </p><p>Finally, the third generation, fully-suspended SPECT-CT system was designed in and developed in our lab. A novel mechanical method using a linear motor was developed for tilting the CT system. A new x-ray source and a custom made 40 x 30 cm2 detector were integrated on to this system. The SPECT system was nested, in the center of the gantry, orthogonal to the CT source-detector pair. The SPECT system tilts on a goniometer, and the newly developed CT tilting mechanism allows ±15° maximum polar tilting of the CT system. The entire gantry is mounted on a rotation stage, allowing complex arbitrary trajectories for each system, without interference from the other, while having a common field of view. This hybrid system shows potential to be used clinically as a diagnostic tool for dedicated breast imaging.</p> / Dissertation

Magister Public Health - MPH / Background Antibiotic resistance is a phenomenon that occurs naturally and is accelerated by use. There have been no studies looking at trends in antibiotic consumption in the public health sector in Namibia, which provides services to 85% of the population. Aim This study described the pattern of antibiotic consumption in the Namibian public health sector based on distribution of antibiotics from Central Medical Stores (CMS) to the 13 regions in the country. Methodology Antibiotic consumption data from distribution records at the Central Medical Store (CMS), public health sector wholesaler, between 1 January 2010 and 31 December 2016 was collated and analysed to describe trends and usage patterns in the public health sector of Namibia. For the purpose of this study DDD per 1000 inhabitants per day (DID) was used as an indicator so as to be comparable with previously conducted studies. DIDs provide information about the proportion of the selected population using a particular medicine per day. The World Health Organization (WHO) recommended anatomical therapeutic classification (ATC)/daily defined dose (DDD) methodology be used to analyse the data and evaluate the consumption. Data was presented using stacked bar charts to demonstrate the variation in consumption by ATC classes in each region and over time.

Orientador: Odair Aparecido Fernandes / Banca: Pedro Takao Yamamoto / Banca: Daniel Junior de Andrade / Resumo: Atualmente, insetos praga estão impactando a produção de soja e táticas de controle não estão sendo eficientes, por causa do uso inadequado no campo. Assim opções para manejo de pragas precisam ser desenvolvidas, tais como novos compostos químicos. Devido a disponibilidade de formulação recentemente desenvolvida (concentrado emulsionável - EC) de indoxacarbe, os objetivos com este estudo foram avaliar a eficiência desta formulação no controle de Helicoverpa armigera (Hübner) e Chrysodeixis includens (Walker) (Lepidoptera: Noctuidae) em soja. Um experimento a campo foi conduzido usando duas formulações (EC e solução concentrada - SC) de indoxacarbe (30 e 60 g i.a. ha-1) e testemunha. Após a pulverização, folíolos foram coletados das regiões mediana e superior das plantas em diferentes períodos. Os folíolos foram infestados com lagartas de 3°. instar de H. armigera e C. includens. As duas formulações do indoxacarbe foram eficientes no controle de ambas as pragas, independente da região da planta. As maiores dosagens causaram mortalidade > 80% em H. armigera somente 1h após a aplicação e em C. includens até 3 dias. No experimento de laboratório, folíolos recém-coletados de soja cultivada em casa-de-vegetação e imersos em soluções com concentrações crescentes das duas formulações de indoxacarbe para construção das curvas dose-resposta. Após secagem, os folíolos foram infestados com lagartas de 3°. instar de H. armigera e C. includens. As curvas dose-resposta foram similares para ... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Currently, insect pests are impacting soybean yield and control tactics are not efficient because of their inappropriate use in the field. Therefore, options for pest management ought to be developed, such as new chemical compounds. Because of the availability of recent developed formulation (emulsifiable concentrate - EC) of indoxacarb, the objectives of this study were to evaluate the effectiveness of this formulation for the control of Helicoverpa armigera (Hübner) and Chrysodeixis includens (Walker) (Lepidoptera: Noctuidae) in soybean. A field experiment was carried out using two formulations (EC and suspension