Global ETD Search

1	Mutation and Genome Evolution Yampolsky, L. Y. 14 April 2016 (has links) Genome composition and architecture is shaped by two types of processes: those that introduce heritable changes (mutagenesis) and those that determine the fate of such changes in the populations (genetic drift and selection). Chemical and biological properties of mutagenesis determines the frequencies at which different type of mutations occur, which, in turn, determines their rates of fixation by drift and affects the spectrum of mutations available for selection to operate on. As the result, genomes of living organisms carry many signatures mutagenesis. copy number variation CpG dinucleotides deletions DNA repair DNA replication ectopic crossing-over gene conversion genome insertions isochores microsatellites mutations segmental duplications selection strand asymmetry transitions transposons Biological Sciences