We consider the problem of testing the equality of two sample means, when the number of tests performed is large. Applying this problem to the context of gene expression data, our goal is to detect a set of genes differentially expressed under two treatments or two biological conditions. A null hypothesis of no difference in the gene expression under the two conditions is constructed. Since such a hypothesis is tested for each gene, it follows that thousands of tests are performed simultaneously, and multiple testing issues then arise. The aim of our research is to make a connection between Bayesian analysis and frequentist theory in the context of multiple comparisons by deriving some properties shared by both p-values and posterior probabilities. The ultimate goal of this work is to use the posterior probability of the one-sided alternative hypothesis (or equivalently, posterior probability of the half-space) in the same spirit as a p-value. We show for instance that such a Bayesian probability can be used as an input in some standard multiple testing procedures controlling for the False Discovery rate.

The occurrence of pharmaceuticals in aquatic environments originating from human consumption has received increased scientific attention during the last decades due to concerns regarding their combined environmental effects. This concerns stress the need of studies quantifying dissipation rates of pharmaceutical in aquatic ecosystems. The aims of this study were: i) to assess the degradation rates of trimethoprim (TPR), diphenhydramine (DPH), diclofenac (DCL), oxazepam (OXZ) and hydroxyzine (HDZ) in laboratory incubations, and ii) to compare laboratory assessment of dissipation rates with previously measured in situ half-lives of these drugs in a pond ecosystem. I hypothesized that the dissipation of these five drugs dissolved, in laboratory incubations, is affected by common environmental parameters such as temperature, UV-light, organic solutes and presences of sediments. In line with my hypothesis, all substances were affected by my treatments. Here, main parameters affecting the dissipation of the drugs were UV light and to a lesser temperature (i.e. through microbial degradation). All drugs were found to be affected by sediment sorption, especially HDZ where 95 % of the applied pharmaceutical was adsorbed. Laboratory estimate with highest environmental relevance (low TOC and 3 °C water temperature or low TOC, sediments and UV light) seemed to predict field estimates fairly well for all of the drugs beside OXZ and DCL. Given the strong adsorption for sediments seen in the laboratory incubations, it seems likely that the mismatch between laboratory inferred half-lives and the in situ half-lives for OXZ was likely caused by sediment exchange processes releasing drugs initially adsorbed to the sediments into water column over time.

