Why are dual-task costs reduced with ideomotor (IM) compatible tasks (see e.g. Greenwald & Shulman, 1973)? In a series of experiments, I tested the way in which task structure affects dual-task performance (Halvorson et al., 2012). The results suggest that in some cases, typical dual-task costs arise from task structure rather than response limitations. Further examination of this question has shown that dual-task costs cannot be predicted solely on the basis of the relationship between the stimuli and the responses; the relationship between the tasks, or the task pairing, plays a critical role in whether the tasks overlap and performance is impaired. A series of experiments using novel task pairings showed that when one task uses a spatial central code and the other uses a verbal central code, dual-task costs are eliminated.

<p>As a consequence of the presence of both mitochondria and chloroplasts in plant cells there is a higher sorting requirement in a plant cell than that in a non-plant cell. Reflecting this, protein import to mitochondria and chloroplasts has been shown to be highly specific. However, there is a group of proteins which are encoded by a single gene in the nucleus, translated in the cytosol and targeted to both mitochondria and chloroplasts. These proteins are referred to as dual targeted proteins. The first protein shown to be dual targeted was pea glutathione reductase (GR). The focus of this thesis is the targeting properties of the dual targeted protein glutathione reductase.</p><p>In order to overcome the limitations with traditional in vitro import systems we have developed an import system for simultaneous import of precursor proteins into mitochondria and chloroplasts (dual import system). The chloroplastic precursor of the small subunit of ribulose bisphosphate carboxylase/oxygenase (SSU) was mis-targeted to pea mitochondria in a single import system, but was imported only into chloroplasts in the dual system. The dual GR reductase precursor was targeted to both mitochondria and chloroplasts in both the single and dual import system.</p><p>We have investigated the targeting and processing properties of the GR targeting signal. Using N-terminal truncations we have demonstrated that the GR targeting signal has a domain organisation. Our results show that GR has evolved a dual targeting signal with the C-terminal part being sufficient for chloroplast import, the internal part required for the mitochondrial import and the N-terminal part housing a “fine-tuning” function. Furthermore, we have constructed a range of point mutations on the GR signal sequence changing positive amino acid residues and stretches of hydrophobic amino acid residues. Overall single mutations had a greater effect on mitochondrial import compared to import into chloroplasts. We have also shown that the recognition of the GR processing site differs between MPP and SPP. Single amino acid substitutions in the vicinity of the processing site clearly affected processing by MPP while processing by SPP showed low sensitivity to single mutations.</p>

<p>Syftet med denna C-uppsats har varit att få en ökad förståelse i hur vårdgivare arbetar med människor i ett mellanrum mellan två kategorier samt att belysa den problematik som finns med att kategorisera människor som dubbeldiagnos. Dubbeldiagnos är en kategorisering som ibland skapar problem som gör att dessa klienter hamnar i ett mellanrum mellan kommunen och landstinget. Denna studie är baserad på en kvalitativ metod med grundad teori som forskningsdesign. Intervjuer har gjorts med respondenter från psykiatrin, boendeverksamhet, öppenvårdsverksamhet och socialtjänsten. Resultatet tyder bland annat på att det som är viktigast i arbetet med dubbeldiagnoser är samverkan mellan vårdgivarna. Diagnosen kan även medföra att klienterna känner sig stämplade. Den viktiga eftervården brister i kvalité som bottnar i de bristande resurser som finns. Detta resultat diskuteras i diskussionen med hjälp av teorier om social kategorisering och typifiering.</p>

<p>Vi ville med detta arbete ta reda på varför svenska sjöbefälstudenter söker sig till Maersks sjöbefälsutbildning istället för till sjöbefälsutbildningen i Kalmar. Vi ville också ta reda på vilka faktorer som spelar in vid val av sjöbefälsutbildning, hur studenterna kommit i kontakt med utbildningen samt hur de upplever sin studietid på SIMAC.</p><p> </p><p>Under ett studiebesök på SIMAC har vi intervjuat svenska studenter. Vi valde att göra en kvalitativ studie med öppna frågeställningar. Intervjuerna följdes upp med en enkätundersökning. Dessa metoder lämpade sig bra då vi ville få fram studenternas åsikter.</p><p> </p><p>Det resultat vi fick fram var att de studenter som deltog i studien uppfattade sin skola som något ostrukturerad. De hade även svårigheter med det danska språket. Den huvudsakliga anledningen till att studenterna går kvar på skolan är anställningen hos Maersk som ger goda möjligheter till ett välbetalt arbete.</p> / <p>With this thesis we would like to find out why Swedish students at a nautical choose to study at Maersks master programme instead of Kalmar Maritime Academy.<strong></strong></p><p>We also wanted to find out what factors play a role in the choice of school, how the students come in contact with the school and how they experience their studies at SIMAC.</p><p>We have interviewed some of the Swedish students during a visit at SIMAC. We chose to perform a qualitative study consisiting of open questions. The interviews were followed up with a questionnaire. These methods were suitable since we were interested in the student´s opinions. Our result is that the students who took part in our study perceived their school sometimes as unstructured and confusing. They also experienced problems with the Danish language. The main reason for staying at the school is the upcomming, remunerative, work at Maersk.</p>