concentrate - SC) of indoxacarb (30 and 60 g a.i. ha-1) and an untreated control. After spray, leaflets were collected from mid and upper regions of the plants at different times. The leaflets were infested with 3rd instar larvae of H. armigera and C. includens. The two indoxacarb formulations were effective in controlling both species, regardless of plant region. Higher doses caused > 80% mortality of H. armigera only 1h after application and of C. includens up to 3 days. In a lab experiment, fresh soybean leaflets were collected from greenhouse and immersed in solutions with increasing concentrations of the two indoxacarb formulations to build the dose-response curves. After drying, they were infested with 3rd instar larvae of H. armigera and C. includens. The dose-response curves were similar for both formulations. For H. armigera, the EC and SC indoxacarb formu... (Complete abstract click electronic access below) / Mestre

Abstract Medical x-ray imaging is used to visualise patients’ anatomical structures and in some cases their physiology. X-rays are ionizing radiation, thus their use needs to be optimised, as stochastic effects are assumed to increase linearly with the exposure dose. Imaging protocols need to be optimised to a radiation dose level that follows the as low as reasonably achievable principle without compromising the diagnostic value of the image. Different methods can be used to help in the optimisation process, such as simulations, radiation dose and image quality assessments with dosimeters and phantoms and utilising the latest technology in the most efficient way. The purpose of this doctoral thesis was to investigate the applicability of metal-oxide-semiconductor-field-effect-transistor (MOSFET) dosimeters for dose determinations in conventional x-ray and computed tomography (CT) examinations. Additionally, dose optimising methods were investigated in dental panoramic imaging using radiophotoluminescence (RPL) dosimeters. Anthropomorphic phantoms were used in every study to simulate patients, as their structures enable dosimeters to be positioned at locations that correspond to different organs. The MOSFET’s properties for dose determinations were evaluated against the reference dosimeter in a conventional x-ray set-up. Comparisons of absorbed and effective doses in thorax x-ray imaging were made between RPLs, MOSEFTs and Monte Carlo simulations. The effect of the organ-based tube current modulation and bismuth shields were compared against the reference imaging method in a chest CT with one scanner model. Absorbed doses and quantitative image quality were evaluated using each method. Possible dose reduction from segmented dental panoramic tomography (sDPT) imaging was compared against full DPT. Dose measurements were done using RPL dosimeters in pediatric and adult set-up using phantoms. MOSFETs are accurate enough to be used in conventional x-ray and CT, but they require a careful calibration before use as their reproducibility is limited with low doses. Bismuth shields provided the best dose reduction, but with a negative impact on quantitative image quality, especially when metal artefact removal software was used. The final study showed that the use of sDPT programmes and pediatric protocols enable a notably dose reduction compared to the full DPT adult protocol. / Tiivistelmä Lääketieteellisessä kuvantamisessa käytetään röntgensäteilyä potilaan anatomian ja joissain tapauksissa fysiologian visualisointiin. Röntgensäteily on ionisoivaa ja stokastisten vaikutusten kasvaessa oletettavasti lineaarisesti säteilyn funktiona, tulee säteilyn olla kokonaisvaltaisesti optimoitua. Kuvauksissa käytetyn röntgensäteilyn käytön tulee noudattaa ALARA-periaatetta, minkä vuoksi kuvauksessa tulee käyttää niin vähän säteilyä kuin vain mahdollista, diagnostiikan vaarantumatta. Optimoinnin apuna voidaan käyttää esim. simulointeja, annos- ja kuvanlaatumäärityksiä dosimetreilla ja fantomeilla, tai laitevalmistajien tuomia uusia teknologioita. Tämän väitöskirjan tarkoituksena oli tutkia metallioksidi-puolijohdekanavatransistorien (MOSFET) soveltuvuutta natiiviröntgentutkimuksissa ja tietokonetomografiassa (TT). Lisäksi työssä tutkittiin hammaskuvauksissa käytettyjä annossäästömenetelmiä radiofotoluminesenssidosimetreilla (RPL). Potilasvasteena työssä käytettiin antropomorfisia fantomeita, minkä ansiosta säteilyannoksia voidaan mitata eri elimiä vastaavilta kohdilta. MOSFET annosmittarin ominaisuuksia arvioitiin