A theoretical formalism to reconstruct structural and dynamical properties of polymer liquids from their coarse-grained description is developed. This formalism relies on established earlier analytical coarse-graining of polymers derived from the first principles of liquid theory. The polymer chain is represented at a mesoscale level as a soft particle. Coarse-grained computer simulations provide input data to the reconstruction formalism and allow one to achieve the most gain in computational efficiency. The structure of polymer systems is reconstructed by combining global information from mesoscale simulations and local information from small united-atom simulations. The obtained monomer total correlation function is tested for a number of systems including polyethylene melts of different degrees of polymerization as well as melts with different local chemical structure. The agreement with full united-atom simulations is quantitative, and the procedure remains advantageous in computational time. The dynamics in mesoscale simulations is artificially accelerated due to the coarse-graining procedure and needs to be rescaled. The proposed formalism addresses two rescalings of the dynamics. First, the internal degrees of freedom averaged out during coarse-graining procedure are reintroduced in "a posteriori" manner, rescaling the simulation time. The second rescaling takes into account the change in friction when switching from a monomer level description to mesoscopic. Both friction coefficients for monomer and soft particle are calculated analytically and their ratio provides the rescaling factor for the diffusion coefficient. The formalism is extensively tested against the united-atom molecular dynamic simulations and experimental data. The reconstructed diffusive dynamics of the center-of-mass for polyethylene and polybutadiene melts of increasing degrees of polymerization show a quantitative agreement, supporting the foundation of the approach. Finally, from the center-of-mass diffusion the monomer friction coefficient is obtained and used as an input into Cooperative Dynamics theory. The dynamics of polymer chains at any length scale of interest is described through a Langevin equation. In summary, the proposed formalism reconstructs the structure and dynamics of polymer melts enhancing computational efficiency of molecular dynamic simulations. This dissertation includes previously published and unpublished co-authored material.

SILVA, Jorge Roberto Pereira da. Invasões múltiplas em meios porosos desordenados. 2013. 73 f. Dissertação (Mestrado em Física) - Programa de Pós-Graduação em Física, Departamento de Física, Centro de Ciências, Universidade Federal do Ceará, Fortaleza, 2013. / Submitted by Edvander Pires (edvanderpires@gmail.com) on 2015-10-22T19:09:24Z No. of bitstreams: 1 2013_dis_jrpsilva.pdf: 6800786 bytes, checksum: 53e5d20e14900eaa6675cb43b9feeb62 (MD5) / Approved for entry into archive by Edvander Pires(edvanderpires@gmail.com) on 2015-10-22T21:33:14Z (GMT) No. of bitstreams: 1 2013_dis_jrpsilva.pdf: 6800786 bytes, checksum: 53e5d20e14900eaa6675cb43b9feeb62 (MD5) / Made available in DSpace on 2015-10-22T21:33:14Z (GMT). No. of bitstreams: 1 2013_dis_jrpsilva.pdf: 6800786 bytes, checksum: 53e5d20e14900eaa6675cb43b9feeb62 (MD5) Previous issue date: 2013 / In this dissertation, we investigate by means of numerical simulations geometrical and transport properties related with the invasion phenomena through disordered porous media in a very slow invasion regime, using two and three dimensions porous medias. Here, the porous media is modeling by means of a random structure, where each pore is represented by a random number comes from a uniform distribution. We assume that the invasion process occurs in the limit of very low viscous force, which means that the invasion process is controlled by capillary force. In this limit the invasion percolation model without trap is suitable. The new aspect incorporated here, consists basically of a multiple invasion process, where after the first invasion takes place only part of the structure of the porous, that was invaded previous, can be invaded again. We study, how the multiple invasion changes the fractal dimension of the invaded cluster. Estimated values for the fractal dimension of the invaded region reveal that the critical exponents vary as a function of the generation number G, i.e., where the number of times the invasion takes place. On base in numerical datas, we show the averaged mass M of the invaded region decreases with a power law as a function of G, M ∼ G{−β} , where the exponents β ≈ 0.59 (2D) and β ≈ 0.73 (3D). We also investigated, how the fractal dimension changes as a function of G, find that the fractal dimension of the invaded cluster changes from df = 1.89 ± 0.02 to ds = 1.22 ± 0.02 and df = 2.52 ± 0.02 to ds = 1.46 ± 0.02 for (2D) and (3D), respectively. These results confirm that the multiple invasion process follows a continuous transition from one universality class (nontrapping invasion percolation) to another (optimal path), furthermore these change are continuos for both dimensionality. Another aspect investigated, was the avalanche distribution in the invasion process. We analyzed how the