Given an undirected network with L possible facility types for each edge, and a partition of the nodes into L levels, the Multi-level Network Design (MLND) problem seeks a fixed cost minimizing design that spans all the nodes and connects the nodes at each level by facilities of the corresponding or higher type. This problem generalizes the well-known Steiner network problem and the hierarchical network design problem, and has applications in telecommunication, transportation, and electric power distribution network design. In a companion paper we introduced the problem, studied alternative model formulations, and analyzed the worst-case performance of heuristics based on Steiner network and spanning tree solutions. This paper develops and tests a dual-based algorithm for the Multi-level Network Design (MLND) problem. The method first performs problem preprocessing to fix certain design variables, and then applies a dual ascent procedure to generate upper and lower bounds on the optimal value. We report extensive computational results on large, random networks (containing up to 500 nodes, and 5000 edges) with varying cost structures. The integer programming formulation of the largest of these problems has 20,000 integer variables and over 5 million constraints. Our tests indicate that the dualbased algorithm is very effective, producing solutions guaranteed to be within 0 to 0.9% of optimality.

The purpose of the present study was to explore and describe the lived experiences of mothers living in dual-career families. Using existential phenomenology as the guiding research methodology, I interviewed 10 mothers living in dual-career families. Analysis of the interview transcripts revealed four themes that stood out as figural for participants in the study: (a) "Free time isn't really free anymore": Timing is Everthing; (b) "It's because of the support I get": Supporting Me; (c) "I feel like I'm lacking in one area all the time, just a little bit": Struggling to Find a Balance; and (d) "I know how I would do things": Knowing Myself. Each theme stood out against the ground of world, specifically the two worlds of home and work and the struggle that existed in integrating the two. Study findings revealed that the two primary struggles faced by these mothers living in dual-career families were those associated with balancing and time. A limited amount of time necessitated a need to try to balance home and work, a balance that was not easily achieved. Mothers perceived support networks and certain personality characteristics as helpful in balancing the two worlds (although personality characteristics were perceived as disadvantageous at times). Although challenges existed for these mothers, they noted overwhelmingly that they desired to have a career. These mothers saw their careers as one of the primary benefits of the dual-career lifestyle, and it was a lifestyle they willingly chose. Two findings from the study warrant future research. First, supportive others in the community were an integral part of the support network for mothers in the present study, and little empirical literature is dedicated to the impact of this type of support on the dual-career family. Second, participants perceived certain personality characteristics as either advantageous or disadvantageous in helping them navigate the dual-career lifestyle, and little empirical literature is dedicated to denoting the impact of individual personality characteristics on managing the dual-career lifestyle. It would behoove family scholars to be aware of these two unique aspects of the study.

The tube hydroforming process has gained increasing attention in recent years. Coordination of the internal pressurization and axial feeding curves is critical in the tube hydroforming process to generate successful parts without fracture or wrinkling failure. The stress state at a given time and location varies with the process history and the design and control of the load paths. A new process parameter, counter-pressure, is introduced to achieve a favorable tri-axial stress state during the deformation process. The new process is referred to as dual hydroforming. The benefits offered by dual hydroforming will be characterized based upon the amount of wall thinning, plastic instability limit and final bulged configuration. An analytical model is developed to analyze the stress and strain state in the part (tube) during the dual hydroforming process. The stress-strain condition analyzed will be used to evaluate and compare thinning for tube hydroforming and dual hydroforming. The effect of applying counter-pressure on the plastic instability of thin-walled tubes with only internal pressure and combination of internal pressure and independent axial loading is considered. Finite element analysis is used to quantify the merits of dual hydroforming in terms of final bulged configuration. A parametric study has been conducted to investigate the effectiveness of dual hydroforming based on the various material properties and process conditions. Dual hydroforming results in different stress and strain states compared to tube hydroforming. The counter-pressure enabled favorable tri-axial stress state during deformation that resulted in different thickness and percentage thinning. Finite element analysis showed that for a particular amount of wall thinning there is an increase of around 8% in bulge height for dual hydroforming. Dual hydroforming delays the onset of plastic instability. This increase in the value of effective strain to failure results in an increase of around 12% in bulge height for dual hydroforming as shown by finite element simulations. Results of this study indicate that dual hydroforming can increase expansion i.e. more difficult parts can be designed and manufactured. Also, for a given part geometry, higher strength and less formable materials can be used.

