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Untersuchungen zur Regulation der TNF-a-stimulierten Matrix-Metalloproteinase-9-Expression durch die MAPKHeidinger, Michael. Unknown Date (has links)
Techn. Universiẗat, Diss., 2006--München.
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Inventarizace a hodnocení růstu dřevin ve VS Olomučany a vybraných paloucích ŠLP ML KřtinySís, David January 2007 (has links)
No description available.
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Comparison of different approaches for biomass inventory in floodplain forestPérez Ferrándiz, Elicerio Luis January 2013 (has links)
No description available.
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Změny krajinné struktury a jejich příčiny v katastrálním území Vranová LhotaMilenovský, Jan January 2013 (has links)
No description available.
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Proposição teórico-metodológica de uma cartografia geográfica crítica e sua aplicação no desenvolvimento do atlas da questão agrária brasileiraGirardi, Eduardo Paulon [UNESP] 18 September 2008 (has links) (PDF)
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girardi_ep_dr_prud.pdf: 4554443 bytes, checksum: 0922f4d2b6d7db3c90b9f4528c9f3224 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / No movimento de renovação da Geografia brasileira, a Geografia Crítica atuou questionando os princípios e práticas da Geografia Tradicional e da Geografia Pragmática frente aos problemas sociais e propôs uma leitura de mundo direcionada ao entendimento e resolução desses problemas. Contudo, a crítica radical às outras duas correntes fez com que a Geografia Crítica desconsiderasse suas contribuições, como por exemplo, o desenvolvimento no campo da Cartografia. Como o mapa era amplamente utilizado pelas correntes tradicionais e pragmáticas, ele também foi negligenciado pela corrente crítica. A Geografia Crítica confundiu a visão de mundo com os procedimentos metodológicos dessas correntes e com isso ignorou o potencial analítico e discursivo do mapa como inerente ao discurso... / During the revisionist movement to renovate Brazilian Geography, the Critical Geography school questioned the principles and practices of Traditional and Pragmatic Geography, arguing that these schools were inadequate to the times and offering a reading of the world directed at the understanding and resolution of social problems. However, the radical critique of the two older currents caused the Critical Geography school to underestimate some useful contributions of these approaches such as Cartography. In fact, since maps were widely used by Traditional and Pragmatic Geography, Critical Geography tended to dismiss their utility. Critical Geography seemingly confused the worldview and methodology of these schools and thus ignored the analytical and discursive potential of maps as inherent to geographical language. As Critical Geography became predominant, maps became neglected in Brazilian... (Complete abstract click electronic access below)
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The use of standard cameras in terrestrial photogrammetryShaw, Raymond Newell January 1959 (has links)
No description available.
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Cenová mapa obvyklého nájemného nebytových prostor ve vybraných lokalitách města Brna / A Price Map of Standard Rent of Commercial Spaces in Selected Areas of the City of BrnoČechmaneková, Simona January 2013 (has links)
The thesis is focused on the creation of price maps commercial real estate lease in the areas of Brno, in selected urban areas. It is divided into two parts: The theoretical section explains the basic concepts related to the thesis, which are: the types of commercial spaces, types of prices in the valuation, introduces us to the situation on the commercial real estate market and the importance of price charts and the methodology to create. The practical part focuses on the formation of price charts, discussed the issue at its orign, the possibility of creating and mapping. The result is a textual and graphical price map, which is the use of the real estate market and facilitates orientation in the prices of renting commercial property types: office, shop and warehouse.
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Evaluation of lessons to teach introductory map skills in grade fourWeinswig, S. Edward January 1962 (has links)
Thesis (Ph.D.)--Boston University.
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Molekulare Charakterisierung von Mitogen-activated Protein Kinase (MAPK)- Komponenten aus \(Echinococcus\) \(multilocularis\) / Molecular characterization of mitogen-activated protein kinase (MAPK) components from \(Echinococcus\) \(multilocularis\)Stoll, Kristin January 2021 (has links) (PDF)