distribution of avalanche changes as function of G, more precisely, how the multiple invasion process changes the exponent τ of the power law distribution. Regardless the values, we find that the behaviour of the exponents τ looks like the same for both dimensions studied. The exponents τ , initially change in a very slow way until reach a region, of certain value of G which depend on the dimension, they start to decrease in a deep way until reach the saturation value. The saturation value is close, for (2D), to one-dimension case. / Nesta dissertação, investigamos por meio de simulação computacional propriedades geométricas e de transportes relacionadas ao fenômeno de invasão em meios porosos desordenados no regime de invasão muito lento em sistemas bidimensionais e tridimensionais. O meio poroso considerado aqui é representado por meio de uma estrutura desordenada onde a cada poro que compõe este meio se associa um número aleatório obtido a partir de uma distribuição uniforme. Considerando o regime lento de invasão, onde as forças capilares dominam o escoamento em relação as forças viscosas, utilizando para a dinâmica de invasão o modelo de percolação invasiva sem aprisionamento. Introduzimos um variante no modelo de percolação invasiva, assumindo o aspecto de múltiplas invasões, onde a cada nova invasão apenas parte do substrato utilizado na invasão anterior pode ser invadido novamente. Em uma primeira parte, estudamos como o processo de múltipla invasão altera as características do agregado invadido. Valores estimados para a dimensão fractal da região invadida revelam que os expoentes críticos variam em função do número de geração G, isto é, o número de vezes que o processo de invasão foi repetido. Com base em dados numéricos, mostramos que a massa média do agregado invadido decresce na forma de uma lei de potência como função de G, M ~ G^{-β}, com o expoente β = 0.59 (2D) e 0.73 (3D). Investigamos como a dimensão fractal do agregado invadido varia em função dos repetitivos processo de invasão, mostrando que as mesmas variam de df = 1.89 ± 0.02 até ds = 1.22 ± 0.02 para o caso (2D) e df = 2.52 ± 0.02 até ds = 1.46 ± 0.02 para o caso (3D). Os resultados confirmam que o processo de múltiplas invasões segue uma transição continua entre as classes de universalidade do modelo de percolação invasiva sem aprisionamento e ótimo caminho, sendo este comportamento observado em duas e três dimensões. Um outro aspecto investigado nessa dissertação, foi o fenômeno de avalanche que ocorre durante o processo de invasão. Investigamos como a distribuição de tamanhos de avalanche, que se comporta na forma de uma lei de potência P(S, L) ~ S^{-τ} , altera-se em função das múltiplas invasões. Mais precisamente, calculamos como o expoente que governa o comportamento das avalanches se altera em função do número de geração G. Verificamos que este comportamento do expoente em função de G é semelhante para duas e três dimensões, apresentando uma região de mudança suave seguida por uma mudança mais acentuada até atingir um limite de saturação, onde o sistema se comporta de maneira parecida com o caso unidimensional.

Master of Science / Department of Diagnostic Medicine/Pathobiology / Dana Vanlandingham / Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus maintained among swine and avian species. In infected pigs, replication of JEV leads to the onset of viremia and the development of neurological and reproductive disease in young and naïve pregnant animals. The high-titer viremia levels associated with JEV infection in pigs, whilst important to the enzootic transmission cycle responsible for viral maintenance, also have human health implications within the zoonotic cycle. Sensitive and specific veterinary diagnostic methods capable of readily detecting JEV infection are critical components of JEV surveillance programs in the Asian Pacific region. In this study, reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) assays were evaluated for use in veterinary diagnosis of JEV. Our hypotheses for this research project were that RT-qPCR assays with fewer oligonucleotide mismatches between the primers and probes of the assays and JEV genomes will be more sensitive for the diagnosis of JEV infection and that oral shedding of JEV in swine would allow for detection of viral RNA using oral fluids. The sensitivity and specificity of three RT-qPCR assays for the detection of JEV were determined using tissue culture fluids of five representative JEV strains belonging to four endemic genotypes. The first assay (assay #1), targeting the highly conserved NS5 gene and 3UTR regions, provided optimum detection for the current predominant genotype, GI-b. All three assays were highly specific for JEV when tested against other selected flaviviruses in the JEV serocomplex. A rope-based collection method allowed for the simplified collection of oral fluids from three-week-old piglets challenged with endemic JEV strain JE-91. These fluids were then evaluated using RT-qPCR assays for the presence of viral RNA. The results suggest that the shedding of JEV in oral fluids can be readily detected and that non-invasive oral fluid collection can serve as a novel sampling method for the diagnosis and surveillance of JEV in swine.

