Approximately 34% of adolescents are overweight or obese which can be accompanied by physical, psychosocial, and economic consequences. Increasingly, pediatric overweight/obesity research has focused on Health Related Quality of Life (HRQoL) as a health outcome. This study examined differences in HRQoL across weight categories in adolescents, specifically, the sensitivity of using a general versus condition-specific measure. Further, the influence of gender was explored. Data were extracted from Wave 2 of Team Up for Healthy Living, a school-based obesity prevention program targeting adolescents in Southern Appalachia. Participants (N = 918; 50% Female; 93% Caucasian; 90% 9th graders) completed the Pediatric Quality of Life (PedsQL) Inventory (general) and PedsQL Multidimensional Fatigue Scale (condition-specific) measures as part of a larger survey. Body mass index-for-age and -sex percentiles were calculated using actual height and weight, and students were classified as underweight, healthy weight, overweight, or obese according to Centers for Disease Control and Prevention (CDC) criteria. Two 4 (weight category: underweight vs. healthy weight vs. overweight vs. obese) x 2 (gender: male vs. female) factorial analyses of variance (ANOVAs) were calculated to compare mean scores of total HRQoL (both generic and condition-specific). Additionally, 7 factorial multivariate analyses of variance (MANOVAs) were conducted with each measure’s subdomains. Fisher’s Least Significant Difference post hoc analyses were run to assess differences between groups, at a significance level of p<0.05. The current study revealed no interaction effect between total HRQoL (assessed via the generic or condition-specific measure) and weight category and gender; however, main effects were found for both weight category (assessed via a generic measure only) and gender (assessed via both generic and condition-specific measures). Additional research is needed to examine the impact of utilizing different measures and the potential role of gender as well as other factors that may influence HRQoL across weight categories. These issues are important as researchers to date utilize a variety of HRQoL measures making interpretation of findings difficult and often do not consider other variables such as gender that may influence findings.

Suicidal behavior, including ideation and attempts, is a significant public health problem. Due to the complexity of suicidal behavior, it is necessary to consider an array of factors that could serve as risk and protective factors. Previous research has shown that deficits in social problemsolving ability are associated with increased risk for suicidal ideation and attempts; conversely, problem solving strengths are associated with reduced risk. This dissertation project, consisting of 3 individual manuscripts, was designed to explore the relationship between social problemsolving ability and suicidal behavior in low-income primary care patients. Furthermore, additional constructs including health related quality of life, interpersonal needs, neuroticism, and hopelessness were also explored as they related to social problem solving and suicidal behavior. In a sample of 220 primary care patients ages 19-79 (M = 44.08; SD = 12.11), we examined the following: 1) health related quality of life as a mediator of the relationship between social problem solving and suicidal behavior, 2) interpersonal needs as a mediator of the relationship between social problem solving and suicidal behavior, and 3) the potential mediating role of hopelessness on the relation between neuroticism and suicidal behavior and the moderating role of social problem-solving ability on these associations. Participants completed self-report questionnaires including the Social Problem Solving Inventory-Revised-Short Form, Suicidal Behaviors Questionnaire-Revised, Short-Form 36, Interpersonal Needs Questionnaire, NEO-Five Factor Inventory, and the Beck Hopelessness Scale. Scores were analyzed using bootstrapped mediation and moderated mediation techniques. In Manuscript 1 mediating effects were found for mental health related quality of life. In Manuscript 2 thwarted belongingness and perceived burdensomeness mediated the relationship between social problem solving and suicidal behavior. Finally, in Manuscript 3 there was a significant indirect effect of neuroticism on suicidal behavior through hopelessness, and this indirect effect was moderated by social problem-solving ability. Our findings indicate that social problem-solving ability serves as both a risk and protective factor for suicidal behavior and impacts other variables that influence suicide risk among primary care patients. Interventions that bolster social problem-solving ability may reduce suicide risk in primary care.

Suicide is a public health problem and complex relationships exist between intrapersonal suicide risk factors and interpersonal risk factors. Health-related quality of life (HRQL) may interact with difficulties with interpersonal relationships and psychopathology. We examined thwarted interpersonal needs and depressive symptoms as potential mediators on the association between HRQL and suicidal behaviors. It was hypothesized that thwarted interpersonal needs would mediate the association between HRQL and suicidal behavior, and that this mediating effect would be dependent on the moderating effect of depressive symptoms. It was hypothesized that thwarted interpersonal needs and then depressive symptoms would sequentially mediate the association between HRQL and suicidal behavior. The mediating roles of thwarted belongingness and perceived burdensomeness on the association between HRQL and suicidal behaviors were supported. Moderated-mediation results were not significant. Serial mediations analyses were partially supported. Our findings suggest the importance of considering both interand intrapersonal factors on suicidal behavior.