Thesis advisor: Zhifeng Ren / Thermoelectric (TE) technology is an environment-friendly one due to reduction of carbon emission, which can be widely used either for power generation or for refrigeration. Basically applications of TEs are based on TE effects, which involve the transition between heat and electricity. Despite the superior advantages of being solid state and providing a clean form of energy, TE technology so far only finds its niche area of application due to the relatively less efficiency compared to traditional methods. The efficiency of a thermoelectric device is solely determined by the dimensionless figure-of-merit (ZT) of thermoelectric materials. According to the definition, ZT is equal to square of Seebeck coefficient times electrical conductivity times absolute temperature divided by thermal conductivity. Therefore, a good thermoelectric material should possess high Seebeck coefficient and electrical conductivity while low thermal conductivity, so called phonon glass electron crystal (PGEC). In bulk materials, it is challenging to further improve ZT or independently vary individual parameters without affecting others, mainly due to the interrelated relationships among these three parameters. Fortunately, nano approach gives us some independent control in parameters adjustment. One important aspect of nano idea lies in the fact that enhanced boundary scattering due to the increased intensities of interfaces arising from nano-sized grains could reduce the thermal conductivity more than the electrical conductivity, which is practically realized in our material system. Since the introduction of nano idea, large ZT as high as above two has been achieved in the superlattice system. Due to the high fabrication cost of superlattices, they are not scalable for mass production. Theoretical calculations indicate that thermal boundary resistance is the main mechanism for the low thermal conductivity in superlattices, rather than the periodicity. Basically, we hope to achieve the supplattice-like ZT in the less costly bulk nanograined materials, based on the idea that reduction of thermal conductivity which is responsible for ZT enhancement in superlattices can be realized in bulk materials with embedded nanostructures as well. Inspired by the nanocomposite idea, in my thesis work I applied the technique of ball milling and then hot press to various thermoelectric materials, from low temperature to high temperature, demonstrating the feasibility of the approach. By ball milling alloyed ingot into nanopowders and DC hot pressing them, we have achieved a 62-89% ZT improvement for p-type half-Heusler samples, mainly due to the significantly enhanced Seebeck coefficient and partially due to the moderately reduced thermal conductivity. Microstructure studies indicated that increased boundaries due to smaller nano-sized grains is the cause for change of parameters. For our ball milled samples, the trend of decreasing thermal conductivities with increasing ball milling time is observed, further substantiating our nano-approach idea because longer ball milling time gives rise to smaller grain sizes and thus stronger boundary scattering. By applying the same technique to n-type half-Heuslers, we also successfully obtained pronounced enhancement in ZT especially at medium and low temperature ranges, which might be useful in medium temperature power generation. By ball milling a mixture of individual constituent elements into alloyed nanopowders and then DC hot pressing them, we did not gain improvement in ZT initially for n-type BiTeSe system mainly due to the simultaneous reduced power factor with the thermal conductivity. Considering anisotropic properties of the n-type BiTeSe single crystal and randomization effect of ball milling process, we repressed the as-pressed bulk samples in a bigger diameter die, during which lateral flow took place, resulting in preferred grain orientation. As a result, a 22% improvement in the peak ZT from 0.85 to 1.04 at 125 oC in n-type Bi₂Te_2.7Se_0.3 has been successfully achieved, arising from the more enhanced power factor than the thermal conductivity. Compared with single crystal, we benefit from the small nano-sized grains in bulk materials. Taking into account the in-plane power factor of single crystal, we still have much room for further ZT improvement if more ab orientation is promoted into the disk plane and/or the crystal plate size and thickness are reduced. By applying our technique of ball milling and then hot press to p-type skutterudites system, we have achieved a peak ZT of 0.95 at 450 <super>o</super>C in NdFe_3.5Co_0.5Sb₁₂, which is comparable to that of the state-of-the-art ingot. Our approach has the advantage of being less costly and more time-efficient compared to traditional fabrication methods. Besides, even lower thermal conductivity and hence higher ZT can be expected, provided that the nanosize of the precursor powder is preserved during hot press. The nanocomposite idea has been substantiated and the feasibility and generality of our ball milling and then hot press approach has been demonstrated, based on the thermoelectric properties data we obtained and the microstructure studies we carried out from various thermoelectric material systems, from low temperature to high temperature. We believe that continued effort in the area of thermoelectrics by our approach should be paid with superlattice-like ZT if ingenious methods are devised to control the grain growth during consolidation. / Thesis (PhD) — Boston College, 2010. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Physics.

Estruturas de dados volumétricas são de extrema utilidade em várias aplicações, e em particular na área de Visualização Científica. Essas estruturas são úteis em duas etapas do processo de visualização. A primeira é na representação de dados, isto é, de informações associadas aos valores, medidos ou simulados, os quais se deseja visualizar. A outra fase que necessita de uma estrutura de dados é a fase de exploração, ou seja, o modelo criado é usado tanto para exploração interativa quanto para a realização de simulações sobre o mesmo, por exemplo, numa cirurgia virtual. Está em desenvolvimento no ICMC, uma estrutura de dados volumétrica, chamada Singular Half-Face, que tem como característica a modelagem explícita das singularidades presentes no modelo, além de outros elementos topológicos. Este trabalho de mestrado visa testar a viabilidade da estrutura num contexto de visualização em fluxo de dados, incorporando-a à biblioteca gráfica de visualização Visualization ToolKit (VTK), que possui definição extremamente pobre da topologia dos objetos que representa. Adicionando essa nova classe e realizando sobre ela técnicas convencionais de visualização e exploração de dados, é estudada sua capacidade de apoiar todas as fases do processo de visualização. / Volumetric data structures are of extreme utility in various applications, and particularly in the area of Scientific Visualization. These structures are useful in two stages of the visualization process. The first one is in data representation, that is, in the organization of information associated with the values, measured or simulated, to be visualized. The other phase of the visualization data flow that needs a data structure is the exploration phase. It would be useful to have a model designed to be used both for interactive exploration and for simulation in a number of application, for example, in virtual surgery. A volumetric data structure, named Singular Half-Face (SHF) is being developed at the ICMC, that has as its main characteristic the explicit modeling of singularities present in the model, besides other essential topological elements. This dissertation aims at testing the viability of this structure in a context of visualization in data flow, by incorporating it in the Visualization ToolKit (VTK) class library, whose data structures are extremely poor in definition of the topology of the objects that they represent. By adding SHF to this library and carrying out conventional visualization and data exploration on it, we wish to study its support to all the phases of the visualization process.