Made available in DSpace on 2015-07-13T12:10:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-07-31. Added 1 bitstream(s) on 2015-07-13T12:25:21Z : No. of bitstreams: 1 000836682.pdf: 2242597 bytes, checksum: 64204d0074211d1723d7ad5c6f876572 (MD5) / Esta dissertação de mestrado faz uma abordagem do trabalho experimental desenvolvido no âmbito de pesquisa de escoamento de fluidos não-newtonianos em canais inclinados. Quando estes escoamentos são colocados em condições favoráveis de inclinação e vazão, pode-se constituir um domínio propício à propagação de instabilidades na superfície livre que, eventualmente, podem evoluir para um tipo específico de ondas, conhecidas na literatura como roll waves. Estas ondas, de comprimento e amplitude bem definidos, são especialmente afetadas pelas características do escoamento e do fluido. Em termos de fluido teste, foi confeccionado, caracterizado reologicamente e utilizado o gel de carbopol, de base polimérica e de propriedade não-newtonianas, com bom ajuste do modelo reológico de Herschel-Bulkley. Como existe na literatura uma grande lacuna no que diz respeito a medidas deste fenômeno tanto na natureza quanto em laboratório, buscou-se neste trabalho, projetar e construir um aparato experimental que fosse capaz de reproduzir as condições necessárias para a geração de roll waves, em condições controladas. Técnicas fotométricas e ultrassônicas foram utilizadas no experimento para aferir informações de altura de escoamento, após o fluido teste (gel de carbopol) ser perturbado, por um sistema específico projetado para este fim. O aparato experimental desenvolvido permite, doravante, simulações de roll waves em diversos cenários para fluidos de reologia diversa, constituindo assim, um suporte de grande valia ao entendimento e controle de roll waves presentes, por exemplo em corridas de lama / This dissertation makes an approach to the experimental work carried out within the research of non-Newtonian fluids drained in inclined channels. When these flows are placed in favorable slope and flow, can be a suitable area to the spread of instability at the free surface which may eventually evolve into a specific type of waves, known in the literature as roll waves. These waves of well- defined length and amplitude are especially affected by the flow characteristics and the fluid. In terms of fluid test was elaborated, rheologically characterized and used carbopol gel, polymer-based and non-Newtonian property, with good adjustment of the rheological model of Herschel-Bulkley. As there is a big gap in the literature regarding to both measures of this phenomenon in nature as in the laboratory, was sought in this work, the formation of an experimental apparatus that was able to reproduce the necessary conditions for the generation of roll waves in the laboratory, under those controlled conditions. Photometric and ultrasonic techniques were used in the experiment for measuring height information of the flow after the test fluid (carbopol gel) being disturbed by a specific system designed for this purpose. The experimental apparatus developed now enables simulations of roll waves in various scenarios for different fluid rheology, is thus an invaluable support to the understanding and control of this roll waves present in mud, for example

Thesis (MTech (Chemical Engineering))--Cape Technikon, 2004 / When designing the open channels to transport the homogenous non-Newtonian slurries, the effect of channel shape is one of the parameters that should be checked and very little research has been conducted to address this matter. Open channels are commonly applied in the mining industry where mine tailings have to be transported to the disposal dams at high concentrations to save water consumption. This thesis addresses the effect of the cross-sectional shape of the channel with emphasis on laminar and transitional flow of non-Newtonian fluids. The literature review on the flow of Newtonian and non-Newtonian fluids has been presented. The most relevant one to this topic is the work done by Straub et al (1958) for Newtonian fluids and the analytical work presented by Kozicki and Tiu (1967) for non-Newtonian fluids. Authors like Coussot (1994) and Haldenwang (2003) referred to their work but did not comprehensively verified it experimentally. Three flume shapes were designed to investigate this problem namely, rectangular, semi circular, and trapezoidal flume shape. The test rig consisted of a 10 m long by 300mm wide tilting flume that can be partitioned into two sections to form a 150 mm wide channel. All three flume shapes were tested in both the 150 mm and 300 mm wide flumes. This flume is linked to the in-line tube viscometer with three tube diameters namely, 13 mm; 28 mm; and 80 mm. The experimental investigation covered a wide range of flow rates (0.1-45l/s), and flume slopes (1-5 degrees). The fluids tested were kaolin suspension (5.4 - 9% v/v), CMC solution (1 - 4% m/m), and bentonite suspension (4.6 and 6.2% mlm). The models found in the literature were evaluated with the large database compiled from the test results to predict the laminar and transitional flow of these fluids with the aim of checking the effect of the cross-sectional shape of these channels selected in these flow regimes. For all the flume shapes and non-Newtonian fluids selected in this thesis it was found that in predicting the laminar flow, the effect of shape is adequately accounted for by the use of hydraulic radius. In predicting the transitional flow, it was found that the effect of shape does not have to be included.