natiiviröntgenasetelmassa referenssimittariin nähden. Absorboituneiden ja efektiivisten annosten eroa MOSFET:tien, RPL:ien ja simulointien kesken tutkittiin keuhkoröntgentutkimuksessa. Pintakudoksia säästävän putkivirranmodulointimenetelmän ja vismuttisuojien vaikuttavuutta verrattiin TT:ssä referenssimetelmää vasten. Vaikuttavuutta arvioitiin absorboituneiden annosten ja kvantitatiivisen kuvanlaadun avulla. Segmentoidun hammaspanoraamakuvauksen (sDPT) annossäästömahdollisuuksia verrattiin tavalliseen panoraamakuvaukseen. Annosmääritykset tehtiin käyttäen RPL dosimetreja lapsi- ja aikuisfantomeissa. MOSFET dosimetreja voidaan käyttää annosmäärityksiin natiiviröntgenkuvauksissa ja TT:ssä, mutta niiden kalibrointi ja toistettavuus matalilla annoksilla aiheuttaa kuitenkin rajoituksia niiden käytölle. Vismuttisuojat tuottivat parhaan annossäästön, huonontaen kuitenkin kuvanlaatua. Kuvanlaadun huonontuminen oli erityisen huomattavaa, kun metallista aiheutuvien kuvavirheiden poistamiseen suunniteltua ohjelmaa käytettiin. Viimeinen tutkimus osoitti, että sDPT ohjelmat ja lapsille suunnatut protokollat mahdollistavat huomattavan annossäästön verrattuna aikuisten kokopanoraamaan.

No description available.

Frente à crescente necessidade de que novas tecnologias sejam capazes de operar com confiabilidade em ambientes hostis, a análise dos efeitos da radiação ionizante em dispositivos semicondutores se tornou um ramo de pesquisa em contínua ascensão, contribuindo para o desenvolvimento de tecnologias estratégicas e promovendo o aprimoramento científico e o desenvolvimento tecnológico da humanidade. Por outro lado, a atual tecnologia CMOS de fabricação de circuitos integrados apresenta sinais de limitação, em grande parte, devido às características físicas inerentes ao seu princípio de funcionamento, sendo necessário, portanto, que dispositivos com novos mecanismos de operação e geometrias sejam desenvolvidos. Dentre eles, transistores de tunelamento induzido por efeito de campo (TFET) se destacam por apresentarem menor corrente de dreno quando desligados e a possibilidade de se atingir inclinações de sublimiar abaixo do limite teórico estabelecido por dispositivos MOSFET de 60 mV/déc à temperatura ambiente, permitindo-se a redução da tensão de alimentação dos transistores para cerca de 0,5 V. Buscando contribuir com as necessidades destas duas áreas de pesquisa, neste projeto de mestrado, foi analisado o comportamento de TFETs de silício com porta tripla, fabricados sobre lâmina SOI (silício sobre isolante), submetidos a até 10 Mrad(Si) de dose acumulada total enquanto não polarizados, gerada por uma fonte de prótons de 600 keV de energia. Em uma análise inicial, após exposição de dispositivos de 1 µm de largura de aleta a uma dose de 1 Mrad(Si), foi possível observar uma redução no nível corrente de dreno de estado ligado do dispositivo (ION ? 300 pA) de até 10%, não associada à uma alteração da corrente de porta. Além disso, o efeito da radiação nesses transistores reduz de 10% para 2% quando se aumenta o comprimento do canal de 150 nm para 1 µm. As razões para ambos os fenômenos foram discutidas com base na competição entre os efeitos de divisão da corrente de dreno na primeira e segunda interfaces e do aumento da resistência de canal em dispositivos mais longos. Para uma análise em função da dose acumulada total, dispositivos SOI TFET e SOI MOSFET, ambos de porta tripla, foram caracterizados eletricamente 14 dias após cada etapa de irradiação. De maneira geral, dispositivos de ambas as tecnologias, com largura de aleta igual a 40 nm, apresentaram baixa susceptibilidade aos efeitos cumulativos da radiação ionizante. No entanto, quando considerados dispositivos com largura de aleta muito maior que a altura da aleta (WFIN = 1 µm), nos quais a influência das portas laterais sobre o acoplamento eletrostático do canal é praticamente inexistente, transistores túnel-FET se destacaram positivamente. Esses dispositivos se mostraram resistentes aos efeitos de dose ionizante total (TID) mesmo para doses de 5 Mrad(Si), enquanto os transistores SOI MOSFET apresentaram uma variação gradual de seus parâmetros a cada dose acumulada. Um exemplo disso é a variação observada na inclinação de sublimiar, de 32,5% nos transistores SOI MOSFET e 5,6% nos transistores SOI TFET. Somente após 10 Mrad(Si) de irradiação por prótons é que os TFETs de aleta larga apresentaram variações mais significativas em sua curva de transferência (ID x