Diss. : Katholisch-theologische Fakultät : Bonn : 1982. - Bibliogr. p. 326-339. -

Würzburg, Univ., Diss., 2009.

Th. de doctorat--Louvain-la-Neuve--Université catholique, 1994. Titre de soutenance : L'évolution de la référence au droit naturel dans l'œuvre théologique de Mgr Philippe Delhaye. / Bibliogr. p. 523-540. Index.

L’endothélium cornéen est responsable de la déturgescence, un processus de déshydratation nécessaire à la transparence de la cornée. La dystrophie endothéliale cornéenne de Fuchs (FECD) est la principale cause de dysfonction endothéliale chez l’humain. C’est une maladie multifactorielle associée à (1) une plus grande apoptose dépendante du stress oxydatif des cellules endothéliales cornéennes, (2) un dépôt accru de protéine matricielle causant un épaississement de la membrane basale, et finalement (3) une perte de la capacité des cellules à assurer la déturgescence cornéenne. Actuellement, les modèles d’étude de la FECD montrent une capacité limitée à caractériser l’étiologie de la maladie, ce qui restreint notre capacité à développer des traitements pharmacologiques appropriés. Le seul traitement pour cette pathologie est la greffe de cornée. Afin d’étudier cette pathologie, mon laboratoire a développé des techniques de culture et de reconstruction par génie tissulaire d’endothélia FECD. Mes travaux ont utilisé ces modèles afin de comparer, par profilage génique, PCR quantitatif, immunofluorescence, résistance transendothéliale et essai de perméabilité, l’expression, la distribution et les capacités fonctionnelles des molécules impliquées dans la déturgescence et la sécrétion matricielle. Les résultats de mes études ont montré que les protéines associées à la fonction des cellules FECD (familles de transporteurs ioniques et de jonctions intercellulaires) n’avaient aucune différence d’expression suivant la mise en culture lorsque comparées à des équivalents non pathologiques. De plus, aucune différence fonctionnelle n’a été déterminée par résistance transendothéliale et essai de perméabilité. Toutefois, une plus grande quantité de fibronectine était déposée sous les cellules. Ce faisant, ces études suggèrent que la perte de fonction dans la FECD n’aurait pas un rôle primaire dans la pathologie et serait secondaire à un dépôt anormal de fibronectine. Des recherches antérieures du laboratoire avaient démontré une amélioration dans l’expression des marqueurs de fonctionnalité suite à des greffes in vivo. Le 3e objectif présenté dans cette thèse était de déterminer si les conditions environnementales in vivo (telle que la pression intraoculaire) étaient impliquées dans cette amélioration. Pour ce faire, nous avons utilisé un système de chambre antérieure artificielle permettant d’exercer une pression sur l’endothélium dans un circuit fermé. Cette étude a montré une plus grande expression de ZO-1 à la périphérie des cellules endothéliales, une protéine associée aux jonctions serrées, par la pression. Ce résultat met en perspective l’importance de l’environnement sur la fonctionnalité de l’endothélium cornéen. / The role of the corneal endothelium is to maintain the corneal transparency by a partial dehydration process named deturgescence. Fuchs endothelial corneal dystrophy (FECD) is the main cause of human endothelial dysfunction. It is a multifactorial disease associated with an increased oxidative-related cell death, a thickened basal lamina and a loss in the endothelial pump function resulting in a corneal opacification. Due to the lack of appropriate models, the exact cause of the pathology remains unknown, which restrains our ability to develop appropriate pharmacological treatments. As of now, the only cure is the transplantation of a healthy endothelium from a deceased donor. My laboratory has previoulsly developed in vitro cell and tissue models of FECD. My research projects used these models and analyzed, by gene profiling, quantitative PCR, immunofluorescence, trans-endothelial resistance and permeability assay, the expression, the distribution and the functional capacity of molecules engaged in deturgescence and extracellular matrix (ECM) deposition. Results show no difference between FECD and healthy cells for genes and proteins related to deturgescence (ion transporters and intercellular jonctions). However, an increased deposition of fibronectin was observed. These studies therefore suggest that the endothelial dysfunction would not be a primary aspect of the pathology and would rather be secondary to an aberrant deposition of fibronectin. A previous in vivo study showed an amelioration of the endothelial phenotype upon transplantation in an animal model. It suggested a beneficial effect from the environment, such as the intraocular pressure (IOP). The effect of pressure on the endothelium was investigated by placing tissue-engineered endothelia in an artificial anterior chamber that mimicked the natural IOP. Increased ZO-1, a protein associated with tight junctions, was observed at the cell periphery. This result suggest that the in vivo environment influences the functionality of the corneal endothelium.