Background: Health-related quality of life (HRQoL) has been recognized as an important target and health outcome in obesity research. The current study aimed to examine HRQoL in overweight or obese children after a 10-week primary-care–based weight management program, Parent-Led Activity and Nutrition for Healthy Living, in southern Appalachia. Methods: Sixty-seven children (ages 5–12 years) and their caregivers were recruited from four primary care clinics, two of which were randomized to receive the intervention. Caregivers in the intervention groups received two brief motivational interviewing visits and four group sessions led by providers as well as four phone follow-ups with research staff. Caregivers completed the PedsQL and demographic questionnaires at baseline and at 3, 6, and 12 months postintervention. Child height and weight were collected to determine standardized BMI. Results: Caregivers of children receiving the weight control intervention reported no statistically significant improvements in child total HRQoL, as compared to the control group, across the course of treatment (β=0.178; 95% confidence interval, −0.681, 1.037; p=0.687). Additionally, no statistically significant improvements were found across other HRQoL domains. Conclusions: Future studies examining HRQoL outcomes in primary care may consider treatment dose as well as methodological factors, such as utilization of multiple informants and different measures, when designing studies and interpreting outcomes.

Obesity is a serious health problem that leads to several chronic diseases and premature deaths. TheIn this project,was used to evaluate the effectiveness of the the Weigh Forward (WF) program, a 10-week weight-loss program administered in retail clinics, was evaluated, and it is provided in retails stores. The project analysis was completed on a limited data set on The population consisted of 15 obese participantsmembers of the program, 18 years and above, at 13 dispersed clinics in Maryland and Virginia.in the WF program from 13 dispersed clinics in Maryland and VirgiObesity is a body mass index (BMI) > 30 kg/m2. Participants were 18 years and above The theory of planned behavior (TPB) was used as the framework from which to view the project. The project was usedpurpose was to determine the efficacy of the WF program for weight reduction by comparing the baseline body mass index (BMI) and the waist circumference (WC) to the BMI and WC at the end of the program. Descriptive The aanalysis was done using correlation coefficient on the 15 participants,, who completed the 10-week WF program. The result, showed the mean and mode for BMI reduction to be 2 kg/m2, and the mean and mode for the WC reduction was 3 inches. The percentage weight loss varied from 3-11%, with the completion rate for the enrolled participants at 29%. Thise study has implications for the social change because the findings support intensive behavioral modification as an effective approach to weight loss. The study can help healthcare providers appreciate the is the need to complete preventive care assessment on patients, identify patients with obesity, and provide these patients with the requisite information on the need to lose weight. Also, the clinicians provide the patients with information and available resources to enable help them lose weight. The mean and mode of 2 kg/m2 for BMI reduction, and 3 inches for the reduction in WC at the end of 10 weeks, showed that the WF program was effective for weight loss because the participants lost significant amount of weight. The findings from the project can guide the development of practice guidelines for administering the WF program in the retail clinic.

Postpartum depression (PPD) is a significant public health issue. Up to 20% of women are affected by depression following childbirth. PPD is associated with anxiety, poor adjustment and health-related quality of life (HRQOL), and may lead to a woman's personal suffering, conflict with family members (especially in the relationship with partner) and developmental delays in children. Given the high prevalence of PPD and deleterious effects on both women and their families, adequate treatment is critical. While existing PPD treatments have strong efficacy data, the treatment literature suggests that many depressed postpartum women either do not receive treatment or receive suboptimal care. Further, barriers to care including medication side effects for breastfeeding women, stigma, and treatment preferences influence treatment decision-making. Thus, it may be worthwhile to examine the efficacy of a complementary and alternative medicine (CAM) treatment option for PPD that is associated with minimal risk and consistent with maternal preferences. The current investigation examined the efficacy of a Gentle Vinyasa Flow yoga intervention for PPD. Fifty-seven postpartum women with a score of ≥12 on the Hamilton Depression Rating Scale (HDRS) were randomly assigned to 1 of 2 groups − yoga n = 28) or wait-list control (WLC) ((italic)n(/italic) = 29). The yoga intervention lasted 8 weeks, and consisted of 16 classes taught by a certified yoga instructor in a studio and the recommendation to practice once a week at home with the use of a DVD that included a 30 minute yoga sequence. The primary outcome, depression, was assessed using the clinician-rated HDRS and self-report measures. The HDRS was administered over the telephone by blinded raters at baseline and after 2, 4, 6, and 8 weeks of treatment. Secondary outcomes were anxiety, postpartum adjustment, and HRQOL, with exploratory outcomes including mindfulness and physical activity. These outcomes were assessed using self-report measures completed on the same schedule as that for the HDRS. Growth curve modeling was used to test the hypotheses that women in the yoga group would experience a significantly greater rate of change over the course of the 8-week intervention on primary and secondary outcome measures, relative to the WLC group. As predicted, controlling for age and social anxiety at baseline, women in the yoga group experienced a greater rate of change in depression and well-being scores over the course of the 8-week intervention. The yoga group also experienced a significantly greater rate of improvement on scores of anxiety, postpartum adjustment, HRQOL, and mindfulness over the 8-week intervention, relative to the control group. These findings support yoga as a promising CAM intervention for PPD; large-scale replication studies are warranted. The findings also shed light on potential mediator and intervention-relevant variables for future research. Yoga is an acceptable and low-risk treatment option that may have broader clinical implications for the PPD treatment literature, and the field of CAM more generally.

