In 1996, the Institute of Medicine made an initial step towards addressing the confusion and controversy regarding the diagnosis of fetal alcohol syndrome (FAS) by proposing a classification scheme and calling for research to evaluate its validity and clinical utility. Previous research evaluated memory, executive functions, and behaviour problems in FAS. Prior to the present study, however, there had not been an empirical evaluation of the existence of a spectrum of diagnostic subgroups or an evaluation of subgroup functioning on neuropsychological components of attention during the pre-teen and adolescent years. Part 1 of this study used categorical data regarding diagnostic domains to determine if an a priori spectrum of four subgroups could be identified. This spectrum included FAS and three fetal alcohol effect (FAE) subgroups, which were defined using teratogenic theory, previous research findings, and logic. The sample consisted of 112 children with a confirmed history of excessive prenatal alcohol exposure. Part 2 evaluated the continuity and comparability of the CNS dysfunction subgroups exhibited by assessing neuropsychological components of attention using models by Mirsky and Conners. The sample consisted of 30 children and subgroups were matched on age, sex, and living situation. Results identified 3 of the 4 potential subgroups. All subgroups exhibited a clinically significant attention deficit. After adjusting for IQ, the FAS and FAE subgroups had comparable levels of functioning on all components of attention with one exception. On the sustain component, the FAE subgroups had more difficulties than the FAS subgroup in maintaining a consistent response-speed in response to changes in the length of time between targets. This study provides empirical and theoretical support for the validity and clinical utility of a spectrum of fetal alcohol subgroups consistent with the IOM's classification. It furthers a theoretical understanding of the dose-response effects of alcohol as a teratogenic agent. It suggests that attention regulation functions are especially vulnerable to the damage caused by prenatal alcohol exposure. The findings emphasize the importance of obtaining a history of prenatal alcohol exposure in individuals presenting with neuropsychological difficulties, and developing treatment programs for pregnant women with an alcohol addiction.

Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2002. / Vita. Includes bibliographical references (leaves 94-106).

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Alkoholinio vaisiaus sindromo sąvoka yra labai plati, ja apibūdinamas kūdikio ar vaiko negrįžtamų anomalijų rinkinys (Lombard et al., 2007). Sindromas pasireiškia motorinio, socialinio, pažintinio ir kalbos vystymosi sutrikimais (Steinhausen et al., 2003), todėl AVS sergantiems asmenims taikomas kompleksinis gydymas (Burd et al., 2003). Tyrimo objektas – alkoholiniu vaisiaus sindromu sergančių vaikų stambioji ir smulkioji motorika. Tyrimo problema – nėra aišku, kokia kineziterapijos ar fizinio aktyvumo forma tinkamiausia alkoholinį vaisiaus sindromą turintiems vaikams, kad gerėtų stambioji ir smulkioji motorika. Darbo tikslas – nustatyti kineziterapijos poveikį vaikų stambiajai ir smulkiajai motorikai esant alkoholiniam vaisiaus sindromui. Šiam tikslui pasiekti iškelti uždaviniai: 1) Įvertinti stambiosios motorikos rodiklius vaikams, turintiems alkoholinį vaisiaus sindromą, taikant bendralavinančius pratimus (kontrolinė grupė) ir judriuosius žaidimus (tiriamoji grupė) prieš ir po kineziterapijos. 2) Įvertinti smulkiosios motorikos rodiklius vaikams, turintiems alkoholinį vaisiaus sindromą, taikant bendralavinančius pratimus (kontrolinė grupė) ir judriuosius žaidimus (tiriamoji grupė) prieš ir po kineziterapijos; 3) palyginti stambiosios ir smulkiosios motorikos rezultatus tarp vaikų, kuriems taikyti bendralavinantys pratimai ir judrieji žaidimai; 4) palyginti bendrą standartinį motorikos rodiklį tarp vaikų, kuriems taikyti bendralavinantys pratimai ir vaikų, kuriems taikyti... [toliau žr. visą tekstą] / Fetal alcohol syndrome is an umbrella term used to describe the irreversible array of anomalies associated with in utero alcohol exposure (Lombard et al, 2007). Fetal alcohol syndrome manifestes by developmental perturbation in motor, social, cognitive and language domain (Steinhaussen et al, 2003). Appropriate management nearly always involves a multidisciplinary team effort with ongoing programming (Burd et al, 2003). Subject: gross and fine motor in children with fetal alcohol syndrome. Problem: there is no clear evidence about the most proper form of physiotherapy or physical activity on purpose to improve gross and fine motor functions in children with fetal alcohol syndrome. Objective: to determine the effectiveness of physiotherapy on gross and fine motor in children with fetal alcohol syndrome. There are four tasks to reach an objective: 1) to determine gross motor indexes for children with fetal alcohol syndrome in casual physiotherapy group (control) and active playing group (investigative) before and after physiotherapy; 2) to determine fine motor indexes for children with fetal alcohol syndrome in casual physiotherapy group (control) and active playing group (investigative) before and after physiotherapy; 3) to compare fine and gross motor indexes between the casual physiotherapy group and active playing group; 4) to compare standard motor score between the casual physiotherapy group (control) and active playing group (investigative); The fine and gross motor... [to full text]

Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 5 uppsatser.

Thesis (Ph. D.)--University of Washington, 1990. / Vita. Includes bibliographical references (leaves [91]-99).

Thesis (M. Sc.)--University of Alberta, 2009. / Title from pdf file main screen (viewed on Sept. 22, 2009). "A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Master of Science in Physiology, Cell and Developmental biology, Biological Sciences, University of Alberta." Includes bibliographical references.

Thesis (Ph. D.)--University of California, San Diego, 2000. / Vita. Includes bibliographical references (leaves 151-168).

Thesis (Ph.D. in Toxicology) -- University of Colorado at Denver and Health Sciences Center, 2005. / Typescript. Includes bibliographical references (leaves 137-149).