In accordance with the notion of the so-called “new musicology” that musicological studies should steer away from the canon of masterpieces, this study concentrates on Robert Fuchs as an example of a Kleinmeister. His Piano Trio in C major, Op. 22, is a demonstration of developing variation, a term coined by Arnold Schoenberg to refer to the technique of motivic development within a musical composition as a whole. According to Schoenberg, the music of Johannes Brahms illustrates the most advanced manifestation of developing variation in that he often starts to develop his motives from the very opening of a piece. The technique of developing variation became one solution to the key problem composers faced in the later nineteenth century, namely how to create large forms from very concise thematic material. The purpose of this study is, firstly, to describe the concept of developing variation, providing** a historical perspective with specific reference to Brahms, and, secondly, to trace the manifestation of developing variation in Robert Fuchs‟s Piano Trio in C major, Op. 22, a work which Fuchs dedicated to Brahms. The empirical section of this study shows that the characteristic feature of the germ cell (G-A-G) that appears at the beginning of this composition, namely a movement away from and a return to the point of departure, manifests on micro- (motivic), meso- (thematic), and macro- (structural) level. On micro-level the germ cell grows teleologically by means of metric displacement, rhythmic changes, augmentation, diminution, intervallic expansion, inversion, retrograde, retrograde inversion, extension, sequential treatment, liquidation and further derivatives of the germ cell until a large form is created: a four-movement work for three instruments. This study also demonstrates how the shape of the germ cell can be found in larger structures as themes and the overall structure of each of the four movements. / PhD (Music Performance), North-West University, Potchefstroom Campus, 2015

In accordance with the notion of the so-called “new musicology” that musicological studies should steer away from the canon of masterpieces, this study concentrates on Robert Fuchs as an example of a Kleinmeister. His Piano Trio in C major, Op. 22, is a demonstration of developing variation, a term coined by Arnold Schoenberg to refer to the technique of motivic development within a musical composition as a whole. According to Schoenberg, the music of Johannes Brahms illustrates the most advanced manifestation of developing variation in that he often starts to develop his motives from the very opening of a piece. The technique of developing variation became one solution to the key problem composers faced in the later nineteenth century, namely how to create large forms from very concise thematic material. The purpose of this study is, firstly, to describe the concept of developing variation, providing** a historical perspective with specific reference to Brahms, and, secondly, to trace the manifestation of developing variation in Robert Fuchs‟s Piano Trio in C major, Op. 22, a work which Fuchs dedicated to Brahms. The empirical section of this study shows that the characteristic feature of the germ cell (G-A-G) that appears at the beginning of this composition, namely a movement away from and a return to the point of departure, manifests on micro- (motivic), meso- (thematic), and macro- (structural) level. On micro-level the germ cell grows teleologically by means of metric displacement, rhythmic changes, augmentation, diminution, intervallic expansion, inversion, retrograde, retrograde inversion, extension, sequential treatment, liquidation and further derivatives of the germ cell until a large form is created: a four-movement work for three instruments. This study also demonstrates how the shape of the germ cell can be found in larger structures as themes and the overall structure of each of the four movements. / PhD (Music Performance), North-West University, Potchefstroom Campus, 2015

Diss.--Graz--Karl-Franzens-Univ., 2003. / Bibliogr. p. 399-408.

The thesis analyses the expedition (TAE) led by Dr.Vivian Fuchs and Sir Edmund Hillary from three vantage points: 1)the years from 1948 to 1955 leading up to the expedition 2) the interaction between the IGY and the TAE projects and 3) the role of the US Navy as the expedition unfolded. The thesis also investigates key events including the purchase of the ship Endeavour from Britain, the competition for leadership of the UK and NZ parties, the 'dash to the Pole' by Hillary, and the search for base sites and routes to the Polar Plateau. The thesis contains an overview historical introduction, a comprehensive literature review as well as a broad-based set of conclusions.

Thesis (doctoral)--Uppsala universitet, 1983. / Summary in English. Includes bibliographical references (p. 110-119).

Universiẗat, Diss., 2005--Münster (Westfalen). / Erscheinungsjahr an der Hauptitelstelle: 2004.