Polycystic ovary syndrome (PCOS) is a chronic illness that affects approximately five million premenopausal women in the United States and is associated with significant cosmetic, reproductive, metabolic, and psychological consequences. Despite its prevalence, few studies have explored the lived experiences and illness perceptions of women living with PCOS. Identifying illness perceptions of women living with (WLW) PCOS is important, because mounting research suggests that a person's perceptions of their chronic illness and its management determine that person's coping behaviors (e.g., adherence, self-management) and, consequently, illness outcomes. In this dissertation, the Common Sense Model (CSM) is used as a framework to identify the illness perceptions of PCOS held by WLW the syndrome. As such, this dissertation is the first to test the ecological validity of the CSM in a population of women diagnosed with PCOS. In addition, the relationship between illness perceptions and (1) infertility, a common symptom of the syndrome, and (2) health-related quality of life (HRQoL) is explored. Lastly, this study makes a novel contribution to the literature by describing one of the first samples of WLW PCOS recruited through a social networking site. This includes a discussion of the participant's demographic information, fertility experiences, and HRQoL. This is a two-phase mixed methods study. Phase one consisted of an online quantitative survey capturing data on 376 participants' demographic information and medical history. Data were also collected on each participant's HRQoL using the SF-36, a generic, well-validated measure of the phenomenon. Of the 376 survey participants, 34 were interviewed via phone or video chat in the fall 2013 and spring 2014 semesters. Quantitative data were downloaded from Qualtrics® and analyzed using SAS statistical software version 9.3. In this analysis, descriptive statistics were generated to describe sample characteristics and SF-36 domain scores were calculated for each participant. In the qualitative analysis, data were analyzed through a series of sorting techniques and transcripts were imported into NVivo 10 and subjected to content analysis. The mean age of survey participants was 31.8 years (SD=5.8). Respondents were primarily non-Hispanic (92.5%), white (88.3%), straight (94.4%), and married (73.4%) with a college education (64.1%). On average, participants reported living with PCOS for 7.6 years (SD=6.1). Approximately half of the sample reported having biological children (47.9%) and currently trying to conceive (42.1%), and most participants reported a history of infertility (70.7%). In addition, almost half of the total sample reported heights and weights that placed them in the morbidly obese category (BMI>35). Lastly, a history of depression (63.6%) and anxiety (68.6%) was common among participants. Few survey participants reported their general health as being excellent (2.6%) or very good (27.4%). Similarly, women reported the lowest levels of functioning on the dimension of vitality, meaning that, in general, women reported feeling tired and being low in energy. Conversely, women reported the highest scores on the dimensions of physical functioning and role limitations due to physical health, meaning that, in general, women did not report that their health limited their physical abilities or caused problems with work or other daily activities. Interview findings suggest that WLW PCOS generally have illness perceptions of the syndrome that are consistent with the domains identified in the CSM. In addition, it was found that, in relation to their illness cognitions, WLW PCOS described the extent to which they felt they had a comprehensive understanding of the syndrome, a phenomenon labeled illness coherence. Similarly, participants identified PCOS as a common condition (i.e. labeled perceived prevalence). Lastly, a number of relationships were identified between illness perceptions and (1) infertility status and (2) HRQoL scores. Overall, this dissertation identifies a number of implications for patient education, provider education, clinical practice, and policy improvements. Examples include addressing (1) unmet information needs, (2) significant psychological morbidity and unmet mental health needs, (3) breastfeeding challenges and need for breastfeeding support, (4) poor quality of care and low patient satisfaction, and (5) limited access to care - all among women living with PCOS.