Thesis (DTech( Mechanical Engineering)-- Cape Peninsula University of Technology, 2014 / Magnetohydrodynamic (MHD) boundary layer flow of an electrically conducting viscous incompressible fluid with a convective surface boundary condition is frequently encountered in many industrial and technological applications such as extrusion of plastics in the manufacture of Rayon and Nylon, the cooling of reactors, purification of crude oil, textile industry, polymer technology, metallurgy, geothermal engineering, liquid metals and plasma flows, boundary layer control in aerodynamics and crystal growth etc. Nanofluid is envisioned to describe a fluid in which nanometer-sized particles are suspended in conventional heat transfer base fluids to improve their thermal physical properties. Nanoparticles are made from various materials, such as metals (Cu, Ag, Au, Al, Fe), oxide ceramics (Al2O3, CuO, TiO2), nitride ceramics (AlN, SiN), carbide ceramics (SiC, tiC), semiconductors, carbon nanotubes and composite materials such as alloyed nanoparticles or nanoparticle core–polymer shell composites. It is well known that, conventional heat transfer fluids, such as oil, water, and ethylene glycol, in general, have poor heat transfer properties compared to those of most solids. Nanofluids have enhanced thermophysical properties such as thermal conductivity; thermal diffusivity, viscosity and convective heat transfer coefficients compared with those of base fluids like oil or water. Owing to their enhanced properties, nanofluids can be used in a plethora of technical and biomedical applications such as nanofluid coolant: electronics cooling, vehicle cooling, transformer cooling, computers cooling and electronic devices cooling; medical applications: magnetic drug targeting, cancer therapy and safer surgery by cooling; process industries; materials and chemicals: detergency, food and drink, oil and gas, paper and printing and textiles.

Thesis (MTech(Civil Engineering))--Cape Peninsula University of Technology, 2006. / The performance of a centrifugal pump is altered for slurry or viscous materials (Stepanoff, 1969) and this needs to be accounted for. Usually, the suitable selection and evaluation of centrifugal pumps is based only on water pump performance curves supplied by the pump manufacturer (Wilson, Addie, Sellgren & Clift, 1997). In 1984 Walker and Goulas conducted a number of pump performance tests with kaolin clay slurries and coal slurries on a Warman 4/3 AH horizontal slurry pump and a Hazleton 3-inch B CTL horizontal pump (Walker and Goulas, 1984). Walker and Goulas have analysed the test data and correlated the performance derating both at the best efficiency flow rate (BEP) and at 10% of the best efficiency flow rate (0.1 BEP) to the modified pump Reynolds number (NRep). They have noticed that the head and the efficiency reduction ratio decreased for the pump Reynolds number less then 10⁶. Furthermore, Walker and Goulas obtained a reasonably good agreement (± 5%) between pump test data for non-Newtonian materials and pump performance prediction using the Hydraulics Institute chart. Sery and Slatter (2002) have investigated pump deration for non-Newtonian yield pseudoplastic materials. The NRep was calculated using the Bingham plastic viscosity (µp). Results have shown good agreement with regard to head and efficiency reduction ratios in comparison with previous work. However, Sery and Slatter's pump performance correlation using the HI chart did not reach the same conclusion. Error margin of ± 20% and ± 10% were found for head and efficiency respectively. This study is an attempt to reconcile the differences between Walker and Goulas (1984) and Sery and Slatter (2002) and extend the evaluation of these derating methods to pseudoplastic materials. The test work was conducted in the Flow Process Research Centre laboratory of the Cape Peninsula University of Technology using two centrifugal pumps; a Warman 6/4 and a GrW 4/3. The materials used were water, CMC solution bentonite and kaolin suspension at different concentrations (7% and 9% by weight for bentonite; 5%, 6% and 7% by weight for CMC; 17%, 19% and 21% by volume for kaolin).