As a consequence of the presence of both mitochondria and chloroplasts in plant cells there is a higher sorting requirement in a plant cell than that in a non-plant cell. Reflecting this, protein import to mitochondria and chloroplasts has been shown to be highly specific. However, there is a group of proteins which are encoded by a single gene in the nucleus, translated in the cytosol and targeted to both mitochondria and chloroplasts. These proteins are referred to as dual targeted proteins. The first protein shown to be dual targeted was pea glutathione reductase (GR). The focus of this thesis is the targeting properties of the dual targeted protein glutathione reductase. In order to overcome the limitations with traditional in vitro import systems we have developed an import system for simultaneous import of precursor proteins into mitochondria and chloroplasts (dual import system). The chloroplastic precursor of the small subunit of ribulose bisphosphate carboxylase/oxygenase (SSU) was mis-targeted to pea mitochondria in a single import system, but was imported only into chloroplasts in the dual system. The dual GR reductase precursor was targeted to both mitochondria and chloroplasts in both the single and dual import system. We have investigated the targeting and processing properties of the GR targeting signal. Using N-terminal truncations we have demonstrated that the GR targeting signal has a domain organisation. Our results show that GR has evolved a dual targeting signal with the C-terminal part being sufficient for chloroplast import, the internal part required for the mitochondrial import and the N-terminal part housing a “fine-tuning” function. Furthermore, we have constructed a range of point mutations on the GR signal sequence changing positive amino acid residues and stretches of hydrophobic amino acid residues. Overall single mutations had a greater effect on mitochondrial import compared to import into chloroplasts. We have also shown that the recognition of the GR processing site differs between MPP and SPP. Single amino acid substitutions in the vicinity of the processing site clearly affected processing by MPP while processing by SPP showed low sensitivity to single mutations.

Syftet med denna C-uppsats har varit att få en ökad förståelse i hur vårdgivare arbetar med människor i ett mellanrum mellan två kategorier samt att belysa den problematik som finns med att kategorisera människor som dubbeldiagnos. Dubbeldiagnos är en kategorisering som ibland skapar problem som gör att dessa klienter hamnar i ett mellanrum mellan kommunen och landstinget. Denna studie är baserad på en kvalitativ metod med grundad teori som forskningsdesign. Intervjuer har gjorts med respondenter från psykiatrin, boendeverksamhet, öppenvårdsverksamhet och socialtjänsten. Resultatet tyder bland annat på att det som är viktigast i arbetet med dubbeldiagnoser är samverkan mellan vårdgivarna. Diagnosen kan även medföra att klienterna känner sig stämplade. Den viktiga eftervården brister i kvalité som bottnar i de bristande resurser som finns. Detta resultat diskuteras i diskussionen med hjälp av teorier om social kategorisering och typifiering.

α-helical membrane proteins comprise about a quarter of all proteins in a cell and carry out a wide variety of essential cellular functions. This thesis is focused on topology analyses of bacterial membrane proteins. The topology describes the two-dimensional structural arrangement of a protein relative to the membrane. By combining large-scale experimental and bioinformatics techniques we have produced experimentally constrained topology models for the major part of the Escherichia coli membrane proteome. This represents a substantial increase in available topology information for bacterial membrane proteins. Many membrane protein structures show signs of internal duplication and approximate two-fold in-plane symmetry. We propose a step-wise pathway to explain how proteins with such internal inverted repeats have evolved. The pathway is based on the ‘positive-inside’ rule and starts with a protein that can adopt two topologies in the membrane, i.e. a “dual” topology protein. The gene encoding the dual topology protein is duplicated and eventually, through re-distribution of positively charge residues, the two resulting homologous proteins become fixed in opposite orientations in the membrane. Finally, the two proteins may fuse into one single polypeptide with an internal inverted repeat structure. Finally, we re-create the proposed step-wise evolutionary pathway in the laboratory by showing that only a small number of mutations are required in order to transform the homo-dimeric, dual topology protein EmrE into a hetero-dimeric complex composed of two oppositely oriented proteins.