Fatigue secondary to chronic illness (FSCI) is a common experience in individuals with chronic conditions, with fatigue impacting on performance of daily activities and health-related quality of life (HRQoL). Due to the higher prevalence of FSCI in women, they may experience even greater disruption to roles and activity engagement. The literature consistently points to three main aspects when defining fatigue regardless of diagnoses; a physical aspect, a psychological aspect, and the impact on activity and participation. Research into the first two aspects has demonstrated relationships between fatigue, pain, depression, and social support. However, examination of the third aspect has been largely overlooked with respect its relationship to, and impact on, fatigue. Leisure theorists have hypothesized that engagement in leisure activities makes a positive contribution to physical and mental health. Previous research has measured leisure activities based on frequency of, or satisfaction with, participation. While some research has shown that physical and social activities have positive health benefits, gaps still exist in understanding the relative contribution of different types of leisure participation to fatigue and HRQoL.For example, little research has examined the contributions of leisure participation and leisure satisfaction to HRQoL and fatigue in women with chronic conditions. One explanation for the lack of research may be the absence of measurement tools developed to classify and quantify participation in different types of leisure activities for women with FSCI. Without a measurement tool, the relative contribution of participation in different activities (by frequency and/or satisfaction) to fatigue and HRQoL cannot be examined. / This PhD research aimed to fill the current gaps in understanding different types of leisure participation in related to fatigue and HRQoL. It sought to address two component parts: development and testing of the Classification of Leisure Participation (CLP) Scale; and an examination of the contribution of leisure participation to fatigue and HRQoL in women with FSCI.

Until recently, long-term effects of a critical illness (CI) have received little attention from intensive care staff, who have traditionally measured outcome from an intensive care unit (ICU) by morbidity and mortality. However, it is now acknowledged that CI is a continuum that begins before ICU and continues to impact on a patient�s quality of life after they have been discharged home. Measuring health related quality of life (HRQOL) is a complex matter due to its multifaceted, subjective and dynamic nature. There has been a lack of consensus in the literature regarding the most appropriate methodological approaches and measuring instruments to use. This disparity has impeded comparison between studies. The aim of this thesis was to review the literature between January 1998 and December 2003 that focused on HRQOL for patients after a CI to identify and summarise themes and key outcomes. There were two main areas of focus - the methods used to measure the effects of the CI, and evaluation of the patient outcomes. An electronic search for relevant articles was conducted using the common clinical research databases and key words such as health related quality of life, outcomes and critical illness. Reference lists from these articles and conference proceedings were reviewed to identify further studies. There were 74 primary papers identified that reflected a number of subcategories including general ICU, Acute Respiratory Distress Syndrome (ARDS), and elderly patients. There were four categories of instruments used in the literature including those that measured acuity of illness, physical functioning, psychological functioning and HRQOL. The majority of studies used more than one measuring instrument, most of which had been previously validated. Results from the studies were diverse, but it is apparent that physical and psychological recovery from a CI may be a slow and varied process. Most studies were observational; only one randomised control study examined the benefits of a physical exercise program for patients post-hospital discharge. In general, there was no evidence of how to translate the study findings into some form of structured program to assist the patient with any identified problems. To enhance continuum of care, integration of ICU, hospital and rehabilitation services could target identified physical and psychological problems to assist patient recovery. However, strong evidence on the benefits of initiatives such as inpatient follow-up, outpatient clinics and use of ICU diaries is yet to be demonstrated.

<p>”Bara du har hälsan är allting bra.” Stämmer detta? Hälsa har länge betraktats som avsaknad av ohälsa, men inkluderar i dag begreppet livskvalitet. Nöjdhet med livet består av många komponenter, tre som nämns ofta är ekonomi, sysselsättning och det sociala livet. Denna studie ämnar utröna hur sambanden ser ut mellan hälsa och nöjdhetsområdena ekonomi, sysselsättning samt det sociala livet. En enkätstudie utfördes på 98 studenter som skattade sin hälsa och nöjdhet. Studien fann låga samband förutom att hälsa korrelerade starkt med nöjdheten med det sociala livet. Studenter som har ett förhållande visade ett högre samband mellan hälsa och nöjdhet än singlar. Denna studie visade att hälsan är nödvändig men inte avgörande för studentens nöjdhet.</p>