Background: Despite previous research and guidelines on how nurses and health care workers should work to reduce the risk of spread hospital acquired infection, there is still many patients in somatic care who get affected by this. Patients will be treated longer in hospitals and provides extra costs for the hospitals and the relationship between nurses and patients’ also get affected. Aim: To describe the nurse's experience of caring for patients with hospital acquired infection in closed care. Method: Literature study with qualitative articles. Results: The results showed two themes, the care relationship to the patient and the external environment. These themes describe how the nurses caring towards the patient and how the nurses experienced obstacles as fear and ignorance while it also showed that the possibilities for diligent care. The nurses wanted to give the best care, even though the patients were affected by a hospital acquired infection. The external environment revealed that increased workload and time contributed to the care relationship, both negative and positive. Conclusion: The nurses' experiences of caring for patients with hospital acquired infections, can lead to improving and maintaining good care for the patients. The hope is to reduce the number of patients to get affected and to influence the nurses' working environment in a more pleasant context.