<div>In this work new methodologies for measuring and monitoring nuclear decay parameters is explored. A determination of the tritium half-life by measuring the current of a betavoltaic device is presented. The benefits of this approach in exploring the possibility of time dependence of nuclear decay parameters is discussed.</div>

The purposes of this dissertation were to examine bilateral asymmetry as a factor of postactivation potentiation, examine and compare the acute effects of ballistic and non-ballistic concentric-only half-squats on squat jump performance, and compare the potentiation and temporal profiles of strong and weak subjects following potentiation protocols that included ballistic and non-ballistic concentric-only half-squats. The following are major findings of the dissertation. Squat jump performance may be acutely enhanced following ballistic concentriconly half-squats; however the changes in performance do not appear to be related to bilateral symmetry. Ballistic concentric-only half-squats acutely improve various squat jump performance variables at various time intervals; however the changes in performance are not related to the bilateral symmetry of the subject. Ballistic concentric-only half-squats produced superior acute potentiation effects with regard to jump height, peak power, and allometricallyscaled peak power as compared to non-ballistic concentric-only half-squats and a control protocol. Stronger subjects potentiated earlier and to a greater extent as compared to their weaker counterparts. This dissertation indicates that bilateral symmetry may not be considered as an underlying factor affecting postactivation potentiation. However, it is suggested that future research should continue to investigate the factors that are associated with postactivation potentiation. The findings of this dissertation also demonstrate the importance of how an individual performs a concentric-only squatting motion. By training with ballistic movements, a greater training stimulus may be achieved as compared to training with non-ballistic movements. While this dissertation discussed the acute potentiation differences between ballistic and nonballistic concentric-only half-squats, longitudinal research is needed to determine if different training effects result from each training method. This dissertation also supports that notion that stronger individuals may benefit more with regard to potentiation effects. In order to optimize performance and realize the greatest potentiation effects, it is recommended that greater levels of relative strength should be sought. It is suggested that further research is needed on the longitudinal differences in the potentiation effects an individual can realize based on their strength levels.

An integrated field, petrographic , structural , and geophysical analysis of the Panther Creek half -graben (PCHG), in east -central Idaho, was undertaken to determine its tectonic origin. Two competing theories as to the origin of the PCHG exist. One suggests that it formed as part of the TransChallis fault system (TCFS) , a system of northeast-trending normal faults, eruptive centers, and graben that formed in Middle Eocene time. The graben of this system are bounded by northeast-striking normal faults, and show evidence of syn-tectonic deposition of basin-filling volcanic strata. The other theory suggests that the PCHG may have evolved as a result of a post-Challis volcanic extension event (Late Eocene to Early Oligocene). Graben of this event are bounded by NNW-striking normal faults, and Challis volcanic strata are uniformly tilted; this evidence suggests post-volcanic basin formation. This study demonstrates that formation of the PCHG was mostly synchronous with volcanism and that there was very little post-volcanic deformation. Other conclusions of this research are 1) Rates of slip on basin-bounding faults were high, and slip was episodic. Slip occurred on both NE and NNWstriking faults, but more occurred on the NE-striking basin-bounding fault. This is consistent with the dominant NE strike of faults within the TCFS. 2) Most of the older volcanic units in the basin dip more steeply to the SE than overlying younger units , this is evidence for synvolcanic deposition . 3) There is significant hanging wall deformation in the form of folds and normal faults, particularly in the northern and southern portions of the basin . 4) Paleocurrents determined from provenance studies and imbricate fabric in exposed conglomerate beds indicate a flow direction largely to the northwest. This paleocurrent flow crosses the strike of the syn-extensional basin-filling units . 5) The composition of the clasts in the post-volcanic basin -fill deposits suggests that the thick volcanic units preserved in the basin never blanketed highlands NE, E, and SE of the basin and that the footwall of the basinbounding fault system was the main source of sediment in the basin. 6) The magnetic and bouguer gravity surveys indicate a sizable intrusion (most likely related to the nearby Casto pluton) beneath the west-central portions of the basin. The intrusion(s) may be responsible for east-plunging folds in the tuff of Castle Rock. 7) Work initiated during this study to determine the 40Ar/39Ar incremental-release mineral ages and the polarity of the tuff of Castle Rock and the tuff of Challis Creek will help determine the relationship between these two units and will precisely date basin development. However, it is clear that the basin was nearly fully formed by the end of Challis volcanism.

