Diplomová práce se zabývá tématem manažerských simulátorů. Je rozdělena na dvě části. První, teoretická pojednává o teoretickém pozadí manažerských simulátorů. Druhá, praktická, se zabývá testováním dvou simulátorů: StartCom a DealSale.

Práce podrobně analyzuje tendence ve vývoji produktové stuktury na českém pojistném trhu. Podrobně se zaměřuje na zachycení změn a jejich přičin ve struktuře pojistných produktů v posledním období. Snahou bylo uvést důležité aspekty vedoucí k přizpůsobování se produktové struktury tržnímu hospodářství. Zmíním produkty nacházející se v současné době na českém pojistném trhu na konkrétních číslech a demonstruji jejich vývoj v posledních letech. Srovnám životní a neživotní pojištění. Prognózování možného a předpokládaného složení struktury obou segmentů do budoucích let nejenom v návaznosti vstupu České republiky do Evropské unie je konečným cílem práce.

Diplomová práce popisuje vývoj objemu a struktury poskytovaných úvěrů v ČR v oblasti veřejného a podnikového zadlužení se zaměřením na zadlužení v segmentu domácností. Zde je provedena analýza faktorů, které ovlivňují změny ve struktuře a dynamice úvěrů. Významný vliv má vývoj úrokových sazeb, změny úvěrových podmínek, růst disponibilních příjmů, trh nemovitostí či nové trendy v přístupu k zadlužování.

The persistence of Marsh fritillary (Euphydryas aurinia) and its relationships with five other closly related and co-occuring Nymphalidae butterflies was studied in identical habitat networks. Basic demography and dispersal patterns, and their consequences for conservation strategies, were investigated across mutliple sites and seasons.

Classical molecular dynamics simulations were applied on complexes of RNA-dependent RNA-polymerase, Ribonuclease H, Argonaute and Ribonuclease L with chemically modified nucleic acids, which are studied as potential chemotherapeutic agents. Powerful graphics processing units, through which these molecular dynamics simulations were performed, enabled to acquire trajectory length from hundreds of nanoseconds to one microsecond. Molecular dynamics simulations allowed capture differences in binding of various modified nucleic acids to the above mentioned enzymes. These identified differences fitted well with experimental results. It opens the door for rational design of the structure of potential chemotherapeutic agents based on chemically modified nucleic acids.

The aim of this diploma thesis was to evaluate the structure and developmental dynamics of natural tree regeneration in the core area of the Boubín virgin forest NNR and also to evaluate the effect of selected factors such as light conditions, water-affection of the site and substrat type on its occurence. By using a system of circular inventory plots all individuals of d1.3 < 10 cm were in 2010, 2012 and 2013 registered and classified into corresponding height class or diameter class. To find out the light conditions of this plots the hemispherical photographies were taken. The main tree species are represented by so-called hercynian mixture (spruce-fir-beech), which is contemporary for the main part in the stage of optimum and the initial stage of disintegration. It emerged that beech (Fagus sylvatica L.) is markedly dominated species in the regeneration layer and is related to water-unaffected sites. On the contrary representation of fir (Abies alba Mill.) is very low and its occurence was not to be found to be conditioned by any of considered factors; neverthless its growing-up has been prooved. Spruce (Picea abies (L.) Karsten) is very poorly able to compete in growing-up with beech, but this fact is not affected by any of analysed factors.

The thesis deals with landscape development in Nová Ves I. The historical development of landscape was based on the evaluation of three maps from different times. The chosen ones were Stable cadastral map (1841), an ortophotomap from 1950´s (1954) and a recent ortophoto map (2015). The first part of the thesis is dedicated to literary research, which is focused on demarcation of related issues. The second part is focused on data processing and analysis. Maps were processed by ArcGIS 10.2 software. Raster data were manually vectorised according to the chosen categories of landscape utilization. The maps of landscape utilization during the times are providing important information about landscape development, mostly in past 170 years. At the end, the results derived from the analysis are put into context with the overall objectives of land consolidation. That show us the possible benefits of land consolidation in area of interest.

This master thesis deals with issues of the disturbance history virgin temperate forests in case study from Boubin virgin forest. For the study disturbance past is used dendrochronological techniques. Thanks to the known locations of trees in the Boubin virgin forest we use of newly developed approaches based on point data. The main outcome of the thesis is a summary disturbance history of Boubin virgin forest and discussing the results.

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Not accounting for the electronic polarizability due to divalent ions such as Ca2+ introduces a significant artifacts to force field-based molecular dynamic simulations of biological systems. Two newly developed parameter refinements were used to compute the free energy profile of the Ca2+ -Cl- ion dissociation in aqueous solutions, to be compared with a free energy profile obtained from ab-intio molecular dynamics and to data from neutron scattering. Next, the computational evidence for the existence of a local free energy min- imum representing a guanidinium-guanidinium contact ion pair in aqueous solu- tions is provided suggesting a global preference for a contact ion pair. Finally, the passive membrane penetration mechanism of oligoarginines was investigated on a cell membrane model systems - lipid vesicles - by fluorescent spectroscopy. In this study, a mechanistic link between membrane penetration and vesicle aggregation and fusion was found. 1