VG). Tanto para a configuração como tipo P quanto para a configuração como tipo N, notou-se um deslocamento de até 80 mV da curva de transferência do dispositivo para a esquerda, provocado, segundo análise via simulações, pelas cargas fixas positivas geradas pela irradiação no óxido enterrado do dispositivo. Adicionalmente, foi possível observar um aumento da corrente de tunelamento assistido por armadilhas (TAT) nesses dispositivos, provocada pelo aumento da densidade de estados de interface causada também pelos efeitos de TID. O aumento de TAT foi reconhecido como o principal responsável pela degradação de 23,3% da inclinação de sublimiar dos TFETs, com WFIN igual 1 µm, após 10 Mrad(Si). Apesar das mudanças observadas, foi possível se sugerir, através da comparação com transistores SOI MOSFET de dimensões equivalentes, que transistores de tunelamento induzido por efeito de campo podem, futuramente, se tornar referência no quesito imunidade aos efeitos de dose ionizante total. / In light of the increasing need for new technologies to be able to operate reliably in harsh environments, the analysis of the effects of ionizing radiation on semiconductor devices has become a continually rising field of research, contributing to the development of strategic technologies and promoting scientific improvement and technological development of humankind. On the other hand, the current CMOS technology for the manufacture of integrated circuits shows signs of limitation, mostly, due to the physical characteristics inherent to its operating principle, thus, it is necessary that devices with new operating mechanisms and geometries be developed. Among them, tunnel field-effect transistors (TFET) stand out because of its lower OFF state current and the possibility of reaching subthreshold swing below the theoretical limit established by MOSFET devices of 60 mV/dec at room temperature, allowing to reduce transistors supply voltage to about 0.5 V. In order to contribute with both areas, the behavior of silicon based triple gate TFETs fabricated on a SOI (silicon-on-insulator) substrate and exposed to a total cumulative dose of 10 Mrad (Si) (while not biased) generated by a 600 keV proton beam was analyzed. In an initial analysis after exposure of 1 µm width devices to 1 Mrad(Si), it was possible to observe an ON state current reduction (ION ? 300 pA) up to 10%, not associated to a gate current change. Beyond that, irradiation effects on these devices reduce from 10% to 2% with the channel length increasing from 150 nm to 1 µm. The reasons behind these phenomena were discussed based on the competition between a high channel resistance present in longer devices and the TFET drain current reduction due to the irradiation. For a total cumulative dose analysis, triple gate SOI TFET and triple gate SOI MOSFET devices were characterized 14 days after each irradiation phase. In general, devices of both technologies, with 40 nm fin width, presented low susceptibility to the cumulative effects of ionizing radiation. However, for devices with fin width larger than fin height (WFIN = 1 µm) in which the influence of side gates on the electrostatic coupling of the channel is weak, tunnel-FET transistors have stood out. These devices were resistant to the effects of total ionizing dose (TID) even for doses as high as 5 Mrad(Si), while SOI MOSFET transistors showed a gradual variation of their parameters at each accumulated dose. The variation observed for the subthreshold swing, for example, was about 32.5% for SOI MOSFET devices and 5.6% for SOI TFET devices. TFETs with wider fin have shown significant variations on its transfer characteristic (ID x VG) only after 10 Mrad(Si) of proton irradiation. For both P-type and N-type configurations, it was observed a shift of the transfer curve to the left up to 80 mV caused by, according to simulations, the positive fixed charges generated in the buried oxide by irradiation. In addition, it was possible to observe a trap assisted tunneling (TAT) current increase caused by interface states promoted by TID effects. The increase of TAT was recognized as the main responsible for the degradation of 23.3% of the subthreshold swing of the TFETs after 10 Mrad(Si). In spite of the observed changes, it was possible to suggest, through comparison with SOI MOSFET devices of equivalent dimensions, which tunnel field-effect transistors may become a reference when considering immunity against total ionizing dose effects.