Early in the history of the field of nuclear science, experiments were performed to ascertain whether the half-lives of the radioactive substances being studied – isotopes then called the “radium emanation” [222Rn], “radium A” [218Po], “radium B” [214Pb], and “radium C” [214Bi] - were dependent upon any external factors. At that time, the external factors deemed most likely to affect half-life were temperature and pressure. After several experiments, designed to pick up any change in half-life in the course of changing temperature or pressure, had failed to find any significant changes, it was concluded that half-life does not depend on the physical properties of external environment. And that was the state of the field for a long time - for almost 100 years, in fact. Fairly recently, however, half-life measurements were recorded, and published, that seemed to show a change in half-life at the few percent level for certain radioactive nuclides which were exposed to extremes of temperature - thus challenging the long-held belief in the unchangeability of half-lives. In addition to half-life changes caused by temperature change, other experiments seemed to find half-life changes caused by other external influences, including the chemical environment of the decaying radioactive nuclide, and even the distance between Earth and the Sun at the time of the half-life measurement. In this study we present evidence that the initial beliefs in the immutability of radioactive half-life (with the exception of a few nuclides decaying by electron capture whose orbital electrons are involved in both the decay and also in the chemical bonding of those nuclides) is indeed correct; we have done this by performing precise half-life measurements on the β− emitter 198Au, the EC emitter 97Ru, and on the β− emitter 198Au when sited in gold(III) oxide, Au2O3, (an insulator for practical purposes). We have performed various experiments designed to detect any half-life change at the level of a few parts in 10^4 due to change in temperature, physical environment, or the Earth-Sun distance. In these experiments, we have found no significant half-life change due to any of these external factors. These results represent the most accurate demonstrations of the immutability of radioactive half-life change ever made.

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In the two novels, The God of Small Things by Arundhati Roy and Midnight’s Children by Salman Rushdie, characters show that their preconceptions and encounter with the Westerners play a big role in how they view Westerners and/or Indians who have adapted to or grown up with the Western lifestyle. Due to Roy’s family being a group of “Anglophiles” and liking the British, they see Sophie Mol being half-Indian as positive. Padma, Saleem’s partner in Rushdie’s novel, on the other hand, is less familiar with the British and therefore has problems accepting that Saleem is half-English. This difference between how the two families view the half-breeds, Sophie Mol and Saleem, can also be connected to the long history of colonialism, where Roy’s family has been trained to like the British, whilst Padma was born after India’s independence and was not trained to like the former colonists. Similarly, Chacko is being more accepted for his adaptation to English ways by his family than Aadam is by his family. However, Chacko is not accepted by the English, where he feels that he belongs, which makes both Chacko and Aadam feel “rootless” in their home culture. It is through these preconceptions and different encounters that characters view and believe that there is a difference in behaviour between the Indian and Western women, and that Westerners have a need to have higher status than the Indians. This essay shows that Indians have different views depending on their knowledge, lack of knowledge, interest or lack of faith in the West.