Orientador: Geraldo Maciel de Freitas / Co-orientador: Cláudio Kitano / Banca: Elaine Maria Cardoso / Banca: José Junji Ota / Resumo: Esta dissertação de mestrado faz uma abordagem do trabalho experimental desenvolvido no âmbito de pesquisa de escoamento de fluidos não-newtonianos em canais inclinados. Quando estes escoamentos são colocados em condições favoráveis de inclinação e vazão, pode-se constituir um domínio propício à propagação de instabilidades na superfície livre que, eventualmente, podem evoluir para um tipo específico de ondas, conhecidas na literatura como roll waves. Estas ondas, de comprimento e amplitude bem definidos, são especialmente afetadas pelas características do escoamento e do fluido. Em termos de fluido teste, foi confeccionado, caracterizado reologicamente e utilizado o gel de carbopol, de base polimérica e de propriedade não-newtonianas, com bom ajuste do modelo reológico de Herschel-Bulkley. Como existe na literatura uma grande lacuna no que diz respeito a medidas deste fenômeno tanto na natureza quanto em laboratório, buscou-se neste trabalho, projetar e construir um aparato experimental que fosse capaz de reproduzir as condições necessárias para a geração de roll waves, em condições controladas. Técnicas fotométricas e ultrassônicas foram utilizadas no experimento para aferir informações de altura de escoamento, após o fluido teste (gel de carbopol) ser perturbado, por um sistema específico projetado para este fim. O aparato experimental desenvolvido permite, doravante, simulações de roll waves em diversos cenários para fluidos de reologia diversa, constituindo assim, um suporte de grande valia ao entendimento e controle de roll waves presentes, por exemplo em corridas de lama / Abstract: This dissertation makes an approach to the experimental work carried out within the research of non-Newtonian fluids drained in inclined channels. When these flows are placed in favorable slope and flow, can be a suitable area to the spread of instability at the free surface which may eventually evolve into a specific type of waves, known in the literature as "roll waves". These waves of well- defined length and amplitude are especially affected by the flow characteristics and the fluid. In terms of fluid test was elaborated, rheologically characterized and used carbopol gel, polymer-based and non-Newtonian property, with good adjustment of the rheological model of Herschel-Bulkley. As there is a big gap in the literature regarding to both measures of this phenomenon in nature as in the laboratory, was sought in this work, the formation of an experimental apparatus that was able to reproduce the necessary conditions for the generation of roll waves in the laboratory, under those controlled conditions. Photometric and ultrasonic techniques were used in the experiment for measuring height information of the flow after the test fluid (carbopol gel) being disturbed by a specific system designed for this purpose. The experimental apparatus developed now enables simulations of roll waves in various scenarios for different fluid rheology, is thus an invaluable support to the understanding and control of this "roll waves" present in mud, for example / Mestre

Orientador: Nereu Carlos Prestes / Banca: Fernada da Cruz Landim-Alvarenga / Banca: Regina Kiomi Takahira / Banca: Wilter Ricardo Russiano Vicente / Banca: Mara Regina S. Balarin / Resumo: Os líquidos fetais possuem diversas funções que são vitais para o feto. Para a espécie eqüina até o presente momento, não está totalmente definida a composição bioquímica do líquido amniótico no decorrer da gestação. O presente trabalho teve como objetivo verificar a composição bioquímica do liquido amniótico e alantoideano das éguas em diferentes fases da gestação. Para isso analisou-se 60 amostras de fluidos fetais, empregando-se kits comerciais para se determinar a concentração bioquímica da Fosfatase Alcalina, Glicose, Proteínas Totais, Uréia, Creatinina, Cálcio, Cloreto, Sódio e Potássio durante a gestação. A concentração da alfa-fetoproteína foi avaliada empregando-se a eletroforese em gel de poliacrilamida. A concentração da Fosfatase Alcalina no liquido amniótico foi maior quando comparada ao liquido alantoideano nas três fases da gestação (p < 0,05). Para a glicose o valor médio entre os dois fluidos não apresentou variações (p < 0,05). Para a Proteína total o valor médio do liquido amniótico foi maior que o alantoideano (p < 