Die alveoläre Echinokokkose (AE), verursacht durch das Metacestoden- Larvenstadium des Fuchsbandwurms Echinococcus multilocularis (E. multilocularis), ist eine lebensbedrohliche Zoonose der nördlichen Hemisphäre mit eingeschränkten therapeutischen Möglichkeiten. Bei der Suche nach neuen Therapeutika haben Mitogen-activated Proteinkinase (MAPK) -Kaskaden als pharmakologische Zielstrukturen aufgrund ihrer essentiellen Rolle bei der Zellproliferation und -differenzierung ein großes Potenzial. In der vorliegenden Arbeit wurden durch BLAST- und reziproke BLAST-Analysen elf potenzielle MAPK Kinase Kinasen (MAP3K), fünf potenzielle MAPK Kinasen (MAP2K) und sechs potenzielle MAPK im E. multilocularis-Genom identifiziert, die teils hoch konserviert sind und in nahezu allen Entwicklungsstadien des Parasiten exprimiert werden. Diese Erkenntnisse lassen auf ein komplexes MAPK-Signaltransduktions- system in E. multilocularis mit großer Bedeutung für den Parasiten schließen. Transkriptomdatenanalysen und Whole Mount in Situ Hybridisierung (WMISH) zeigten, dass emmkkk1 (EmuJ_000389600) als einzige MAP3K neben der Expression in postmitotischen Zellen in besonderem Maße in proliferativen Stammzellen des Parasiten exprimiert wird und somit eine wichtige Rolle bei der Differenzierung von Stammzellen spielen könnte. In Yeast-Two-Hybrid (Y2H) -Wechselwirkungsassays wurden Interaktionen von mehreren upstream- (EmGRB2) und downstream- wirkenden Signalkaskadekomponenten des JNK (EmMKK3, EmMPK3) und ERK (EmMKK3, EmMPK4) -Signalwegs gefunden. Daraus lässt sich schließen, dass EmMKKK1, analog zu seinem humanen Homolog HsM3K1, eine zentrale Rolle bei der Echinococcus-Wachstumsregulation durch Rezeptortyrosinkinasen und vielfältige weitere Funktionen im Parasiten besitzt. Anhand von Erkenntnissen an Platyhelminthes kann daher von einem großen Potenzial dieser neu charakterisierten Signalwege als chemotherapeutische Angriffspunkte ausgegangen werden, wenngleich erste RNA-Interferenz (RNAi)- und Inhibitorstudien an emmkkk1, emmpk1 und emmpk4 keine durchschlagenden Effekte auf das Überleben von Primärzellkulturen und die Bildung von Metacestodenvesikeln zeigten. Zusammenfassend konnte in der vorliegenden Arbeit mit EmMKKK1 und neuen ERK- und JNK-Signalwegen zentrale Komponenten der komplexen MAPK-Signalkaskaden in E. multilocularis identifiziert werden, die höchstwahrscheinlich einen großen Beitrag zur enormen Regenerationsfähigkeit der Echinococcus-Stammzellen leisten und vom Wirt abgeleitete Signale wie Insulin, Epidermaler Wachstumsfaktor (EGF) und Fibroblasten-Wachstumsfaktor (FGF) über EmGRB2 in Proliferationsnetzwerke des Parasiten integrieren. Arzneimittel-Screening-Assays, die auf diese Signalwege abzielen, könnten daher zu alternativen Arzneimitteln führen, die alleine oder in Kombination mit einer bestehenden Chemotherapie (Benzimidazol) die Prognose von für AE-Patienten verbessern könnten. / Alveolar echinococcosis (AE), caused by the metacestode larval stage of the fox tapeworm Echinococcus multilocularis (E. multilocularis), is a life-threatening zoonosis of the Northern Hemisphere with limited therapeutic options. In searches for a new chemotherapy, mitogen-activated protein kinase (MAPK) cascades are of great potential as new drug targets due to their essential role in cell proliferation and differentiation. In this work eleven potential MAPK kinase kinases (MAP3K), five potential MAPK kinases (MAP2K) and six potential MAPK were identified in the E. multilocularis genome by BLAST and reciprocal BLAST analyses, of which some are highly conserved and expressed in almost all developmental stages of the parasite. These findings suggest a complex MAPK signal transduction system in E. multilocularis with major importance for the parasite. Transcriptome data analysis and Whole Mount in Situ Hybridization (WMISH) showed that emmkkk1 (EmuJ_000389600) is the only MAP3K being decisively expressed in the proliferative parasite in addition to expression in postmitotic cells, and thus could play an important role in the differentiation of stem cells. In Yeast-Two-Hybrid (Y2H) interaction assays, interactions between several upstream (EmGRB2) and downstream signaling cascade components of JNK (EmMKK3, EmMPK3) and ERK (EmMKK3, EmMPK4) signaling pathways were detected. Thus, EmMKKK1, like its human homologue HsM3K1, appears to play a central role in Echinococcus growth regulation by receptor tyrosine kinases and seems to have diverse other functions in the parasite. Based on findings on other platyhelminths it can be expected that these newly characterized signaling pathways are of great potential as drug target, although first RNA interference (RNAi) and inhibitor studies on emmkkk1, emmpk1 and emmpk4 revealed no substantive effects on the survival of primary cell cultures and the formation of metacestode vesicles. In conclusion, the present work identified with EmMKKK1 and new ERK and JNK signaling pathways central components of the complex MAPK signaling cascades in E. multilocularis, which most likely contribute to the enormous regenerative capacity of Echinococcus stem cells and integrate host derived signals such as insulin, epidermal growth factor (EGF), and fibroblast growth factor (FGF) via EmGBR2 into proliferative networks of the parasite. Targeting these signaling pathways in drug screening assays might thus lead to alternative drugs that alone, or in combination with existing chemotherapy (benzimidazole), could improve the prognose of AE patients.
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Captain John Smith's Map of Virginia, reproduced from an engraving in the Library of Congress (file mapcoll_002_06)22 February 2022 (has links)
Scale 1 inch = 6 leagues. Library of Congress facsimile No. 1a, which is based on the sixth out of ten issues (known as "states"). The original map was published in 1612, and the revisions comprising the sixth state are from 1624. The map includes ca. 200 names including Native American tribes, and is considered the first authoritative map of Virginia. / https://dc.etsu.edu/rare-maps/1122/thumbnail.jpg
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