0,05). A Uréia sofreu variações na concentração entre as fases, mas não há diferenças dos valores médios (p > 0,05) entre os fluidos. Para a Creatinina os valores presentes no liquido alantoideano são mais altos que os valores do liquido amniótico (p < 0,05). As concentrações dos íons Cloreto e Sódio apresentaram-se mais elevados (p < 0,05) no liquido amniótico. As concentrações dos íons Cálcio e Potássio foram mais elevadas nos líquidos alantoideanos (p<0,05). A eletroforese identificou duas bandas protéicas que podem ser a alfa-fetoproteína, ela parece aumentar a concentração durante o período gestacional. Porém, faltam estudos na espécie eqüina para a comparação dos resultados do presente trabalho. / Abstract: Fetal fluids play a vital role in the development of the fetus. The biochemical composition of the amniotic fluid along pregnancy in horses had not been described until this present study. Sixty samples of fetal fluids were collected and the concentrations of Alkaline Phosphatase (FA), Glucose, Total Proteins (PT), Urea, Creatinin, Calcium (Ca), Chloride (Cl), Sodium (Na) and Potassium (K) along pregnancy were determined using commercially available kits. The levels of alpha-fetoprotein (AFT) were measured by polyacrylamide gel electrophoresis. During the three stages of pregnancy the concentrations of FA in the amniotic fluid were higher than those determined in the allantoic fluid (p < 0,05). The glucose levels did not differ between the fluids (p < 0,05). The mean values for the concentrations of PT were higher in the amniotic fluid than in the allantoic (p < 0,05). The urea levels differ among the pregnancy stages, but there were no differences in the mean values of urea (p > 0,05) between the two fluids. The concentrations of creatinin obtained in the allantoic fluid were higher than those obtained in the amniotic fluid (p < 0,05). The concentrations of Cl and Na were elevated (p < 0,05) in the amniotic fluid. The levels of the ions Ca e K were higher in the allantoic fluid (p<0,05). Polyacrylamide gel electrophoresis identified two protein bands that could be alpha-fetoprotein, which appears to have its concentration increased during pregnancy. There is a need for more studies in the biochemical composition of fetal fluids in horses to compare the results obtained in this study. / Doutor

This thesis explores the interconnection of sacramental eating and humoural curing in selected plays by William Shakespeare and Ben Jonson. It contends that the drama actively participated in the medico-religious debates of post-Reformation England. Investigating the health benefits attributed to the Eucharistic meal in its pre- and post-Reformation forms, this thesis shows that early modern religious debates occupy an important place in contemporaneous drama, proposing that aspects of religion, particularly the Eucharist, were explored by Shakespeare and Jonson with regards to the Sacrament's medicinal efficacy. The thesis suggests that the drama identifies religious anxiety as medico-spiritual trauma, and offers performative sacramento-humoural therapy. In tracing intersections of sacramentality, cannibalism, and Galenic humourism in six plays, the thesis analyses early modern concepts of the body, blood, food, medicinal practices, the Eucharist, and morality, showing that drama was used as a medical and didactic tool. Chapter 1 explores issues of corporeality and community in Coriolanus, unearthing interconnected concepts of humoural eating and changing religious communities. Chapter 2 investigates early modern medical practices in Titus Andronicus, placing medicinal cannibalism at the nexus of martyrdom, sacramentality, and humoural disease. Chapter 3 develops notions of sacramentality by analysing the philosophy of neo-stoicism in Julius Caesar and linking it with acts of penance. Chapter 4 discusses the portrayal of these themes in Bartholomew Fair, examining Jonson's investigative approach to dramatic portrayals of medico-religious debates. Chapter 5 compares Every Man In His Humour and Every Man Out of His Humour, identifying themes of the medieval morality play, and showing that they were employed for didactic and medicinal purposes. This thesis concludes that interconnected discourses of sacramental eating and humoural curing constitute dramatic commentary on contemporaneous medico-religious issues, and offer temporary, performative salvation for a religiously troubled nation.